Disclosed are β-amino acid monomers containing cylcoalkyl, cycloalkenyl, and heterocylic substituents which encompass the α and β carbons of the peptide backbone and β-polypeptides made from such monomers. Method of generating combinatorial libraries of polypeptides containing the β-peptide residues and libraries formed thereby are disclosed.

The present invention relates to muscle repair promoters for local application that contain a colony-stimulating factor (CSF) as an active ingredient. The muscle repair promoters of the present invention exhibit their effect at low doses, particularly when they are administered intramuscularly.

Provided herein are novel compounds and novel protected compounds that can be derived from polymyxin, including, e.g., polymyxin A. The novel compounds have antibacterial properties against a diverse range of Gram negative bacteria and reduced toxicity compared to polymyxins such as polymyxin A. Also provided are antibacterial pharmaceutical compositions containing the novel compounds and novel protected compounds, as well as methods for preparing the antibacterial compounds and protected compounds.

The present inventors investigated the effects of anti-IL-6 receptor antibodies on improving the condition of infarcted areas in myocardial infarction, and on suppressing left ventricular remodeling after myocardial infarction. As a result, the administration of anti-IL-6 receptor antibodies significantly suppressed the increase of MPO activity in the infarcted area and suppressed myocardial MCP-1 expression in both the infarcted area and the non-infarcted area. Furthermore, echocardiography and histological examinations revealed that cardiac hypertrophy is also suppressed.

The present invention provides variable mass labeling reagents, a set of the variable mass labeling reagents, and a multiplexed set of variable mass labeling reagents.

The present invention provides for a bio-mimetic polymer capable of catalyzing CO2 into a carbonate.

The present invention provides processes for the manufacturing of polypeptide conjugates. In particular, the invention provides methods for the purification of polypeptide conjugates, which include at least one polymeric modifying groups, such as a poly(alkylene oxide) moiety. Exemplary poly(alkylene oxide) moieties include poly(ethylene glycol) (PEG) and poly(propylene glycol). In an exemplary process, hydrophobic interaction chromatography (HIC) is used to resolve different glycoforms of glycoPEGylated polypeptides.

The present invention relates to treating a tissue in a mammal from the effects of reperfusion using flagellin.

The present invention is relevant to human medicine, and, in particular, to the use of Epidermal Growth Factor (EGF) in a pharmaceutical composition, said composition is administered through infiltration at the periphery of nerve trunks and/or ganglia, for the morphofunctional restoration of peripheral nerves in painful, sensory-motor neuropathy, as well as ischemic neuritis. It is also relevant to an EGF containing composition, where this molecule can be formulated together with anesthetic or analgesic drugs, or encapsulated in microspheres, and their use for the morphofunctional restoration of peripheral nerves in painful, sensory-motor neuropathy, as well as in ischemic neuritis.

A rotary element assembly structure in which a rotary element 53 is assembled to a tip side of a hollow shaft B1 provided upright on a pedestal 60. A cylindrical portion 53c for fitting with the hollow shaft is provided to a rotation center portion of the rotary element. In the cylindrical portion, a hook strut portion 53s that has a hook portion 53f overhanging in the radial direction at its tip side and that extends substantially in the fitting direction is arranged. A base end portion of the hook strut portion and a base end portion of the cylindrical portion are coupled with each other by a resin-made thin plate portion 53p. A small diameter portion B1s which is smaller in diameter than a hollow portion B1d of the hollow shaft is provided on the tip side of the hollow shaft. The radius of the overhang tip portion of the hook portion is set to be greater than the radius of the small diameter portion of the hollow shaft, and to be smaller than the radius of the hollow portion. By fitting the hollow shaft with the cylindrical portion of the rotary element, the hook portion on the tip side of the hook strut portion is pushed into the hollow portion via the small diameter portion on the tip side of the hollow shaft. Thereby, the hook portion engages with a stepped portion formed by the hollow portion and the small diameter portion.

In one embodiment an enclosure for a high-density storage system, comprises a backplane to which a plurality of data storage devices may be coupled, a front panel opposite the backplane and defining a first airflow channel adjacent a front side of the data storage devices, a back panel opposite the front panel and comprising a second airflow channel adjacent the backplane, a floor panel and a top panel, a first side panel comprising an array of air flow inlets, a second side panel comprising at least one air flow outlet, and a fan assembly to expel air from the at least one air outlet.

