ind Device for loading printing plates on a plate cylinder of a rotary offset press By www.freepatentsonline.com Published On :: Tue, 14 Apr 2015 08:00:00 EDT The loading device according to the invention comprises a magazine for receiving at least one printing plate and transferring it from the magazine to the plate cylinder. It also comprises at least one guide rail to guide a printing plate during transfer thereof by cooperation with a notch of a front edge of the printing plate, the notch sliding along the guide rail during the transfer. Full Article
ind Method and apparatus to position and align pre-punched printing plates on an imaging cylinder By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT An apparatus and method for positioning and aligning one or more pre-punched printing plates on a cylinder for imaging a plate in a computer-to-plate drum imaging device. The apparatus includes an imaging cylinder and a registration device connectable to the cylinder. The apparatus includes at least one groove and one pair of register pins, with a first register pin in a fixed position, and a second register pin movable in the groove to a second position, and collinear with the first register pin in the axial direction of the cylinder, arranged such that when connected to the cylinder, the registration device allows a plurality of pre-punched printing plates with variable widths to be positioned and aligned on the cylinder with simplicity. Full Article
ind Printer cylinder assembly for a printing machine By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT A printing cylinder assembly for a printing machine having a sleeve cylinder which can be simply coupled to and decoupled from a rotating shaft and which can be exchanged easily. The sleeve cylinder is mounted to fit on the rotating shaft so that it can be fitted on, and be extracted from, the rotating shaft, constituting a printing cylinder. The rotating shaft is provided with a cam shaft and a coupling member that constitutes a coupling mechanism. In a coupling and a decoupling state which the coupling mechanism comes into, rotations of the cam shaft cause the coupling member to couple and decouple the sleeve cylinder to and from the rotating shaft when the coupling member is diametrically urged against, and parted from, the inner diametric surface of the sleeve cylinder, respectively. Full Article
ind Apparatus for applying indicia on web substrates By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A contact printing system is disclosed. A gravure cylinder having a plurality of discrete cells having an aspect ratio of at least about 25:1 disposed upon an outer surface thereof. A first portion of a first fluid and a second portion of a second fluid are disposed from a respective channel disposed internal to the gravure cylinder. Full Article
ind Inductively heatable cylinder By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A device for heating at least one tool that is disposed on the circumference of a rotating cylinder, for example on the circumference of an embossing cylinder. The embossing tool is produced from a magnetizable material and it is fixed to a carrier sleeve that is produced from a non-magnetizable material. Full Article
ind Bluetooth low energy frequency offset and modulation index estimation By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A Bluetooth Low Energy (BLE) device, having a demodulator configured to translate in-phase and quadrature components of a received BLE signal into a differential phase signal; an estimator configured to estimate a frequency offset of the differential phase signal; and a detector configured to detect information in the differential phase signal corrected by the estimated frequency offset. Full Article
ind Window covering sizing method and apparatus By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT A method and apparatus for cutting a window covering comprises saw for cutting the window blind. A clamp assembly moves the window covering relative to the saw. A controller moves the clamp assembly to automatically position the window covering relative to the saw. The saw is moved into engagement with the window covering to cut the window covering. Full Article
ind Dispersible hydroentangled basesheet with triggerable binder By www.freepatentsonline.com Published On :: Tue, 14 Apr 2015 08:00:00 EDT The present disclosure is generally directed to a dispersible moist wipe comprising hydroentangled fibers and a binder composition. The moist wipe demonstrates high initial wet strength while maintaining effective dispersion in an aqueous environment. The moist wipe has potential application as a flushable surface cleaning product and/or a flushable cleansing cloth. Full Article
ind Paper coating or binding formulations and methods of making and using same By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT Paper coating or binding formulations are provided that comprise aqueous copolymer emulsions including copolymers derived from one or more copolymerizable surfactants of formula I and one or more monomers. The paper coating or binding formulations can include one or more mineral fillers, coating pigments, or mixtures thereof, wherein the total weight concentration of the one or more mineral fillers, coating pigments, or mixtures thereof is 65% or higher, based on the total weight of the composition. Paper products coated with the paper coating or binding formulations, methods of making the paper coating or binding formulations, and methods of making the coated paper products are also disclosed. Full Article
