Molten metal of a first composition is fed into a mold cavity, via a first control apparatus, wherein the control apparatus is open, wherein the feeding includes at least flowing out of a first feed chamber. The first control apparatus is closed. A second control apparatus is opened. Molten metal of a second composition is fed into the mold cavity, via the second control apparatus, wherein at least a portion of the metal of the first composition in the mold cavity is sufficiently molten so that an initial feed of molten metal of the second composition mixes with the molten metal of the first composition in the mold cavity, wherein the feeding includes at least flowing out of a second feed chamber, wherein the second composition is different from the first composition. An ingot is removed from the mold cavity, wherein the ingot as a top section, a middle section, and a bottom section, wherein the bottom section is composed of metal of the first composition, wherein the top section is composed of metal of the second composition, wherein the middle section is composed of a mixture of metal of the first composition and the second composition.

A non-electroslag remelting type clean metal ingot mold includes an ingot mold body and a insulating riser arranged on the ingot mold body; an insulated heating and heat preservation device is vertically arranged in the ingot mold body and divides the space in the ingot mold body into a plurality of independent cavity units; and the cavity units are distributed in two rows in the ingot mold body. Because the insulated heating and heat preservation device is arranged in the ingot mold body and divides the space in the ingot mold body into a plurality of independent cavity units, most of impurities and segregates in liquid metals are enriched in the part in contact with the isolation and heat insulation mechanism during the directional solidification and crystallization of the liquid metals and the enriched alloy segregates, and the impurities can be easily eliminated by utilizing flame or other processing methods.

A clean metal ingot mold comprises an ingot mold body and an insulating riser arranged on the ingot mold body. The bottom mold plate of the ingot mold is provided with at least a ridge connected thereto. The region having a V-shape containing impurities produced during the crystallization process of the liquid metal moves upwards because of the ridge, and then the impurities depart from the center of the cast ingot and the impurities are more centralized. A water-cooling device is arranged in the ridge to allow the temperature of the metal in the ingot mold to decrease rapidly, and the crystallization process of the metal to be rapid.

Non-naturally occurring peptides are provided that act as a Src SH2 domain antagonist of cardiotonic steroids. Pharmaceutical compositions comprising the peptides are also provided along with vectors encoding the peptides. Methods of treating a Src-associated disease and reducing Src activity in a cell are further provided and include administering or contacting a cell with an effective amount of the peptide.

In one aspect, the invention relates to a method of loading exosomes with oligonucleotide cargo, by incubating an oligonucleotide comprising one or more hydrophobic modifications with a population of exosomes for a period of time sufficient to allow loading of the exosomes with the oligonucleotide. Exosomes loaded with hydrophobic ally modified oligonucleotide cargo, and uses thereof, are also provided.

The present invention concerns cancer biomarkers. In particular, the invention concerns HGF as a biomarker for patient selection and patient prognosis in cancer, as well as methods of therapeutic treatment, articles of manufacture and methods for making them, diagnostic kits, methods of detection and methods of advertising related thereto.

A safety tool is specifically adapted to aid in opening hinged rear doors of industrial containers safely, while also ensuring that the operator of the safety tool remain outside the potential zone of danger whenever the rear door has the potential to swing open. The present safety tool not only provides convenience and leverage for commonly performed door opening procedures, but also ensures that the operator's body and hands remain safely distanced from the direction of door travel and the potential discharge path of material contained within the cargo box. In addition, the present safety tool is lightweight and compact, allowing the tool to be easily stowed in or around a cargo box and/or truck to and thereby ensure that the safety tool is available whenever it may be needed to aid in opening and/or closing the cargo box door.

The invention comprises using a fabric cut into several pieces which are further assembled together by stitches, the stitches being made using a sewing machine comprising at least two needles (A', B') operating in-line one behind the other so that the sewing stitch of the second needle (B') is made on the threads of the sewing stitch made by the first needle (A') in order to cover the perforation made by the first needle and so that the perforation made by the second needle (B') is made through said thread (11), thereby filling said perforation with said thread (11).