A disc drive unit is configured with a plurality of disc drives as one unit. At least one of a pair of opposed disc drives arranged on an identical horizontal plane is provided with a tray support member for supporting a front end of a tray of the other disc drive when the tray is ejected. The tray support member is capable of protruding from the one disc drive and withdrawing into the same.

An optical disc device according to the present invention performs, in parallel, a first control to convey a first tray in the first optical disc drive group from the disc replacing position to the recording and reproducing position, and a second control to convey a second tray in the second optical disc drive group 40R from the recording and reproducing position to the disc replacing position. The second tray is opposed to the first tray.

A cartridge drive apparatus includes a holder, a lock plate, and a drive unit. The holder is configured to hold a cartridge inserted therein. The lock plate is attached with respect to the holder to be movable in one of an insertion direction and a discharge direction of the cartridge and includes a locking mechanism configured to lock the cartridge. The drive unit is configured to drive the holder and the lock plate in one of the insertion direction and the discharge direction of the cartridge.

A fixing structure of an optical component is composed of a device chassis; a holder holding an optical component; first and second plate parts for joint to the device chassis and a connecting part of both the plate parts are formed in the holder; a plurality of joint holes are formed in the second plate part; a U-groove into which the connecting part of the holder is fitted and a plurality of through-holes are formed in the device chassis; and an adhesive that is extended in a circular columnar shape and is made by inserting the holder into the U-groove of the device chassis, and applying a UV-curing adhesive in such a manner that the UV-curing adhesive is bonded to the first plate part of the holder and is continuous to the inside of the joint hole via the inside of the through-hole, and radiating UV light along the through-hole.

A magazine box is provided for removably storing a plurality of disc-storing magazines used in a disc apparatus for feeding a disc to each of a plurality of disc drives. The magazines each include a tray for storing the disc, a case for removably storing the tray, and a first locking mechanism for releasably locking the tray to the case. The magazine box further includes a second locking mechanism for releasably locking the case of each of the plurality of magazines to the magazine box, and the second locking mechanism maintains the locked state at least during the automatic tray-ejection from the case in the disc apparatus is conducted.

An optical disc drive (ODD) includes one or more sensors which detect a user placing a disc in the loading path. In response, a process is triggered for sensing the thickness of a protective layer of the disc even while the disc is moving toward a turntable. An initial determination of the type of the disc (e.g. CD, DVD or Blu-ray®) can be determined based on the thickness and reported to a host computing device. The host, in turn, determines an application to load based on the disc type. The loading of the application can begin sooner than if the ODD waited until the disc was seated on the turntable to detect the disc type. A final determination of the disc type can be made while the disc is seated as well. The host is informed if there is a disagreement between the initial determination and the final determination.

There is provided a disk drive apparatus including a first chassis unit that has a pickup base at which an optical pickup and a disk table have been disposed, and a first base chassis to which the pickup base has been attached, and a second chassis unit that has a second base chassis and at which a chucking pulley has been disposed. A first rectifying plate part is provided at the first base chassis. A second rectifying plate part is provided at the second base chassis.

A disc drive including a tray, a housing configured to receive the tray, a pickup device installed on the tray, and a main circuit board installed on the tray and connected to the pickup device.

The disk-shaped information recording medium having an outer diameter and an inner diameter comprises a substrate having a predetermined thickness, a first side that is one side of the substrate, a second side that is the other side of the substrate, a cylindrical portion forming a through hole formed at a center of the substrate, and a thin portion formed so as to surround an outer diameter of the cylindrical portion. The thin portion is thinner than the predetermined thickness and includes a non-inclined surface and an inclined surface formed on an outer diameter side of the non-inclined surface. The inclined surface is inclined at a predetermined angle to the non-inclined surface and is larger than the non-inclined surface in the thin portion.

Provided is an object lens driving device that includes a wire holder coupled to a support portion and on which an end of a plurality of suspension wires are fixed. The wire holder includes a first area supported on the support portion and a second area extending from the first area and on which the end of each of the plurality of suspension wires is fixed. In this example, a thickness of the second area is thinner than a thickness of the first area.

An apparatus for rotating disc is provided, the apparatus according to an exemplary embodiment is characterized in that an anti-slip torque that is applied to the upper face of the disc by using the clamp unit and the elastic member is stronger than a rotation torque that is generated by the turn table to inhibit slipping of the optical disc from the turn table.

