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Fluorescence Imaging-Guided Multifunctional Liposomes for Tumor-Specific Phototherapy for Laryngeal carcinoma

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Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00249F, Paper
Di Wu, zheng zhao, nan wang, xinrui zhang, honghong yan, xiaoqi chen, yunyun fan, weiwei liu, xuekui liu
Reliable diagnosed and efficient targeted therapy regime is important and may in turn lead to more effective laryngeal carcinoma treatments. Multifunctional nano-theranostic agents demonstrate great potential in tumor theranostic applications....
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A disulfide based low molecular weight gel for the selective sustained release of biomolecules

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00508H, Paper
Nitin D. Bansode, Kotagudda Ranganath Sindhu, Chloe Morel, Murielle Rémy, Julien Verget, Claudine Boiziau, Philippe Barthélémy
Constructing biocompatible soft materials via supramolecular approaches remains an important challenge for in vivo applications.
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A conductive PEDOT/alginate porous scaffold as a platform to modulate the biological behaviors of brown adipose-derived stem cells

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/C9BM02012H, Paper
Boguang Yang, Fanglian Yao, Lei Ye, Tong Hao, Yabin Zhang, Lei Zhang, Dianyu Dong, Wancai Fang, Yan Wang, Xiaoyang Zhang, Changyong Wang, Junjie Li
The development of three-dimensional conductive scaffolds is vital to support the adhesion, proliferation and myocardial differentiation of stem cells in cardiac tissue engineering.
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Multifunctional Antibacterial Dental Sealants Suppress Biofilms Derived from Children at High Risk of Caries

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Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00370K, Paper
Maria Salem Ibrahim, Isadora Martini Garcia, Taissa Vila, Abdulrahman A. Balhaddad, Fabricio Mezzomo Collares, Michael D Weir, Huakun Xu, Mary Anne Melo
Dental caries in children is a leading worldwide concern for oral health. Combining antibacterial and remineralizing additives within dental sealants is a promising approach for caries prevention. Saliva contains oral...
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Additively manufactured functionally graded biodegradable porous zinc

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Biomater. Sci., 2020, 8,2404-2419
DOI: 10.1039/C9BM01904A, Paper
Open Access
Y. Li, P. Pavanram, J. Zhou, K. Lietaert, F. S. L. Bobbert, Yusuke Kubo, M. A. Leeflang, H. Jahr, A. A. Zadpoor
First report on the effect of topology design on the biodegradation, mechanical properties, and cell responses of additively manufactured Zn.
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Oral biofilm elimination by combining iron-based nanozymes and hydrogen peroxide-producing bacteria

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Biomater. Sci., 2020, 8,2447-2458
DOI: 10.1039/C9BM01889A, Paper
Yanqiu Wang, Xinyu Shen, Shang Ma, Qianqian Guo, Wei Zhang, Lu Cheng, Liming Ding, Zhuobin Xu, Jing Jiang, Lizeng Gao
Combining nanozymes and bacteria to eliminate dental biofilms in a mixed-species model.
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In situ conversion of rose bengal microbubbles into nanoparticles for ultrasound imaging guided sonodynamic therapy with enhanced antitumor efficacy

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Biomater. Sci., 2020, 8,2526-2536
DOI: 10.1039/C9BM02046B, Paper
Rui Hou, Xiaolong Liang, Xiaoda Li, Xu Zhang, Xiaotu Ma, Fan Wang
Sonosensitizer microbubbles enhance drug accumulation and the antitumor efficacy of sonodynamic therapy by ultrasound mediated micro to nano conversion.
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A riboflavin–ultraviolet light A-crosslinked decellularized heart valve for improved biomechanical properties, stability, and biocompatibility

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Biomater. Sci., 2020, 8,2549-2563
DOI: 10.1039/C9BM01956A, Paper
Chungeng Liu, Weihua Qiao, Hong Cao, Jinchi Dai, Fei Li, Jiawei Shi, Nianguo Dong
Riboflavin–ultraviolet light A could effectively crosslink a decellularized heart valve to improve its biomechanical properties, stability and biocompatibility.
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Tumor localization of oncolytic adenovirus assisted by pH-degradable microgels with JQ1-mediated boosting replication and PD-L1 suppression for enhanced cancer therapy

