4 h

36 deaths, 957 cases in 24 hrs; COVID-19 toll 488

36 deaths have been reported since Friday evening -- 12 from Madhya Pradesh, 10 from Gujarat, seven from Maharashtra, four from Delhi and one each from Andhra Pradesh, Bihar and Jammu and Kashmir.Of the 488 deaths, Maharashtra tops the list with 201 fatalities, followed by Madhya Pradesh at 69, Gujarat at 48 and Delhi at 42 and Telangana at 18.




4 h

47 COVID-19 deaths, 1,975 cases in 24 hrs; toll 826

The number of active COVID-19 cases stood at 20,177 while 5,913 people (21.96 percent) were cured and discharged, and one patient has migrated, the ministry said.The total number of cases include 111 foreign nationals.Of the 47 deaths reported since Saturday evening, 22 are from Maharashtra, eight in Rajasthan, seven from Madhya Pradesh, six Gujarat and one each from Delhi, Uttar Pradesh, Jammu and Kashmir and Tamil Nadu.






4 h

Covid19: TN eases lockdown restrictions even as 526 more active cases reported in last 24 hours

Another 279 patients in Chennai, taking the tally to 3,330




4 h

128 Covid deaths, 3,277 cases in 24 hrs; toll 2,109

Of the 2,109 fatalities, Maharashtra tops the tally with 779 deaths. Gujarat comes second with 472 deaths, followed by Madhya Pradesh at 215, West Bengal at 171, Rajasthan at 106, Uttar Pradesh at 74, Delhi at 73, and Andhra Pradesh and Tamil Nadu at 44.




4 h

The PRR14 heterochromatin tether encodes modular domains that mediate and regulate nuclear lamina targeting [RESEARCH ARTICLE]

Kelly L. Dunlevy, Valentina Medvedeva, Jade E. Wilson, Mohammed Hoque, Trinity Pellegrin, Adam Maynard, Madison M. Kremp, Jason S. Wasserman, Andrey Poleshko, and Richard A. Katz

A large fraction of epigenetically silent heterochromatin is anchored to the nuclear periphery via "tethering proteins" that function to bridge heterochromatin and the nuclear membrane or nuclear lamina. We identified previously a human tethering protein, PRR14, that binds heterochromatin through an N-terminal domain, but the mechanism and regulation of nuclear lamina association remained to be investigated. Here we identify an evolutionarily conserved PRR14 nuclear lamina binding domain (LBD) that is both necessary and sufficient for positioning of PRR14 at the nuclear lamina. We also show that PRR14 associates dynamically with the nuclear lamina, and provide evidence that such dynamics are regulated through phosphorylation-dephosphorylation of the LBD. Furthermore, we identified a PP2A phosphatase recognition motif within the evolutionarily conserved PRR14 C-terminal Tantalus domain. Disruption of this motif affected PRR14 localization to the nuclear lamina. The overall findings demonstrate a heterochromatin anchoring mechanism whereby the PRR14 tether simultaneously binds heterochromatin and the nuclear lamina through two separable, modular domains. The findings also describe an optimal PRR14 LBD fragment that could be used for efficient targeting of fusion proteins to the nuclear lamina.




4 h

This cozy concrete house was 3-D printed in under 24 hours

Housing charity New Story teams with 3-D printing startup ICON to fabricate 100 affordable and innovative abodes in El Salvador.



  • Remodeling & Design

4 h

MNN's 2014 holiday gift guide

Bamboo globes, reclaimed sailcloth planters and the requisite pair of socks are just some of this year's exceptionally giftable finds.




4 h

Watch: 24 hours of Walmart

This time-lapse video explores a full day at the checkout lanes of a Walmart store in New Brunswick, New Jersey.



  • Wilderness & Resources

4 h

First drive: 2014 Honda Accord PHEV

Honda will enter the plug-in hybrid market with the early 2013 release of the Accord PHEV.




4 h

Al Gore announces 24 Hours of Reality to counter misinformation

The former vice president has a new video project that he hopes can be a response to attacks from the fossil fuel industry.



  • Arts & Culture

4 h

Lloyd's to close underwriting room for 24 hours in coronavirus stress test

Market to test its readiness by invoking its emergency trading protocol.




4 h

Belgium Hockey launch New Vacatures Page partnering with Recruitment 4 Hockey

In a new partnership with Recruitment 4 Hockey, the only global hockey recruitment and job board website, Hockeybe have released their new Vacatures (Vacancies) page to help the Belgian Hockey Community




4 h

All About Garage Doors Serve Boston at 24 Hours Basis Now

All About Garage Doors Services Boston has experts and is very well-informed in the repair and service of a number of well known brands.




