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Critically acclaimed wine turns out to be something else as decades-old mix-up revealed

In 1979, the CSIRO imported a boutique wine grape from France. Since then the drop has been celebrated by growers and experts alike — but it turns out they've been enjoying a different variety all along.




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Legacy of Australia's last glass eye maker Paul McClarin there for all to see at National Museum

The skills of Paul McClarin are no longer available in Australia, but the results of his vocation are there for all to see at the National Museum in Canberra.




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Indigenous art depicting bush medicine draws acclaim from critics and collectors

In the remote Northern Territory community of Ampilatwatja, paintings show the prescriptions for thousands of years of traditional healing.



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Riversleigh fossil deposit, acclaimed by Sir David Attenborough, still giving up its secrets

In the depths of rural Queensland is a fossil deposit so amazing that Sir David Attenborough regards it as one of the most important palaeontological sites in the world.




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HC Patrick Ewing: Mac McClung returning to Georgetown




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Agency: McClung still testing NBA draft process




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McClain v. Sav-On Drugs

(Supreme Court of California) - Held that customers who had paid sales tax on purchases they believed to be exempt did not have an equitable cause of action to compel the retailers to seek a tax refund from the state, under the facts here. Affirmed a judgment sustaining the retailers' demurrer.




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McClain v. Kissler

(California Court of Appeal) - Affirmed. Plaintiff filed suit alleging that Defendant failed to pay them for their work growing marijuana as agreed under a contract. Defendant failed to file a responsive pleading. The trial court ordered Plaintiff to take the Defendant’s default by a specified date. The default was taken. Defendant then sought to set-aside the default. The trial court denied relief. The appeals court found no abuse of discretion finding that the Defendant’s failure to respond to the complaint was knowing and deliberate.




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McCleery v. Allstate Insurance Co.

(California Court of Appeal) - Affirmed the denial of class certification in a wage-and-hour case involving property inspectors in the insurance industry. The inspectors proposed to establish liability and damages using a method of anonymously surveying class members, but the trial court found flaws with the plan, and its decision to deny class certification was upheld on appeal.




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Internationally Acclaimed Soul Artist CORNELL “CC” CARTER To Release New Single “I SEE LOVE” From Upcoming Album ABSOULUTELY

CC Is Now Set To Unleash His Highly Anticipated New Single “I SEE LOVE” On All Digital Services August 9, 2019.




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McClain v. Kissler

(California Court of Appeal) - Affirmed. Plaintiff filed suit alleging that Defendant failed to pay them for their work growing marijuana as agreed under a contract. Defendant failed to file a responsive pleading. The trial court ordered Plaintiff to take the Defendant’s default by a specified date. The default was taken. Defendant then sought to set-aside the default. The trial court denied relief. The appeals court found no abuse of discretion finding that the Defendant’s failure to respond to the complaint was knowing and deliberate.




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Rep. Tom McClintock / School Timelines, Sliding Reading Skill Levels / Baking Bread During The Pandemic

Republican California Rep. Tom McClintock on Congress’ coronavirus relief efforts. We check in with a pair of superintendents on prospective timelines for opening their schools, and finding comfort in baking during the pandemic.




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Acclaimed Folk Bluegrass Artist Marion Halliday’s First Solo Album Soars To The Top Of The Charts

Rings Around Saturn Debuts At #3 With Halliday Named As #3 “Top Artist”




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Critically-Acclaimed Folk Artist Mara Levine Announces Northeast Fall Tour Dates And Prestigious Juried Showcase At The Northeast Regional Folk Alliance Conference

Facets Of Folk Hit #1 On The Folk Alliance International Folk DJ Charts And Is Now On The List For Consideration For The Grammy® For Best Folk Album




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Critically-Acclaimed Folk Artist Mara Levine Announces Northeast Fall Tour Dates And Prestigious Juried Showcase At The Northeast Regional Folk Alliance Conference

Facets Of Folk Hit #1 On The Folk Alliance International Folk DJ Charts And Is Now On The List For Consideration For The Grammy® For Best Folk Album




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Next Week On Lift Every Voice: Donnie McClurkin & More



Donnie McClurkin and John P. Kee take the hot seat.




