eve

Looking for a new IT gig? Here are vacancies around the world for developers, cloud engineers, infosec analysts, Jira admin, and more

Advertise your open positions here for free, no catch, and find opportunities within

Job Alert This week we've got job openings from all over the globe to tempt you, your friends or your past colleagues back into work, or indeed into new ventures.…




eve

DEF CON is canceled... No, for real. The in-person event is canceled. We're not joking. It's canceled. We mean it

Virus knocks hackers online: Show will try going virtual amid pandemic

Annual Las Vegas hacker gathering DEF CON has officially called off its physical conference for this year due to the coronavirus pandemic.…




eve

I've seen things you people wouldn't believe. Spacecraft with graphene sails powered by starlight and lasers

Nice way to get to Alpha Centauri though boffin tells us: 'Such a laser system could be used as a weapon'

Coin-sized pieces of graphene can be accelerated by firing low-powered lasers at them in micro-gravity conditions, say scientists. The technology could be a stepping stone to graphene solar sails, which could propel future spacecraft using starlight or a laser array.…




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2/16/14 - Never went in there




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3/9/14 - Even the things I don't like




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7/06/14 - Never say to her




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9/14/14 - After about seven years




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12/14/14 - Nothing I've ever tried




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01/04/15 - Be together forever




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05/17/15 - The last thing she ever said




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07/19/15 - I"m yours forever




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08/23/15 - Never have the courage




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09/13/15 - Every single day




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03/06/16 - Everyone says




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06/12/16 - And I felt so relieved




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07/10/16 - Everything I knew




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08/01/16 - You never lived up to my dreams




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09/18/16 - Not even a moment




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11/20/16 - And we never complained




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02/12/17 - Never give up




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03/12/17 - Everywhere I look




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04/30/17 - Everyone I ever loved




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08/27/17 - Every day is a new day




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12/03/17 - Every book that will never be written




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12/09/18 - Everyone you've ever met will be dead




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1/27/19 - No one will ever




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Chocobo’s Mystery Dungeon EVERY BUDDY! Original Soundtrack

-Album Details- Title: Chocobo’s Mystery Dungeon EVERY BUDDY! Original Soundtrack Publisher: Square Enix Music Catalog Number: SQEX-10710 Release Date: April 24th, 2019 Ripped by: Razakin -Info- Khew!  Some classic FF tracks arranged again for a Chocobo-game, the 2019 remaster of Final Fantasy Fables: Chocobo’s Dungeon. Enjoy. Purchase Link(s) CDJapan




eve

Featured - How Products are Born: What exactly is going on in research and development anyway?

OK, let’s pick up our discussion where we left off last week, at feasibility.  You did it. You successfully convinced a room full of vice presidents and directors, or maybe even the CEO that they should take your fabulous product idea to the next level.  You’ve got marketing on board, excited to promote it and now it’s time for the work to begin.You are the lead scientist s; (read more)

Source: Suzy - Discipline: BioTech




eve

If Kids Aren’t Playing with Most of Their Toys NOW, Let’s Assume They Never Will

“Even after weeks of staying home, my kids are just not interested in all the stuff we have. Let’s be honest. If a toy isn’t getting any action amid this distraction-free, stuck-at-home living, chances are it’s never getting touched again.” Liz Russell figures out what really engages and changes kids during the quarantine, and will […]




eve

Is the COVID Quarantine Making Kids Less Anxious (and Maybe Even More Helpful)?

At least for some kids, yes, being flung from the stress of a super-structured, super-supervised existence is having a calming, life-expanding effect. I discuss this amazing phenom in this Big Think article, including six short essays by kids themselves, and also in this interview with Bored Panda,  the  pop culture site, where I note that […]




eve

Stop Throwing Away Those Little Silica Gel Packets! You and the Kids Can Use Them a Ton of Clever Ways

Parents, kids: Fear not the silica gel pack. Sure it says DO NOT EAT and THROW AWAY. But you should only follow one of those rules.    Instead, save the packs and use them a whole lot of ways: Place them on the car dashboard by the windshield to keep it from fogging up.   […]




eve

JoT #2700: Coronavirus changes everything!



