Hackers linked to Iran have targeted staff at U.S. drugmaker Gilead Sciences Inc in recent weeks, according to publicly-available web archives reviewed by Reuters and three cybersecurity researchers, as the company races to deploy a treatment for the COVID-19 virus.

Gentex Purchases Microchip’s 25 Billionth MCU, Advancing its HomeLink Interface

CES 2014, LAS VEGAS – HARMAN, the premium global audio and infotainment group (NYSE:HAR), today announced at the Consumer Electronics Show (CES) that GRAMMY Award-winning, multi-platinum alternative rock band Linkin Park will be the new brand ambassadors for the Infinity brand. Reflective of a common history of pushing boundaries, challenging convention, and producing cutting-edge sound, the exclusive five-year partnership between Linkin Park and Infinity will go beyond advertising to include collaboration in product design. To mark the new relationship, Linkin Park will help unveil a sneak peek of two all-new Infinity product lines – the Infinity Reference Loudspeakers Series and the brand’s first portable wireless sound system, called Infinity One.

CES 2015, LAS VEGAS – HARMAN, the premium global audio, visual, infotainment and enterprise automation group (NYSE:HAR), introduced today at CES 2015 the Infinity® BassLink SM, the latest subwoofer in the BassLink line. The compact under seat subwoofer is designed to reinforce the low-end bass performance in vehicles and put the richness back into the music.

CES 2017, Las Vegas – January 4, 2017 - Today, HARMAN International Industries, Incorporated (NYSE:HAR), the premier connected technologies company for automotive, consumer and enterprise markets, announced the Infinity BassLink DC compact powered ...

Nouvelles lignes de basse percutantes et solos de guitare à tomber : les enceintes JBL Link Portable et Link Music viennent de sortir. Avec leur son signature 360 JBL, le Wi-Fi et le Bluetooth, Chromecast et Google Assistant intégrés, les enceintes sont aussi belles qu’intelligentes.

Satte Bässe oder heiße Gitarrensolos! Die neuen JBL Link Portable und JBL Link Music sind ab sofort verfügbar. Mit 360°-JBL Signature Sound, WLAN und Bluetooth-Konnektivität, integriertem Chromecast und Google Assistant klingen die beiden Lautsprecher genauso gut wie sie aussehen.

Van knallende baslijnen tot vloeiende gitaarsolo’s, JBL introduceert de JBL Link Portable en Link Music. Ze zijn net zo handig als ze mooi zijn, de speakers zijn voorzien van 360 graden JBL’s kenmerkende sound, Wifi- en Bluetooth-connectiviteit en ingebouwde Chromecast en Google assistent.

From heart-thumping basslines to face-melting guitar solos, the new JBL Link Portable and Link Music have arrived. With 360 JBL Signature Sound, Wi-Fi and Bluetooth connectivity, Chromecast and Google Assistant built-in, they’ve got brains to match their beauty.

A terminal in the U.S. is now linked to the Tijuana International Airport via a cross-border bridge. Julie Noce reports.

Title: More Studies Link Vaping to Asthma, COPD
Category: Health News
Created: 1/14/2020 12:00:00 AM
Last Editorial Review: 1/14/2020 12:00:00 AM

Title: AHA News: Persistent Asthma Linked to Increased Risk for Heart Rhythm Disorder
Category: Health News
Created: 2/4/2020 12:00:00 AM
Last Editorial Review: 2/5/2020 12:00:00 AM

Title: Epilepsy Drug Linked to Low IQ
Category: Health News
Created: 5/4/2007 12:00:00 AM
Last Editorial Review: 5/4/2007 12:00:00 AM

Title: Allergy-Linked Mouth Breathing Spells Trouble for Kids
Category: Health News
Created: 4/23/2010 12:10:00 PM
Last Editorial Review: 4/26/2010 12:00:00 AM

Title: Chewing Khat Linked to Severe Liver Damage
Category: Health News
Created: 4/28/2010 6:10:00 PM
Last Editorial Review: 4/29/2010 12:00:00 AM

Title: Extreme Obesity Linked to Dangerous Behaviors in Teens
Category: Health News
Created: 4/26/2011 1:55:00 PM
Last Editorial Review: 4/27/2011 12:00:00 AM

Title: Rate of Statin-Linked Muscle Woes Unclear, Study Suggests
Category: Health News
Created: 4/27/2012 4:05:00 PM
Last Editorial Review: 4/30/2012 12:00:00 AM

Title: Study Finds Direct Link Between Obesity, Heart Disease
Category: Health News
Created: 5/2/2012 10:05:00 AM
Last Editorial Review: 5/2/2012 12:00:00 AM

