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Fin24.com | SA pensioners in dire financial state, report shows

Under a fifth of South Africans over the age of 60 are receiving private pensions, a new report has shown.




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Fin24.com | In your 20s? Why the current market crash may offer opportunity

Are you in your twenties and wonder how you can use the current market crash caused by fears related to the coronavirus pandemic as a way to get into the investment market?




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Fin24.com | MONEY CLINIC: My pension is in an aggressive portfolio. Is it too late to opt for a lower risk?

Investment consultant, Andre Tuck, tackles the question of investment strategy.




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Grammy-winning, genre-smashing quartet to visit Williamsport

Groundbreaking, Grammy-winning quartet Béla Fleck & The Flecktones is celebrating its 30th anniversary with an extended tour that will stop by the Community Arts Center on Tuesday, March 24, at 7:30 p.m.




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Parents Report Obstacles in Filing Special Education Complaints, Watchdog Says

The Government Accountability Office finds that parents often have a hard time initiating complaints about special education services, but that these barriers don't affect all parents in the same way.




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Quality Counts 2017: State Report Cards Map

This interactive map offers a quick way to examine state-by-state grades and summary data.




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Maniche's Portugal piledriver

We go back to UEFA EURO 2004 as Maniche recalls his memorable semi-final strike.




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Fin24.com | OPINION | Coronavirus survival guide for entrepreneurs: Build an opportunity matrix

Now, more than ever, we need to be listening for market signals and ensuring that our businesses are primed to both take advantage of opportunities and to mitigate risks, says Allon Raiz.




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First hatches reported: Spotted lanternfly expert provides tips for management

Even before the recent news of the season’s first confirmed spotted lanternfly hatches in the Philadelphia region, homeowners in many parts of Pennsylvania were gearing up for their annual battle with the destructive pest.




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Study reveals important flowering plants for city-dwelling honey bees

Trees, shrubs and woody vines are among the top food sources for honey bees in urban environments, according to an international team of researchers. By using honey bees housed in rooftop apiaries in Philadelphia, the researchers identified the plant species from which the honey bees collected most of their food, and tracked how these food resources changed from spring to fall. The findings may be useful to homeowners, beekeepers and urban land managers who wish to sustain honey bees and other bee and pollinator species.




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'Feed the Future' grant to support women's empowerment research project in Ghana

A $450,000 grant from the U.S. Agency for International Development’s Feed the Future Innovation Lab for Peanut Research will aid researchers in Penn State’s College of Agricultural Sciences as they explore the potential to empower women farmers in northern Ghana through peanut production.




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After MONUC, Should MONUSCO Continue to Support Congolese Military Campaigns?

For more than a year and a half, UN peacekeepers have continuously supported military operations conducted by the Congolese armed forces (FARDC) against the Rwandan rebels of the Democratic Forces for the Liberation of Rwanda (FDLR) in North and South Kivu.




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Black Gold in the Congo: Threat to Stability or Development Opportunity?

Renewed oil interest in the Democratic Republic of the Congo (DRC) could nurture communal resentments, exacerbate deep-rooted conflict dynamics and weaken national cohesion.




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California Moves Toward New Test-Score Reporting

Federal law requires states to report student test scores in achievement levels, but leaders in the Golden State want to take a different approach.




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In Some States, ESSA Goals for English-Learners Are 'Purely Symbolic,' Report Finds

More than four years after the passage of ESSA, English-language-learner education policies across the country remain "disjointed and inaccessible," a new report concludes.




