French translation of the BIS press release about the BIS Quarterly Review, September 2018

Neonatal stroke is as frequent as stroke in the elderly, but many pathophysiological injury aspects are distinct in neonates, including immune signaling. While myeloid cells can traffic into the brain via multiple routes, the choroid plexus (CP) has been identified as a uniquely educated gate for immune cell traffic during health and disease. To understand the mechanisms of myeloid cell trafficking via the CP and their influence on neonatal stroke, we characterized the phenotypes of CP-infiltrating myeloid cells after transient middle cerebral artery occlusion (tMCAO) in neonatal mice of both sexes in relation to blood-brain barrier permeability, injury, microglial activation, and CX3CR1-CCR2 signaling, focusing on the dynamics early after reperfusion. We demonstrate rapid recruitment of multiple myeloid phenotypes in the CP ipsilateral to the injury, including inflammatory CD45⁺CD11b⁺Ly6c^highCD86⁺, beneficial CD45⁺CD11b⁺Ly6c^lowCD206⁺, and CD45⁺CD11b⁺Ly6c^lowLy6g^high cells, but only minor leukocyte infiltration into acutely ischemic-reperfused cortex and negligible vascular albumin leakage. We report that CX3CR1-CCR2-mediated myeloid cell recruitment contributes to stroke injury. Considering the complexity of inflammatory cascades triggered by stroke and a role for TLR2 in injury, we also used direct TLR2 stimulation as an independent injury model. TLR2 agonist rapidly recruited myeloid cells to the CP, increased leukocytosis in the CSF and blood, but infiltration into the cortex remained low over time. While the magnitude and the phenotypes of myeloid cells diverged between tMCAO and TLR2 stimulation, in both models, disruption of CX3CR1-CCR2 signaling attenuated both monocyte and neutrophil trafficking to the CP and cortex.

SIGNIFICANCE STATEMENT Stroke during the neonatal period leads to long-term disabilities. The mechanisms of ischemic injury and inflammatory response differ greatly between the immature and adult brain. We examined leukocyte trafficking via the choroid plexus (CP) following neonatal stroke in relation to blood-brain barrier integrity, injury, microglial activation, and signaling via CX3CR1 and CCR2 receptors, or following direct TLR2 stimulation. Ischemia-reperfusion triggered marked unilateral CX3CR1-CCR2 dependent accumulation of diverse leukocyte subpopulations in the CP without inducing extravascular albumin leakage or major leukocyte infiltration into the brain. Disrupted CX3CR1-CCR2 signaling was neuroprotective in part by attenuating monocyte and neutrophil trafficking. Understanding the migratory patterns of CP-infiltrating myeloid cells with intact and disrupted CX3CR1-CCR2 signaling could identify novel therapeutic targets to protect the neonatal brain.

The newly formed group, which plans to challenge the Council for Accreditation of Educator Preparation for market share, wants feedback from the public on its proposed standards and processes.

The current system for accrediting schools of education isn't working, argue two former senior U.S. Department of Education officials. They think school districts and philanthropists can help.

Baby-Friendly Hospital Initiative (BFHI) accreditation can have a positive effect on breastfeeding initiation and continuation rates; however, little is known about the effect of BFHI accreditation in populations with high breastfeeding-initiation rates and where infant-friendly practices are common.

BFHI accreditation per se does not improve breastfeeding rates at 1 and 4 months when breastfeeding-initiation rates are high and accredited and nonaccredited hospitals have infant-friendly practices. Baby-friendly practices are more important than accreditation. (Read the full article)

Accreditation process starts on 1 June 2013

Delaware’s state museum system has been accredited by the American Alliance of Museums (AAM), the highest recognition afforded to museums in the United States. Administered by the Delaware Division of Historical and Cultural Affairs, the system includes five museums as well as the archaeological and historic objects collections curated by the state.

Accreditation is the highest recognition afforded to museums in the United States.

Accreditation is the highest recognition afforded to museums in the United States.

Accreditation is the highest recognition afforded to museums in the United States.

Accreditation is the highest recognition afforded to museums in the United States.

Accreditation is the highest recognition afforded to museums in the United States.

Accreditation is the highest recognition afforded to museums in the United States.

Accreditation is the highest recognition afforded to museums in the United States.

Accreditation is the highest recognition afforded to museums in the United States.

Accreditation is the highest recognition afforded to museums in the United States.

Accreditation is the highest recognition afforded to museums in the United States.

Accreditation is the highest recognition afforded to museums in the United States.

(Smyrna, Delaware) – On December 13, 2019, the Delaware Emergency Management Agency (DEMA) officially earned accreditation by the Emergency Management Accreditation Program (EMAP). Only nine programs nationwide completed the rigorous assessment process in 2019 to achieve either initial accreditation or reaccreditation. This is the initial accreditation for DEMA and the State’s emergency management program. “Congratulations […]

In an attempt to improve the processes involved in the visa application mechanism, the Royal Danish Embassy in New Delhi is keen on and has decided upon a new and obligatory mechanism wherein travel agencies would have to receive formal recognition and…

Following the public consultation on the draft UCR 2016 and CCR 2016, the new regulations have now been laid before Parliament and will come into force on 18 April 2016 (subject to a number of exceptions in the UCR 2016 which will come into force at...