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How Woody McClain Went Viral



Woody McClain breaks the internet with a funny skit.




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BCCL To Host Open House On March 14

The Bermuda Centre for Creative Learning [BCCL] will be hosting an open house on Saturday, March 14 from 9.00am to 11.00am. A spokesperson said, “BCCL is a private school for students who have a language-based learning difference, beginning at age six. Prospective parents are welcome to attend and learn more about BCCL’s personalized learning approach. […]

(Click to read the full article)




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The Check-In: USC's McClain brothers find some good during coronavirus shutdown

Abdul-Malik and Munir McClain, who play football at USC, are living a new normal during the pandemic. It's virtual classrooms and virtual lessons from coaches.




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Just one Oscar category for sound? The pros are happy to share the acclaim

At today's board of governors meeting, the Academy of Motion Picture Arts and Sciences voted to create one consolidated category: "Achievement in Sound."




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McClaren under instant pressure

England's new coach will not have a honeymoon period




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Learning with laughter: an interview with Kevin McCloskey

Kevin McCloskey delivers fascinating information in digestible, user-friendly formats, which appeal to not only young readers but experienced ones as well.




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Forthcoming in JHBS: Quêtelet on Deviance, McClelland on Leadership, Psychological Warfare, and More

A number of articles now in press at the Journal of the History of the Behavioral Sciences will be of interest to AHP readers. Full details below. “Uncovering the metaphysics of psychological warfare: The social science behind the Psychological Strategy Board’s operations planning, 1951–1953,” Gabrielle Kemmis. Abstract: In April 1951 president Harry S. Truman established … Continue reading Forthcoming in JHBS: Quêtelet on Deviance, McClelland on Leadership, Psychological Warfare, and More




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Trailblazers : 100 inspiring South Australian women / Carolyn Collins and Roy Eccleston.

Women -- South Australia -- Biography.




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Intravenous Magnesium Sulfate for Vaso-occlusive Episodes in Sickle Cell Disease

Vaso-occlusive episodes (VOEs) are a common complication of sickle cell disease, resulting in morbidity. Magnesium is a vasodilator and has been shown to improve red blood cell hydration. Previous small studies have suggested that treatment with magnesium may decrease VOEs.

Intravenous magnesium sulfate is well tolerated in relatively high doses but had no effect on the length of stay in hospital, pain scores, or cumulative analgesia used in children admitted with painful VOEs in sickle cell disease. (Read the full article)




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Exclusive Breastfeeding and Risk of Dental Malocclusion

Breastfeeding provides a protective effect against some malocclusions, and there is a strong inverse correlation between the duration of breastfeeding and the duration of pacifier use.

The protective effects of predominant and exclusive breastfeeding against malocclusion are distinct: exclusive breastfeeding reduces the risk of malocclusions regardless of pacifier use, whereas the effect of predominant breastfeeding depends on the duration of the pacifier use. (Read the full article)




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Delaware Flag Lowered to Half Staff for Fallen Fire Fighter Tim McClanahan

On Sunday, Delaware will lay to rest fallen firefighter Tim McClanahan. Mr. McClanahan passed away on Monday, July 11, 2016, following a Delaware Air Rescue Team training accident. He was a graduate of Cape Henlopen High School, was a past member of Milton and Rehoboth Beach Fire Departments, and a current member of the Lewes […]




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21st Century Community Learning Centers (21st CCLC)

Agency: DOE Closing Date: 5/27/2020




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DNREC Mirror Lake clean-up earns more national acclaim; innovative approach reduces pollutants in the Christina River

DNREC announced it has successfully used an innovative approach to reduce polychlorinated biphenyls (PCBs) in two Delaware waterways.




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Len McCluskey wins Unite election

Len McCluskey has been elected leader of the UK's biggest trade union, Unite. It was a comfortable victory, polling 101,000 votes ahead of second-placed Jerry Hicks, who had 52,000 votes. However, he is short of an overwhelming endorsement, given an...




