dementia

Resilience and wellbeing in people living with dementia in relation to perceived attitudes in their communities

This is a paper produced as part of the PROP2 (Practitioner Research: Outcomes and Partnership) programme, a partnership between the Centre for Research on Families and Relationships (CRFR) at the University of Edinburgh and Iriss that was about health and social care in Scotland. This paper was written by Geraldine Ditta from Alzheimer Scotland who participated in the PROP2 programme. People living with dementia are at risk of becoming socially isolated and disconnected from their local communities. Reactions from others on being told someone has dementia can have a significant impact on the person with dementia’s sense of self. This study sought to explore the perceptions of people with dementia in relation to attitudes within their communities and how they subsequently respond. Semi-structured interviews were carried out to examine how they feel about their lives with dementia.




dementia

Can yoga create calm in people with dementia?

This is a paper produced as part of the PROP2 (Practitioner Research: Outcomes and Partnership) programme, a partnership between the Centre for Research on Families and Relationships (CRFR) at the University of Edinburgh and Iriss that was about health and social care in Scotland. This paper was written by Sarah Duff from Alzheimer Scotland who participated in the PROP2 programme and is a research study exploring the experience of group yoga classes and music with those affected by dementia




dementia

Dementia Services Development Centre (DSDC)

The Dementia Services Development Centre (DSDC) draws on research and practice, from across the world, to provide a comprehensive, up-to-date resource on all aspects of dementia.




dementia

Rethinking Respite for People Affected by Dementia

The ‘Dementia: More Than Just Memory Loss’ report, was published in 2016, and set out some of the key issues affecting people with dementia in Wales, in particular: • A widespread lack of knowledge and understanding of dementia amongst professionals and the wider public. • A lack of flexibility to effectively meet the needs of people living with dementia and their carers. • A lack of co-operation between services creates unnecessary difficulties and barriers for people living with dementia and their carers. The authors of the report called for a range of actions to address this, and there has been some progress, however, despite a range of changes across society at a policy, practice and community level, there is still a long way to go to transform services and drive the cultural change needed to effectively meet the needs of people affected by dementia.  The author of this report has consistently focused on the importance of meaningful outcomes for people with dementia and their carers, to ensure that their lives have value, meaning and purpose. This is fundamental to ‘Rethinking Respite’ and to delivering the Welsh Government’s vision of ‘a dementia friendly nation that recognises the rights of people with dementia to feel valued and to live as independently as possible in their communities as outlined in the new Dementia Action Plan for Wales. 




dementia

Understanding and Responding to the Needs of Carers of People with Dementia in the UK, US and Beyond

This research compares the different approaches to supporting carers of people with dementia across the UK, US and beyond.  Carried out by the University of Birmingham, this work explores the role and experience of carers in different national contexts, highlighting good practice examples and making policy and practice recommendations.  Unsurprisingly perhaps, the report highlights just how much we have in common with other countries in trying to make available effective, personalised supports against a backdrop of increased demand and diminishing resource.  Interestingly, the report explores the language of ‘respite’ which it suggests has ‘negative overtones’ and proposes a more creative approache to service provision is needed.





dementia

Type 2 Diabetes, Cognition, and Dementia in Older Adults: Toward a Precision Health Approach

Brenna Cholerton
Nov 1, 2016; 29:210-219
From Research to Practice




dementia

Confirmation of 123I-FP-CIT-SPECT (ioflupane) quantification methods in dementia with Lewy body and other neurodegenerative disorders