This speedbrief outlines the current state of play on some important issues relating to trusteeship, following on from the Pensions Regulator’s Future of trusteeship and governance consultation response this month and recent ind...

Leukocyte recruitment is a universal feature of tissue inflammation and regulated by the interactions of chemokines with their G protein–coupled receptors. Activation of CC chemokine receptor 2 (CCR2) by its cognate chemokine ligands, including CC chemokine ligand 2 (CCL2), plays a central role in recruitment of monocytes in several inflammatory diseases. In this study, we used phosphoproteomics to conduct an unbiased characterization of the signaling network resulting from CCL2 activation of CCR2. Using data-independent acquisition MS analysis, we quantified both the proteome and phosphoproteome in FlpIn-HEK293T cells stably expressing CCR2 at six time points after activation with CCL2. Differential expression analysis identified 699 significantly regulated phosphorylation sites on 441 proteins. As expected, many of these proteins are known to participate in canonical signal transduction pathways and in the regulation of actin cytoskeleton dynamics, including numerous guanine nucleotide exchange factors and GTPase-activating proteins. Moreover, we identified regulated phosphorylation sites in numerous proteins that function in the nucleus, including several constituents of the nuclear pore complex. The results of this study provide an unprecedented level of detail of CCR2 signaling and identify potential targets for regulation of CCR2 function.

Upper Lutetian–Bartonian sedimentary mélanges, corresponding to ancient mud-rich submarine mass transport deposits, are widely distributed over an area c. 300 km long and tens of kilometres wide along the exhumed outer part of the External Ligurian accretionary wedge in the Northern Apennines. The occurrence of methane-derived carbonate concretions (septarians) in a specific tectonostratigraphic position below these sedimentary mélanges allows us to document the relationships among a significant period of regional-scale slope failure, climate change (the Early and Mid-Eocene Optimum stages), the dissociation of gas hydrates and accretionary tectonics during the Ligurian Tectonic Phase (early–mid-Lutetian). The distribution of septarians at the core of thrust-related anticlines suggests that the dissociation of gas hydrates was triggered by accretionary tectonics rather than climate change. The different ages of slope failure emplacement and the formation of the septarians support the view that the dissociation of gas hydrates was not the most important trigger for slope failure. The latter occurred during a tectonic quiescence stage associated with a regressive depositional trend, and probably minor residual tectonic pulses, which followed the Ligurian Tectonic Phase, favouring the dynamic re-equilibrium of the External Ligurian accretionary wedge. Our findings provide useful information for a better understanding of the factors controlling giant slope failure events in modern accretionary settings, where they may cause tsunamis.

We document that the undifferentiated chaotic Ligurian Units of the Monferrato–Torino Hill sector (MO-TH) at the Alps–Apennines junction consist of three different units that are comparable with the Cassio, Caio and Sporno Units of the External Ligurian Units of the Northern Apennines. Their internal stratigraphy reflects the character of units deposited in an ocean–continent transition (OCT) zone between the northwestern termination of the Ligurian–Piedmont oceanic basin and the thinned passive margin of Adria microcontinent. The inherited wedge-shaped architecture of this OCT, which gradually closed toward the north in the present-day Canavese Zone, controlled the Late Cretaceous–early Eocene flysch deposition at the trench of the External Ligurian accretionary wedge during the oblique subduction. This favoured the formation of an accretionary wedge increasing in thickness and elevation toward the SE, from the MO-TH to the Emilia Northern Apennines. Our results therefore provide significant information on both the palaeogeographical reconstruction of the northwestern termination of the Ligurian–Piedmont oceanic basin and the role played by inherited along-strike variations (stratigraphy, structural architecture and morphology) of OCT zones in controlling subduction–accretionary processes.

Supplementary material: A spreadsheet with X-ray fluorescence spectrometry and inductively coupled plasma mass spectrometry whole-rock major and trace element composition of mantle peridotites, and photomicrographs of mantle peridotites are available at https://doi.org/10.6084/m9.figshare.c.4519643

The Verisae solution is the first web-enabled site and asset management software created to meet the unique needs of multi-site owners. We offer a powerful suite of web-based process management solutions for facilities, the assets in those facilities, and the people who manage them.

Certification on products and services has become imperative to ensure safety and reliability. A similar standard fo

The Categorization Results from Canada Database containing the categorization results for substances on the Canadian Domestic substance list now contains supporting data on Human health regarding : potential for exposure, previous assessments, simple hazard assessment and complex hazard assessment. Users are now able to find these additional specific endpoint properties through the eChemPortal search by substance identity.

She's the design expert who normally goes from room to room critiquing the interiors of the homes on Seven's House Rules.

The stunning manner of Anthony Joshua's first career defeat - a bout in which he was knocked down four times - prompted fans and pundits to scrutinise revered trainer Rob McCracken.

BAZ BAMIGBOYE: Helen McCrory and Damian Lewis have been toying with the idea of making their first West End appearance together.

Andy Holt suggests football clubs should go into 'protective hibernation' to safeguard their futures during this uncertain period and fears games may not be played in front of crowds for a long time.

The 78-year-old racing pundit chatted on the show yet fans were thrown by his appearance as he appeared remarkably slimmer less than a year

John McCririck has revealed he is 'not dying' and that his 'gaunt and frail' appearance is down to a bout of serious flu during an interview on Monday's This Morning.