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Clear Channel Outdoor Holdings, Inc. (CCO) CEO William Eccleshare on Q1 2020 Results - Earnings Call Transcript




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Clear Channel Outdoor Holdings, Inc. (CCO) CEO William Eccleshare on Q1 2020 Results - Earnings Call Transcript




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Consequences of being phenotypically mismatched with the environment: no evidence of oxidative stress in cold- and warm-acclimated birds facing a cold spell [RESEARCH ARTICLE]

Ana Gabriela Jimenez, Emily Cornelius Ruhs, Kailey J. Tobin, Katie N. Anderson, Audrey Le Pogam, Lyette Regimbald, and Francois Vezina

Seasonal changes in maximal thermogenic capacity (Msum) in wild black-capped chickadees suggests that adjustments in metabolic performance are slow and begin to take place before winter peaks. However, when mean minimal ambient temperature (Ta) reaches –10°C, the chickadee phenotype appears to provide enough spare capacity to endure days with colder Ta, down to –20°C or below. This suggests that birds could also maintain a higher antioxidant capacity as part of their cold-acclimated phenotype to deal with sudden decreases in temperature. Here, we tested how environmental mismatch affected oxidative stress by comparing cold-acclimated (–5°C) and transition (20°C) phenotypes in chickadees exposed to an acute 15°C drop in temperature with that of control individuals. We measured superoxide dismutase, catalase and glutathione peroxidase activities, as well as lipid peroxidation damage and antioxidant scavenging capacity in pectoralis muscle, brain, intestine and liver. We generally found differences between seasonal phenotypes and across tissues, but no differences with respect to an acute cold drop treatment. Our data suggest oxidative stress is closely matched to whole-animal physiology in cold-acclimated birds compared with transition birds, implying that changes to the oxidative stress system happen slowly.




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A rapid intrinsic heart rate resetting response with thermal acclimation in rainbow trout, Oncorhynchus mykiss [RESEARCH ARTICLE]

Rachel L. Sutcliffe, Shaorong Li, Matthew J. H. Gilbert, Patricia M. Schulte, Kristi M. Miller, and Anthony P. Farrell

We examined cardiac pacemaker rate resetting in rainbow trout following a reciprocal temperature transfer. In the original experiment, performed in winter, 4°C-acclimated fish transferred to 12°C reset intrinsic heart rate after just 1 h (from 56.8±1.2 to 50.8±1.5 bpm); 12°C-acclimated fish transferred to 4°C reset intrinsic heart rate after 8 h (from 33.4±0.7 to 37.7±1.2 bpm). However, in a replicate experiment, performed in the summer using a different brood year, intrinsic heart rate was not reset, even after 10 weeks at a new temperature. Using this serendipitous opportunity, we compared mRNA expression changes of a suite of proteins in sinoatrial node (SAN), atrial and ventricular tissues after both 1 h and longer than 3 weeks for both experimental acclimation groups to identify those changes only associated with pacemaker rate resetting. Of the changes in mRNA expression occurring after more than 3 weeks of warm acclimation and associated with pacemaker rate resetting, we observed downregulation of NKA α1c in the atrium and ventricle, and upregulation of HCN1 in the ventricle. However, in the SAN there were no mRNA expression changes unique to the fish with pacemaker rate resetting after either 1 h or 3 weeks of warm acclimation. Thus, despite identifying changes in mRNA expression of contractile cardiac tissues, there was absence of changes in mRNA expression directly involved with the initial, rapid pacemaker rate resetting with warm acclimation. Importantly, pacemaker rate resetting with thermal acclimation does not always occur in rainbow trout.




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Body temperature maintenance acclimates in a winter-tenacious songbird [RESEARCH ARTICLE]

Maria Stager, Nathan R. Senner, Bret W. Tobalske, and Zachary A. Cheviron

Flexibility in heat generation and dissipation mechanisms provides endotherms the ability to match their thermoregulatory strategy with external demands. However, the degree to which these two mechanisms account for seasonal changes in body temperature regulation is little explored. Here we present novel data on the regulation of avian body temperature to investigate how birds alter mechanisms of heat production and heat conservation to deal with variation in ambient conditions. We subjected Dark-eyed Juncos (Junco hyemalis) to chronic cold acclimations of varying duration and subsequently quantified their metabolic rates, thermal conductance, and ability to maintain normothermia. Cold-acclimated birds adjusted traits related to both heat generation (increased summit metabolic rate) and heat conservation (decreased conductance) to improve their body temperature regulation. Increases in summit metabolic rate occurred rapidly, but plateaued after one week of cold exposure. In contrast, changes to conductance occurred only after nine weeks of cold exposure. Thus, the ability to maintain body temperature continued to improve throughout the experiment, but the mechanisms underlying this improvement changed through time. Our results demonstrate the ability of birds to adjust thermoregulatory strategies in response to thermal cues and reveal that birds may combine multiple responses to meet the specific demands of their environments.