4 h

The SLD-DIM-XG4 has been added to GRE Alpha's Growing Line of High-quality Lighting Control Modules

GRE Alpha expands their popular line of LED power supplies




4 h

4 handy tips to get the most from your gadgets

If you are using a Windows computer with a standard hard drive, sooner or later the computer will become sluggish. One way out is to tweak Windows to perform better with your existing hardware.




4 h

US adds 1,635 coronavirus deaths in 24 hours: Tracker

The country -- hardest hit by the pandemic in terms of the number of fatalities -- has now confirmed a total of 1,283,829 cases, Johns Hopkins University reported.




4 h

Coronavirus in West Bengal: 11 deaths, 108 fresh cases reported in last 24 hours

Coronavirus in West Bengal: 11 deaths, 108 fresh cases reported in last 24 hours





4 h

No new coronavirus deaths in Hampshire hospitals in past 24 hours

NO further deaths from coronavirus have been reported in Hampshire hospitals in the past 24 hours.




4 h

Saints 4 Huddersfield 1




4 h

No new coronavirus deaths in Hampshire hospitals in past 24 hours

NO further deaths from coronavirus have been reported in Hampshire hospitals in the past 24 hours.




4 h

24 Hour News Cycle

We live in an era with push notifications and all-day news coverage, but is keeping up to date with the latest development really that important? In this episode of Two Guys on Your Head, Dr. Art Markman and Dr. Bob Duke discuss 24 hour news cycle.




4 h

In roughly 24 hours coronavirus makes sports, a longtime sanctuary in times of crisis, disappear


Sports has always been the escape during times of crisis and collective stress. But now the very act of conducting sports threatens to add exponentially to perpetuating the coronavirus pandemic and growing the stress.




4 h

In roughly 24 hours coronavirus makes sports, a longtime sanctuary in times of crisis, disappear


Sports has always been the escape during times of crisis and collective stress. But now the very act of conducting sports threatens to add exponentially to perpetuating the coronavirus pandemic and growing the stress.




4 h

In roughly 24 hours coronavirus makes sports, a longtime sanctuary in times of crisis, disappear


Sports has always been the escape during times of crisis and collective stress. But now the very act of conducting sports threatens to add exponentially to perpetuating the coronavirus pandemic and growing the stress.




4 h

In roughly 24 hours coronavirus makes sports, a longtime sanctuary in times of crisis, disappear


Sports has always been the escape during times of crisis and collective stress. But now the very act of conducting sports threatens to add exponentially to perpetuating the coronavirus pandemic and growing the stress.




4 h

In roughly 24 hours coronavirus makes sports, a longtime sanctuary in times of crisis, disappear


Sports has always been the escape during times of crisis and collective stress. But now the very act of conducting sports threatens to add exponentially to perpetuating the coronavirus pandemic and growing the stress.




4 h

2448 COVID-19 Deaths In 24 Hours In US; Biggest Rise This Month

The United States recorded 2,448 coronavirus-related deaths in the past 24 hours, the biggest rise this month, taking the total death toll to more than 75,000. A total of 75,670 Covid-19 deaths were recorded in the U.S., as per latest data compiled by the Center for Systems Science and Engineering at Johns Hopkins University. This makes up nearly one third of the global cases, and more than on




4 h

US Records Nearly 2000 Covid-19 Deaths In Past 24 Hours

After a lull in coronavirus-related death toll in the United States since the beginning of this month, the country recorded nearly 2,000 deaths in the past 24 hours. Daily death toll has been moving around 1000 since May 1, but it rose to the 2000 range for the third day in a row. On Wednesday, 1,949 people died of the killer disease in the U.S. The new surge in casualties brought the total numb




4 h

How to ditch your day job and start a small business in fewer than 44 hours a week

Thinking about going into small business? Matt Godfrey ditched his career as a geologist to sell dumplings from a food truck. His best advice is to find a gap in the market and be realistic about money.




4 h

Commodore 64 home computer's revolution unites gamers in nostalgia for C64 month

In the 1980s, a revolutionary new computer, run by cassette, was changing lives forever.



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4 h

24 hours of rain offers some NSW farmers much-needed drought relief

Heavy rainfall across south-west New South Wales has provided some farmers with much-needed relief, many measuring the best falls they have seen in over two years.