ind Hybrid lock cylinder By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT An exemplary lock assembly includes a plurality of discs, one or more wafer housings housing one or more wafers, a spindle, a locking bar, and a lock assembly housing. Each wafer housing is provided with one or more wafers that are spring biased in a first direction. The discs, wafer housing, and wafers may include recesses. When no key is inserted, the lock assembly is locked by both the wafers and the locking bar. When a proper key is utilized, the locking bar is free to move into the recesses to release the spindle. Full Article
ind Hybrid lock cylinder By www.freepatentsonline.com Published On :: Tue, 12 May 2015 08:00:00 EDT The present disclosure provides for a lock cylinder having a rotatable spindle with at least one disc and at least one wafer housing rotatingly engaged therewith. A slidable wafer is carried on the wafer housing. A locking bar is operable to prevent rotation of the lock cylinder in a locked position and permit rotation of the lock cylinder in an unlocked position. Full Article
ind Lock cylinder By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A lock cylinder includes a housing and first and second key plugs rotatably received in the housing about an axis. The first and second key plugs are axially spaced in the housing and each includes a keyway for insertion of a corresponding key. The keyways of the first and second key plugs are aligned with each other along the axis. The lock cylinder further includes a blocking core fixedly mounted in the housing and between the first and second key plugs along the axis. The blocking core includes a through-hole aligned with the keyways of the first and second key plugs along the axis. The lock cylinder can effectively prevent an illegal picking tool from inserting into the keyways of the first and second key plugs and from turning the key plugs, thereby providing an enhanced anti-theft effect. Full Article
ind Fish finder By www.freepatentsonline.com Published On :: Tue, 29 May 2018 08:00:00 EDT Full Article
ind Indicia for razor with a rotatable portion By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A razor comprises a first component comprising a first indicia on a surface of the first component. The razor also comprises a second component configured to rotate relative to the first component about a first axis of rotation, the second component comprising at least one blade and a second indicia on a surface of the second component, the second component configured to rotate relative to the first component about a second axis of rotation, wherein the second axis of rotation and the first axis of rotation are non-coplanar. The second component is in a preloaded neutral position when at rest such that rotation about the second axis of rotation generates a return torque and wherein the first indicia and the second indicia are in alignment at rest and out of alignment when the second component has been rotated about the first axis of rotation. Full Article
ind Apparatus and method for operating a gas turbine engine during windmilling By www.freepatentsonline.com Published On :: Tue, 17 Mar 2015 08:00:00 EDT A gas turbine engine according to an exemplary aspect of the present disclosure includes a windmill pump driven by a spool. A first pump driven by said spool with an air-oil cooler is located downstream of the first pump. A second pump is also driven the spool with an air-air precooler located downstream of the second pump. A method of operating a gas turbine engine during a “windmilling” condition includes driving a windmill pump with a spool during a “windmilling ” condition. A lubricant is communicated to a geared architecture with the windmill pump. A first pump is driven by the spool and an air-oil cooler is located downstream of the first pump. Full Article
ind Wind driven automatic lubricator for a motorcycle drive chain By www.freepatentsonline.com Published On :: Tue, 17 Mar 2015 08:00:00 EDT One embodiment (100) collects air pressure created from forward motion of a motorcycle (300) in a reservoir assembly (1001) which stores a liquid lubricant, is attached to motorcycle frame (302), and comprises a containment chamber (102), cap (106), cap seal (104), air inlet port (107), lubricant outlet port (109), and an air inlet connector (108) and a lubricant outlet connector (110) to facilitate the external attachment of conduit. The air pressure is collected by and delivered to reservoir assembly (100-1) via an air collection conduit (118) attached to motorcycle front portion (306) by a mount (130) and urges liquid lubricant through a suction conduit (124), flow restrictor (112) and delivers lubricant via discharge conduit (114) to a chain applicator (116) attached to a motorcycle swing arm assembly (304) and to the inner circumference of drive chain (310). Lubricant flow ceases after motorcycle is stopped. Other embodiments are described and shown. Full Article