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Metronidazole-Treated Porphyromonas gingivalis Persisters Invade Human Gingival Epithelial Cells and Perturb Innate Responses [Mechanisms of Resistance]

Periodontitis as a biofilm-associated inflammatory disease is highly prevalent worldwide. It severely affects oral health and yet closely links to systemic diseases like diabetes and cardiovascular disease. Porphyromonas gingivalis as a ‘keystone' periodontopathogen drives the shift of microbe-host symbiosis to dysbiosis, and critically contributes to the pathogenesis of periodontitis. Persisters are a tiny subset of biofilm-associated microbes highly tolerant to lethal treatment of antimicrobials, and notably metronidazole-tolerant P. gingivalis persisters have recently been identified by our group. This study further explored the interactive profiles of metronidazole-treated P. gingivalis persisters (M-PgPs) with human gingival epithelial cells (HGECs). P. gingivalis cells (ATCC 33277) at stationary phase were treated with lethal dosage of metronidazole (100 μg/ml, 6 hours) for generating M-PgPs. The interaction of M-PgPs with HGECs was assessed by microscopy, flow cytometry, cytokine profiling and qPCR. We demonstrated that the overall morphology and ultra-cellular structure of M-PgPs remained unchanged. Importantly, M-PgPs maintained the capabilities to adhere to and invade into HGECs. Moreover, M-PgPs significantly suppressed pro-inflammatory cytokine expression in HGECs at a comparable level with the untreated P. gingivalis cells, through the thermo-sensitive components. The present study reveals that P. gingivalis persisters induced by lethal treatment of antibiotics could maintain their capabilities to adhere to and invade into human gingival epithelial cells, and perturb the innate host responses. Novel strategies and approaches need to be developed for tackling P. gingivalis and favourably modulating the dysregulated immuno-inflammatory responses for oral/periodontal health and general wellbeing.




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Emergence of the phenicol exporter gene fexA in Campylobacter coli and Campylobacter jejuni of animal origin [Letters]

Bacteria of the genus Campylobacter are major foodborne pathogens which have become increasingly resistant to clinically important antimicrobial agents (1)....




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Imipenem population pharmacokinetics: therapeutic drug monitoring data collected in critically ill patients with or without extracorporeal membrane oxygenation [Pharmacology]

Carbapenem pharmacokinetic profiles are significantly changed in critically ill patients because of the drastic variability of the patients' physiological parameters. Published population PK studies have mainly focused on specific diseases and the majority of these studies had small sample sizes. The aim of this study was to develop a population PK model of imipenem in critically ill patients that estimated the influence of various clinical and biological covariates and the use of Extracorporeal Membrane Oxygenation (ECMO) and Continuous Renal Replacement Therapy (CRRT). A two-compartment population PK model with Creatinine clearance (CrCL), body weight (WT), and ECMO as fixed effects was developed using the non-linear mixed effect model (NONMEM). A Monte Carlo simulation was performed to evaluate various dosing schemes and different levels of covariates based on the pharmacokinetic/pharmacodynamic index (f%T>MIC) for the range of clinically relevant minimum inhibitory concentrations(MICs). The results showed that there may be insufficient drug use in the clinical routine drug dose regimen, and 750mg Q6h could achieve a higher treatment success rate. The blood concentrations of imipenem in ECMO patients were lower than that of non-ECMO patients, therefore dosage may need to be increased. The dosage may need adjustment for patients with CrCL ≤ 70ml/min, but dose should be lowered carefully to avoid the insufficient drug exposure. Dose adjustment is not necessary for patients within the WT ranging from 50-80 kg. Due to the large variation in PK profile of imipenem in critically ill patients, TDM should be carried out to optimize drug regimens.




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Mutation of kvrA causes OmpK35/36 porin downregulation and reduced meropenem/vaborbactam susceptibility in KPC-producing Klebsiella pneumoniae. [Mechanisms of Resistance]

Meropenem/vaborbactam resistance in Klebsiella pneumoniae is associated with loss of function mutations in the OmpK35 and OmpK36 porins. Here we identify two previously unknown loss of function mutations that confer cefuroxime resistance in K. pneumoniae. The proteins lost were NlpD and KvrA; the latter is a transcriptional repressor controlling capsule production. We demonstrate that KvrA loss reduces OmpK35 and OmpK36 porin production, which confers reduced susceptibility to meropenem/vaborbactam in a KPC-3 producing K. pneumoniae isolate.




