w Front line stories - How corona is changing acute care By feeds.bmj.com Published On :: Tue, 14 Apr 2020 22:33:14 +0000 As we cover the covid-19 outbreak, we want to hear some of the stories from the frontline - And who better to heart of what this pandemic is doing to the profession in the UK, than some of the people who write regularly for The BMJ? In this first one, we wanted to look specifically at acute care - those at the sharp end of the response, so we're... Full Article
w Wellbeing - some advice for telehealth in secondary care By feeds.bmj.com Published On :: Thu, 16 Apr 2020 18:30:00 +0000 We’ve published info on Telehealth in primary care - and have been overwhelmed by the response from GPs who are finding it useful. But it’s not only primary care that is dramatically shifting to remote care - routine hospital care is moving online too, so we’ve asked Rowena McCash - GP and out of hours triage trainer joins us to give some tips... Full Article
w Wellbeing – advice from a military medic to frontline clinicians By feeds.bmj.com Published On :: Wed, 22 Apr 2020 11:53:26 +0000 There is no doubt that anxiety levels that clinicians are feeling during this pandemic are high. One military medic believes the current situation is comparable to his experience when posted during British campaigns in Afghanistan and Iraq. Cormac Doyle offers advice on how to deal with high-stress conditions, both in a work and at home, as... Full Article
w Feeling the fear with Iona Heath and Danielle Ofri By feeds.bmj.com Published On :: Wed, 22 Apr 2020 17:11:52 +0000 A new podcast from The BMJ, to help GP's feel more connected, heard, and supported. Subscribe on; Apple podcasts - https://bit.ly/applepodsDBI Spotify - https://bit.ly/spotifyDBI Google podcasts - https://bit.ly/googlepodsDBI This week, our topic is fear: we try to get a better understanding of fear, how it affects all of us as clinicians for... Full Article
w Teleconsulting with Trish Greenhalgh and Fiona Stevenson By feeds.bmj.com Published On :: Wed, 22 Apr 2020 17:41:46 +0000 A new podcast from The BMJ, to help GP's feel more connected, heard, and supported. Subscribe on; Apple podcasts - https://bit.ly/applepodsDBI Spotify - https://bit.ly/spotifyDBI Google podcasts - https://bit.ly/googlepodsDBI In our first episode, we discuss the highs and lows of video consultations, and how coronavirus has altered the landscape... Full Article
w Talk Evidence - covid ethics, waste and a minimum RCT size By feeds.bmj.com Published On :: Fri, 24 Apr 2020 16:19:18 +0000 For the next few months Talk Evidence is going to focus on the new corona virus pandemic. There is an enormous amount of uncertainty about the disease, what the symptoms are, fatality rate, treatment options, things we shouldn't be doing. We're going to try to get away from the headlines and talk about what we need to know - to hopefully give... Full Article
w Frontline stories - working as a GP during covid By feeds.bmj.com Published On :: Mon, 27 Apr 2020 16:56:13 +0000 As the pandemic plays out - the way in which doctors in the UK practice is changing, hospitals are reconfigured to increase critical care capacity, GPs are working from home and doing their day to day work remotely. Some of the changes have come at the detriment of staff and patient wellbeing but covid-19 has also helped cut through some of the... Full Article
w Wellbeing – how one junior doctor found a way to support frontline staff By feeds.bmj.com Published On :: Wed, 29 Apr 2020 17:17:18 +0000 How can we help frontline clinicians? Sometimes medics may feel uneasy or even guilty and that they could be doing more. That was what a junior doctor in Abergavenny in Wales felt and she did something about it. In this podcast, we speak to Josie Cheetham about how she started her initiative to provide support boxes in hospitals for her... Full Article
w Talk Evidence covid-19 update - lack of testing transparency, how to give good debate By feeds.bmj.com Published On :: Mon, 04 May 2020 16:25:18 +0000 For the next few months Talk Evidence is going to focus on the new corona virus pandemic. There is an enormous amount of uncertainty about the disease, what the symptoms are, fatality rate, treatment options, things we shouldn't be doing. We're going to try to get away from the headlines and talk about what we need to know - to hopefully give you... Full Article
w Coping with Covid with Monica Schoch-Spana and Jud Brewer By feeds.bmj.com Published On :: Wed, 06 May 2020 23:27:26 +0000 In this week’s episode, we discuss bystander guilt, convergence, brain hacks and “how you can sneeze on someone’s brain from anywhere in the world”. How can GPs cope with the myriad worries around treating patients during the current pandemic, both on the frontline and in general practice? How do we recognise and break unhelpful anxious behaviour... Full Article