Is the new normal a new normal for you?




eve

Hepatic CEACAM1 expression indicates donor liver quality and prevents early transplantation injury

Although CEACAM1 (CC1) glycoprotein resides at the interface of immune liver injury and metabolic homeostasis, its role in orthotopic liver transplantation (OLT) remains elusive. We aimed to determine whether/how CEACAM1 signaling may affect hepatic ischemia-reperfusion injury (IRI) and OLT outcomes. In the mouse, donor liver CC1 null mutation augmented IRI-OLT (CC1-KO→WT) by enhancing ROS expression and HMGB1 translocation during cold storage, data supported by in vitro studies where hepatic flush from CC1-deficient livers enhanced macrophage activation in bone marrow–derived macrophage cultures. Although hepatic CC1 deficiency augmented cold stress–triggered ASK1/p-p38 upregulation, adjunctive ASK1 inhibition alleviated IRI and improved OLT survival by suppressing p-p38 upregulation, ROS induction, and HMGB1 translocation (CC1-KO→WT), whereas ASK1 silencing (siRNA) promoted cytoprotection in cold-stressed and damage-prone CC1-deficient hepatocyte cultures. Consistent with mouse data, CEACAM1 expression in 60 human donor liver biopsies correlated negatively with activation of the ASK1/p-p38 axis, whereas low CC1 levels associated with increased ROS and HMGB1 translocation, enhanced innate and adaptive immune responses, and inferior early OLT function. Notably, reduced donor liver CEACAM1 expression was identified as one of the independent predictors for early allograft dysfunction (EAD) in human OLT patients. Thus, as a checkpoint regulator of IR stress and sterile inflammation, CEACAM1 may be considered as a denominator of donor hepatic tissue quality, and a target for therapeutic modulation in OLT recipients.




eve

Clinical and immunological features of severe and moderate coronavirus disease 2019

BACKGROUND Since December 2019, an outbreak of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan, and is now becoming a global threat. We aimed to delineate and compare the immunological features of severe and moderate COVID-19.METHODS In this retrospective study, the clinical and immunological characteristics of 21 patients (17 male and 4 female) with COVID-19 were analyzed. These patients were classified as severe (11 cases) and moderate (10 cases) according to the guidelines released by the National Health Commission of China.RESULTS The median age of severe and moderate cases was 61.0 and 52.0 years, respectively. Common clinical manifestations included fever, cough, and fatigue. Compared with moderate cases, severe cases more frequently had dyspnea, lymphopenia, and hypoalbuminemia, with higher levels of alanine aminotransferase, lactate dehydrogenase, C-reactive protein, ferritin, and D-dimer as well as markedly higher levels of IL-2R, IL-6, IL-10, and TNF-α. Absolute numbers of T lymphocytes, CD4+ T cells, and CD8+ T cells decreased in nearly all the patients, and were markedly lower in severe cases (294.0, 177.5, and 89.0 × 106/L, respectively) than moderate cases (640.5, 381.5, and 254.0 × 106/L, respectively). The expression of IFN-γ by CD4+ T cells tended to be lower in severe cases (14.1%) than in moderate cases (22.8%).CONCLUSION The SARS-CoV-2 infection may affect primarily T lymphocytes, particularly CD4+ and CD8+ T cells, resulting in a decrease in numbers as well as IFN-γ production by CD4+ T cells. These potential immunological markers may be of importance because of their correlation with disease severity in COVID-19.TRIAL REGISTRATION This is a retrospective observational study without a trial registration number.FUNDING This work is funded by grants from Tongji Hospital for the Pilot Scheme Project, and partly supported by the Chinese National Thirteenth Five Years Project in Science and Technology for Infectious Disease (2017ZX10202201).




eve

GPR160 de-orphanization reveals critical roles in neuropathic pain in rodents

Treating neuropathic pain is challenging and novel non–opioid-based medicines are needed. Using unbiased receptomics, transcriptomic analyses, immunofluorescence, and in situ hybridization, we found that the expression of the orphan GPCR Gpr160 and GPR160 increased in the rodent dorsal horn of the spinal cord following traumatic nerve injury. Genetic and immunopharmacological approaches demonstrated that GPR160 inhibition in the spinal cord prevented and reversed neuropathic pain in male and female rodents without altering normal pain response. GPR160 inhibition in the spinal cord attenuated sensory processing in the thalamus, a key relay in the sensory discriminative pathways of pain. We also identified cocaine- and amphetamine-regulated transcript peptide (CARTp) as a GPR160 ligand. Inhibiting endogenous CARTp signaling in spinal cord attenuated neuropathic pain, whereas exogenous intrathecal CARTp evoked painful hypersensitivity through GPR160-dependent ERK and cAMP response element–binding protein (CREB). Our findings de-orphanize GPR160, identify it as a determinant of neuropathic pain and potential therapeutic target, and provide insights into its signaling pathways. CARTp is involved in many diseases including depression and reward and addiction; de-orphanization of GPR160 is a major step forward understanding the role of CARTp signaling in health and disease.




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Apple's Work on High-End Over-Ear Headphones: Everything We Know

Apple has been selling audio accessories since December 2016 when the original AirPods launched. We now have the ‌AirPods‌ 2 and the AirPods Pro, and Apple is planning to add to its lineup with new over-ear Apple-branded headphones.