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Biomater. Sci., 2020, 8,2472-2480
DOI: 10.1039/D0BM00172D, Paper
Haishi Qiao, Xingmei Chen, Qiming Wang, Junmei Zhang, Dechun Huang, Enping Chen, Hongliang Qian, Yinan Zhong, Qi Tang, Wei Chen
Illustration of pH-degradable microgels (MGs) for the simultaneous encapsulation of OA and JQ1 for an enhanced oncolytic viral treatment with JQ1-meidated boosting viral replication and PD-L1 suppression.
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Trastuzumab targeted micellar delivery of docetaxel using dendron–polymer conjugates

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Biomater. Sci., 2020, 8,2600-2610
DOI: 10.1039/C9BM01764J, Paper
Burcu Sumer Bolu, Bianka Golba, Amitav Sanyal, Rana Sanyal
Incorporation of a therapeutic antibody into nanosized drug delivery systems can improve their target specificity.
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Engineering red-emitting multi-functional nanocapsules for magnetic tumour targeting and imaging

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Biomater. Sci., 2020, 8,2590-2599
DOI: 10.1039/D0BM00314J, Paper
Julie Tzu-Wen Wang, Umberto Martino, Rehan Khan, Maasoomeh Bazzar, Paul Southern, Dönüş Tuncel, Khuloud T. Al-Jamal
Self-red-emitting magnetic PLGA-PEG nanocapsules for optical imaging and magnetic tumour targeting.
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Dual-responsive click-crosslinked micelles designed for enhanced chemotherapy for solid tumors

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Biomater. Sci., 2020, 8,2507-2513
DOI: 10.1039/D0BM00078G, Paper
Rong Jin, Jing Sun, Liefu Zhou, Xuelian Guo, Aoneng Cao
Core-crosslinked dual-responsive micelles can be readily constructed from a pair of clickable copolymers and applied for controlled release of anticancer drugs in cancer therapy.
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Super-assembled core/shell fibrous frameworks with dual growth factors for in situ cementum–ligament–bone complex regeneration

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Biomater. Sci., 2020, 8,2459-2471
DOI: 10.1039/D0BM00102C, Paper
Tian Ding, Jianhua Li, Xingshuang Zhang, Lingqian Du, Yang Li, Dengwang Li, Biao Kong, Shaohua Ge
In this work, a super-assembled framework (SAF) was fabricated to achieve sequential delivery of bFGF and BMP-2 for in situ cementum–ligament–bone complex regeneration.
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A nanosystem loaded with perfluorohexane and rose bengal coupled upconversion nanoparticles for multimodal imaging and synergetic chemo-photodynamic therapy of cancer

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Biomater. Sci., 2020, 8,2488-2506
DOI: 10.1039/C9BM02081K, Paper
Hai-yan Wang, Li Hou, Hai-liang Li, Xu Wang, Yang Cao, Bo-yu Zhang, Jing-tao Wang, Shi-jie Wei, Hong-wan Dang, Hai-tao Ran
A novel nanosystem (FURH-PFH-NPs) combined with LIFU and laser irradiation realized multimodal imaging, targeted release of HCPT, UCNPs-RB and synergetic chemo-photodynamic therapy of cancer.
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Enhanced selectivity, cellular uptake, and in vitro activity of an intrinsically fluorescent copper–tirapazamine nanocomplex for hypoxia targeted therapy in prostate cancer

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Biomater. Sci., 2020, 8,2420-2433
DOI: 10.1039/C9BM01905G, Paper
Vera L. Silva, Abdessamad Kaassis, Ashkan Dehsorkhi, Cédrik-Roland Koffi, Maja Severic, Moustafa Abdelhamid, Duuamene Nyimanu, Christopher J. Morris, Wafa’ T. Al-Jamal
Cu(TPZ)2 complex as a promising hypoxia selective cytotoxin in prostate cancer.
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Bioinspired inorganic nanoparticles and vascular factor microenvironment directed neo-bone formation

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Biomater. Sci., 2020, 8,2627-2637
DOI: 10.1039/D0BM00041H, Paper
Hwan D. Kim, Jungha Park, Sivashanmugam Amirthalingam, R. Jayakumar, Nathaniel S. Hwang
VEGF-overexpressing human tonsil-derived stem cells (VEGF-hTMSCs) and a whitlockite microenvironment induce vascularized bone tissue formation in biodegradable polymeric scaffolds.
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A medical adhesive used in a wet environment by blending tannic acid and silk fibroin

