This analysis aimed to identify clinical factors associated with positivity on repeat ⁶⁸Ga-PSMA-11 PET/CT after a negative scan in patients with recurrent prostate cancer (PCa) under observation. Methods: This single-center, retrospective analysis included patients who underwent at least 2 ⁶⁸Ga-PSMA-11 PET/CT scans (PET1 and PET2) at UCLA between October 2016 and June 2021 for recurrent PCa with negative PET1 and no PCa-related treatments between the 2 scans. Using Prostate Cancer Molecular Imaging Standardized Evaluation criteria to define negative and positive scans, the final cohort was divided into PET2-negative (PET2-Neg) and PET2-positive (PET2-Pos). The same PET1 was used twice in the more than 2 PET cases with inclusion criteria fulfilled. Patient characteristics and clinical parameters were compared between the 2 cohorts using Mann–Whitney U test and Fisher exact test. Areas under the curve (AUCs) of the receiver operating characteristic and the Youden index were computed to determine the discrimination ability of statistically significant factors and specific cut points that maximized sensitivity and specificity, respectively. Results: The final analysis included 83 sets of 2 PET/CT scans from 70 patients. Thirty-nine of 83 (47%) sets were PET2-Neg, and 44 of 83 (53%) sets were PET2-Pos. Prostate-specific antigen (PSA) increased from PET1 to PET2 for all 83 (100%) sets of scans. Median PSA at PET1 was 0.4 ng/mL (interquartile range, 0.2–1.0) and at PET2 was 1.6 ng/mL (interquartile range, 0.9–3.8). We found higher serum PSA at PET2 (median, 1.8 vs. 1.1 ng/mL; P = 0.015), absolute PSA difference (median, 1.4 vs. 0.7 ng/mL; P = 0.006), percentage of PSA change (median, +270.4% vs. +150.0%: P = 0.031), and median PSA velocity (0.044 vs. 0.017 ng/mL/wk, P = 0.002) and shorter PSA doubling time (DT; median, 5.1 vs. 8.3 mo; P = 0.006) in the PET2-Pos cohort than in the PET2-Neg cohort. Receiver operating characteristic curves showed cutoffs for PSA at PET2 of 4.80 ng/mL (sensitivity, 34%; specificity, 92%; AUC, 0.66), absolute PSA difference of 0.95 ng/mL (sensitivity, 62%; specificity, 71%; AUC, 0.68), percentage of PSA change of a positive 289.50% (sensitivity, 48%; specificity, 82%; AUC, 0.64), PSA velocity of 0.033 ng/mL/wk (sensitivity, 57%; specificity, 80%; AUC, 0.70), and PSA DT of 7.91 mo (sensitivity, 71%; specificity, 62%; AUC, 0.67). Conclusion: Patients with recurrent PCa under observation after a negative ⁶⁸Ga-PSMA-11 PET/CT scan with markedly elevated serum PSA levels and shorter PSA DT are more likely to have positive findings on repeat ⁶⁸Ga-PSMA-11 PET/CT.

The historic ocean liner SS United States, whose fate had been in limbo for years, will begin its transition into the world's largest sunken artificial reef beginning this week in Philadelphia, its owner says.

Oregon, Ohio State, Georgia and Miami lead the first edition of the 2024-25 College Football Playoff rankings, the selection committee announced.

Four agricultural workers in Washington state have tested positive for bird flu, the first human cases of H5N1 virus to be reported in the state. Washington is the sixth state to report a human infection of avian flu.

Not only does hearing this statement lower IQ, it also makes people more aggressive, other studies have shown.

Montana Superintendent Elsie Arntzen offers practical advice to schools that could open as early as May 7, even as she says "how they open schools and how learning takes place is up to them."

As Montana's governor pursues a plan to gradually reopen the state, the state education department is relying in part on public opinion to decide whether to reopen schools this year.

State leadership is on the ballot in dozens of states as they grapple with the pandemic's impact on schools, the economy, and their relationship to federal officials.

Pennsylvania's rejection of a formal complaint from the state Catholic Conference over COVID aid and private school students highlights a messy dispute taking place in many states.

Rhode Island today became the first state in the nation adopt the Next Generation Science Standards.