Title: Arthritis in Children Linked to Infections
Category: Health News
Created: 5/1/2012 4:05:00 PM
Last Editorial Review: 5/2/2012 12:00:00 AM

Title: Overly Long Pregnancies Linked to Behavioral Problems in Toddlers
Category: Health News
Created: 5/3/2012 10:05:00 AM
Last Editorial Review: 5/3/2012 12:00:00 AM

Title: Poor Parenting Styles Linked to Bullying Behavior in Kids
Category: Health News
Created: 4/26/2013 12:36:00 PM
Last Editorial Review: 4/29/2013 12:00:00 AM

Title: Some Antidepressants Linked to Bleeding Risk With Surgery
Category: Health News
Created: 4/29/2013 4:35:00 PM
Last Editorial Review: 4/30/2013 12:00:00 AM

Title: Study Debunks Lyme Disease-Autism Link
Category: Health News
Created: 4/30/2013 12:35:00 PM
Last Editorial Review: 5/1/2013 12:00:00 AM

Title: General Anesthesia Not Linked to Raised Risk for Dementia
Category: Health News
Created: 5/1/2013 12:35:00 PM
Last Editorial Review: 5/2/2013 12:00:00 AM

Title: Low-Dose 'Pill' Linked to Pain During Orgasm, Study Finds
Category: Health News
Created: 5/3/2013 12:35:00 PM
Last Editorial Review: 5/3/2013 12:00:00 AM

Title: Higher Doses of Antidepressants Linked to Suicidal Behavior in Young Patients: Study
Category: Health News
Created: 4/28/2014 4:36:00 PM
Last Editorial Review: 4/29/2014 12:00:00 AM

Title: No Link Found Between Playing Football in Hot Weather, Concussion Risk
Category: Health News
Created: 4/28/2014 4:36:00 PM
Last Editorial Review: 4/29/2014 12:00:00 AM

Title: Y Chromosome Loss Linked to Higher Cancer Risk in Men
Category: Health News
Created: 4/28/2014 12:35:00 PM
Last Editorial Review: 4/29/2014 12:00:00 AM

Title: HPV-Linked Oral Cancers May Not Be 'Contagious'
Category: Health News
Created: 4/29/2014 2:36:00 PM
Last Editorial Review: 4/30/2014 12:00:00 AM

Title: Trampolines Linked to More Than 1 Million ER Visits Over a Decade
Category: Health News
Created: 5/2/2014 12:35:00 PM
Last Editorial Review: 5/2/2014 12:00:00 AM

Title: Childhood Self-Control Linked to Better Job Prospects Later in Life
Category: Health News
Created: 4/24/2015 12:00:00 AM
Last Editorial Review: 4/27/2015 12:00:00 AM

Title: No Link Between Anti-Smoking Drugs, Mental Health Issues: Study
Category: Health News
Created: 4/22/2016 12:00:00 AM
Last Editorial Review: 4/25/2016 12:00:00 AM

Title: Could Certain Fatty Foods Be Linked to Aggressive Prostate Cancer?
Category: Health News
Created: 4/22/2016 12:00:00 AM
Last Editorial Review: 4/25/2016 12:00:00 AM

Title: Trouble With Sense of Direction May Be Linked to Early Alzheimer's: Study
Category: Health News
Created: 4/26/2016 12:00:00 AM
Last Editorial Review: 4/27/2016 12:00:00 AM

Title: Some Antibiotics Linked to Miscarriage Risk
Category: Health News
Created: 5/1/2017 12:00:00 AM
Last Editorial Review: 5/1/2017 12:00:00 AM

Title: Raw Oysters From British Columbia Linked to Norovirus Outbreaks
Category: Health News
Created: 5/3/2018 12:00:00 AM
Last Editorial Review: 5/3/2018 12:00:00 AM

Title: Device Might Detect Breast Cancer-Linked Swelling Sooner
Category: Health News
Created: 5/3/2018 12:00:00 AM
Last Editorial Review: 5/4/2018 12:00:00 AM

Title: Vampire Facials at New Mexico Spa Linked to HIV Infections
Category: Health News
Created: 5/1/2019 12:00:00 AM
Last Editorial Review: 5/1/2019 12:00:00 AM

Title: Breast Implants Linked to Cancer Can Still be Sold in U.S.: FDA
Category: Health News
Created: 5/3/2019 12:00:00 AM
Last Editorial Review: 5/3/2019 12:00:00 AM

Title: COVID-19 Now Linked With Strokes in Young Patients
Category: Health News
Created: 4/29/2020 12:00:00 AM
Last Editorial Review: 4/29/2020 12:00:00 AM

Title: Screen Time for Tiniest Tots Linked to Autism-Like Symptoms
Category: Health News
Created: 4/20/2020 12:00:00 AM
Last Editorial Review: 4/21/2020 12:00:00 AM

Dr Harpreet Bajaj summarizes the known and unknown links between diabetes and COVID-19, focusing on three clinical questions.

