Rebecca Hall ('Vicky Christina Barcelona') stars in HBO's 'Parade's End' with Benedict Cumberbatch.

He plays a KGB spy in 'The Americans'.

Project Bike Tech offers students diverse skills and options when they leave high school.

Take your old writing instruments to Office Depot this week and earn Sanford coupons.

Incredible enzyme is capable of breaking down the PET in plastic bottles into raw materials in as little as 10 hours.

Mountain bikers wind through the misty temperate rain forest of Whistler, British Columbia, leaving stunning long-exposure light trails in their wake.

A public transportation strike in the Netherlands leads thousands of commuters to ride their bicycles instead.

Topics

In this report, authors present results that they gathered from more than 150 E&C executives who shared their experiences and strategies from the last downturn, how they focused their energy, and what key lessons they learned.

If you're wondering what could be common between a game of relay and a cyclical mutual fund, there are quite a few to state.

We show that every 4-uniform hypergraph with $n$ vertices and minimum pair degree at least $(5/9+o(1))n^2/2$ contains a tight Hamiltonian cycle. This degree condition is asymptotically optimal.

A chordless cycle, or equivalently a hole, in a graph $G$ is an induced subgraph of $G$ which is a cycle of length at least $4$. We prove that the ErdH{o}s-P'osa property holds for chordless cycles, which resolves the major open question concerning the ErdH{o}s-P'osa property. Our proof for chordless cycles is constructive: in polynomial time, one can find either $k+1$ vertex-disjoint chordless cycles, or $c_1k^2 log k+c_2$ vertices hitting every chordless cycle for some constants $c_1$ and $c_2$. It immediately implies an approximation algorithm of factor $mathcal{O}(sf{opt}log {sf opt})$ for Chordal Vertex Deletion. We complement our main result by showing that chordless cycles of length at least $ell$ for any fixed $ellge 5$ do not have the ErdH{o}s-P'osa property.

SOUTHAMPTON students are invited to go along to a bike event hosted by police tomorrow.

Starkenn Sports, which retails sport cycles under the Starkenn brand, plans to roll out its first made-in-India power cycles by August next year.

Hero Cycles plans to set up a fully owned assembly plant in Poland to cater exclusively to Europe, with special emphasis on the UK and Germany.

Hero Cycles picked up majority stake in UK-based Avocet Sports to mark entry into high-end bicycle market in Europe for an undisclosed sum.

Om Prakash Munjal Chairman Hero Cycles died at the age of 86 at Ludhiana in the Hero Heart Institute of Dayanand Medical College and hospital on Thursday morning.

We need to go greener!

Cone photoreceptors in the retina enable vision over a wide range of light intensities. However, the processes enabling cone vision in bright light (i.e. photopic vision) are not adequately understood. Chromophore regeneration of cone photopigments may require the retinal pigment epithelium (RPE) and/or retinal Müller glia. In the RPE, isomerization of all-trans-retinyl esters to 11-cis-retinol is mediated by the retinoid isomerohydrolase Rpe65. A putative alternative retinoid isomerase, dihydroceramide desaturase-1 (DES1), is expressed in RPE and Müller cells. The retinol-isomerase activities of Rpe65 and Des1 are inhibited by emixustat and fenretinide, respectively. Here, we tested the effects of these visual cycle inhibitors on immediate, early, and late phases of cone photopic vision. In zebrafish larvae raised under cyclic light conditions, fenretinide impaired late cone photopic vision, while the emixustat-treated zebrafish unexpectedly had normal vision. In contrast, emixustat-treated larvae raised under extensive dark-adaptation displayed significantly attenuated immediate photopic vision concomitant with significantly reduced 11-cis-retinaldehyde (11cRAL). Following 30 min of light, early photopic vision was recovered, despite 11cRAL levels remaining significantly reduced. Defects in immediate cone photopic vision were rescued in emixustat- or fenretinide-treated larvae following exogenous 9-cis-retinaldehyde supplementation. Genetic knockout of Des1 (degs1) or retinaldehyde-binding protein 1b (rlbp1b) did not eliminate photopic vision in zebrafish. Our findings define molecular and temporal requirements of the nonphotopic or photopic visual cycles for mediating vision in bright light.

Research Event

Event participants

Charu Lata Hogg, Associate Fellow, Asia-Pacific Programme, Chatham House
Hameed Hakimi, Research Associate, Asia-Pacific Programme and Europe Programme, Chatham House
Chair: Champa Patel, Head of Asia-Pacific Programme, Chatham House

Researcher: Jim Papadopoulos, Northeastern University
Description: Jim Papadopoulos talks about his years of research analyzing bicycles.