ind System and method for lubricating gears in a wind turbine By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A system and method for lubricating gears in a wind turbine blade pitch drive are provided, wherein the pitch drive comprises a drive pinion gear with gear teeth that engage a pitch bearing gear coupled to a respective wind turbine blade. A grease distributor is configured to mount onto and rotate with the pinion gear, and is configured to deliver grease from an external grease supply to at least one valley defined between adjacent teeth of the pinion gear in a contact area of the pinion gear with the bearing gear without the distributor contacting inter-engaging teeth of the bearing gear. Full Article
ind Industrial fluid circuits and method of controlling the industrial fluid circuits using variable speed drives on the fluid pumps of the industrial fluid circuits By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT An industrial fluid circulating system having at least one fluid circulation circuit, includes a plurality of pumps connected in parallel to circulate the fluid through each of the fluid circulation circuit, a separate motor driving each pump, a load detector to sense operating loads on the system and each circuit, and a speed control to vary the speed of each motor to thereby vary the pumping capacity of each pump in response to the detected load on the system, each pump of each respective circuit running simultaneously at a substantially similar speed or a predetermined equal reduced speed of the respective circuit or an almost equal reduced speed or a similar reduced speed. Full Article
ind Indoor expansion valve initialization sequence for an air conditioner By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT This invention relates to a multi-room air conditioning system with a plurality of indoor expansion valves. A method for sequencing the initialization of each indoor expansion valve upon system startup is disclosed. The method includes the following steps: 1. Initializing expansion valves corresponding to active indoor units,2. Turning on the compressor,3. Adjusting the indoor expansion valves corresponding to active indoor units,4. Initializing and adjusting indoor expansion valves corresponding to inactive indoor units. Full Article
ind METHOD AND SYSTEM FOR SYNCHRONIZING AN INDEX OF DATA BLOCKS STORED IN A STORAGE SYSTEM USING A SHARED STORAGE MODULE By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A storage system includes a first and second control modules (CMs) connected to a client and a storage module over a communication fabric. In response to a data fragment written to the storage module, the first CM is to create a table of contents (TOC) entry in a TOC page maintained in a first storage partition of the storage module, update its FTL map, determine whether the TOC page contains a predetermined number of TOC entries, and in response to determining that the TOC page contains the predetermined number of TOC entries, send a control signal to the second CM via an inter-processor link. In response to the control signal received from the first CM via the inter-processor link, the second CM is to copy the TOC page from the first storage partition to a memory associated with the second CM to allow the second CM to update its FTL map. Full Article
ind DELAYED READ INDICATION By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT A requester sends, to a responding component, a request to cause the responding component to perform a computation. The requester sends, to the responding component, a delayed read indication, where the delayed read indication indicates that a result of the computation is not to be returned to the requester from the responding component until a data value at a target address of the delayed read indication has changed. The requester receives, from the responding component, an acknowledgment of the delayed read indication, and after receiving the acknowledgment, receives a response to the request without the requester sending another request to the responding component. Full Article
ind Window mounting for thermal expansion in an oven appliance By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT Mounting for a window in an oven appliance is provided so as to allow for thermal expansion during oven use. More particularly, an expansion zone is provided around the window such that, during heating of the window from oven operation, the window is allowed to expand without restraint that could cause cracking or shattering. Space can be allowed for both lateral and longitudinal expansion of the window. Full Article
ind Induced-draft low swirl burner for low NOx emissions By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A burner for use with an induced draft furnace and which satisfies reduced nitrous oxide (NOx) emission standards is disclosed. The burner may employ a mechanical swirler that introduces a rotational vector to the emitted air and fuel mixed by the burner. By introducing the rotational vector, the resulting flame is more stable and sustainable even with the relatively low air flow afforded by an induced system. Such flame stability can be enhanced by positioning the burner directly within an inlet to a heat exchanger and manufacturing the inlet with reception surfaces that form a frusto-conically shaped flame expansion zone. In doing so, a secondary source of air is avoided and NOx emissions are reduced. Full Article