A wobble determining apparatus is provided with: a calculating device for calculating (i) a first time required until reaching a number of revolutions of a motor which allows a predetermined linear velocity, and (ii) a second time required to move an optical head to a position which allows the predetermined linear velocity, on the basis of the number of revolutions of the motor and the position of the optical head; a judging device for judging whether to keep the optical head in accordance with the calculated first time and the calculated second time; and a controlling device for controlling a moving device not to move the optical head if it is judged to keep the optical head, and for controlling the moving device to move the optical head to the position which allows the predetermined linear velocity if it is judged not to keep the optical head.

Provided is an optical disk drive including a carrying roller for carrying an optical disk in a first direction. The carrying roller includes a first roller portion and a second roller portion which are aligned in a second direction along the optical disk and orthogonal to the first direction and which are so disposed as to make contact with a surface on one side of the optical disk. An axis of the first roller portion is so inclined that a distance between the axis of the first roller portion and the one-side surface of the optical disk gradually increases toward a central portion of the carrying roller. An axis of the second roller portion is so inclined that a distance between the axis of the second roller portion and the one-side surface of the optical disk gradually increases toward the central portion.

A holding portion includes at least three pressing members which are operable to press an inner peripheral of a hole formed on the medium. The pressing members are movable between first positions where the pressing members do not come in contact with the inner peripheral and second positions where the pressing members come in contact with and press the inner peripheral. Each of the pressing members is adapted to interlockingly move with each other when moving toward the first positions and to press the inner peripheral independently from the other members when positioning the second positions.

A disc drive that includes: a housing configured to receive a tray, a pickup mounted on the tray; a connector installed on the housing for outputting signals obtained from the optical pickup; a ribbon cable that includes a first end which is connected to the connector, including a plurality of wire layers, and a part installed adjacent to a side of a body of the housing; and at least one penetration hole formed in a side of the body of the housing so as to reduce a capacitive coupling between the ribbon cable and the body of the housing.

An electromagnetic interference (EMI) absorber includes an EMI conductive sheet having first and second portions, the first portion absorbing EMI from an EMI absorption target and the second portion for conducting EMI to an EMI discharge target, and an elastic member covered by the first portion.

There is provided a cartridge including a running portion which causes both end portions of a disc-shaped recording medium to run, and a pressing portion which presses one end portion of the disc-shaped recording medium to press the other end portion against the running portion. Static friction coefficients of a portion of the pressing portion coming in contact with the one end portion and a portion of the running portion coming in contact with the other end portion are different.

A data storage media may have at least a multi-layer recording lamination with a predetermined coercivity. The multi-layer recording lamination can be configured to record at least one servo format mark for a plurality of data tracks with a solid immersion mirror and program a data bit on the multi-layer recording lamination with a near field transducer.

Provided is an optical pickup device that compensates for an aberration caused by a beam splitter. When a beam of light is reflected from a disc and proceeds towards a beam splitter, the beam splitter is designed to allow the reflected beam to pass therethrough. However, the beam splitter can cause an astigmatism in the reflected beam due to diffraction. According to various aspects herein, an optical pickup device may include a compensation device that generates an inverse astigmatism to compensate for the astigmatism generated by the beam splitter.

Provided is a disk conveying device including a conveying mechanism configured to convey a disk recording medium inside and outside a disk cartridge including a plurality of holding grooves into which both end portions of the disk recording medium positioned at opposite sides with a center hole interposed therebetween are inserted, the plurality of holding grooves being formed in a line in a thickness direction of the disk recording medium, and a discharge lever configured to press an outer circumferential surface of the disk recording medium to the disk cartridge side when the disk recording medium is conveyed by the conveying mechanism.

A CD player, which comprises a conveying roller, a first sensing rod, a second sensing rod, a linkage member, a first switch and a second switch; wherein the linkage member is used for transmitting the rotation of the first sensing rod to the second sensing rod and provided with a first retaining part, a first clamping part, a second retaining part, a second clamping part; the two retaining parts are respectively arranged on both sides of a centerline of a CD conveying path; when the first sensing rod is prevented from rotating by the first retaining part, the second sensing rod is used for releasing the behavior; and when the second sensing rod is prevented from rotating by the second retaining part, the first sensing rod is used for releasing the behavior. The player can avoid the malfunction of a major-diameter CD detection switch and has a very simple structure.