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Comparative Genomic Analysis of Third Generation Cephalosporin-Resistant Escherichia coli Harboring blaCMY-2-Positive IncI1 group, IncB/O/K/Z, and IncC Plasmids Isolated from Healthy Broilers in Japan. [Epidemiology and Surveillance]

The off-label use of third generation cephalosporin (3GC) during in ovo vaccination or vaccination of newly hatched chicks, was a common practice worldwide. CMY-2-producing Escherichia coli have been disseminated among broiler production. The objectives of this study were to determine the epidemiological linkage of blaCMY-2-positive plasmids among broilers both within and outside Japan because grandparent stock and parent stock were imported in Japan. We examined the whole genome sequences of 132 3GC-resistant E. coli isolates collected from healthy broilers during 2002-2014. The predominant 3GC-resistance gene was blaCMY-2, which was detected in the plasmids of 87 (65.9%) isolates. The main plasmid replicon types were IncI1-I (n=21; 24.1%), IncI (n=12; 13.8%), IncB/O/K/Z (n=28; 32.2%), and IncC (n=22; 25.3%). Those plasmids were subjected to gene clustering and network analyses and plasmid multi-locus sequence typing (pMLST). The chromosomal DNA of isolates was subjected to MLST and single nucleotide variant (SNV)-based phylogenetic analysis.

MLST and SNV-based phylogenetic analysis revealed high diversity of E. coli isolates. ST429 harboring blaCMY-2-positive IncB/O/K/Z was closely related to isolates from broiler in Germany harboring blaCMY-2-positive IncB/O/K/Z. pST55-IncI and pST12-IncI1-I and pST3-IncC were prevalent in western Japan. pST12-IncI1-I and pST3-IncC were closely related to those detected in E. coli isolates from chicken in American continent, whereas 26 IncB/O/K/Z were related to those in Europe. These data will be useful to reveal the whole picture of transmission of CMY-2-producing bacteria in and out of Japan.




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Inhibition of SARS-CoV-2 infection by the cyclophilin inhibitor Alisporivir (Debio 025) [Antiviral Agents]

Cyclophilins play a key role in the lifecycle of coronaviruses. Alisporivir (Debio 025) is a non-immunosuppressive analogue of cyclosporin A with potent cyclophilin inhibition properties. Alisporivir reduced SARS-CoV-2 RNA production in a dose-dependent manner in VeroE6 cell line, with an EC50 of 0.46±0.04 μM. Alisporivir inhibited a post-entry step of the SARS-CoV-2 lifecycle. These results justify that a proof-of-concept Phase 2 trial be rapidly conducted with alisporivir in patients with SARS-CoV-2 infection.




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Report: Apple Dropped Plans for Fully-Encrypted iCloud Backups

Six sources confirmed Apple changed its mind on end-to-end encrypted backups two years ago following an FBI complaint and concerns users could lose access to their own data.




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Report: Hack of Amazon's CEO Phone Tied to Saudi Prince

The stunning allegation reportedly comes from a forensic analysis Amazon CEO Jeff Bezos commissioned to determine the culprit behind the hack, which resulted in his private photos ending up in the hands of the National Enquirer.




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Oops! Microsoft Briefly Leaked 250M Customer Support Records

The records involved conversation logs between Microsoft support agents and customers across the globe, dating back to 2005. Most of the records were redacted of customer contact information, but not all.




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Hackers Pose as Wall Street Journal Reporter to Phish Victims

Watch out for suspicious interview requests. 'The main focus of this phishing campaign was stealing email account information of the victims, and finding information about their contacts/networks,' the cybersecurity experts at Certfa Lab warned on Wednesday.




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The God of India, Singapore and the Middle East

Doron's experience on Logos Hope shows him God's faithfulness and uncovers leadership abilities he is using today in a new role.