4 h

Police break up three house parties in 24 hours after coronavirus restrictions ease in Queensland

Queensland police shut down three house parties in the 24 hours after some coronavirus restrictions are relaxed and erect fencing at Burleigh Heads where large crowds were dispersed over the weekend.




4 h

Three inmates die in four days — two in 24 hours — in Queensland prisons

Queensland's Corrective Services Investigation Unit is examining the deaths of three prisoners over the past five days — two of which occurred at the same facility in 24 hours.




4 h

Soldiers and spouses smash 24 hour challenge at Lavarack Barracks

In the early hours of Friday morning when most people were waking and getting ready for work or school, 200 military personnel in north Queensland were close to finishing 24 hours of hard work.




4 h

Tiny koala joey rescued after mother hit by car is cared for in makeshift pouch 24 hours a day

A koala joey, only months old, is defying the odds after being rescued when her mother was hit by a car in Port Macquarie on the NSW mid-north coast. Pixie is now in home care and being carried in a makeshift pouch 24 hours a day.




4 h

More patients waited over 24 hours at the Royal's ED than Victoria's four big hospitals combined

The head of the Royal Hobart Hospital's emergency department tells an inquest of a large increase in the number of mental health patients trying to access care, and of more suicide attempts at the facility.




4 h

Teamsters Local 404 Health Services and Insurance Plan v. King Pharmaceuticals, Inc.

(United States Second Circuit) - Held that it was proper to remand to New York state court a case in which a labor union health plan sought disclosure of a patent dispute settlement agreement between pharmaceutical companies and the generic manufacturer of the EpiPen. Affirmed the district court's remand order, in this special proceeding under New York law seeking pre‐action disclosure.




4 h

Karting: Bermuda Compete In 24 Hour Endurance

Team Bermuda finished 29th competing in the CRG 24 Hours Endurance Karting Race of Italy 2019, joining teams from China, Italy, Romania, Czech Republic, Germany, Spain, Ecuador, France and Ukraine in the endurance event. The Bermuda team included David Selly, Jordan Fletcher [pit crew], Owen Decosta, David Barbosa, Scott Barnes, Jeff Sousa, Blake Horseman, Marcus […]

(Click to read the full article)




4 h

TRPV4 helps Piezo1 put the squeeze on pancreatic acinar cells

Alterations in calcium signaling in pancreatic acinar cells can result in pancreatitis. Although pressure changes in the pancreas can elevate cytosolic calcium (Ca2+) levels, it is not known how transient pressure-activated elevations in calcium can cause prolonged calcium changes and consequent pancreatitis. In this issue of the JCI, Swain et al. describe roles for the mechanically activated plasma membrane calcium channels Piezo1 and transient receptor potential vanilloid subfamily 4 (TRPV4) in acinar cells. The authors used genetic deletion models and cell culture systems to investigate calcium signaling. Notably, activation of the Piezo1-dependent TRPV4 pathway was independent of the cholecystokinin (CCK) stimulation pathway. These results elegantly resolve an apparent discrepancy in calcium signaling and the pathogenesis of pancreatitis in pancreatic acinar cells.




4 h

20204 Huntington Beach California USA

Huntington Beach California USA Huntington Beach




4 h

Less than 24 hours

We leave the house in about 26 hours...Bill is busy packing the bikes in their boxes...discovered that the clips for the front bags are on the touring bikes at the bike shop so will have to pick them up later today. The bike ride free so long as they weig




4 h

Day 24 Ho Chi Minh to Mekong Delta

We left HCM at 8.30 by taxi and arrived in Mekong Delta around midday. We met our guide Nam and boarded a long wooden boat to take us down the river making several stops along the way.The first stop was a brick factory where Nam told me about how bri




4 h

BBC UK weather forecast stuns viewers as snow replaces record heatwave in next 24 hours



THE FREEZING plunge in temperatures over the next 24 hours even sparked disbelief from the meteorologist on BBC Breakfast, who warned that Britain could go from its warmest day of the year on Saturday to being hit by snow on Sunday.




4 h

Four shootings in Sheffield in 24 hours

The incidents took place in the Burngreave, Sharrow and Nether Edge areas of Sheffield during Friday.




4 h

Two bears were fatally hit by cars on the same freeway within 24 hours

A bear in Castaic was fatally struck by a car while walking through traffic near the northbound 5 Freeway the early Friday morning hours.





4 h

Social care providers 'about 24 hours away' from running out of PPE

Community care providers across the UK "are down to about 24 hours' worth of PPE" for their staff, Sky News has learned.