The public tours of the historic residence hadn't been overhauled in decades. For two years, the first lady's office has been working to make them more interactive and educational

A new exhibition spotlights the Spanish artist's printmaking talents, which he began honing in his 20s. In the decades that followed, he produced thousands of breathtaking creations

When fishermen found the endangered loggerhead sea turtle off Vancouver Island in February, she was listlessly floating in a bed of kelp

This brief chapter of art history is often overlooked. Now, an exhibition in New York City makes a strong argument for the integral role played by four artists in the city of Siena

The Art Gallery of New South Wales is showcasing works full of the Surrealist artist's signature motifs—such as apples, pipes and bowler hats—in addition to lesser-known pieces

The Manhattan district attorney's office has obtained an arrest warrant for Edoardo Almagià, who has been accused of working with looters and dealing stolen artifacts for years

Thousands of years ago, our ancestors used symbols to track the sale of textile and agricultural products. New research suggests that these markings informed the development of writing

Born October 30 to parents Gloria and Otto at the Edinburgh Zoo in Scotland, the hippo is already gaining popularity, following in the footsteps of viral sensation Moo Deng

Steve Lazarides' personal collection of prints, original works, handwritten press releases and burner phones sold at auction for around $1.4 million

The 4,500-year-old pyramids of Giza are the backdrop for "Forever Is Now," which features sculptures, installations and immersive artworks that explore the relationship between the past and present

The viral king penguin chick at Sea Life Melbourne Aquarium is beginning to lose his youthful down, a process that will give him his distinctive and waterproof adult plumage

While testing the "infinite monkey theorem," mathematicians found that the odds of a chimpanzee typing even a short phrase like "I chimp, therefore I am" before the death of the universe are 1 in 10 million billion billion

Once the first primate made a break, the 42 others followed suit in a simple case of monkey-see, monkey-do

‘Our goal is to provide full flexibility, 24/7,’ one resident said. ‘If you want to cut the lawn at 4 a.m., then you do it.’

During a release of captive-bred snails in September, researchers discovered wild-born individuals from the Partula tohiveana species—which had been considered extinct in the wild—marking a huge milestone in a global effort to save them

Sharks have been losing teeth for 400 million years. Here’s a guide to uncovering some of these plentiful fossils across the country

These shots from the Smithsonian Magazine Photo Contest show why it’s one of the most-visited nations on earth

Cenotes in the Yucatán Peninsula are time capsules preserving remnants of Maya culture and fossils of extinct megafauna

From Setsubun in Japan to Fèt Gede in Haiti, these festivals relish in the macabre

These images from the Smithsonian Magazine Photo Contest capture quintessentially Cuban scenes

Pedestrians in Montreal, Grand Rapids and other locations can time-travel thanks to installations that map historical scenes directly onto the cityscapes

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In one reef, three million sea cucumbers released 64,000 metric tons of nutrient-packed poo back into the ecosystem

As of last Wednesday, at least 3,500 sea turtles have been rescued from freezing waters in the midst record-breaking winter storm

The trend is a result of women deciding to have children later in life and the use of medically assisted reproduction methods

Renaissance paintings, medieval archives, cloistered orchards—how one Italian scientist is uncovering secrets that could help combat a growing agricultural crisis

On the island of Laeso in Denmark, one man is reviving the lost art of eelgrass thatching and, in doing so, bringing attention to a plant that has great potential

Bombardier control box recovered during second dive to a World War 2 bomber at the bottom of Gander Lake.

Have a photo you'd like us to see? Email us! Our address is nlphotos@cbc.ca.

Pat White, an entrepreneur who launched EVAS Air and the Gander Flight Training, has died. He was 69 years old.

A researcher studying the rise of extremism in Atlantic Canada warns Ku Klux Klan Halloween costumes are just one example of an insidious effort by far-right groups to normalize hateful attitudes.

Volunteers will be cutting hair at a salon based inside a Cape Breton food bank. The goal is to provide clients with the same salon experience paying customers would receive.

The new mayor and council are planning big changes for the Cape Breton Regional Municipality, and one of those is at the top of the staff organizational chart now that chief administrative officer Marie Walsh is set to retire.

Shilei Du, 36, was charged Monday morning with the premeditated murder of his partner, Guangmei Ye, whose body was found Sunday in a residence on Fontenelle Street in Candiac, Que.