w Wellbeing – coping with Covid fatigue By feeds.bmj.com Published On :: Fri, 08 May 2020 10:00:46 +0000 We are more than six weeks into the lockdown and if you were to gauge the mood of the nation, it would be one of fatigue. It started as an all-hands-on-deck emergency situation, but it now transpires that the current work situation for healthcare professionals is not going to change any time soon. This is a marathon rather than a sprint. So how... Full Article
w C-Reactive Protein Is an Independent Predictor of Risk for the Development of Diabetes in the West of Scotland Coronary Prevention Study By diabetes.diabetesjournals.org Published On :: 2002-05-01 Dilys J. FreemanMay 1, 2002; 51:1596-1600Complications Full Article
w Morbidity and Mortality in Diabetics In the Framingham Population: Sixteen Year Follow-up Study By diabetes.diabetesjournals.org Published On :: 1974-02-01 Mariano J GarciaFeb 1, 1974; 23:105-111Original Contribution Full Article
w High Incidence of Metabolically Active Brown Adipose Tissue in Healthy Adult Humans: Effects of Cold Exposure and Adiposity By diabetes.diabetesjournals.org Published On :: 2009-07-01 Masayuki SaitoJul 1, 2009; 58:1526-1531Metabolism Full Article
w Relation Between Antioxidant Enzyme Gene Expression and Antioxidative Defense Status of Insulin-Producing Cells By diabetes.diabetesjournals.org Published On :: 1997-11-01 Markus TiedgeNov 1, 1997; 46:1733-1742Original Article Full Article
w Mechanisms of Pancreatic {beta}-Cell Death in Type 1 and Type 2 Diabetes: Many Differences, Few Similarities By diabetes.diabetesjournals.org Published On :: 2005-12-01 Miriam CnopDec 1, 2005; 54:S97-S107Section III: Inflammation and beta-Cell Death Full Article
w From the Triumvirate to the Ominous Octet: A New Paradigm for the Treatment of Type 2 Diabetes Mellitus By diabetes.diabetesjournals.org Published On :: 2009-04-01 Ralph A. DeFronzoApr 1, 2009; 58:773-795Banting Lecture Full Article
w Lipid-Induced Insulin Resistance in Human Muscle Is Associated With Changes in Diacylglycerol, Protein Kinase C, and I{kappa}B-{alpha} By diabetes.diabetesjournals.org Published On :: 2002-07-01 Samar I. ItaniJul 1, 2002; 51:2005-2011Rapid Publications Full Article
w Role of oxidative stress in diabetic complications: a new perspective on an old paradigm By diabetes.diabetesjournals.org Published On :: 1999-01-01 JW BaynesJan 1, 1999; 48:1-9Articles Full Article
w Preservation of Pancreatic {beta}-Cell Function and Prevention of Type 2 Diabetes by Pharmacological Treatment of Insulin Resistance in High-Risk Hispanic Women By diabetes.diabetesjournals.org Published On :: 2002-09-01 Thomas A. BuchananSep 1, 2002; 51:2796-2803Pathophysiology Full Article
w Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascade By diabetes.diabetesjournals.org Published On :: 1999-06-01 ME GriffinJun 1, 1999; 48:1270-1274Articles Full Article
w U.K. Prospective Diabetes Study 16: Overview of 6 Years' Therapy of Type II Diabetes: A Progressive Disease By diabetes.diabetesjournals.org Published On :: 1995-11-01 U.K. Prospective Diabetes Study GroupNov 1, 1995; 44:1249-1258Perspectives in Diabetes Full Article
w Quantification of the Relationship Between Insulin Sensitivity and {beta}-Cell Function in Human Subjects: Evidence for a Hyperbolic Function By diabetes.diabetesjournals.org Published On :: 1993-11-01 Steven E KahnNov 1, 1993; 42:1663-1672Original Article Full Article
w Triggering and amplifying pathways of regulation of insulin secretion by glucose By diabetes.diabetesjournals.org Published On :: 2000-11-01 JC HenquinNov 1, 2000; 49:1751-1760Articles Full Article
w Isolation of INS-1-derived cell lines with robust ATP-sensitive K+ channel-dependent and -independent glucose-stimulated insulin secretion By diabetes.diabetesjournals.org Published On :: 2000-03-01 HE HohmeierMar 1, 2000; 49:424-430Articles Full Article
w {beta}-Cell Deficit and Increased {beta}-Cell Apoptosis in Humans With Type 2 Diabetes By diabetes.diabetesjournals.org Published On :: 2003-01-01 Alexandra E. ButlerJan 1, 2003; 52:102-110Islet Studies Full Article