ind Process for recycling of steel industry iron bearing by-products, pellet obtained in that process and use thereof By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT The present invention relates to a process for the recycling of steel industry iron bearing by-products into a shape suitable for feeding into a direct reduction furnace, comprising the steps of mixing and grinding 50 to 99 wt % of ore and pellet fines and 1 to 50 wt % of slurry, mill scale and/or bag house dust, pelletizing the mixture and indurating the pellets so obtained by heating for 5-60 minutes at a temperature in the range of 1100-1350° C.; and a pellet produced from Iron bearing waste material and having compression strength of at least 2.8 kN and/or a drop number of at least 3. Full Article
ind Steel for induction hardening, roughly shaped material for induction hardening, producing method thereof, and induction hardening steel part By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT A steel for an induction hardening including, by mass %, C: more than 0.75% to 1.20%, Si: 0.002 to 3.00%, Mn: 0.20 to 2.00%, S: 0.002 to 0.100%, Al: more than 0.050% to 3.00%, P: limited to 0.050% or less, N: limited to 0.0200% or less, O: limited to: 0.0030% or less, and the balance composing of iron and unavoidable impurities, wherein an Al content and a N content satisfy, by mass %, Al−(27/14)×N>0.050%. Full Article
ind Electric induction heating of a rail head with non-uniform longitudinal temperature distribution By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT Apparatus and method are provided for making the longitudinal temperature distribution of the bulbous end of a longitudinally oriented workpiece, such as a rail's head, generally uniform when the head has a non-uniform longitudinal temperature distribution. A combination of crown and skirt electric inductors is used to achieve the generally uniform temperature distribution by modulating the magnetic field intensity produced by current flow through one or more of the combination of crown and skirt inductors as required for the non-uniformly heated regions of the rail's head. Full Article
ind Slot wear indicator for a grinding tool By www.freepatentsonline.com Published On :: Tue, 07 Oct 2014 08:00:00 EDT Wear indicators for abrasive articles are presented. Specifically, indicator marks that are parallel to a bonding edge of a grinding element are presented. Tools comprising a carrier element and one or more grinding elements comprising one or more indicators are also presented. Full Article
ind Gear grinding machine By www.freepatentsonline.com Published On :: Tue, 11 Nov 2014 08:00:00 EST Provided is a gear grinding machine the maintainability of which can be improved and which is capable of being miniaturized. More specifically, provided is a gear grinding machine wherein a threaded grinding stone (17) and a workpiece (W) are engaged with each other and are rotated in this state, resulting in the workpiece (W) being ground, and wherein between a dressing position (P2) where the threaded grinding stone (17) can be dressed and a retreat position (P1) to which a retreat is made from the dressing position (P2) during grinding, a disk dresser (66) which, by being driven into rotation, dresses the threaded grinding stone (17) is swung about an axis (C2) which is parallel to an axis (C1) that is the rotational axis for the workpiece (W) and which intersects, at right angles, the direction in which the threaded grinding stone (17) is fed toward the workpiece (W). Full Article
ind Independently supported concrete saw apparatus and method By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT A saw apparatus for sawing paving slabs has a frame mounted on a ground contacting propulsion member such that the frame may move above a slab to be cut without touching the slab. A first saw support assembly disposes a blade of a saw in cutting engagement with the slab for a transverse cut. A second saw support assembly disposes a blade of another saw in cutting engagement with the slab for a longitudinal cut. The saws are mounted on the saw assemblies and the saw assemblies are mounted on the frame and the frame is mounted on the ground contact propulsion members such that no part of said frame need contact the slab during cutting. Full Article
ind Dressing device for a grinding wheel and its use in a centreless nuclear fuel pellet grinder By www.freepatentsonline.com Published On :: Tue, 05 May 2015 08:00:00 EDT The invention relates to a device for dressing a grinding wheel, comprising a sleeve to hold a corundum rod laterally and to guide it along its longitudinal axis, a ram to apply constant thrust force onto the corundum rod held in place and guided in the sleeve, to bring it into contact with the grinding wheel, means of rigidly connecting the ram shaft to the end of the corundum rod, and linear guide means for the sleeve for translating the corundum rod parallel to the axis of the grinding wheel while keeping the rod pressed against the grinding wheel with a constant force. Application to a centerless grinder in which the grinding wheel is used to grind nuclear fuel pellets. Full Article
ind ***WITHDRAWN PATENT AS PER THE LATEST USPTO WITHDRAWN LIST***Cold chamber die casting of amorphous alloys using cold crucible induction melting techniques By www.freepatentsonline.com Published On :: Tue, 31 Mar 2015 08:00:00 EDT Various embodiments provide systems and methods for casting amorphous alloys. Exemplary casting system may include an insertable and rotatable vessel configured in a non-movable induction heating structure for melting amorphous alloys to form molten materials in the vessel. While the molten materials remain heated, the vessel may be rotated to pour the molten materials into a casting device for casting them into articles. Full Article