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Biomater. Sci., 2020, 8,2694-2701
DOI: 10.1039/D0BM00322K, Paper
Xijie Gao, Qiyuan Dai, Longtao Yao, Hua Dong, Qingtao Li, Xiaodong Cao
A medical adhesive called TASK based on polyphenol-gel systems was developed and showed wet-adhesive, stretchable, self-healing and restorable properties.
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Nanomedicine – a promising therapy for hematological malignancies

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Biomater. Sci., 2020, 8,2376-2393
DOI: 10.1039/D0BM00129E, Review Article
Lifen Huang, Jun Huang, Junbin Huang, Hongman Xue, Zhiqing Liang, Jun Wu, Chun Chen
Nanoparticles (NPs) are used for the diagnosis and treatment of hematological tumors by loading various pharmacodynamic molecules.
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A thermo-responsive, self-assembling biointerface for on demand release of surface-immobilised proteins

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Biomater. Sci., 2020, 8,2673-2681
DOI: 10.1039/C9BM01957J, Paper
Angela Saccardo, Mikhail Soloviev, Enrico Ferrari
Engineering of the neuronal SNARE proteins yields chimeric bio-materials that reversibly assemble and disassemble at set temperatures.
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Highly responsive and rapid hydrogen peroxide-triggered degradation of polycaprolactone nanoparticles

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Biomater. Sci., 2020, 8,2394-2397
DOI: 10.1039/C9BM02019E, Communication
Peng-Hao Hsu, Carina Arboleda, Alexandra Stubelius, Ling-Wei Li, Jason Olejniczak, Adah Almutairi
Nanoparticles formulated from fast-degrading oxidation-responsive polycaprolactone are responsive to 50 μM of H2O2.
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Topography induced stiffness alteration of stem cells influences osteogenic differentiation

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Biomater. Sci., 2020, 8,2638-2652
DOI: 10.1039/D0BM00264J, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Liangliang Yang, Qi Gao, Lu Ge, Qihui Zhou, Eliza M. Warszawik, Reinier Bron, King Wai Chiu Lai, Patrick van Rijn
Topography-driven alterations to single cell stiffness rather than alterations in cell morphology, is the underlying driver for influencing cell biological processes, particularly stem cell differentiation.
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Biodegradable nanocomposite fibrous scaffold mediated local delivery of vancomycin for the treatment of MRSA infected experimental osteomyelitis

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Biomater. Sci., 2020, 8,2653-2665
DOI: 10.1039/D0BM00140F, Paper
Amit G. Krishnan, Raja Biswas, Deepthy Menon, Manitha B. Nair
The study shows the development of a biodegradable bi-functional composite scaffold that can reduce bacterial infection, while promotes bone regeneration in osteomyelitis, without the need for revision surgery.
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Advances in living cell-based anticancer therapeutics

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Biomater. Sci., 2020, 8,2344-2365
DOI: 10.1039/D0BM00036A, Review Article
He Dong, Xiao Xu, Leikun Wang, Ran Mo
This review summarizes recent advances in the applications of living cells as drug carriers or active drugs for anticancer drug delivery and cancer therapy.
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Interfacing human induced pluripotent stem cell-derived neurons with designed nanowire arrays as a future platform for medical applications

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Biomater. Sci., 2020, 8,2434-2446
DOI: 10.1039/D0BM00182A, Paper
Jann Harberts, Undine Haferkamp, Stefanie Haugg, Cornelius Fendler, Dennis Lam, Robert Zierold, Ole Pless, Robert H. Blick
Nanostructured substrates such as nanowire arrays form a powerful tool for building next-generation medical devices.
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Particle-mediated delivery of frataxin plasmid to a human sensory neuronal model of Friedreich's ataxia

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Biomater. Sci., 2020, 8,2398-2403
DOI: 10.1039/C9BM01757G, Communication
Ewa Czuba-Wojnilowicz, Serena Viventi, Sara E. Howden, Simon Maksour, Amy E. Hulme, Christina Cortez-Jugo, Mirella Dottori, Frank Caruso
Multilayered particles in gene therapy for Friedreich's ataxia induce a 27 000-fold increase in frataxin gene expression in a patient-derived cell model.
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A multifunctional metal-biopolymer coordinated double network hydrogel combined with multi-stimulus responsiveness, self-healing, shape memory and antibacterial properties