w Assessment of MTNR1B Type 2 Diabetes Genetic Risk Modification by Shift Work and Morningness-Eveningness Preference in the UK Biobank By diabetes.diabetesjournals.org Published On :: 2020-01-20T12:00:26-08:00 Night shift work, behavioral rhythms, and the common MTNR1B risk single nucleotide polymorphism (SNP), rs10830963, associate with type 2 diabetes; however, whether they exert joint effects to exacerbate type 2 diabetes risk is unknown. Among employed participants of European ancestry in the UK Biobank (N = 189,488), we aimed to test the cross-sectional independent associations and joint interaction effects of these risk factors on odds of type 2 diabetes (n = 5,042 cases) and HbA1c levels (n = 175,156). Current shift work, definite morning or evening preference, and MTNR1B rs10830963 risk allele associated with type 2 diabetes and HbA1c levels. The effect of rs10830963 was not modified by shift work schedules. While marginal evidence of interaction between self-reported morningness-eveningness preference and rs10830963 on risk of type 2 diabetes was seen, this interaction did not persist when analysis was expanded to include all participants regardless of employment status and when accelerometer-derived sleep midpoint was used as an objective measure of morningness-eveningness preference. Our findings suggest that MTNR1B risk allele carriers who carry out shift work or have more extreme morningness-eveningness preference may not have enhanced risk of type 2 diabetes. Full Article
w Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study By diabetes.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 Children at increased genetic risk for type 1 diabetes (T1D) after environmental exposures may develop pancreatic islet autoantibodies (IA) at a very young age. Metabolic profile changes over time may imply responses to exposures and signal development of the first IA. Our present research in The Environmental Determinants of Diabetes in the Young (TEDDY) study aimed to identify metabolome-wide signals preceding the first IA against GAD (GADA-first) or against insulin (IAA-first). We profiled metabolomes by mass spectrometry from children’s plasma at 3-month intervals after birth until appearance of the first IA. A trajectory analysis discovered each first IA preceded by reduced amino acid proline and branched-chain amino acids (BCAAs), respectively. With independent time point analysis following birth, we discovered dehydroascorbic acid (DHAA) contributing to the risk of each first IA, and -aminobutyric acid (GABAs) associated with the first autoantibody against insulin (IAA-first). Methionine and alanine, compounds produced in BCAA metabolism and fatty acids, also preceded IA at different time points. Unsaturated triglycerides and phosphatidylethanolamines decreased in abundance before appearance of either autoantibody. Our findings suggest that IAA-first and GADA-first are heralded by different patterns of DHAA, GABA, multiple amino acids, and fatty acids, which may be important to primary prevention of T1D. Full Article
w Workers blame Iberostar for failure to benefit from SET Cash COVID relief - Employees charge that hotel did not to pay over tax deductions to State By jamaica-gleaner.com Published On :: Fri, 08 May 2020 00:23:02 -0500 Western Bureau: Some displaced Iberostar employees in Rose Hall, St James, are angry with their employer, charging that they have been unable to benefit from the Government’s COVID-19 relief programme because of the hotel’s failure to pay over... Full Article
w Fear, grief grip west Kingston after children murdered By jamaica-gleaner.com Published On :: Fri, 08 May 2020 00:24:29 -0500 Tears flowed yesterday down the face of Donaree Anderson, cousin of 15-year-old Nyron Taylor, one of two children shot dead in west Kingston hours apart on Wednesday. Eight-year-old Toya Brown was the other child killed just days into the month... Full Article
w COVID burnout! - Health workers burdened as they fight stubborn virus By jamaica-gleaner.com Published On :: Fri, 08 May 2020 00:25:45 -0500 Edmond Campbell/Senior Parliamentary Reporter Conceding that healthcare workers in the public sector are burnt out as they combat COVID-19, Health and Wellness Minister Dr Christopher Tufton says the Government is taking steps to boost its... Full Article
w St Mary COVID crackdown - Health teams go house to house tracing virus as quarantine hits Dover, Annotto Bay, Enfield By jamaica-gleaner.com Published On :: Fri, 08 May 2020 00:26:31 -0500 Days after The Gleaner reported a clarion call from Port Maria Mayor Richard Creary for the quarantine of St Mary communities owing to growing concerns about the spread of COVID-19 in the parish, the Government responded with the lockdown of three... Full Article
w Heartbreak again ... Unhappy landing for ship workers, other Jamaicans By jamaica-gleaner.com Published On :: Fri, 08 May 2020 15:15:24 -0500 It was not the landing the Jamaicans who arrived at Kingston’s Norman Manley International Airport on Wednesday evening would want again. The 43 Jamaican ship workers of the Marella Discovery 2 were among the 115 people aboard the TUI charter flight that touched down amid the Kingston breeze and evening sunset. Full Article
w PNP wants Gov’t to issue quarantine order for St Mary By jamaica-gleaner.com Published On :: Sat, 09 May 2020 00:17:24 -0500 The People’s National Party (PNP) has asserted that the absence of a quarantine order for three St Mary communities is adding to the state of confusion. The 14-day measure began on Thursday in Dover, Enfield and Annotto Bay at 6 a.m. “The lack of... Full Article