Rationale: To conduct a retrospective study comparing three 123I-FP-CIT-SPECT quantitative methods in patients with neurodegenerative syndromes as referenced to neuropathological findings. Methods: 123I-FP-CIT-SPECT and neuropathological findings among patients with neurodegenerative syndromes from the Mayo Alzheimer's Disease Research Center and Mayo Clinic Study of Aging were examined. Three 123I-FP-CIT-SPECT quantitative assessment Methods: MIMneuro (MIM Software Inc.), DaTQUANT (GE Healthcare), and manual region of interest (ROI) creation on an Advantage Workstation (GE Healthcare) were compared to neuropathological findings describing the presence or absence of Lewy body disease (LBD). Striatum to background ratios (SBRs) generated by DaTQUANT were compared to the calculated SBRs of the manual method and MIMneuro. The left and right SBRs for caudate, putamen and striatum were evaluated with the manual method. For DaTQUANT and MIMneuro the left, right, total and average SBRs and z-scores for whole striatum, caudate, putamen, anterior putamen, and posterior putamen were calculated. Results: The cohort included 24 patients [20 (83%) male, aged 75.4 +/- 10.0 at death]. The antemortem clinical diagnoses were Alzheimer’s disease dementia (ADem, N = 6), probable dementia with Lewy bodies (pDLB, N = 12), mixed ADem/pDLB (N = 1), Parkinson’s disease with mild cognitive impairment (N = 2), corticobasal syndrome (N = 1), idiopathic rapid eye movement sleep behavior disorder (iRBD) (N = 1) and behavioral variant frontotemporal dementia (N = 1). Seventeen (71%) had LBD pathology. All three 123I-FP-CIT-SPECT quantitative methods had area under the receiver operating characteristics (AUROC) values above 0.93 and up to 1.000 (p<0.001) and showed excellent discrimination between LBD and non-LBD patients in each region assessed, p<.001. There was no significant difference between the accuracy of the regions in discriminating the two groups, with good discrimination for both caudate and putamen. Conclusion: All three 123I-FP-CIT-SPECT quantitative methods showed excellent discrimination between LBD and non-LBD patients in each region assessed, using both SBRs and z-scores.




dementia

Amyloid PET in Dementia Syndromes: A Chinese Multicenter Study

Cerebral β-amyloid deposits and regional glucose metabolism assessed by positron emission tomography (PET) are used to distinguish between Alzheimer's disease (AD) and other dementia syndromes. In the present multicenter study, we estimated the prevalence of β-amyloid deposits on PET imaging in a wide variety of dementia syndromes and mild cognitive impairment (MCI) within a memory clinic population. Methods: Of the 1193 consecutive patients with cognitive impairment (CI) who received combined 18F-AV45 and/or 11C-PIB PET, 960 were diagnosed with AD, 36 with frontotemporal dementia (FTD), 5 with dementia with Lewy bodies (DLB), 144 with MCI, 29with vascular dementia (VaD), 4 with corticobasal syndrome (CBS) and 15 with unclassifiable dementia. Baseline clinical diagnoses were independently established without access to PET imaging results. ApoE genotype analysis was performed in CI patients and 231 gender- and age-matched controls. Results: Of the 1193 CI patients, 860 (72.1%) were amyloid-positive. The prevalence of amyloid positivity in AD and MCI patients was 86.8% (833/960) and 9.7% (14/144), respectively. In FTD patients, the prevalence of β-amyloid deposits was 5.6% (2/36). In the 4 CBS patients, two were amyloid-positive. Three of the 5 DLB patients showed amyloid positivity, as did 6 of the 29 VaD (20.7%) patients. The ApoE4 allele frequency was significantly increased in amyloid-positive CI patients (30.5%) as compared with other amyloid-negative CI patients (14%) or controls (7.3%). Conclusion: Amyloid imaging may potentially be the most helpful parameter for differential diagnosis in dementia, particularly to distinguish between AD and FTD. Amyloid PET can be used in conjunction with the ApoE4 allele genetic risk test for amyloid deposits.




dementia

High density lipoprotein and its apolipoprotein-defined subspecies and risk of dementia [Patient-Oriented and Epidemiological Research]