ind Cold chamber die casting of amorphous alloys using cold crucible induction melting techniques By www.freepatentsonline.com Published On :: Tue, 11 Aug 2015 08:00:00 EDT Various embodiments provide systems and methods for casting amorphous alloys. Exemplary casting system may include an insertable and rotatable vessel configured in a non-movable induction heating structure for melting amorphous alloys to form molten materials in the vessel. While the molten materials remain heated, the vessel may be rotated to pour the molten materials into a casting device for casting them into articles. Full Article
ind Dial of circular hosiery knitting machine of the type with cylinder and dial with yarn cutting device By www.freepatentsonline.com Published On :: Tue, 08 Jul 2014 08:00:00 EDT A dial of a circular hosiery knitting machine of the type with a cylinder and dial with yarn cutting device. The dial comprises a dial body which is substantially disk-shaped. The dial is provided with a cutting device, which comprises a plurality of cutting sectors which are distributed around the axis of the dial body and have cutting edges. The cutting sectors are arranged at sectors of the dial body which are intended to be free from needles. The cutting device comprises a cutter which is adapted to abut against the cutting edges of the cutting sectors to cut at least one yarn engaged by one of the cutting sectors in its rotary motion about the axis of the dial body with respect to the cutter. Full Article
ind Double-cylinder circular machine, particularly for knitting hosiery items or the like, with simplified actuation mechanism By www.freepatentsonline.com Published On :: Tue, 16 Sep 2014 08:00:00 EDT A double-cylinder circular machine, particularly for knitting hosiery items, with simplified actuation mechanism, comprising a supporting structure which comprises a footing, which supports a lower needle cylinder, and a column which extends substantially vertically, protrudes upwardly from the footing and supports an upper needle cylinder, which is arranged above and coaxially with respect to the lower needle cylinder, and further comprising elements for the actuation of the lower needle cylinder and of the upper needle cylinder with a rotary motion about a common axis, the actuation elements comprising an electric motor which is connected kinematically to the lower needle cylinder and to the upper needle cylinder and is accommodated inside the column. Full Article
ind Independently controlled rollers for take-down assembly of knitting machine By www.freepatentsonline.com Published On :: Tue, 02 Dec 2014 08:00:00 EST A knitting machine includes a take-down assembly that includes a first take-down roller and a second take-down roller. The first take-down roller is configured to rotatably contact and apply tension to a first portion of a knit component. The second take-down roller is configured to rotatably contact and apply tension to a second portion of the knit component. The knitting machine further includes a first actuator that actuates to selectively adjust tension applied by the first take-down roller on the first portion of the knit component. Furthermore, the knitting machine includes a second actuator that actuates to selectively adjust tension applied by the second take-down roller on the second portion of the knit component. Additionally, the knitting machine includes a controller that is operably coupled to the first actuator and the second actuator to selectively and independently control actuation of the first actuator and the second actuator. Full Article
ind Independently controlled rollers for take-down assembly of knitting machine By www.freepatentsonline.com Published On :: Tue, 17 Mar 2015 08:00:00 EDT A knitting machine includes a take-down assembly that includes a first take-down roller and a second take-down roller. The first take-down roller is configured to rotatably contact and apply tension to a first portion of a knit component. The second take-down roller is configured to rotatably contact and apply tension to a second portion of the knit component. The knitting machine further includes a first actuator that actuates to selectively adjust tension applied by the first take-down roller on the first portion of the knit component. Furthermore, the knitting machine includes a second actuator that actuates to selectively adjust tension applied by the second take-down roller on the second portion of the knit component. Additionally, the knitting machine includes a controller that is operably coupled to the first actuator and the second actuator to selectively and independently control actuation of the first actuator and the second actuator. Full Article
ind System and method for forming a design from a flexible filament having indicators By www.freepatentsonline.com Published On :: Tue, 12 May 2015 08:00:00 EDT The present disclosure is directed to a flexible filament that includes a length of material configured to be used in forming at least a portion of a textile product to have at least a portion of a visual pattern that is visible on at least one of a first side or a second side of the textile product. The material includes a plurality of stitch indicators formed on the material to separate the material into a plurality of segmented regions, at least one of the stitch indicators or the segmented regions forming at least the portion of the visual pattern visible on the at least one of the first side or the second side of the textile product. Full Article