w Taxis complying with social-distancing protocol By jamaica-gleaner.com Published On :: Sat, 09 May 2020 00:17:35 -0500 Many taxi and bus operators in sections of Kingston and St Andrew are seemingly adhering to social-distancing guidelines outlined by the Government for the sector, in terms of the number of passengers they are allowed to transport at a time. These... Full Article
w Lockdown pains! - Vendor suffers double setback from COVID strictures By jamaica-gleaner.com Published On :: Sat, 09 May 2020 00:08:31 -0500 It was a double whammy of inconvenience for Sharon Carter, a vendor in Metcalfe Market, Annotto Bay. Carter, who lives in St Catherine, had just recently been relieved of the lockdown in the parish and is now being affected by the quarantine which... Full Article
w Downswell reaches out to Central Village - Carry Me singer delivers care packages to community By jamaica-gleaner.com Published On :: Sat, 09 May 2020 00:05:37 -0500 The wet weather last Saturday (May 2) could not dampen the spirits of award-winning gospel artiste and ordained evangelist Kevin Downswell as he ventured into the St Catherine community of Central Village, where he spent some of his formative years... Full Article
w World Bank predicts sharpest decline of remittances to Caribbean By jamaica-gleaner.com Published On :: Thu, 23 Apr 2020 15:26:53 -0500 WASHINGTON, CMC – The World Bank has predicted the sharpest decline of remittances to Latin America and the Caribbean, saying that global remittances on a whole are projected to fall by about 20 percent in 2020 due to the economic crisis... Full Article
w Barbados to end 24-hour lockdown Monday By jamaica-gleaner.com Published On :: Wed, 29 Apr 2020 21:22:51 -0500 Barbados Prime Minister Mia Mottley has announced a phased reopening of government and business operations, ending a mandatory 24-hour lockdown imposed on April 3 amid the global coronavirus pandemic. The phased reopening will begin on... Full Article
w St Vincent denies US-based airline from landing with stranded nationals By jamaica-gleaner.com Published On :: Wed, 29 Apr 2020 10:42:19 -0500 KINGSTOWN, St Vincent, CMC – The St Vincent and the Grenadines Government has denied a United States-based airline permission to land, dashing hopes that an estimated 300 nationals employed with a US-based cruise line would have arrived home... Full Article
w Trinidad warns of fraud in COVID-19 support programme By jamaica-gleaner.com Published On :: Sun, 03 May 2020 10:07:31 -0500 PORT OF SPAIN, Trinidad, CMC – The Trinidad and Tobago government Saturday said it had uncovered a plot by persons to defraud the state and that a new mechanism would be put in place Monday in providing rental assistance to people impacted by... Full Article
w 2020 hurricane season will be more active than normal - CSU forecasters By jamaica-gleaner.com Published On :: Mon, 04 May 2020 10:15:00 -0500 BRIDGETOWN, Barbados, CMC – A few weeks before the official start of the 2020 Atlantic Hurricane Season, forecasters at the US-based Colorado State University are warning that the six-month period will be more active than normal. The CSU... Full Article
w Dominica going ahead with national examinations By jamaica-gleaner.com Published On :: Thu, 07 May 2020 13:55:50 -0500 ROSEAU, Dominica, CMC –A senior education official Thursday said students would sit the Grade Six National Assessment examinations later this year, despite the disruption caused to the education system by the coronavirus (COVID-19). Dominica... Full Article
w Rotating night shift work and adherence to unhealthy lifestyle in predicting risk of type 2 diabetes: results from two large US cohorts of female nurses By feeds.bmj.com Published On :: Wednesday, November 21, 2018 - 23:31 Full Article
w Type 2 diabetes: sweetened drinks pose greater risk than other sugary foods By feeds.bmj.com Published On :: Thursday, November 22, 2018 - 06:30 Full Article
w Type 2 diabetes affects 7000 young people in England and Wales, analysis shows By feeds.bmj.com Published On :: Thursday, November 22, 2018 - 06:31 Full Article
w The growing problem of diabetes By feeds.bmj.com Published On :: Thursday, November 22, 2018 - 12:15 Full Article
w Rammya Mathew: Liquid diets offer promise, but we still need upstream solutions By feeds.bmj.com Published On :: Thursday, January 3, 2019 - 10:25 Full Article
w Diabetes: precision approach will improve outcomes, says research director By feeds.bmj.com Published On :: Friday, January 11, 2019 - 13:51 Full Article
w Public health leaders slam Boris Johnson over “sin tax” review plan By feeds.bmj.com Published On :: Thursday, July 4, 2019 - 13:01 Full Article