Data from a large US cohort suggest systemic anticoagulation may confer a survival benefit in hospitalized patients without a spike in bleeding events.

In response to the growing interest in the availability of data associated with articles, PMC is reviewing current practices around data and seeking feedback on how to best serve the data needs of the research community.

As part of these efforts, the PMC policy statement on supplementary data was recently updated to more clearly articulate the requirement that any supplementary data (images, tables, video, or other documents / files) that are associated with an article must be deposited in PMC with an article. The search filter "has suppdata[filter]" can be used in PMC to discover records with associated supplementary data files.

In addition to providing supplementary data with an article, NLM is also encouraging journals and authors to make research data available in a public repository and include the relevant data citation(s) in the paper. Guidance for PMC data providers on tagging data citations is available in the Tagging Guidelines. This guidance is based on the JATS4R recommendations on data citations.

Starting this month, the NIH Manuscript Submission (NIHMS) system will also accept deposits of small datasets accompanying deposits of funded author manuscripts for inclusion of PMC. (Guidance for authors is available in the NIHMS FAQ.)

If you have suggestions on future directions in data for PMC to consider, please let us know at pubmedcentral@ncbi.nlm.nih.gov.

Title: Heavy Pot Use Linked to Mental Problems, Even After Quitting
Category: Health News
Created: 4/30/2020 12:00:00 AM
Last Editorial Review: 5/1/2020 12:00:00 AM

Title: Study Links Menopausal Night Sweats to Impaired Thinking
Category: Health News
Created: 9/25/2019 12:00:00 AM
Last Editorial Review: 9/25/2019 12:00:00 AM

ABSTRACT

The Candida albicans high-affinity phosphate transporter Pho84 is required for normal Target of Rapamycin (TOR) signaling, oxidative stress resistance, and virulence of this fungal pathogen. It also contributes to C. albicans’ tolerance of two antifungal drug classes, polyenes and echinocandins. Echinocandins inhibit biosynthesis of a major cell wall component, beta-1,3-glucan. Cells lacking Pho84 were hypersensitive to other forms of cell wall stress beyond echinocandin exposure, while their cell wall integrity signaling response was weak. Metabolomics experiments showed that levels of phosphoric intermediates, including nucleotides like ATP and nucleotide sugars, were low in pho84 mutant compared to wild-type cells recovering from phosphate starvation. Nonphosphoric precursors like nucleobases and nucleosides were elevated. Outer cell wall phosphomannan biosynthesis requires a nucleotide sugar, GDP-mannose. The nucleotide sugar UDP-glucose is the substrate of enzymes that synthesize two major structural cell wall polysaccharides, beta-1,3- and beta-1,6-glucan. Another nucleotide sugar, UDP-N-acetylglucosamine, is the substrate of chitin synthases which produce a stabilizing component of the intercellular septum and of lateral cell walls. Lack of Pho84 activity, and phosphate starvation, potentiated pharmacological or genetic perturbation of these enzymes. We posit that low substrate concentrations of beta-d-glucan- and chitin synthases, together with pharmacologic inhibition of their activity, diminish enzymatic reaction rates as well as the yield of their cell wall-stabilizing products. Phosphate import is not conserved between fungal and human cells, and humans do not synthesize beta-d-glucans or chitin. Hence, inhibiting these processes simultaneously could yield potent antifungal effects with low toxicity to humans.

IMPORTANCE Candida species cause hundreds of thousands of invasive infections with high mortality each year. Developing novel antifungal agents is challenging due to the many similarities between fungal and human cells. Maintaining phosphate balance is essential for all organisms but is achieved completely differently by fungi and humans. A protein that imports phosphate into fungal cells, Pho84, is not present in humans and is required for normal cell wall stress resistance and cell wall integrity signaling in C. albicans. Nucleotide sugars, which are phosphate-containing building block molecules for construction of the cell wall, are diminished in cells lacking Pho84. Cell wall-constructing enzymes may be slowed by lack of these building blocks, in addition to being inhibited by drugs. Combined targeting of Pho84 and cell wall-constructing enzymes may provide a strategy for antifungal therapy by which two sequential steps of cell wall maintenance are blocked for greater potency.

