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Design and synthesis of novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators

RSC Med. Chem., 2024, 15,3800-3816
DOI: 10.1039/D4MD00585F, Research Article
Marwa Abdel-Motaal, Dalal Ali Aldakhili, Ayman B. Farag, Ayman Abo Elmaaty, Marwa Sharaky, Nadia A. Mohamed, Saad Shaaban, Abdullah Yahya Abdullah Alzahrani, Ahmed A. Al-Karmalawy
Novel multi-target tetrabromophthalimides as CBS and Topo-II inhibitors and DNA intercalators.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Metro Rail services to be extended to Medchal and other parts of northern Hyderabad under Phase-III: Telangana CM




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Sharandeep grinds out a half-century on a slow-moving opening day

The Jharkhand opener exhibits ample patience and a tight defence




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Kunnummal, Akshay score resolute half-centuries

Kerala ends the opening day against the home team Haryana at 138 for two with pacer Kamboj claiming both the wickets to fall




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Sharandeep grinds out a half-century on a slow-moving opening day

The opener exhibits ample patience and a tight defence as Jharkhand reached 136 for three in the 55 overs that were possible after the start of play was delayed by two hours




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FIR against Hinduvta activist Puneeth Kerehalli




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L-G approves proposal to deploy former bus marshals on anti-pollution duties




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Lanthanum-doped nickel-based composite metal oxide catalyst for hydrogenation of isophthalonitrile to produce meta-xylenediamine

Catal. Sci. Technol., 2024, Advance Article
DOI: 10.1039/D4CY00802B, Paper
Heng Shao, Jing Guo, Rulong Li, Dekun Ji, Long Huang, Haibin Chu
Lanthanum-doped nickel-based composite metal oxide catalysts exhibited excellent activity in IPN hydrogenation reactions with remarkable stability in fixed-bed reactors.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Sri Kanaka Mahalakshmi temple hundi collection crosses ₹39 lakh in 63 days in Visakhapatnam




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BluSmart achieves 77% GMV growth in first half of FY25

BluSmart’s GMV has grown multifold over 2 years, with GMV in October 2022 at over ₹4 crore, now surging to over ₹55 crore in October 2024




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Mid-market GCCs make up almost half of India’s GCC ecosystem

As of September 2024, there are over 800 mid-market GCCs in India collectively employing more than 2.2 lakh professionals




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Delicious Food The Mughal Emperors Ate

The range of food at banquets at the Mughal court consisted of delicacies that commoners could not ever dream of.




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DNA TV Show: Arsh Dalla, Khalistani terrorist, arrested in Canada

He also had a connection with Khalistani terrorist Hardeep Singh Nijjar, who was killed in a gang war last year.




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Halloween and Spiritual Warfare

On this episode, Fr. Barnabas welcomes Fr. Lawrence Farley, author of the Bible Study Companion series and teacher on the Coffee Cup Commentaries. They discuss demons, demonology, and Halloween.




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Un avance hacia medicamentos y vacunas inhalables de ARNm

A la mayoria de la gente no le gusta aplicarse vacunas o inyecciones para recibir tratamientos. Por eso, los investigadores trabajan para crear mas medicamentos, como los que se fabrican a partir de ARN mensajero (ARNm), que puedan pulverizarse e inhalarse. Un estudio publicado en la revista Journal of the American Chemical Society informa sobre los avances para hacer posible los medicamentos de ARNm inhalables. Los investigadores indican que la nanoparticula de polimero lipidico, que es estable cuando se nebuliza y libera aerosoles (gotitas liquidas) en los pulmones de ratones de forma satisfactoria, se optimizo para contener el ARNm.




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OSCE Mission to Bosnia and Herzegovina’s youth summits challenge stereotypes and promote tolerance to counter violent extremism

Some 100 high school students, pedagogues and psychologists from across Bosnia and Herzegovina (BiH) took part in two youth summits in Teslić and Vogosća this week co-hosted by the OSCE Mission to BiH and the BiH Security Ministry ...