Lecture by Claudio Borio, Head of the Monetary and Economic Department, at the University of Zürich, Zürich, 19 November 2019.

Ride 2 Transform takes its third tour of southern Malawi for ministry and support.

EICMA 2019 is running in full swing and the past few hours have seen the unveiling of some of the most exciting and awaited motorcycles on the planet. Here we have picked the top five that will be launched in India in the coming months.

It’s the best of both worlds – matching the thrill of the open road on two wheels with the ultimate in convenience, connectivity and entertainment at your fingertips. HARMAN is pleased to work with Yamaha to help perfect this blend with the introduction...

Cone photoreceptors in the retina enable vision over a wide range of light intensities. However, the processes enabling cone vision in bright light (i.e. photopic vision) are not adequately understood. Chromophore regeneration of cone photopigments may require the retinal pigment epithelium (RPE) and/or retinal Müller glia. In the RPE, isomerization of all-trans-retinyl esters to 11-cis-retinol is mediated by the retinoid isomerohydrolase Rpe65. A putative alternative retinoid isomerase, dihydroceramide desaturase-1 (DES1), is expressed in RPE and Müller cells. The retinol-isomerase activities of Rpe65 and Des1 are inhibited by emixustat and fenretinide, respectively. Here, we tested the effects of these visual cycle inhibitors on immediate, early, and late phases of cone photopic vision. In zebrafish larvae raised under cyclic light conditions, fenretinide impaired late cone photopic vision, while the emixustat-treated zebrafish unexpectedly had normal vision. In contrast, emixustat-treated larvae raised under extensive dark-adaptation displayed significantly attenuated immediate photopic vision concomitant with significantly reduced 11-cis-retinaldehyde (11cRAL). Following 30 min of light, early photopic vision was recovered, despite 11cRAL levels remaining significantly reduced. Defects in immediate cone photopic vision were rescued in emixustat- or fenretinide-treated larvae following exogenous 9-cis-retinaldehyde supplementation. Genetic knockout of Des1 (degs1) or retinaldehyde-binding protein 1b (rlbp1b) did not eliminate photopic vision in zebrafish. Our findings define molecular and temporal requirements of the nonphotopic or photopic visual cycles for mediating vision in bright light.

Australia’s peak representative body for cyclists has called on governments to transform roads into cycleways to ease traffic on bike paths

Australian bike retailers are struggling to keep up with the boom in sales since coronavirus restrictions came into force last month.

“We’re the new toilet paper and everyone wants a piece,” Grant Kaplan, manager of Giant Sydney, a bike store in Sydney’s CBD, tells Guardian Australia.

African Union summit focuses on “silencing the guns” This week, the African Union (AU) held its 33rd annual Heads of State and Government Summit in Addis Ababa, Ethiopia. This year’s theme, "Silencing the Guns: Creating Conducive Conditions for Africa's Development,” refers to Aspiration 4 of Agenda 2063, “a peaceful and secure Africa.” Despite the AU’s…

Billions of chopsticks are thrown out each year worldwide. This Vancouver company is trying to turn some of of these into new items for the home.

Mattresses have plenty of reusable materials, but most recyclers don't want them. Landfills don't like them either. But a Tennessee nonprofit does.

This is Paris' largest mural, made with hand-folded origami paper birds and a bit of spraypaint.

...or does this augur the final breakdown of civilization?

Flying can be a divisive topic when it comes to curbing emissions, but airplanes have other environmental impacts too.

As a result of half a century of planning, Copenhagen has achieved a fabulous cycling goal - during the morning rush hour more bikes and mopeds pound the inner city streets than personal cars and buses. Just a bit more than a third of inhabitants get

Toronto, a city rated as one of the most livable in the world by The

My favorite day of the year is a shadow of its former self.

We take a tour of a sustainable factory that turns discarded glass into durable building materials.

After the beautiful Xylophone of the Forest I shared with you last month, I came across a selection of amazing wooden designs from Spain, both century-old and brand new ones. Confemadera put together an impressive selection

Made from TigerBamboo and hand sculpted flax fiber composite joints, the bikes weigh around 1.75 kg, and, according to the designers, “have a ride quality similar to high end steel, but with better vibration absorption”. And they look funky!

Recycled aluminum and silver get another shot at becoming beautiful with this handmade collection, created with Japanese origami papers.

Norwegian engineering students debut an electric motorcycle made from carbon fiber. They say it will be fast, cheap, and get 100 kilometers to a charge.