ABSTRACT

Human milk oligosaccharides (HMOs) may provide health benefits to infants partly by shaping the development of the early-life intestinal microbiota. In a randomized double-blinded controlled multicentric clinical trial, healthy term infants received either infant formula (control) or the same formula with two HMOs (2'-fucosyllactose and lacto-N-neotetraose; test) from enrollment (0 to 14 days) to 6 months. Then, all infants received the same follow-up formula without HMOs until 12 months of age. Breastfed infants (BF) served as a reference group. Stool microbiota at 3 and 12 months, analyzed by 16S rRNA gene sequencing, clustered into seven fecal community types (FCTs) with marked differences in total microbial abundances. Three of the four 12-month FCTs were likely precursors of the adult enterotypes. At 3 months, microbiota composition in the test group (n = 58) appeared closer to that of BF (n = 35) than control (n = 63) by microbiota alpha (within group) and beta (between groups) diversity analyses and distribution of FCTs. While bifidobacteriaceae dominated two FCTs, its abundance was significantly higher in one (FCT BiH for Bifidobacteriaceae at high abundance) than in the other (FCT Bi for Bifidobacteriaceae). HMO supplementation increased the number of infants with FCT BiH (predominant in BF) at the expense of FCT Bi (predominant in control). We explored the association of the FCTs with reported morbidities and medication use up to 12 months. Formula-fed infants with FCT BiH at 3 months were significantly less likely to require antibiotics during the first year than those with FCT Bi. Previously reported lower rates of infection-related medication use with HMOs may therefore be linked to gut microbiota community types. (This study has been registered at ClinicalTrials.gov under registration number NCT01715246.)

IMPORTANCE Human milk is the sole and recommended nutrition for the newborn infant and contains one of the largest constituents of diverse oligosaccharides, dubbed human milk oligosaccharides (HMOs). Preclinical and clinical association studies indicate that HMOs have multiple physiological functions largely mediated through the establishment of the gut microbiome. Until recently, HMOs were not available to investigate their role in randomized controlled intervention trials. To our knowledge, this is the first report on the effects of 2 HMOs on establishing microbiota in newborn infants. We provide a detailed description of the microbiota changes observed upon feeding a formula with 2 HMOs in comparison to breastfed reference infants' microbiota. Then, we associate the microbiota to long-term health as assessed by prescribed antibiotic use.

ABSTRACT

The multifunctional nature of viral proteins is essentially driven by posttranslational modifications (PTMs) and is key for the successful outcome of infection. For influenza A viruses (IAVs), a composite pattern of PTMs regulates the activity of viral proteins. However, almost none are known that target the PB2 replication protein, except for inducing its degradation. We show here that PB2 undergoes a nonproteolytic ubiquitination during infection. We identified E3 ubiquitin ligases catalyzing this ubiquitination as two multicomponent RING-E3 ligases based on cullin 4 (CRL4s), which are both contributing to the levels of ubiquitinated forms of PB2 in infected cells. The CRL4 E3 ligase activity is required for the normal progression of the viral cycle and for maximal virion production, indicating that the CRL4s mediate a ubiquitin signaling that promotes infection. The CRL4s are recruiting PB2 through an unconventional bimodal interaction with both the DDB1 adaptor and DCAF substrate receptors. While able to bind to PB2 when engaged in the viral polymerase complex, the CRL4 factors do not alter transcription and replication of the viral segments during infection. CRL4 ligases catalyze different patterns of lysine ubiquitination on PB2. Recombinant viruses mutated in the targeted lysines showed attenuated viral production, suggesting that CRL4-mediated ubiquitination of PB2 contributes to IAV infection. We identified K29-linked ubiquitin chains as main components of the nonproteolytic PB2 ubiquitination mediated by the CRL4s, providing the first example of the role of this atypical ubiquitin linkage in the regulation of a viral infection.

IMPORTANCE Successful infection by influenza A virus, a pathogen of major public health importance, involves fine regulation of the multiple functions of the viral proteins, which often relies on post-translational modifications (PTMs). The PB2 protein of influenza A viruses is essential for viral replication and a key determinant of host range. While PTMs of PB2 inducing its degradation have been identified, here we show that PB2 undergoes a regulating PTM signaling detected during infection, based on an atypical K29-linked ubiquitination and mediated by two multicomponent E3 ubiquitin ligases. Recombinant viruses impaired for CRL4-mediated ubiquitination are attenuated, indicating that ubiquitination of PB2 is necessary for an optimal influenza A virus infection. The CRL4 E3 ligases are required for normal viral cycle progression and for maximal virion production. Consequently, they represent potential candidate host factors for antiviral targets.