Provided is an objective lens driving unit that prevents an electrical short circuit between very closely spaced second terminals in the objective lens driving unit. The objective lens driving unit is capable of being used in a slim-type optical disc drive.

A holding mechanism is operable to hold a top medium from a plurality of plate-shaped media accommodated in a stacker in a stacked manner. A transport arm supports the holding mechanism. When the lift mechanism lifts down the transport arm, one of a first elastic pressing force and a second elastic pressing force greater than the first elastic pressing force is selectively applied from the holding mechanism to an upper surface of the top medium.

An optical disc drive (ODD) including a tray having a spindle motor, an optical pickup unit, and a transfer motor, may have first and second flat cables. The first flat cable may be connected to the transfer motor, and the second flat cable may have a first terminal part connected to the first flat cable and a second terminal part connected to a circuit board. The circuit board may be arranged at the front of the tray. The second flat cable may include a plurality of signal lines covered by an insulator. One or more exposure parts may be formed in the second flat cable to expose at least one of the plurality of signal lines. An electric actuator of a locking unit may be connected to the one or more of the plurality of signal lines through the one or more exposure parts.

There is provided a disk cartridge including a case body in which a plurality of disk-shaped recording media are configured to be able to be received in an axial direction of a central shaft in parallel, and a first shell having a base surface section parallel to a recording surface of the disk-shaped recording medium and a second shell having a basal surface section parallel to the recording surface of the disk-shaped recording medium are coupled and separated through separation and connection in the axial direction, and a presser spring having a section to be attached, which is attached to the case body, and a pressing section configured to come in contact with an outer circumferential surface of the disk-shaped recording medium and to press the disk-shaped recording medium. The presser spring is formed of a resin material.

A spindle structure for an optical disc and an optical disc drive employing the spindle structure are provided. The spindle structure includes a spindle motor having a rotation axis, a spindle that is coupled to the rotation axis, and a sliding cone coupled to the spindle and inserted into a center hole of the optical disc. The sliding cone includes a plurality of hook-shaped guide rods extended toward the spindle, and the spindle includes guide holes, to which the plurality of hook-shaped guide rods are inserted into and coupled.

A disk device and a method of driving a tray of the disk device. The method includes outputting a tray driving control signal in response to a tray opening instruction, and maximizing an output voltage of the tray driving control signal during a time period in which the tray is expected to be stalled.

A turn table for a spindle motor and a spindle motor having the turn table are provided, the turn table for a spindle motor according to an exemplary embodiment comprising a clamping plate configured to have a locking protrusion protruding from an inner surface of a first recess thereof, the first recess being concavely formed in an outer circumference of the clamping plate; and a turn-table body configured to have a second recess to receive the clamping plate, and a plurality of protrusions protruding from an inner surface defined by the second recess towards the first recess to lock the locking protrusion.

The disk-shaped information recording medium having an outer diameter and an inner diameter comprises a substrate having a predetermined thickness, a first side that is one side of the substrate, a second side that is the other side of the substrate, a cylindrical portion forming a through hole formed at a center of the substrate, and a thin portion formed so as to surround an outer diameter of the cylindrical portion. The thin portion is thinner than the predetermined thickness and includes a non-inclined surface and an inclined surface formed on an outer diameter side of the non-inclined surface. The inclined surface is inclined at an angle greater than or equal to 25 degrees and less than or equal to 35 degrees with respect to the non-inclined surface.

Provided are apparatuses for grounding the objective lens driving unit of an optical pickup device. An optical pickup device includes an objective lens driving unit and a base that supports the objective lens driving unit, and wherein the objective lens driving unit includes a moving structure including an objective lens and a plurality of drive coils; a static structure comprising magnets corresponding to the plurality of drive coils, a yoke that supports the magnets, and a wire holder that has a plurality of wiring layers including a ground wiring layer; a plurality of suspension wires that connect the plurality of drive coils to the plurality of wiring layers; a supporting portion connected to the yoke and fixed to the wire holder; a projection extending from the supporting portion and disposed adjacent to the ground wiring layer; and conductive bonding material connects the ground wiring layer with the projection.

A turn table of a spindle motor is provided, wherein an outer diameter of a vertical portion at the disk insertion unit facing an inner periphery of a small-diameter disk is smaller by 0.01% to 0.15% than the inner periphery of the small-diameter disk to enable a chucking of the small-diameter disk having an inner diameter of an inner periphery smaller than 15 mm.