Apple already sells over-ear headphones under its Beats brand, but as with the ‌AirPods‌, Apple is also working on headphones that will be Apple branded rather than Beats branded. These headphones are said to be aimed at the high-end market.


Design


The headphones will feature an all-new design, and while we don't know a lot about it, we do know some details shared by Bloomberg.

Apple is said to be working on two versions of the high-end over-ear headphones, including a premium version with leather-like fabrics and a fitness-focused model that uses lighter, breathable materials with small perforations for better airflow.

Prototypes of the headphones have been described as having a retro-like look with over-ear cups that swivel along with a headband connected with thin metal arms.

Apple is planning to attach the ear pads and the head padding to the headphone's frame magnetically, allowing users to swap different colors and variants in and out for customization purposes.

An icon representing the headphones was found in the code in a leaked version of iOS 14, but little detail can be gleaned from the imagery.

Rumored Features


According to Apple analyst Ming-Chi Kuo, Apple's over-ear headphones will feature Active Noise Cancellation, a high-end feature baked into the Beats Studio 3 headphones, Solo Pro headphones, and the ‌AirPods Pro‌.

Active Noise Cancellation is designed to cut down on ambient noise so you can focus on what you're listening to. If it mimics ANC on the ‌AirPods Pro‌, there will be a transparency mode that will enable noise cancelling features, but with an option to continue to hear what's going on around you.

Sound quality is expected to be better than the sound quality of the ‌AirPods‌.

Pricing


Apple could price the new headphones at around $350.

Launch Date


Current rumors indicate the headphones will launch at some point in 2020, though a specific date has not yet been nailed down. Mass production on the headphones is scheduled to begin in mid-2020, which perhaps suggests a fall 2020 launch.

There were rumors indicating that Apple initially planned to launch the headphones at some point in 2019, but that did not happen.

Over-Ear Headphones Rumor History



Guide Feedback


Have a question about Apple's over-ear headphones, know of something we left out, or want to offer feedback? Send us an email here.
This article, "Apple's Work on High-End Over-Ear Headphones: Everything We Know" first appeared on MacRumors.com

Discuss this article in our forums




eve

Ranking every furry skin in Fortnite from worst to best

Fortnite Battle Royale (or just Fortnite) is a “battle royale” shooter that has been around since 2017, and while its getting a bit long in the tooth, it’s still hanging around and still free to play. Last year, the game finally implemented skill-based matchmaking, which means for casual and new players, it’s never been easier to get into. In many ways, it is comparable to Nintendo properties such as Super Smash Bros. or Mario Kart, taking a more traditionally “hardcore” video game genre and making it more accessible with gimmicky gameplay, goofy items, cartoony visuals and massive amounts of RNG.

Of course, the game isn’t exactly furry in and of itself, but the game makes its money selling cosmetic upgrades to player’s in game characters, and quite a few of them feature either characters in animal costumes, or, more recently, straight up anthropomorphic animals. In the time-honored tradition of clickbait listicals, here is my ranking of those skins.

read more




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'Effects Achieved as I Had Hoped for This Dosage', by DoctorB (Phenibut)

Erowid Exp98591



  • Erowid : Experience :

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Thinking of using TurboTax to file your tax returns? Think again. The Minnesota Department of Revenue advises against using Intuit software to file tax returns!

Thinking of using TurboTax to file your tax returns? Think again. The Minnesota Department of Revenue advises against using Intuit software to file tax returns! It found unacceptable errors in Intuit tax software, including TurboTax, ProSeries, Lacerte, and Intuit online. Continue reading



  • Accountants CPA Hartford
  • calculation errors found in Intuit tax software
  • Department of Revenue advises against using ProSeries
  • Department of Revenue advises against using TurboTax
  • Department of Revenue finds errors in Intuit software unacceptable
  • Intuit online
  • Lacerte
  • Minnesota Department of Revenue
  • multiple issues with Intuit tax software
  • ProSeries
  • The Minnesota Department of Revenue advises you not to use Intuit to file your tax returns
  • thinking of using TurboTax to file tax return
  • Thinking of using TurboTax to file your tax returns? Think again. The Minnesota Department of Revenue advises you not to use Intuit to file your tax returns!
  • TurboTax

eve

Have you ever noticed that the Internal Revenue Service’s regulations often are illogical?