Rhode Island's Council on Elementary and Secondary Education has postponed a decision on whether school districts can charge for summer school.

Many states have recently enacted laws or rules designed to ensure that teachers are well versed in evidence-based reading instruction. Here are some highlights.

Rhode Island may become the first state to adopt the Next Generation Science Standards. The state board will vote later today.

The Chan-Zuckerberg Initiative and other funders are supporting Rhode Island's efforts to define and research personalized learning in traditional public schools.

Lisa Duty of The Learning Accelerator, a Rhode Island Department of Education (RIDE) and Highlander Institute funding partner, outlines the Rhode Islands's commitment to a blended learning future. She describes how the state is developing its new five-year strategic plan that's engaging RIDE's Ambas

The move to assume broad powers over the Providence school system illustrates both the attraction and challenges of high-profile approaches to troubled or low-performing schools and districts.

Teachers in North Carolina and Oregon plan to walk out of their classrooms in protest in May.

Not having to negotiate with federal officials on the finer points of teacher evaluation, rigorous standards, or school turnarounds has made it easier to chart their own paths, some education leaders say.

Some states, such as California, Kentucky and North Dakota plan to use the Every Student Succeeds Act to bolster the decision-making powers of their local school boards in the coming years.

Lawmakers in Michigan, Mississippi, North Dakota, and Utah have all gave previews this to their 2018 fiscal year budget proposals.

With the plan's approval, North Dakota's educators will experience some of the nation's most dramatic changes under the Every Student Succeeds Act this fall.

Ohio auditor Dave Yost, a Republican, says that virtual schools should be compensated based on what their students learn.

Here are summaries of recent annual addresses by governors around the country.

"We have a responsibility to save lives," Ohio Gov. Mike DeWine said on Twitter. "We could have waited to close schools, but based on advice from health experts, this is the time to do it."

Governors in several natural resource-dependent states said recently they will have to continue to cut public education funding because prices for oil and coal have not rebounded.

Several states already offer a state-sanctioned LMS option to their schools, with some encouraging results in their efforts to cut costs and improve technical capabilities.

A collection of stories from the previous week that you may have missed.

Maryland may be a model for how states should approach educating students for the workforce of the future, according to a new policy brief.

The political landscape for updating school finance systems won’t be any easier in the 2020 legislative season, despite a surging economy, state flexibility under ESSA, and single-party control in many states.

Schools may have to continue closures in the fall if the coronavirus resurges, state schools chiefs in Maryland and Washington said. The warnings came the same week thata key federal official predicted schools would be able to reopen for the 2020-21 school year.

The political landscape for updating school finance systems won’t be any easier in the 2020 legislative season, despite a surging economy, state flexibility under ESSA, and single-party control in many states.

Danville Christian Academy is seeking emergency relief from the COVID-19 closure order after losing in federal appeals court.

After a couple years of clashes with teachers in the state, West Virginia Senate President Mitch Carmichael was ousted in Tuesday's Republican primary election by a teacher.

State Superintendent Steve Canavero resigned just two weeks before the state's legislative session was to begin, with more than 80 education-related proposals, including a new funding formula, is on the agenda.

Several states this year sought to replace their funding formulas, a monumental fiscal and political feat, but only a handful of legislatures have been able to get proposals to their governors' desks.

Several states this year sought to replace their funding formulas, a monumental fiscal and political feat, but only a handful of legislatures have been able to get proposals to their governors' desks.

A collection of short news stories from this week.

The state's elected superintendent and the governor-appointed state board have been in a legal dispute since 2016 over who should oversee the many tasks of the education department.

States are tweaking voter registration laws for teenage voters and schools are busing students to the polls. Will these efforts help young people get in the habit of voting?

Teachers in North Carolina and Oregon plan to walk out of their classrooms in protest in May.

A collection of stories from the previous week that you may have missed.

Students returning to schools in Virginia and New York this fall will be required to participate in mental-health education as part of their health and physical education courses.

The New York state legislature passed a bill that would make the use of state test scores in these evaluations optional, leaving the decision up to districts and making it subject to collective bargaining.

A collection of articles you may have missed from the previous week.