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Seizing every opportunity

Buenos Aires, Argentina :: Maintenance crew share Christ's love with local welders helping repair Logos Hope.




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PSU-LV faculty and staff support students during pandemic

Both in and out of the virtual classroom, Penn State Lehigh Valley departments are connecting with students during remote learning




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Fin24.com | SA inequality grows as rich take larger share - report

New research has found that inequality in SA has increased, with wealth becoming ever more concentrated among the rich.




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Mental Health of Transgender Children Who Are Supported in Their Identities

Kristina R. Olson
Mar 1, 2016; 137:e20153223-e20153223
ARTICLES




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Women's Under-17 EURO elite round report

Holders Germany, former winners Spain and Poland, England, the Netherlands, Finland and Italy have joined hosts Lithuania in May's finals.




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Women's U17 EURO qualifying round report

The elite round line-up is set, with 26 teams earning spots alongside Germany and holders Spain in the 23 November draw.




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WU17 EURO elite round report

Holders Spain, Austria, Denmark, England, Germany, Netherlands and Portugal have joined hosts Bulgaria in the finals.




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The Bizarre Disdain for High School Sports

Students who play high school sports get better grades, select more challenging courses, and are more likely to enroll in college.




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The Lost Senior Year: Credits, Proms, Sports All in Jeopardy

The coronavirus closures are shaping a disruptive end to a tumultuous academic career for the Class of 2020.




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Groups seek injunction to stop Idaho transgender sports ban




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North Dakota spring high school sports, activities cancelled




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Youth Olympics futsal qualifying report

The future of European futsal – male and female – was displayed over the last week in qualifying for the 2018 Youth Olympic games with Russia and Portugal coming out on top.




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Futsal EURO final: Portugal v Spain – all you need to know

Holders Spain face neighbours Portugal for the second time in a UEFA Futsal EURO final, putting their title on the line in Ljubljana on Saturday: read the full lowdown, including where to watch.




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Portugal win Futsal EURO, Ricardinho top scorer: at a glance

Portugal are UEFA Futsal EURO winners for the first time while Ricardinho dominated the individual honours in a record-breaking personal tournament: the full story.




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The God of India, Singapore and the Middle East

Doron's experience on Logos Hope shows him God's faithfulness and uncovers leadership abilities he is using today in a new role.




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Seizing every opportunity

Buenos Aires, Argentina :: Maintenance crew share Christ's love with local welders helping repair Logos Hope.




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New Penn State Hazleton scholarship supports students in STEM

A new endowed scholarship has been created to support those studying science, technology, engineering or math at Penn State Hazleton.




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Inter, Barcelona, Sporting and Győr reach finals

Holders Inter FS, two-time winners Barcelona, Sporting CP and Győr will contest the UEFA Futsal Cup finals in April after topping their elite round groups to make the last four.




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Futsal Cup semi-finals: Inter-Barcelona, Győr-Sporting

Spanish co-hosts Inter FS and Barcelona will face off in the UEFA Futsal Cup semi-finals after being drawn together in the last four of this year's event in Zaragoza, while Győr face Sporting CP.




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Apple Boosts AppleCare+ Battery Support

If your battery capacity ever drops below 80 percent when you have AppleCare+, you're in luck!




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Report: Apple Pushing iPods to Stores' Accessory Wall

Customers in the U.S. should begin noticing in-store changes starting today.




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How to Capture Important Data With Scanning and OCR Apps

With the best scanning and OCR apps, you can save whiteboard text, business cards, and important documents so that you can not only read them, but also edit them.




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WD Teases Super-Fast 8TB Portable SSD, New Game Drives

The 8TB SSD prototype includes SuperSpeed USB 20Gbps support; WD also showed off a portable Luxe drive with USB-C and five WD_Black drives for console and PC gamers




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Parents Report Obstacles in Filing Special Education Complaints, Watchdog Says

The Government Accountability Office finds that parents often have a hard time initiating complaints about special education services, but that these barriers don't affect all parents in the same way.