Have you ever noticed that the Internal Revenue Service's regulations often are illogical? Does anyone at the IRS think through its regulations? Continue reading



  • Accountants CPA Hartford
  • Does anyone at the IRS think through its regulations?
  • Form 1120 filing requirements
  • Have you ever noticed that the Internal Revenue Service's regulations often are illogical?
  • Internal Revenue Service instructions
  • IRS regulations
  • short year filing requirement
  • short year filing requirements
  • tax forms unavailable for short years
  • The irrationality of IRS regulations
  • when to file

eve

Bernie Sanders can win even though the Democratic Party is run by the Corporate Democrats and they have already anointed Hillary Clinton as their candidate for President

Even though Corporate America has anointed Hillary Clinton as its next President, Senator Bernie Sanders' populist message is already in a week's time raising individual contributions totaling millions of dollars from hundreds of thousands of people! Continue reading



  • Accountants CPA Hartford
  • Articles
  • bankers
  • Bernie Sanders can win - deal with it
  • Bernie Sanders can win even though the Democratic Party is run by the Corporate Democrats and they have already anointed Hillary Clinton as their candidate for President
  • Can Bernie Sanders Beat Hillary Clinton
  • DCCC
  • Democratic Party split
  • Ed Schultz
  • Farron Cousins
  • Hillary Clinton
  • Keystone XL Pipeline
  • Mike Papntonio
  • populist
  • progressives vs corporate democrats
  • Ring of Fire Radio
  • The Democratic Party is run by the Corporate Democrats and they have already anointed Hillary Clinton
  • The Democratic Party is run by the Corporate Democrats and they have already anointed Hillary Clinton as their candidate for President but Senator Bernie Sanders can win
  • The Democratic Party is run by the Corporate Democrats and they have anointed Hillary Clinton as their candidate for President
  • the Ed Show
  • Tom Hartmann
  • TPP
  • TransCanada
  • transcript
  • video
  • Wall Street

eve

Bernie Sanders was never a real candidate but was merely this election’s sheepdog for Hillary Clinton to herd progressives back into the corral of the Democratic Party.

Bernie Sanders and Jane Sanders are mere actors serving as pressure valves which release from time to time all excess heat emanating from failed policies, scandals, and the worsening economic conditions, so that a catastrophic systems’ collapse can be prevented. They are sheepdogs for Hillary Clinton, preventing progressives from supporting a third party progressive candidate and to herd them back into the corral of the Democratic Party. Continue reading




eve

STEVE HACKETT выпустит автобиографию

В июле 2020 состоится релиз автобиографии гитарист GENESIS STEVE'a HACKETT'a, которая получила название "A Genesis In My Bed". Steve рассказывает в ней о своей жизни в детстве и юношестве, о времени в GENESIS и детально об отношении с остальными участниками команды, давай возможность узнать о том, каковы были отношения в одной из самых известных рок групп мира. #Steve_Hackett #SteveHackett #ProgressiveRock #Progressive_Rock #AvantgardeRock #Avantgarde_Rock




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August and everything after.

It’s weird to me to look at my blog and realize that I haven’t posted anything to it since the end of May, as so much has happened since then and I have spent so much time since then writing … Continue reading




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United Nations Disaster Resilience Scorecard, Developed by AECOM and IBM, Helps Cities Prepare for Disaster

An updated Disaster Resilience Scorecard to help cities and local government agencies improve their preparedness and reduce risks from disasters was launched today at the Global Platform for Disaster Risk Reduction. Developed for the UN Office for Disaster Risk Reduction by AECOM, IBM with support from USAID and the European Commission, the Scorecard gives better access to information, knowledge resources, and tools to effectively reduce risks from the impacts of natural hazards and climate change.




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IBM Achieves Major Climate Protection Goals Four Years Early

Today, IBM announced that it achieved two major commitments four years ahead of schedule in its effort to help combat climate change.




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PREVIEW: The origin of Punchline is revealed in the JOKER 80TH ANNIVERSARY SPECIAL

The Joker 80th Anniversary 100-Page Super Spectacular #1 will feature an all-star creative team including James Tynion IV, Dan Mora, Tom Taylor, and many more

The post PREVIEW: The origin of Punchline is revealed in the JOKER 80TH ANNIVERSARY SPECIAL appeared first on The Beat.





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Can We Use This Time of Self Isolation for Self Development?

If we want to answer any question like, how should we live, what should we do, what should we work on, what should we change, quit or start (not should really but could) it’s always best to do so from your values. If you aren’t sure about your personal values, now could be a great time to explore, clarify and prioritize your values so you can tap into your own source of wisdom and motivation, and answer all those ‘should’ questions for yourself.




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IBM Unveils New AI Software, Reduces Barriers for Data Scientists to Fuel Cognitive Development

IBM today announced a significant new release of its PowerAI deep learning software distribution on Power Systems that attacks the major challenges facing data scientists and developers by simplifying the development experience with tools and data preparation while also dramatically reducing the time required for AI system training from weeks to hours.