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Assessment of Apparent Internal Carotid Tandem Occlusion on High-Resolution Vessel Wall Imaging: Comparison with Digital Subtraction Angiography [EXTRACRANIAL VASCULAR]

BACKGROUND AND PURPOSE:

Not all tandem occlusions diagnosed on traditional vascular imaging modalities, such as MRA, represent actual complete ICA occlusion. This study aimed to explore the utility of high-resolution vessel wall imaging in identifying true ICA tandem occlusions and screening patients for their suitability for endovascular recanalization.

MATERIALS AND METHODS:

Patients with no signal in the ICA on MRA were retrospectively reviewed. Two neuroradiologists independently reviewed their high-resolution vessel wall images to assess whether there were true tandem occlusions and categorized all cases into intracranial ICA occlusion, extracranial ICA occlusion, tandem occlusion, or near-occlusion. DSA classified patient images into the same 4 categories, which were used as the comparison with high-resolution vessel wall imaging. The suitability for recanalization of occluded vessels was evaluated on high-resolution vessel wall imaging compared with DSA.

RESULTS:

Forty-five patients with no ICA signal on MRA who had available high-resolution vessel wall imaging and DSA images were included. Among the 34 patients (34/45, 75.6%) with tandem occlusions on DSA, 18 cases also showed tandem occlusions on high-resolution vessel wall imaging. The remaining 16 patients, intracranial ICA, extracranial ICA occlusions and near-occlusions were found in 2, 6, and 8 patients, respectively, on the basis of high-resolution vessel wall imaging. A total of 20 cases (20/45, 44.4%) were considered suitable for recanalization on the basis of both DSA and high-resolution vessel wall imaging. Among the 25 patients deemed unsuitable for recanalization by DSA, 11 were deemed suitable for recanalization by high-resolution vessel wall imaging.

CONCLUSIONS:

High-resolution vessel wall imaging could allow identification of true ICA tandem occlusion in patients with an absence of signal on MRA. Findings on high-resolution vessel wall imaging can be used to screen more suitable candidates for recanalization therapy.




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Glasgow Coma Scale on Presentation Predicts Outcome in Endovascular Treatment for Acute Posterior Large-Vessel Occlusion [INTERVENTIONAL]

SUMMARY:

Use of mechanical thrombectomy for stroke has increased since the publication of trials describing outcome improvement when used in the anterior circulation. These results, however, cannot be directly translated to the posterior circulation. While a high NIHSS score has demonstrated an association with poor outcomes in posterior stroke, the NIHSS is weighted toward hemispheric disease, and complex scores potentially delay definitive imaging diagnosis. We performed a retrospective analysis to ascertain whether any rapidly obtainable demographic or clinical and imaging data have a correlation with patient outcome postthrombectomy. Seventy-three cases were audited between September 2010 and October 2017. Presenting with a Glasgow Coma Scale score of >13 meant that the odds of reaching the primary end point of functional independence (defined as a 90-day modified Rankin Scale score of 0–2) were 5.70 times greater; similarly, presenting with a posterior circulation ASPECTS of >9 resulted in the odds of reaching the primary end point being 4.03 times greater. Older age correlated to a lower odds of independence (0.97, p = .04).




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CT Angiography in Evaluating Large-Vessel Occlusion in Acute Anterior Circulation Ischemic Stroke: Factors Associated with Diagnostic Error in Clinical Practice [INTERVENTIONAL]

BACKGROUND AND PURPOSE:

It is currently not completely clear how well radiologists perform in evaluating large-vessel occlusion on CTA in acute ischemic stroke. The purpose of this study was to investigate potential factors associated with diagnostic error.