Amid rapid global advances and deployment of artificial intelligence technologies, the federal government has invested millions to combine the minds of three existing institutes into one that can keep an eye on potential dangers ahead.

Genetically encoded calcium indicators (GECIs) allow for the noninvasive evaluation of neuronal activity in vivo, and imaging GECIs in Drosophila has become commonplace for understanding neural functions and connectivity in this system. GECIs can also be used as read-outs for studying sleep in this model organism. Here, we describe a methodology for tracking the activity of neurons in the fly brain using a two-photon (2p) microscopy system. This method can be adapted to perform functional studies of neural activity in Drosophila under both spontaneous and evoked conditions, as well as during spontaneous or induced sleep. We first describe a tethering and surgical procedure that allows survival under the microscopy conditions required for long-term recordings. We then outline the steps and reagents required for optogenetic activation of sleep-promoting neurons while simultaneously recording neural activity from the fly brain. We also describe the procedure for recording from two different locations—namely, the top of the head (e.g., to record mushroom body calyx activity) or the back of the head (e.g., to record central complex activity). We also provide different strategies for recording from GECIs confined to the cell body versus the entire neuron. Finally, we describe the steps required for analyzing the multidimensional data that can be acquired. In all, this protocol shows how to perform calcium imaging experiments in tethered flies, with a focus on acquiring spontaneous and induced sleep data.

Sleep studies in Drosophila melanogaster rely mostly on behavioral read-outs to support molecular or circuit-level investigations in this model. Electrophysiology can provide an additional level of understanding in these studies to, for example, investigate changes in brain activity associated with sleep manipulations. In this protocol, we describe a procedure for performing multichannel local field potential (LFP) recordings in the fruit fly, with a flexible system that can be adapted to different experimental paradigms and situations. The approach uses electrodes containing multiple recording sites (16), allowing the acquisition of large amounts of neuronal activity data from a transect through the brain while flies are still able to sleep. The approach starts by tethering the fly, followed by positioning it on an air-supported ball. A multichannel silicon probe is then inserted laterally into the fly brain via one eye, allowing for recording of electrical signals from the retina through to the central brain. These recordings can be acquired under spontaneous conditions or in the presence of visual stimuli, and the minimal surgery promotes long-term recordings (e.g., overnight). Sleep and wake can be tracked using infrared cameras, which allow for the measurement of locomotive activity as well as microbehaviors such as proboscis extensions during sleep. The protocol has been optimized to promote subject survivability, which is an important factor when performing long-term (~16-h) recordings. The approach described here uses specific recording probes, data acquisition devices, and analysis tools. Although it is expected that some of these items might need to be adapted to the equipment available in different laboratories, the overall aim is to provide an overview on how to record electrical activity across the brain of behaving (and sleeping) flies using this kind of approach and technology.

Tammy Roberts, Home Base's executive director, said before these services launched, there was "no place for youth to go" other than the emergency room or to RCMP cells. 

Water quality guidelines for mercury are 0.02 micrograms per litre of water. Several results show that levels at four sites are far above that threshold. During the second week of October, one value close to the mine was more than seven times the acceptable level.

Hay River RCMP say they believe two weekend incidents, including one in which a person was shot, are linked to drugs and organized crime.

A man who fled from police, drove onto a walking trail, triggered a shelter-in-place advisory for the Chateau Nova hotel in Yellowknife and subsequently broke into a home was on bail at the time and under house arrest, police say.

In a new biopic starring Kate Winslet, Miller's many lives—as an artist, model, muse, cook and war correspondent—need little embellishment

The bronze wreath immortalized the moment when the members of the Honor Guard removed their hats and placed them on the president's grave during his burial

Emergency officials said the fire at the Herring Pub and Restaurant on Water Street broke out around 4 p.m. and appears to have started in an air conditioning unit.   

New Brunswick’s Court of Appeal has reserved judgment in the case of a man found guilty of criminal negligence in the death of Fredericton teenager in 2018.

Even as they fundraise for other community organizations, some legions across Canada are having trouble keeping their own lights on amid rising inflation and maintenance costs.

A South East Asian OM worker shared about how her relationship with Jesus has changed her life from one of fear to leading others and modeling Christ's love.

Service Team members share why they enjoy being onsite during Setup Week, when the vision of TeenStreet becomes a reality for them, and what part of the upcoming conference they are most excited for.

How do you encapsulate everything that goes into a full week of teaching, worship music, workshops, meals and so much more? Enjoy a brief overview of TeenStreet 2019.