A medium processing device may include a head which reads or writes data to a recording medium; and a flexible cable which is connected with the head. The flexible cable may be formed in a multilayer structure including a data signal layer formed with a data signal pattern and disconnection detecting signal layers which cover a front face and a rear face of the data signal layer and are formed with a disconnection detecting signal pattern. The flexible cable may also include a terminal connecting part formed with a through hole into which a signal terminal of the head is inserted and a terminal covering part folded to cover the terminal connecting part and fixed to the terminal connecting part.

Hay equipment is provided, having a plurality of unplugging devices operatively connected to the equipment. The plurality of unplugging devices are configured to move to remove a plug of material in the equipment. A controller is configured to activate substantially simultaneously the plurality of unplugging devices and to return the plurality of unplugging devices to normal operating positions once the plug of material is removed.

A machine which provides for both leaf stripping and grading can be used to process plants, such as burley tobacco plants, by continuously moving the plants in a first direction while simultaneously varying the position of the plants in a second direction relative to a defoliating apparatus. The plants may be moved horizontally through a machine by a transporter engaging the plant stalks while the vertical distance between the transporter (and thus the plants) is varied relative to the defoliating apparatus. The transporter and defoliating apparatus may be positioned at an angle to one another. Due to the changing amount of vertical distance, leaves from different sections of the plants, such as leaves at different stalk heights, can be contacted and removed at different corresponding horizontal locations in the machine. Accordingly, leaves can be graded based on the location(s) from which they are retrieved after removal.

A cleaning system for use in a combine harvester including an auger bed mounted within a frame such that when the combine harvester is laterally inclined from the horizontal, the cleaning system, including the auger bed and a sieve, may be leveled or substantially leveled to a generally horizontal position. The auger bed can include a plurality of augers located side by side with their axes positioned generally longitudinally in the combine harvester.

The airflow through a harvesting machine is adjusted by calculating a G-factor at a first point on an upper chaffer to determine if it is greater than 1+n, where n represents a desired factor. A blower is adjusted to reduce an airstream if the G-factor is greater than 1+n. A MOG factor is calculated if the G-factor is less than 1+n. The blower is adjusted to increase the airstream if the MOG-factor is less than 1+x, where x represents a desired factor. A MOG-factor is calculated at a second point if the MOG-factor at the point is greater than 1+x and the blower is adjusted to reduce the airstream if the MOG-factor at the second point is greater than 1+y, where y represents a desired factor or adjusted to increase the airstream if the MOG-factor at the second point is less than 1+y.

A cob conveying and cleaning system for use with a corn harvester, incorporating air induction in cooperation with an air flow from the harvester, for cleaning and separating lighter crop residue to be returned to the field from a mixed flow of the residue and cobs, such that the cleaned cobs can be collected, and the lighter residue optionally spread on the field. The air flow and induction are combined to cooperatively lift or draw the lighter residue from the mixed flow, and to optionally spread the removed lighter residue over a field. The induction apparatus can be located on the harvester, and used as a residue spreader when cobs are not collected.

A grain conveyor for a combine harvester capable of increasing capacity and reducing component wear is disclosed. The grain conveyor includes a grain elevator, a transition chamber and an auger assembly. The grain elevator has an inlet for receiving a flow of grain. The transition chamber includes an inlet and an outlet in fluid communication with the transition chamber inlet and the grain elevator inlet. The transition chamber outlet has an asymmetric non-circular opening larger than the non-cylindrical opening of the transition chamber inlet. The auger assembly is operatively connected to the transition chamber and includes an inlet for receiving a flow of grain and an outlet in fluid communication with the transition chamber inlet.

A harvesting system includes a self-propelled harvesting machine and a drivable collecting container equipped with a drive unit, which can be positioned relative to the harvesting machine and moved in parallel therewith. Crop is fed directly or indirectly to the collecting container during harvesting operation from the harvesting machine using a feed pipe equipped with an outlet chute. The collecting container is equipped with a device for loading it with crop in a uniform manner. The collecting container is moved in a constant position relative to the harvesting machine by way of a control device while the crop is being conveyed. The collecting container is preferably a filling device, by way of which uniform distribution of the crop in the collecting container (8) can be attained.