Whether HDL is associated with dementia risk is unclear. In addition to apoA1, other apolipoproteins are found in HDL, creating subspecies of HDL that may have distinct metabolic properties. We measured apoA1, apoC3, and apoJ levels in plasma and apoA1 levels in HDL that contains or lacks apoE, apoJ, or apoC3 using a modified sandwich ELISA in a case-cohort study nested within the Ginkgo Evaluation of Memory Study. We included 995 randomly selected participants and 521 participants who developed dementia during a mean of 5.1 years of follow-up. The level of total apoA1 was not significantly related to dementia risk, regardless of the coexistence of apoC3, apoJ, or apoE. Higher levels of total plasma apoC3 were associated with better cognitive function at baseline (difference in Modified Mini-Mental State Examination scores tertile 3 vs. tertile 1: 0.60; 95% CI: 0.23, 0.98) and a lower dementia risk (adjusted hazard ratio tertile 3 vs. tertile 1: 0.73; 95% CI: 0.55, 0.96). Plasma concentrations of apoA1 in HDL and its apolipoprotein-defined subspecies were not associated with cognitive function at baseline or with the risk of dementia during follow-up. Similar studies in other populations are required to better understand the association between apoC3 and Alzheimer’s disease pathology.




dementia

Dementia prevalance in 2040

The Alzheimer’s society, in the UK, predicts that if the rates of dementia remain constant there’ll be 1.7 million people in the country living with the condition by 2050. We also know that things like improvements in cardiovascular health are changing those rates. New research published on bmj.com attempts to model what the outcomes of those...




dementia

Predictive Value of 18F-Florbetapir and 18F-FDG PET for Conversion from Mild Cognitive Impairment to Alzheimer Dementia

The present study examined the predictive values of amyloid PET, 18F-FDG PET, and nonimaging predictors (alone and in combination) for development of Alzheimer dementia (AD) in a large population of patients with mild cognitive impairment (MCI). Methods: The study included 319 patients with MCI from the Alzheimer Disease Neuroimaging Initiative database. In a derivation dataset (n = 159), the following Cox proportional-hazards models were constructed, each adjusted for age and sex: amyloid PET using 18F-florbetapir (pattern expression score of an amyloid-β AD conversion–related pattern, constructed by principle-components analysis); 18F-FDG PET (pattern expression score of a previously defined 18F-FDG–based AD conversion–related pattern, constructed by principle-components analysis); nonimaging (functional activities questionnaire, apolipoprotein E, and mini-mental state examination score); 18F-FDG PET + amyloid PET; amyloid PET + nonimaging; 18F-FDG PET + nonimaging; and amyloid PET + 18F-FDG PET + nonimaging. In a second step, the results of Cox regressions were applied to a validation dataset (n = 160) to stratify subjects according to the predicted conversion risk. Results: On the basis of the independent validation dataset, the 18F-FDG PET model yielded a significantly higher predictive value than the amyloid PET model. However, both were inferior to the nonimaging model and were significantly improved by the addition of nonimaging variables. The best prediction accuracy was reached by combining 18F-FDG PET, amyloid PET, and nonimaging variables. The combined model yielded 5-y free-of-conversion rates of 100%, 64%, and 24% for the low-, medium- and high-risk groups, respectively. Conclusion: 18F-FDG PET, amyloid PET, and nonimaging variables represent complementary predictors of conversion from MCI to AD. Especially in combination, they enable an accurate stratification of patients according to their conversion risks, which is of great interest for patient care and clinical trials.




dementia

Sex Difference in Effects of Low-Dose Aspirin on Prevention of Dementia in Patients With Type 2 Diabetes: A Long-term Follow-up Study of a Randomized Clinical Trial

OBJECTIVE

To evaluate and compare the efficacy of long-term use of low-dose aspirin for the prevention of dementia in men and women.