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00425A, Paper
Kun Yan, Feiyang Xu, Chunyu Wang, Yingying Li, Yuanli Chen, Xiufang Li, Zhentan Lu, Dong Wang
A universal, straightforward macroscale assembly technology has been presented for fabrication of polysaccharide-based multifunctional DN gels based on metal coordination chemistry.
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A super-stretchable, self-healing and injectable supramolecular hydrogel constructed by a host–guest crosslinker

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00290A, Paper
Yang Zhou, Yuanhao Zhang, Zhaobo Dai, Fang Jiang, Jia Tian, Weian Zhang
Supramolecular hydrogels based on host–guest interactions have drawn considerable attention due to their unique properties and promising applications.
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A versatile ultrafine and super-absorptive H+-modified montmorillonite: application for metabolic syndrome intervention and gastric mucosal protection

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00474J, Paper
Qiwen Wang, Jie Shen, Enqi Mo, Haotian Zhang, Jianwei Wang, Xiurong Hu, Jun Zhou, Hongzhen Bai, Guping Tang
An H+-modified montmorillonite (H-MMT) was prepared using an acid modification method to obtain powerful absorption ability as a theranostic platform for both metabolic syndrome and gastric mucosa protection.
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Optically controlled hybrid metamaterial of plasmonic spiky gold inbuilt graphene sheets for bimodal imaging guided multimodal therapy

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00312C, Paper
Kunnumpurathu Jibin, Jayaram S. Prasad, Giridharan Saranya, Sachin J. Shenoy, Kaustabh K. Maiti, Ramapurath S. Jayasree
Gold–graphene nanohybrid for simultaneous dual-imaging guided triple therapy as a new paradigm in light-triggered cancer theranostics. The material demonstrates excellent therapeutic efficacy and treatment monitoring features.
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A transport system based on a quantum dot-modified nanotracer is genetically and developmentally stable in pregnant mice

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00311E, Paper
Open Access
Hye Jin Kim, Ji Sun Park, Se Won Yi, Minyeon Go, Hye-Ryun Kim, Su Jin Lee, Jong Min Park, Dong Hyun Cha, Sung Han Shim, Keun-Hong Park
The use of nanoscale materials (NMs) could cause problems such as cytotoxicity, genomic aberration, but the impacts of NM exposure during pregnancy remain uncharacterized in the context of clinical applications.
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Surface engineering of titanium alloy using metal-polyphenol network coating with magnesium ions for improved osseointegration

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Biomater. Sci., 2020, Advance Article
DOI: 10.1039/D0BM00566E, Paper
Sangmin Lee, Yun-Young Chang, Jinkyu Lee, Sajeesh Kumar Madhurakkat Perikamana, Eun Mi Kim, Yang-Hun Jung, Jeong-Ho Yun, Heungsoo Shin
Although titanium-based implants are widely used in orthopedic and dental clinics, improved osseointegration at the bone–implant interface is still required.
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A biomimetic orally targeted delivery of Bindarit for immunotherapy of atherosclerosis

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Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00418A, Paper
Luqi Yin, Cuiping Peng, Yue Tang, Yuchuan Yuan, Jiaxing Liu, Tingting Xiang, Feila Liu, Zhou Xing, Xiaohui Li
Monocyte chemoattractant protein-1 (MCP-1) plays an important role in the development of atherosclerosis. However, the application of bindarit (a specific synthetic inhibitor of MCP-1) in atherosclerosis has not been confirmed...
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Functionalized Biomaterials to Combat Biofilm

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Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00526F, Minireview
Dan-ni Huang, Jing Wang, Kefeng Ren, Jian Ji
Pathogenic microbial biofilms readily form on implantable medical devices or human tissues have posed a great threat to worldwide healthcare. Hopes are focused on preventive strategies of biofilms, leaving a...
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Effective intracellular delivery of bevacizumab via PEGylated polymeric nanoparticles targeting CD44v6 receptor in colon cancer cells

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Biomater. Sci., 2020, Accepted Manuscript
DOI: 10.1039/D0BM00556H, Paper
Ana Baião, Flávia Sousa, Ana Oliveira, Carla Oliveira, Bruno Sarmento
Colorectal cancer (CRC) is one of the most incident and mortal cancers in the world, mainly due to its metastatic and metabolic ability. CD44 receptor isoform containing exon 6 (CD44v6)...
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Serum miRNAs are differentially altered by ethanol and caffeine consumption in rats