MATERIALS AND METHODS:

Five hundred twenty consecutive patients with a clinical diagnosis of acute ischemic stroke (49.4% men; mean age, 72 years) who underwent CTA to evaluate large-vessel occlusion of the proximal anterior circulation were included. CTA scans were retrospectively reviewed by a consensus panel of 2 neuroradiologists. Logistic regression analysis was performed to investigate the association between several variables and missed large-vessel occlusion at the initial CTA interpretation.

RESULTS:

The prevalence of large-vessel occlusion was 16% (84/520 patients); 20% (17/84) of large-vessel occlusions were missed at the initial CTA evaluation. In multivariate analysis, non-neuroradiologists were more likely to miss large-vessel occlusion compared with neuroradiologists (OR = 5.62; 95% CI, 1.06–29.85; P = .04), and occlusions of the M2 segment were more likely to be missed compared with occlusions of the distal internal carotid artery and/or M1 segment (OR = 5.69; 95% CI, 1.44–22.57; P = .01). There were no calcified emboli in initially correctly identified large-vessel occlusions. However, calcified emboli were present in 4 of 17 (24%) initially missed or misinterpreted large-vessel occlusions.

CONCLUSIONS:

Several factors may have an association with missing a large-vessel occlusion on CTA, including the CTA interpreter (non-neuroradiologists versus neuroradiologists), large-vessel occlusion location (M2 segment versus the distal internal carotid artery and/or M1 segment), and large-vessel occlusion caused by calcified emboli. Awareness of these factors may improve the accuracy in interpreting CTA and eventually improve stroke outcome.




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Labour confession: Len McCluskey's blunt analysis of Jeremy Corbyn's impact revealed



AS THE Labour Party prepares itself for four years under the leadership of Sir Keir Starmer, the leader of Unite the Union explained how he believes Jeremy Corbyn has changed the face of the party forever.




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Devs season 2: Will Alex Garland's acclaimed TV show return for new episodes?

Garland says sci-fi show is 'companion piece' to 2014 film Ex Machina




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Macclesfield Town deducted seven points for failing to fulfil League Two fixture and non-payment of players

Macclesfield Town have been hit with an immediate seven-point deduction for failing to fulfil a fixture along with non-payment of their players.




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Michael McClure, the poet whose roar helped launch the '60s, dies at 87

The countercultural poet, actor and musician was present, Zelig-like, at key moments in San Francisco's Beat heyday and beyond.




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John Charles Mccluskey to Receive Life Prison Sentence for Murdering Oklahoma Couple

– John Charles McCluskey, 48, will receive a life prison sentence for a host of crimes arising out of the carjacking and murder of a couple from Tecumseh, Oklahoma



  • OPA Press Releases

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John Charles Mccluskey Sentenced to Life in Prison for Carjacking and Murdering Oklahoma Couple

John Charles McCluskey, 49, was sentenced this morning by U.S. District Judge Judith C. Herrera of the District of New Mexico to serve life in prison followed by a consecutive term of 2,820 months (235 years) in prison for carjacking and murdering a retired couple from Oklahoma in August 2010.



  • OPA Press Releases

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Th22 cells are efficiently recruited in the gut by CCL28 as an alternative to CCL20 but do not compensate for the loss of Th17 cells in treated HIV-1-infected individuals




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A single-centre investigator-blinded randomised parallel-group study protocol to investigate the influence of an acclimatisation appointment on children’s behaviour during N<sub>2</sub>O/O<sub>2</sub> sedation as measured by psycho




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Irradiation induces cancer lung metastasis through activation of the cGAS–STING–CCL5 pathway in mesenchymal stromal cells




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Do malocclusions affect oral health related quality of life?




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Raikkonen needs time to acclimatise, says Watson

Former grand prix winner John Watson says that Kimi Raikkonen will need time to familiarise himself with the new technicalities of the sport when he returns to drive for Lotus Renault for the 2012 season




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'Stop moaning about Hamilton' - Ecclestone

Bernie Ecclestone has told Lewis Hamilton's rivals to "stop moaning" about the on-track tactics of the 2008 world champion