RESEARCH DESIGN AND METHODS

This study is a follow-up cohort study of the Japanese Primary Prevention of Atherosclerosis With Aspirin for Diabetes (JPAD) trial, which was a randomized, open-label, standard care–controlled trial examining the effects of low-dose aspirin on cardiovascular events. We followed up 2,536 Japanese patients with type 2 diabetes (T2D) enrolled in the JPAD trial from 2002 to 2017. The primary outcome of this post hoc analysis was the incidence of dementia, which was defined by the prescription of antidementia drugs or admission due to dementia.

RESULTS

Among the originally enrolled patients, 2,121 (84%) retained their original allocation. During a median follow-up of 11.4 years, 128 patients developed dementia. The overall effect of low-dose aspirin on the prevention of dementia adjusted for age, sex, and other established risk factors was not significant (hazard ratio [HR] 0.82, 95% CI 0.58–1.16). However, a significant reduction was seen in the risk of dementia in women (HR 0.58, 95% CI 0.36–0.95), but not in men (HR 1.27, 95% CI 0.75–2.13) (Pinteraction = 0.03).

CONCLUSIONS

Long-term use of low-dose aspirin may reduce the risk for dementia in women with T2D.




dementia

Dementia is different : not just another ordinary illness / Ludomyr Mykyta.

Dementia.




dementia

Live and laugh with dementia : the essential guide to maximizing quality of life / Lee-Fay Low.

Dementia -- Treatment.




dementia

Die Gehirnerweichung der Irren (Dementia paralytica) fur Aerzte und Studirende / bearbeitet von Theodor Simon.

Hamburg : Wilhelm Mauke, 1871.




dementia

Manual of Screeners for Dementia

Larner, A. J. author. aut http://id.loc.gov/vocabulary/relators/aut
9783030416362 978-3-030-41636-2




dementia

Indigenous peoples and dementia : new understandings of memory loss and memory care

9780774837835 (hardcover)




dementia

What it feels like ... to be a music detective for dementia charity Playlist for Life

Andy Lowndes, music detective for dementia charity Playlist for Life




dementia

Dementia Friendly Delaware to Support Those with Dementia, Their Families

Lt. Governor Bethany Hall-Long and the Delaware Department of Health and Social Services’ Division of Services for Aging and Adults with Physical Disabilities (DSAAPD) are hosting an event on Tuesday, April 30, in Dover to show what Dementia Friendly Delaware can offer for Delawareans living with dementia and their families. Dementia Friendly Delaware (DFD) is […]



  • Delaware Health and Social Services
  • Lt. Governor Bethany Hall-Long
  • News
  • Office of the Lieutenant Governor
  • Alzheimer's disease
  • caregivers
  • dementia
  • Dementia Friendly Delaware
  • Division of Services for Aging and Adults with Physical Disabilities

dementia

‘I don’t mind if she doesn’t know me,’ says 70-year-old Hong Kong man caring for wife with dementia

After taking care of his wife the whole day, Lam Man-hing, 70, finally has a little time to himself before bedtime.He browses the news, checks messages from friends on his smartphone and watches some television, with his wife Tang Siu-man, 74, asleep by his side.He checks on her from time to time, and keeps the TV volume low to avoid disturbing her.In the morning, like every day, she might not remember him.Tang has Alzheimer’s disease, a progressive form of dementia that begins with…




dementia

AHA News: Hearing Loss and the Connection to Alzheimer's Disease, Dementia

Title: AHA News: Hearing Loss and the Connection to Alzheimer's Disease, Dementia
Category: Health News
Created: 5/6/2020 12:00:00 AM
Last Editorial Review: 5/7/2020 12:00:00 AM




dementia

Mediterranean Diet Might Help Stave Off Dementia

Title: Mediterranean Diet Might Help Stave Off Dementia
Category: Health News
Created: 4/29/2013 4:35:00 PM
Last Editorial Review: 4/30/2013 12:00:00 AM




dementia

General Anesthesia Not Linked to Raised Risk for Dementia

Title: General Anesthesia Not Linked to Raised Risk for Dementia
Category: Health News
Created: 5/1/2013 12:35:00 PM
Last Editorial Review: 5/2/2013 12:00:00 AM