A ‘bioactive’ composition that has one or more oligogalacturonans ((1→4)-α-D-galacturonan) or any other oligosaccharides (oligoguluronans) that may present an ‘egg box’ conformation, this conformation being further stabilized by one or more polycationic saccharide(s), preferably either a chitosan oligosaccharide or a chitosan polysaccharide. A method prepares this composition and it is used, in medical, pharmaceutical, agricultural, nutraceutical, food, feed, textile, cosmetic, industrial and/or environmental applications.

The present invention provides an improved height adjustable tower with integrated cargo rack apparatus for wakeboard boats. The inventive apparatus enables the adjustability of the height of the cargo rack/bimini which is accomplished by lowering or raising the lower tower legs with an actuator after releasing a locking mechanism. The apparatus also includes a displacement mechanism which allows the cargo rack to be simultaneously translated and rotated. The benefit to the user is the ability to control the amount of shade/sun for the people in the general cockpit area. It also allows a user to achieve a higher walk-through height for ease of maneuvering in the boat and provides easy access to items stored on top of the cargo rack.

A controlled environment enclosure is disclosed. The enclosure has a tank with a lid, wherein the lid and tank are capable of creating a sealed enclosure. The enclosure also has a fluid filling inlet for introduction of a filling fluid into the tank, a fluid sensor for detecting a fluid other than the filling fluid, and a controller connected to the fluid sensor and the fluid filling inlet for selectively allowing the filling of the enclosure by the filling fluid through the fluid filling inlet.

A group of tertiary amine azides are useful as hypergolic fuels for hypergolic bipropellant mixtures. The fuels provide higher density impulses than monomethyl hydrazine (MMH) but are less toxic and have lower vapor pressures that MMH. In addition, the fuels have shorter ignition delay times than dimethylaminoethylazide (DMAZ) and other potential reduced toxicity replacements for MMH.

Provided is a fuel of catalytic metal-containing ionic liquid (MCIL) and an IL, to spur hypergolic ignition of such liquids upon contact with an oxidizer to define a hypergolic bipropellant.

Reduced toxicity fuels containing hydrocarbons having both strained rings and internal, conjugated triple bonds are disclosed. The fuels described herein are hypergolic with nitrogen tetroxide and/or inhibited red fuming nitric acid.

A device for stopping and/or aligning transport goods on a conveying device, in particular a roller conveyor, device has a main part and a stopping device that can be moved out of the main part into a conveying path of the conveying device in order to stop and/or align the transport goods that are transported along the conveying path. The stopping device comprises at least two separate stops that can be moved between a working position, which projects into the conveying plane, and a rest position, which is retracted with respect to the conveying plane, by means of a common actuator device.

A GOA (Gate driver On Array) for an LCD (Liquid Crystal Display) device is disclosed herein. The LCD device comprises a plurality of scanning lines. The GOA circuit comprises a plurality of GOA units, which are cascaded with each other as a plurality of level GOA units. The (n)th level GOA unit comprises a clock circuit, a pull-down circuit, a bootstrap capacitor circuit, a pull-up circuit, and a pull-down sustain circuit, to improve the color shift issue of a Tri-gate.

A GOA circuit located in a display panel is disclosed. The GOA circuit includes a first thin film transistor, a second thin film transistor, a third thin film transistor, a fourth thin film transistor, a fifth thin film transistor, a sixth thin film transistor, a seventh thin film transistor, an eighth thin film transistor, a ninth thin film transistor, a first boost thin film transistor, a second boost thin film transistor, a boost capacitor, a twelfth thin film transistor, a thirteenth thin film transistor, a fourteenth thin film transistor, and a fifteenth thin film transistor. Through the first boost thin film transistor, the second boost thin film transistor, and the boost capacitor, a voltage level of a gate output signal outputted by a gate of the second thin film transistor is lifted.