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Shale and pyrite Re-Os ages from the Hornby Bay and Amundsen basins provide new chronological markers for Mesoproterozoic stratigraphic successions of northern Canada

Rainbird, R H; Rooney, A D; Creaser, R A; Skulski, T. Earth and Planetary Science Letters vol. 548, 116492, 2020 p. 1-10, https://doi.org/10.1016/j.epsl.2020.116492
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20200341.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20200341.jpg" title="Earth and Planetary Science Letters vol. 548, 116492, 2020 p. 1-10, https://doi.org/10.1016/j.epsl.2020.116492" height="150" border="1" /></a>




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Organic geochemical data from northern Canada. Part II: biomarkers in organic extracts from Devonian black shales (Horn River Group and basal Imperial Formation), Norman Wells area, Northwest Territories

Jiang, C; Obermajer, M; Kabanov, P; Mort, A. Geological Survey of Canada, Open File 8663, 2020, 7 pages, https://doi.org/10.4095/321479
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/of8663.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/of8663.jpg" title="Geological Survey of Canada, Open File 8663, 2020, 7 pages, https://doi.org/10.4095/321479" height="150" border="1" /></a>




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Transient Permian-Triassic euxinia in the southern Panthalassa deep ocean

Grasby, S E; Bond, D P G; Wignall, P B; Yin, R; Strachan, L J; Takahashi, S. Geology vol. 49, no. 8, 2021 p. 889-893, https://doi.org/10.1130/G48928.1
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20210010.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20210010.jpg" title="Geology vol. 49, no. 8, 2021 p. 889-893, https://doi.org/10.1130/G48928.1" height="150" border="1" /></a>




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Magma-shale interaction in large igneous provinces: implications for climate warming and sulphide genesis

Deegan, F M; Bédard, J H; Grasby, S E; Dewing, K; Geiger, H; Misiti, V; Capriolo, M; Callegaro, S; Svensen, H H; Yakymchuk, C; Aradi, L E; Freda, C; Troll, V R. Journal of Petrology vol. 63, 2022 p. 1-10, https://doi.org/10.1093/petrology/egac094
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20220242.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20220242.jpg" title="Journal of Petrology vol. 63, 2022 p. 1-10, https://doi.org/10.1093/petrology/egac094" height="150" border="1" /></a>




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Magnetic and gravity models, northern half of the Taltson Magmatic Zone, Rae Craton, Northwest Territories: insights into upper crustal structure

Thomas, M D. Geological Survey of Canada, Current Research (Online) 2022-1, 2022, 22 pages, https://doi.org/10.4095/328244
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/gid_328244.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/gid_328244.jpg" title="Geological Survey of Canada, Current Research (Online) 2022-1, 2022, 22 pages, https://doi.org/10.4095/328244" height="150" border="1" /></a>




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Highly fractionated Hg isotope evidence for dynamic euxinia in shallow waters of the Mesoproterozoic ocean

Wu, Y; Tian, H; Yin, R; Chen, D; Grasby, S E; Shen, J; Li, T; Ju, S; Peng, P. Earth and Planetary Science Letters 616, 118211, 2023 p. 1-9, https://doi.org/10.1016/j.epsl.2023.118211
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20230261.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20230261.jpg" title="Earth and Planetary Science Letters 616, 118211, 2023 p. 1-9, https://doi.org/10.1016/j.epsl.2023.118211" height="150" border="1" /></a>




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Climax in Wrangellia LIP activity coincident with major Middle Carnian (Late Triassic) climate and biotic changes: mercury isotope evidence from the Panthalassa pelagic domain

Jin, X; Tomimatsu, Y; Yin, R; Onoue, T; Franceschi, M; Grasby, S E; Du, Y; Rigo, M. Earth and Planetary Science Letters vol. 607, 118075, 2023 p. 1-10, https://doi.org/10.1016/j.epsl.2023.118075
<a href="https://geoscan.nrcan.gc.ca/images/geoscan/20220607.jpg"><img src="https://geoscan.nrcan.gc.ca/images/geoscan/20220607.jpg" title="Earth and Planetary Science Letters vol. 607, 118075, 2023 p. 1-10, https://doi.org/10.1016/j.epsl.2023.118075" height="150" border="1" /></a>




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UPS: After a challenging 18-month period, our company returned to revenue and profit growth

UPS today announced third-quarter 2024 consolidated revenues of $22.2 billion, a 5.6% increase from the third quarter of 2023.




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SingPost: Our first-half results demonstrate the resilience across our businesses

Singapore Post Limited (SingPost) has announced its results for the first half ended 30 September 2024. Group revenue rose by 20.0% YoY to S$992.4 million from S$827.3 million, and net profit increased by 65.5% YoY to S$22.2 million.




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“Air freight users should be prepared for long-term challenges caused by economic uncertainties”

The Q2 2024 results for the DHL Hong Kong Air Trade Leading Index (DTI) have been published.




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African Elephants Face Severe Decline Over Past Half-Century

A groundbreaking study released today reveals the alarming state of African elephant populations over the last 50 years. Both forest and savanna elephant species have experienced widespread declines due to overexploitation and habitat loss, mirroring the global trend affecting large-bodied animals.




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An Advance Toward Inhalable mRNA Medications, Vaccines

A study in the Journal of the American Chemical Society reports steps toward making inhalable mRNA medicines a possibility. Researchers outline their improved lipid-polymer nanoparticle for holding mRNA that is stable when nebulized and successfully delivers aerosols (liquid droplets) in mice's lungs.