dementia

Loving, Supportive Kids May Help Lower Seniors' Dementia Risk

Title: Loving, Supportive Kids May Help Lower Seniors' Dementia Risk
Category: Health News
Created: 5/2/2017 12:00:00 AM
Last Editorial Review: 5/3/2017 12:00:00 AM




dementia

Mid-Life Stresses May Be Tied to Late-Life Dementia Risk

Title: Mid-Life Stresses May Be Tied to Late-Life Dementia Risk
Category: Health News
Created: 4/30/2018 12:00:00 AM
Last Editorial Review: 5/1/2018 12:00:00 AM




dementia

Newly Discovered Illness May Cause Nearly 1 in 5 Dementias, Experts Say

Title: Newly Discovered Illness May Cause Nearly 1 in 5 Dementias, Experts Say
Category: Health News
Created: 4/30/2019 12:00:00 AM
Last Editorial Review: 5/1/2019 12:00:00 AM




dementia

Heart Drug Combos Might Also Lower Your Dementia Risk: Study

Title: Heart Drug Combos Might Also Lower Your Dementia Risk: Study
Category: Health News
Created: 3/13/2020 12:00:00 AM
Last Editorial Review: 3/16/2020 12:00:00 AM




dementia

Study Ties Brain Inflammation to Several Types of Dementia

Title: Study Ties Brain Inflammation to Several Types of Dementia
Category: Health News
Created: 3/18/2020 12:00:00 AM
Last Editorial Review: 3/18/2020 12:00:00 AM




dementia

Daily Aspirin Won't Stop Dementia, Study Finds

Title: Daily Aspirin Won't Stop Dementia, Study Finds
Category: Health News
Created: 3/25/2020 12:00:00 AM
Last Editorial Review: 3/26/2020 12:00:00 AM




dementia

Dirty Air Might Raise Your Odds for Dementia

Title: Dirty Air Might Raise Your Odds for Dementia
Category: Health News
Created: 3/31/2020 12:00:00 AM
Last Editorial Review: 4/1/2020 12:00:00 AM




dementia

Which Foods Might Reduce Your Odds for Dementia?

Title: Which Foods Might Reduce Your Odds for Dementia?
Category: Health News
Created: 4/14/2020 12:00:00 AM
Last Editorial Review: 4/14/2020 12:00:00 AM




dementia

Levodopa-induced dyskinesia in dementia with Lewy bodies and Parkinson disease with dementia

Objective

To investigate the frequency of levodopa-induced dyskinesia in dementia with Lewy bodies (DLBs) and Parkinson disease with dementia (PDD) and compare these frequencies with patients with incident Parkinson disease (PD) through a population-based cohort study.

Methods

We identified all patients with DLB, PDD, and PD without dementia in a 1991–2010 population-based parkinsonism-incident cohort, in Olmsted County, Minnesota. We abstracted information about levodopa-induced dyskinesia. We compared patients with DLB and PDD with dyskinesia with patients with PD from the same cohort.

Results

Levodopa use and dyskinesia data were available for 141/143 (98.6%) patients with a diagnosis of either DLB or PDD; 87 (61.7%), treated with levodopa. Dyskinesia was documented in 12.6% (8 DLB and 3 PDD) of levodopa-treated patients. Among these patients, median parkinsonism diagnosis age was 74 years (range: 64–80 years); 63.6%, male. The median interval from levodopa initiation to dyskinesia onset was 2 years (range: 3 months–4 years); the median daily levodopa dosage was 600 mg (range: 50–1,600 mg). Dyskinesia severity led to levodopa adjustments in 5 patients, and all improved. Patients with dyskinesia were diagnosed with parkinsonism at a significantly younger age compared with patients without dyskinesia (p < 0.001). Levodopa dosage was unrelated to increased risk of dyskinesias among DLB and PDD. In contrast, 30.1% of levodopa-treated patients with PD developed dyskinesia. In age-, sex-, and levodopa dosage–adjusted models, Patients with DLB and PDD each had lower odds of developing dyskinesia than patients with PD (odds ratio = 0.42, 95% CI 0.21–0.88; p = 0.02).