ind Apparatus for separating melon flesh from rind By www.freepatentsonline.com Published On :: Tue, 28 Apr 2015 08:00:00 EDT An apparatus for preparing a melon juice concentrate, such as watermelon juice concentrate, includes a finisher with brushes for separating melon flesh from melon rind including leaving at least 1/16 inch flesh on the rind and screens for separating juice from flesh. The apparatus also includes a steamer to reduce bacteria count on whole melon, a chopper for chopping melons into pieces less than about 16 inches square, an extractor for extracting juice from the flesh, and an evaporator for concentrating melon juice to form melon juice concentrate. The steamer includes a cylinder frame, steam jets directing steam through apertures in the cylinder frame at whole melon therein, and a motivator to move the whole melon along the cylinder frame. The apparatus can also process cantaloupe, honeydew melon, and other melon. Full Article
ind Pressure cooker fitted with an information window By www.freepatentsonline.com Published On :: Tue, 12 May 2015 08:00:00 EDT The invention relates to a domestic cooking pot (1) comprising means of controlling (7) at least part of its operation, wherein said control means (7) have a mobile mounting between a plurality of positions, wherein said pot (1) is characterized in that it is further fitted with an information window (8) and at least an indicator (10) that is representative of one of the positions of the control means (7), and in that the window (8), the indicator (10) and the control means (7) work together so that said indicator (10) appears in the window (8) when the control means (7) are in the corresponding position. Full Article
ind FACTOR H BINDING PROTEIN VARIANTS AND METHODS OF USE THEREOF By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT Variant factor H binding proteins that can elicit antibodies that are bactericidal for at least one strain of Neisseria meningitidis, compositions comprising such proteins, and methods of use of such proteins, are provided. Full Article
ind MULTI-SPECIFIC ANTI-PSEUDOMONAS PSL AND PCRV BINDING MOLECULES AND USES THEREOF By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT This disclosure relates to combination therapies comprising anti-Pseudomonas Psl and PcrV bispecific binding molecules and related compositions, for use in prevention and treatment of Pseudomonas infection. Full Article
ind OPOID RECEPTOR BINDING AGENTS AND USES THEREOF By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT Agents that specifically bind to an opioid receptor in a conformationally specific way can be used to induce a conformational change in the receptor. Such agents have therapeutic applications and can be used in X-ray crystallography studies of the receptor. Such agents can also be used to improve drug discovery via compound screening and/or structure-based drug design. Full Article
ind NOTCH1 RECEPTOR BINDING AGENTS AND METHODS OF USE THEREOF By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT The present invention relates to compositions and methods for characterizing, diagnosing, and treating cancer. In particular the invention provides the means and methods for the diagnosis, characterization, prognosis and treatment of cancer and specifically targeting cancer stem cells. The present invention provides an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor and inhibits tumor growth. The present invention further provides a method of treating cancer, the method comprising administering a therapeutically effective amount of an antibody that specifically binds to a non-ligand binding membrane proximal region of the extracellular domain of a human Notch receptor protein and inhibits tumor growth. Full Article
ind VEGF/DLL4 Binding Agents and Uses Thereof By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT The present invention relates to VEGF-binding agents, DLL4-binding agents, VEGF/DLL4 bispecific binding agents, and methods of using the agents for treating diseases such as cancer. The present invention provides antibodies that specifically bind human VEGF, antibodies that specifically bind human DLL4, and bispecific antibodies that specifically bind human VEGF and/or human DLL4. The present invention further provides methods of using the agents to inhibit tumor growth. Also described are methods of treating cancer comprising administering a therapeutically effect amount of an agent or antibody of the present invention to a patient having a tumor or cancer. Full Article
ind Human Antigen Binding Proteins That Bind To a Complex Comprising beta-Klotho and an FGF Receptor By www.freepatentsonline.com Published On :: Thu, 29 Jun 2017 08:00:00 EDT The present invention provides compositions and methods relating to or derived from antigen binding proteins capable of inducing B-Klotho, and or FGF21-like mediated signaling. In embodiments, the antigen binding proteins specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. In some embodiments the antigen binding proteins induce FGF21-like signaling. In some embodiments, an antigen binding protein is a fully human, humanized, or chimeric antibodies, binding fragments and derivatives of such antibodies, and polypeptides that specifically bind to a complex comprising β-Klotho and at least one of (i) FGFR1c, (ii) FGFR2c and (iii) FGFR3c. Other embodiments provide nucleic acids encoding such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, cells comprising such polynucleotides, methods of making such antigen binding proteins, and fragments and derivatives thereof, and polypeptides, and methods of using such antigen binding proteins, fragments and derivatives thereof, and polypeptides, including methods of treating or diagnosing subjects suffering from type 2 diabetes, obesity, NASH, metabolic syndrome and related disorders or conditions. Full Article