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Toxicol. Res., 2019, 8,842-849
DOI: 10.1039/C9TX00069K, Paper
M. Martinez, I. M. U. Rossetto, R. M. S. Arantes, F. S. N. Lizarte, L. F. Tirapelli, D. P. C. Tirapelli, L. G. A. Chuffa, F. E. Martinez
Alcoholism is a multifactorial disease with high risk for dependence determined by genetic background, environmental factors and neuroadaptations.
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Integrated network pharmacology and targeted metabolomics to reveal the mechanism of nephrotoxicity of triptolide

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Toxicol. Res., 2019, 8,850-861
DOI: 10.1039/C9TX00067D, Paper
Wei Huang, Chuanxin Liu, Lijuan Xie, Yuming Wang, Yanyan Xu, Yubo Li
Integrated network pharmacology and targeted metabolomics to reveal the nephrotoxicity mechanism of triptolide.
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Eco-friendly synthesis of glutathione-capped CdTe/CdSe/ZnSe core/double shell quantum dots: their cytotoxicity and genotoxicity effects on Chinese hamster ovary cells

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Toxicol. Res., 2019, 8,868-874
DOI: 10.1039/C9TX00113A, Paper
Neo Mervyn Monaheng, Sundararajan Parani, Mary Gulumian, Oluwatobi Samuel Oluwafemi
In this work, we report green one-pot synthesis, cytotoxicity and genotoxicity of glutathione-capped CdTe/CdSe/ZnSe heterostructured quantum dots (QDs) using a label-free xCELLigence RTCA system as well as the Cytokinesis Blocked Micronucleus assay.
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miR-140-5p mediates bevacizumab-induced cytotoxicity to cardiomyocytes by targeting the VEGFA/14-3-3γ signal pathway

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Toxicol. Res., 2019, 8,875-884
DOI: 10.1039/C9TX00100J, Paper
Xuan-Ying Chen, Wei-Lin Huang, Xiao-Ping Peng, Yan-Ni Lv, Jun-He Li, Jian-Ping Xiong
Bevacizumab (BVZ) is a widely investigated angiogenesis inhibitor in cancer patients. Although the anti-tumor effects has been verified, cardiotoxicity may be the most serious side-effect for BVZ.
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Kaempferol derivatives isolated from Lens culinaris Medik. reduce DNA damage induced by etoposide in peripheral blood mononuclear cells

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Toxicol. Res., 2019, 8,896-907
DOI: 10.1039/C9TX00176J, Paper
Magdalena Kluska, Michał Juszczak, Daniel Wysokiński, Jerzy Żuchowski, Anna Stochmal, Katarzyna Woźniak
Bioactive compounds isolated from plants are considered to be attractive candidates for cancer therapy.
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Gynura divaricata ameliorates hepatic insulin resistance by modulating insulin signalling, maintaining glycolipid homeostasis and reducing inflammation in type 2 diabetic mice

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Toxicol. Res., 2019, 8,928-938
DOI: 10.1039/C9TX00191C, Paper
Xuan Dong, Shu-Xiang Zhao, Bing-Qing Xu, Yu-Qing Zhang
Oral lyophilized powder of Gynura divaricata, an edible medicinal plant, can alleviate both hyperglycaemia and hepatic insulin resistance in type 2 diabetic mice.
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Lipoic acid antagonizes paraquat-induced vascular endothelial dysfunction by suppressing mitochondrial reactive oxidative stress

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Toxicol. Res., 2019, 8,918-927
DOI: 10.1039/C9TX00186G, Paper
Li Pang, Ping Deng, Yi-dan Liang, Jing-yu Qian, Li-Chuan Wu, Ling-ling Yang, Zheng-ping Yu, Zhou Zhou
α-Lipoic acid antagonizes paraquat toxicity.
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Thyroid endocrine status and biochemical stress responses in adult male Wistar rats chronically exposed to pristine polystyrene nanoplastics

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Toxicol. Res., 2019, 8,953-963
DOI: 10.1039/C9TX00147F, Paper
Fatemeh Amereh, Akbar Eslami, Simin Fazelipour, Mohammad Rafiee, Mohammad Ismail Zibaii, Mohammad Babaei
At this time, little is known about the long-term effects of micro(nano)plastics on public health. In the present study, early warning signs of thyroid endocrine disruption were noticed in adult Wistar rats from the ingestion of virgin polystyrene nanoparticles.
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Cadmium telluride quantum dot-exposed human bronchial epithelial cells: a further study of the cellular response by proteomics