Conclusions

The dyskinesia risk for levodopa-treated patients with DLB or PDD was substantially less than for levodopa-treated patients with PD.




dementia

Newly discovered mechanism can explain increased risk of dementia

Millions of people around the world use acid suppressants called proton pump inhibitors for conditions like heartburn, gastritis and stomach ulcers. Researchers at Karolinska Institutet in Sweden now report that how the long-term use of these drugs could increase the risk of developing dementia. Their results are published in the journal Alzheimer's & Dementia.




dementia

Care home nurse&apos;s quick-thinking helps save lives of 13 dementia patients displaying coronavirus symptoms

A care home nurse used the knowledge she gained during the swine flu outbreak to help save the lives of 13 dementia patients who were displaying symptoms of the coronavirus.





dementia

Newly discovered mechanism can explain increased risk of dementia

Millions of people around the world use acid suppressants called proton pump inhibitors for conditions like heartburn, gastritis and stomach ulcers. Researchers at Karolinska Institutet in Sweden now report that how the long-term use of these drugs could increase the risk of developing dementia. Their results are published in the journal Alzheimer's & Dementia.




dementia

Benzodiazepine, Z-Drug Use: No Dementia Risk?

A Danish study of more than 200,000 patients has concluded that individuals with affective disorders who use benzodiazepines and other anxiolytics are not at increased risk of developing dementia.
Medscape Medical News




dementia

Sweating in a sauna may delay dementia

Perhaps we should have included one in our perfect bathroom.




dementia

9 lifestyle choices to help prevent dementia

With one in 3 cases of dementia preventable, a sweeping new report identifies modifiable factors in early, mid- and late life that make a difference




dementia

11 foods linked to lower risk of Alzheimer's dementia

Researchers find an intriguing link between foods + drinks rich in flavonol and staving off dementia.




dementia

Academics and industry unite to improve dementia patients' lives

An EU-funded project has linked scientists with experts in industry to forge partnerships aimed at creating new products to improve the lives of people with dementia. The research is creating tools to help remind people with dementia to undertake the tasks critical to their daily lives.




dementia

Aspirin a Day Does Not Keep Dementia at Bay, Says Study

Daily dose of aspirin provided no benefit to study participants at either preventing dementia or slowing cognitive decline, stated study published in




dementia

How Acid Suppressants Raise the Risk of Dementia Explained

How the long-term use of proton pump inhibitors could increase the risk of developing dementia has been explained in a study published in the journal iAlzheimer's (and) Dementia/i.




dementia

Processed Meats Linked to Dementia Risk

People whose diets consisted of processed meats, potatoes, and snacks like cookies and cakes are at an increased dementia risk years later than people




dementia

Air Pollution can Put You at Risk of Dementia and Heart Disease

People continuously exposed to air pollution are at a higher risk of developing dementia and heart disease. However, the risk is even higher in people




dementia

Down Syndrome Linked to Dementia

Three in five people with Down syndrome were found to be diagnosed with dementia by age 55, revealed new study of 3,000 people in Wisconsin. Not




dementia

Dementia Study Links Gene with Damage to Brain Connections: Study

Insights into how a gene that raises the risk of Alzheimer's disease and disrupts brain cells have been revealed by a new study. The findings of the study




dementia

Midlife Hypertension Linked to Dementia Risk

High blood pressure patterns in middle age followed by low blood pressure later in life was linked to higher risk for dementia compared to having normal blood pressure, revealed new study findings.




dementia

How Acid Suppressants Raise the Risk of Dementia Explained

Millions of people around the world use acid suppressants called proton pump inhibitors for conditions like heartburn, gastritis and stomach ulcers. New research revealed how they induce dementia.