This disclosure describes methods, devices, and systems related to an OFDMA Distributed Channel Access. Devices are disclosed comprising: at least one processor; and at least one memory that stores computer-executable instructions, wherein the at least one processor is configured to access the at least one memory and execute the computer-executable instructions to identify a trigger frame received on the communication channel from the computing device. The at least one processor may determine an uplink frame to be sent to a computing device on a communication channel. The at least one processor may identify one or more random access resource allocations, wherein the one or more random access resource allocations are associated with the trigger frame. The at least one processor may assign a respective numerical value to each of the one or more random access resource allocations. The at least one processor may also select a numerical value based at least in part on a probability distribution. The at least one processor may also determine a particular resource allocation of the one or more random access resource allocations that corresponds to the numerical value. The at least one processor may also cause the uplink frame to be sent to the computing device using the particular resource allocation.

A system and method for inspection and quality control for goods determines whether the goods comply with desired configurations. In an embodiment, an inspection and quality control system for a good includes a template. The template includes a template body and a positive offset. The positive offset includes a maximum length of the good and a maximum width of the good. The positive offset is configured for the good to be disposed in the positive offset when the good is less than the maximum length and the maximum width. The system also includes a negative inset. The negative inset includes a minimum length for the good and a minimum width for the good. The negative inset is configured to be disposed in the positive offset over the good disposed in the positive offset.

A saddle latigo strap is threaded to secure a saddle. A body portion of a saddle latigo is looped through a permanent saddle rigging. A first end of the saddle latigo having a tapered portion is inserted through a second end. Notches of the body portion are engaged with holes of the first end to secure the saddle.

Embodiments of a loop clip used with a golf bag and methods to manufacture a golf bag are generally described herein. Other embodiments of the loop clip may be described and claimed.

An aerial disposal and dispersal of cremated remains device is presented. It is used to spread the remains of loved ones over a desired area. The device comprises a canister and a mortar, the canister being cylindrical in shape having cardboard walls, the canister further containing an igniter and burster charge in an inner cardboard tube, such inner tube being fitted with an upper cap, the mortar being cylindrical in shape with steel walls, the mortar further comprising a lifting charge which sits below an obturator disc, the obturator disc having a hole in the center, the canister fitting inside the mortar such that the canister's igniter sits atop the hole in the obturator disc. At least one device is fitted to a horizontal member to launch remains from any location.

Described herein is an apparatus that rests on a forearm of a user and supports a cargo handle is described. A longitudinal axis of the forearm extends in a first direction and the cargo handle extends in a second direction substantially perpendicular to the first direction. The apparatus includes a base member that is positionable between the cargo handle and forearm. Additionally, an upper surface is defined by the base member where the upper surface includes a handle reception recess. Further, a lower surface is defined by the base member where the lower surface is curved about an axis that is substantially parallel to the first direction when engaged with the forearm of the user.

A multi-layered garment may comprise components that are affixed using integrated belt loops. In particular, shorts belt loops of a shorts component may pass through an opening created when single-layer skirt belt loops of a skirt component are oriented outwards. Both the skirt belt loops and the shorts belt loops may be fully functional and aesthetically pleasing belt loops. Additionally, the shorts belt loops may be combined with the skirt belt loops to form integrated belt loops, thereby allowing a belt to pass beneath both sets of belt loops simultaneously to affix the shorts component to the skirt component.

This invention relates to a means of securing a lens member into a snow goggle frame member, wherein the goggle frame member includes first insertion apertures, with first locating blocks at front edge, the lens member has a lens secured thereon, the lens includes first troughs to receive a corresponding first block therein, a pair of first rails are formed at respective sides of the first trough, each first rail has a first notch which includes a pair of second notches thereat, retainers are secured to the goggle frame and lens frame respectively, one end of the first insertion aperture includes a first insertion post at one end and a first insertion section at the other end thereof to receive the first insertion post therein, the first insertion section is then inserted into the first notch. The goggle may be replaced with various lenses and secured firmly.