ind Apparatus and lower thread winding-spool for detecting the ending region of lower thread of sewing machine By www.freepatentsonline.com Published On :: Tue, 24 Feb 2015 08:00:00 EST A lower thread ending region detection apparatus prevents problems associated with false stitchings occurring from inability to detect lower thread's exhaustion during sewing operation. The lower thread ending region detection apparatus comprises: light control unit, which contacts a part of lower thread wound on a thread bobbin and activates or inactivates at least one of the functions of emitting light, reflecting light, passing light and blocking light, due to the effect of the physical movement force generated depending on whether the lower thread of the ending region is unwound; light receiving unit, which receives the light transferred out by the light control unit and outputs a detection signal; and control and notification unit, which analyzes the detection signal output from the light receiving unit to determine whether the lower thread has reached the ending region and outputs the result to the user. Full Article
ind Inductive/capacitive hybrid plasma source and system with such chamber By www.freepatentsonline.com Published On :: Tue, 19 May 2015 08:00:00 EDT A plasma processing chamber having capacitive and inductive coupling of RF power. An RF power source is connected to an inductive coil and to a top electrode via a variable capacitor to control the ratio of power applied to the coil and electrode. The bottom electrode, which is part of the chuck holding the substrates, is floating, but has parasitive capacitance coupling to ground. No RF bias is applied to the chuck and/or the substrate, but the substrate is chucked using DC power. In a system utilizing the chamber, the chuck is movable and is loaded with substrates outside the chamber, enter the chamber from one side for processing, exit the chamber from an opposite side after the processing, and is unloaded in an unloading chamber. The chuck is then transported back to the loading chamber. Substrates are delivered to and removed from the system using conveyor belts. Full Article
ind Inductively coupled plasma reactor with multiple magnetic cores By www.freepatentsonline.com Published On :: Tue, 26 May 2015 08:00:00 EDT There is provided an inductively coupled plasma reactor. The inductively coupled plasma reactor is connected to a transformer with multiple magnetic cores and a primary winding, to transfer an electromotive force for plasma discharge to a plasma discharge chamber of a reactor body. Parts of magnetic core positioned in side the plasma discharge chamber are protected by being entirely covered by a core protecting tube. The primary winding is electrically connected to a power supply source providing radio frequency power. In the inductively coupled plasma reactor, since a number of magnetic core cross sectional parts are positioned inside the plasma discharge chamber, the efficiency of transferring the inductively coupled energy to be connected with plasma is very high. Full Article
ind Devices for thermally induced transformations controlled by irradiation of functionalized fullerenes By www.freepatentsonline.com Published On :: Tue, 21 Apr 2015 08:00:00 EDT An electromagnetic radiation activated device comprises a property changing material and at least one functionalized fullerene that upon irradiation of the functionalized fullerenes with electromagnetic radiation of one or more frequencies a thermally activated chemical or physical transformation occurs in the property changing material. The thermal activated transformation of the property changing material is triggered by the heating or combustion of the functionalized fullerenes upon their irradiation. The device can include a chemical agent that is embedded in the property changing material and is released when the material is heated by the functionalized fullerenes upon irradiation. Full Article
ind Control device for slat blinds By www.freepatentsonline.com Published On :: Tue, 11 Jan 2011 08:00:00 EST A control device for blinds includes a transmission unit, a scrolling unit and a tilting unit, the transmission unit includes a case in which a coil spring and a gear unit are received. The coil spring is connected between the gear unit and the case. The scrolling unit includes two scrolling rods which are rotated with a transmission rod. Each scrolling rod has a lift cord wrapped thereon and extending through slats of the blinds. The tilting unit includes two tilt members connected to two respective end sections of the two scrolling rods. Two tilt cords have two respective positioning members which are clamped in two clamp grooves of the two tilt members and the tilt cords extend through the slats. The gears in the gear unit can be adjusted so as to cooperate with slats of different weights. Full Article