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Toxicol. Res., 2019, 8,994-1001
DOI: 10.1039/C9TX00126C, Paper
Yan-Ming Xu, Heng Wee Tan, Wei Zheng, Zhan-Ling Liang, Fei-Yuan Yu, Dan-Dan Wu, Yue Yao, Qiu-Hua Zhong, Rui Yan, Andy T. Y. Lau
A comparative proteome analysis was conducted to identify global changes in the protein expression profiles of cadmium telluride quantum dot-exposed human bronchial epithelial BEAS-2B cells.
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Synergistic antioxidant capacity of CsNPs and CurNPs against cytotoxicity, genotoxicity and pro-inflammatory mediators induced by hydroxyapatite nanoparticles in male rats

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Toxicol. Res., 2019, 8,939-952
DOI: 10.1039/C9TX00221A, Paper
Israa F. Mosa, Mokhtar Youssef, Maher Kamel, Osama F. Mosa, Yasser Helmy
Due to their dynamic characteristics, hydroxyapatite nanoparticles (HAP-NPs) have been employed numerous times in nanomedicine and in tissue engineering, particularly as diagnostic and therapeutic agents.
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Mice with a Sertoli cell-specific knockout of the Ctr1 gene exhibit a reduced sensitivity to cisplatin-induced testicular germ cell apoptosis

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Toxicol. Res., 2019, 8,972-978
DOI: 10.1039/C9TX00142E, Paper
Open Access
Rashin Ghaffari, John H. Richburg
Exposure to the chemotherapeutic agent cis-diamminedichloroplatinum(II) (cDDP) is well known to instigate acute and prolonged testicular injury in male patients.
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Effects of moderate red wine on cardiovascular risk factors in diabetics: a systematic review and meta-analysis of randomized controlled trials

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Toxicol. Res., 2019, 8,979-987
DOI: 10.1039/C9TX00227H, Paper
Saavia Alice Naame, Decheng Li, Ruixue Huang
Diabetes mellitus is of major public health concerns; its incidence is continuously increasing.
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Methanol extract of Iphiona aucheri ameliorates CCl4 induced hepatic injuries by regulation of genes in rats

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Toxicol. Res., 2019, 8,815-832
DOI: 10.1039/C9TX00157C, Paper
Jawaid Ahmed Zai, Muhammad Rashid Khan, Zaib un Nisa Mughal, Riffat Batool, Irum Naz, Sonia Maryam, Zartash Zahra
Alteration in expression of ER stress associated genes, inflammatory genes and antioxidant biochemical induced with CCl4 in liver of rats were restored towards the control rats by co-administration of methanol extract of Iphiona aucheri to rats.
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Astaxanthin reduces perfluorooctanoic acid cytotoxicity in Saccharomyces cerevisiae

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Toxicol. Res., 2019, 8,1009-1015
DOI: 10.1039/C9TX00215D, Paper
S. J. Sudharshan, Raghavendra Tirupathi, Madhu Dyavaiah
Perfluorooctanoic acid (PFA) has been identified as an environmental contaminant of high concern for human health.
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Nanoparticle induced barrier function assessment at liquid–liquid and air–liquid interface in novel human lung epithelia cell lines

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Toxicol. Res., 2019, 8,1016-1027
DOI: 10.1039/C9TX00179D, Paper
Open Access
Lars Leibrock, Sandra Wagener, Ajay Vikram Singh, Peter Laux, Andreas Luch
To answer questions about nanoparticle toxicity, translocation and biokinetics following inhalation exposure, in vitro models should have functional barrier properties to mimic the in vivo situation as closely as possible.
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Phytochemicals protect L02 cells against hepatotoxicity induced by emodin via the Nrf2 signaling pathway

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Toxicol. Res., 2019, 8,1028-1034
DOI: 10.1039/C9TX00220K, Paper
Yan Yan, Kang Wang, Xu Tang, Jun-feng Gao, Bin-yu Wen
Dihydromyricetin (DMY), hyperoside and silybin are phytochemicals that belong to a class called flavonoids, and they have been used in liver protection pharmaceutical preparations, but the specific mechanism of these chemicals is still unclarified.
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