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New Research Highlights Potential Role of the Thalamus in Complex Reasoning




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MITCH MALLOY опубликовал демо VAN HALEN

Вокалист Mitch Malloy (ex-GREAT WHITE) опубликовал демо песни "It's The Right Time". Эта композиция была написана им вместе с Эдди Ван Халеном в середине 90-ых, когда он стал первым кандидатом на вакантное место вокалиста группы после ухода с этого поста Sammy Hagar'a:

«Я должен быть в состоянии пожинать плоды своего искусства, над совершенствованием которого я работал всю свою жизнь Какой человек не получает повышения за свои достижения? В Америке так и должно быть. Вместо того, чтобы получить признание как первый выбор Van Halen на место Sam'а, мне остается только отстаивать себя. Это неправильно и несправедливо по отношению ко мне. И я в некотором роде зол. Любой другой не справился бы с этим так хорошо, как я. Эд сказал мне об этом, когда я видел его в последний раз. Я просто хотел бы, чтобы в конце концов он рассказал прессе правду, чтобы мне не пришлось это делать. Я бы хотел, чтобы никто не знал, если честно. Но раз уж они знают, то должны услышать результат. Вот он».
#Van_Halen #VanHalen #HardRock #Hard_Rock
Видео: https://www.youtube.com/watch?v=nMi9SdwbD3o




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Daniel Khalife denies asking Iran for help after prison escape

The former soldier has pleaded guilty to escaping from prison but still faces other charges.




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Kids challenged to share the gospel

The AIDS Hope team encourages children in their afterschool program in Mamelodi to share the gospel with the community.




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“What shall I do with Buddha now?”

A Discipleship centre student from an unreached people group meets a girl with the same ethnic background and tells to her about salvation.




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Challenged to take the walk

OM Philippines completes their annual mission training and exposure programme in the tribal areas of Palawan, Philippines.




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Challenged to think differently

Six young people joined STEP OUT 2014 and an outreach in the Philippines to challenge their comfort zones, and they were not disappointed.




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Challenging the culture

“God is working in this community,” James said. He and other Christians in his village are challenging the culture by living their lives for Christ.




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Lifehope Transit Challenge: God’s heart for Europe

OM Lifehope coordinates the Transit Challenge, sending out teams all over Europe to love, serve and proclaim Christ.




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Retirement challenge

A Canadian couple spends two of their retirement years with OM in Italy, learning that it’s never too late to change the world around them.




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'Crazy, inspiring and challenging'

During their visits in Serbia, Moldova and Montenegro the two MDT Love Europe teams had many experiences, as well as opportunities to share God’s love.




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Challenging the traditional concept of missions

Historically, the Netherlands has sent missionaries around the world to share about Jesus. Now, the Netherlands is a mission field.




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The joy of Jesus despite challenges

An OM worker in Bosnia shares how the enduring faith of two elderly women of God has inspired her to also persevere to the end.




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Challenged to live a healthy life

OM team members in El Salvador reach out to young people in their country, challenging them to live a healthy life.




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3 Major Omnichannel Challenges Today

Fraud, privacy, and tracking the customer journey will continue to be key issues for marketers doing omnichannel.




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‘Mahavatar’: Vicky Kaushal looks fierce as Parashurama in Amar Kaushik’s next

Produced by Maddock Films, the action epic will release in theatres on Christmas, 2026 




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Shivarajkumar in talks to star in Vijay’s ‘Thalapathy 69’

Shivarajkumar, who will next be seen in ‘Bhairathi Ranagal’, said that the makers of Vijay’s ‘Thalapathy 69’ has approached him with an interesting character





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Indian-American Nikki Haley Likely To Be U.S. Secretary Of State

Indian American Governor Nikki Haley is one of the contenders for Secretary of State or other cabinet positions in the Donald Trump administration, according to media reports on Wednesday.




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BITS Pilani Opens the Registration for its International Startup Challenge

Conquest, BITS Pilani�s International Startup Conclave, has once again gathered center-stage attraction as the registrations are finally open for the long awaited event.




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Arunachal Pradesh Lottery Singam Pinnacle Noon Winners 13 November - Full Results And Prizes

Arunachal Pradesh Lottery Singam Pinnacle Noon Winners 13 November. Discover the latest results and winning ticket numbers.




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Arunachal Pradesh Lottery Singam Pinnacle Evening Winners 13 November - Full Results And Prize Details

Arunachal Pradesh Lottery Singam Pinnacle Evening Winners 13 November. Discover the prize details and winning ticket numbers here.