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In vivo and in vitro evaluation of dihydroartemisinin prodrug nanocomplexes as a nano-drug delivery system: characterization, pharmacokinetics and pharmacodynamics

RSC Adv., 2020, 10,17270-17279
DOI: 10.1039/D0RA02150D, Paper
Open Access
Guolian Ren, Pei Chen, Jiaqi Tang, Wenju Guo, Rongrong Wang, Ning Li, Yujie Li, Guoshun Zhang, Ruili Wang, Shuqiu Zhang
To develop new, more effective and lower toxicity antitumor dihydroartemisinin (DHA) nanocomplexes, a DHA prodrug synthesized in this study was used to prepare DHA prodrug self-assembled nanocomplexes (DHANPs) by molecular self-assembly technology.
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The function of crocodile hatchling (Crocodylus acutus) distress calls