Hillary Clinton is the subject of a new documentary series on Hulu. It's fair to describe Hillary as a warts-and-all portrait. The four-part documentary shuttles between the 2016 presidential campaign and Hillary Rodham Clinton's life.…

The Richmond pop-up is a new contender for best fried chicken sandwich. There's no shortage of smog check stations on Richmond's 23rd Street, but on a sunny Saturday afternoon, a steady stream of cars piled into Super Star Smog's tiny parking lot, causing a minor traffic jam on the adjacent side street. On a Wednesday afternoon, an otherwise quiet industrial and residential Richmond street filled with cars, and people hastily headed into what appeared to be a warehouse (but was actually a motorcycle club).…

The invention is drawn to novel nanostructures comprising hollow nanospheres and nanotubes for use as chemical sensors, conduits for fluids, and electronic conductors. The nanostructures can be used in microfluidic devices, for transporting fluids between devices and structures in analytical devices, for conducting electrical currents between devices and structure in analytical devices, and for conducting electrical currents between biological molecules and electronic devices, such as bio-microchips.

The present invention relates to in vitro methods of assessing the susceptibility or responsiveness of a subject to the treatment with an epidermal growth factor receptor (EGFR) inhibitor/antagonist, wherein the subject has been diagnosed or suspected of suffering from inflammation-associated. These methods comprise determining the level of expression of EGFR in myeloid cells in a sample from the subject, wherein an expression of EGFR in the myeloid cells is indicative of the subject being susceptible to the treatment with an EGFR inhibitor/antagonist. The invention also relates to EGFR inhibitors/antagonists for use in the treatment or amelioration of inflammation-associated cancer. The invention furthermore provides in vitro methods of prognosing the survival time, progression-free survival time or disease course of a subject that has been diagnosed or suspected of suffering from from inflammation-associated cancer. In addition thereto, the invention relates to in vitro diagnostic methods of assessing the proneness of a subject to develop inflammation-associated cancer in which the expression of EGFR is determined in myeloid cells from the subject.

HE MAY NOT be held in the highest regard by the public but there’s something to love about Piers Morgan on Good Morning Britain.

As shocking fact is laid upon shocking fact, it becomes hard to judge SS Mendi- Dancing The Drill Of Death at NST City as a piece of theatre, such is one’s outrage at how the British behaved towards black people from the Empire a hundred years ago. But Isango Ensemble have created a powerful musical to tell the human story behind the appalling facts.

Covid-19 propels push for federal cannabis relief; advocates see parallel with Prohibition Major political and social changes often seem impossible until they happen. The Supreme Court's 2015 ruling recognizing gay marriage surprised most observers, including those who had been working toward the goal for decades.…

News you don't want to miss for May 7:

Just a few months ago, California was sitting on an overflowing reserve fund. After covid-19, the state is now reconciling with a massive $54.3 billion deficit over the next fiscal year, Calmatters reports.…

'Tax-Free Childcare' is a confusing and inaccurately named scheme that launched in April 2017. It can be worth thousands of pounds, but only 250,000 of the 1.5 million eligible families are collecting it.

THE happy couple's wedding day has been saved – thanks to some help from Daily Echo readers.

More people have been choosing to get married in recent years.

A TEST Valley school has improved its Ofsted rating following a five-year wait.

A TEST Valley school has improved its Ofsted rating following a five-year wait.

TWO first-time landlords are having 'lots of fun' running their Winchester pub – and hope to become a key part of the local community.

Eastleigh came from behind to defeat struggling Chesterfield and move themselves safely into midtable in the National League.

HAMPSHIRE legend Gordon Greenidge has been awarded a knighthood in the New Year honours list.

SAINTS cannot afford many more missed opportunities if they are to survive this season.

New Liverpool signing Adam Lallana believes England's World Cup failure will make him mentally tougher.

A POLICE probe continues as part of efforts to catch a masked flasher.

SOUTHAMPTON'S buzzing live music scene has always been criminally underrated in my humble opinion.

WICKHAM Festival organisers are still hoping to go ahead with the 2020 event amid a host of other coronavirus cancellations to Hampshire events this summer.

Playing Agony feels like penance for all your past gaming sins.

A POPULAR Southampton tea rooms will not reopen following the coronavirus crisis after becoming the latest victim of the pandemic.

TOWN crier John Melody is helping launch this year's Race For Life - afte revealing he is battling cancer himself

A SOUTHAMPTON orchestra is going virtual - and global.