Nearly half of phase 3 cancer clinical trials carried out by the NCI-sponsored SWOG Cancer Research Network were associated with clinical care guidelines or new drug approvals, a study in JAMA Network Open shows.

An NCI clinical trial finds the drug selumetinib improves outcomes for children with neurofibromatosis type 1 (NF1), shrinking inoperable tumors called plexiform neurofibromas, reducing pain, and improving function and overall quality of life.

Statement from the National Cancer Institute providing information regarding treatment of cancer patients and participation in clinical trials during the COVID-19 pandemic.

Douglas, Wilfrid H. (Wilfrid Henry)

Sang, Guoyuan, 1975-

Yang, Lianrui, 1963- author

Zhu, Xiaomei

Liu, Zhuo, author

The government will provide doctors with a checklist to follow regarding treatment. We will also be applying to ICMR to seek permission to conduct lung biopsies after the death of patients and for clinical autopsies. This will help in providing critical patients with more effective care and bring down mortality rates, Health and Family Welfare Commissioner Pankaj Kumar Pandey said.

Resident doctors, MBBS students and those serving their bond are at the frontline in the fight against Covid-19 in the city as senior clinicians stay away from their duty, leaving the young team of medical professionals firefighting the crisis on their own.

Hayden Library - PT2603.R397 Z8853 2014

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Rotch Library - PT735.K45 2015

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Hayden Library - PT2671.L84 B6513 2017

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Alexei Bylinskii discusses friction at the atomic level and Braxton Boren talks about the acoustics of historical spaces, and David Grimm discusses daily news stories with Sarah Crespi. Hosted by Susanne Bard. [Img: Pericles' Funeral Oration by Philipp von Foltz, 1852]

News stories on using pets in clinical trials to test veterinarian drugs, debunking the Piltdown Man once and for all, and deciding just how smart crows can be, with David Grimm.   From the magazine It’s really difficult to figure out how old a free-living animal is. Maybe you can find growth rings in bone or other calcified body parts, but in sharks like the Greenland shark, no such hardened parts exist. Using two different radiocarbon dating approaches, Julius Neilsen and colleagues discovered that the giant Greenland shark may live as long as 400 years.   Read the research.   [Image: James Howard McGregor/Wikimedia Commons/Music: Jeffrey Cook]

This week we hear stories on what to do with experimental brain implants after a study is over, how gene therapy gave a second skin to a boy with a rare epidermal disease, and how bone markings thought to be evidence for early hominid tool use may have been crocodile bites instead, with Online News Editor Catherine Matacic. Sarah Crespi interviews Gary King about his new experiment to bring fresh data to the age-old question of how the news media influences the public. Are journalists setting the agenda or following the crowd? How can you know if a news story makes a ripple in a sea of online information? In a powerful study, King’s group was able to publish randomized stories on 48 small and medium sized news sites in the United States and then track the results.  Listen to previous podcasts. [Image: Chad Sparkes/Flickr; Music: Jeffrey Cook]

We now live in the Meghalayan age—the last age of the Holocene epoch. Did you get the memo? A July decision by the International Commission on Stratigraphy, which is responsible for naming geological time periods, divided the Holocene into three ages: the Greenlandian, the Northgrippian, and the Meghalayan. The one we live in—the Meghalayan age (pronounced “megalion”)—is pegged to a global drought thought to have happened some 4200 years ago. But many critics question the timing of this latest age and the global expanse of the drought. Staff writer Paul Voosen talks with host Sarah Crespi about the evidence for and against the global drought—and what it means if it’s wrong. Sarah also talks to staff writer Kelly Servick about her feature story on what happens when biocontrol goes out of control. Here’s the setup: U.S. Department of Agriculture researchers wanted to know whether brown marmorated stink bugs that have invaded the United States could be controlled—aka killed—by importing their natural predators, samurai wasps, from Asia. But before they could find out, the wasps showed up anyway. Kelly discusses how using one species to combat another can go wrong—or right—and what happens when the situation outruns regulators. This week’s episode was edited by Podigy. Download a transcript of this episode (PDF) Listen to previous podcasts. [Image: Melissa McMasters/Flickr; Music: Jeffrey Cook] 

Plan S, an initiative that requires participating research funders to immediately publish research in an open-access journal or repository, was announced in September 2018 by Science Europe with 11 participating agencies. Several others have signed on since the launch, but other funders and journal publishers have reservations. Host Meagan Cantwell speaks with Contributing Correspondent Tania Rabesandratana about those reservations and how Plan S is trying to change publishing practices and research culture at large. Some 1.7 million Jewish people were murdered by the Nazis in the 22 months of Operation Reinhard (1942–43) which aimed to eliminate all Jews in occupied Poland. But until now, the speed and totality of these murders were poorly understood. It turns out that about one-quarter of all Jews killed during the Holocaust were murdered in the autumn of 1942, during this operation. Meagan talks with Lewi Stone, a professor of biomathematics at Tel Aviv University in Israel and mathematical science at RMIT University in Melbourne, Australia, about this shocking kill rate, and why researchers are taking a quantitative approach to characterizing genocides. This week’s episode was edited by Podigy. Download the transcript (PDF) Listen to previous podcasts. About the Science Podcast [Image: Michael Beckwith; Music: Jeffrey Cook]

The groundwater of Rockford, Michigan, is contaminated by per- and polyfluoroalkyl substances, chemicals found in everything from nonstick pans to dental floss to—in the case of Rockford—waterproofing agents from a shoe factory that shut down in 2009. Science journalist Sara Talpos talks with host Meagan Cantwell about how locals found the potentially health-harming chemicals in their water, and how contamination from nonstick chemicals isn’t limited to Michigan. Also this week, host Sarah Crespi talks with Shyamnath Gollakota of the University of Washington in Seattle about his work diagnosing ear infections with smartphones. With the right app and a small paper cone, it turns out that your phone can listen for excess fluid in the ear by bouncing quiet clicks from the speaker off the eardrum. Clinical testing shows the setup is simple to use and can help parents and doctors check children for this common infection. This week’s episode was edited by Podigy. Ads on this show: Science Rules! podcast with Bill Nye Download the transcript (PDF)  Listen to previous podcasts. About the Science Podcast [Image: Dennis Wise/University of Washington; Music: Jeffrey Cook]

Though a law requiring clinical trial results reporting has been on the books for decades, many researchers have been slow to comply. Now, 2 years after the law was sharpened with higher penalties for noncompliance, investigative correspondent Charles Piller took a look at the results. He talks with host Sarah Crespi about the investigation and a surprising lack of compliance and enforcement. Also this week, Sarah talks with Brett Finlay, a microbiologist at the University Of British Columbia, Vancouver, about an Insight in this week’s issue that aims to connect the dots between noncommunicable diseases like heart disease, diabetes, and cancer and the microbes that live in our guts. Could these diseases actually spread through our microbiomes? This week’s episode was edited by Podigy. Listen to previous podcasts. About the Science Podcast Download a transcript (PDF). [Image: stu_spivack/Flickr; Music: Jeffrey Cook]

As part of a special issue on chemicals for tomorrow’s Earth, we’ve got two green chemistry stories. First, host Sarah Crespi talks with contributing correspondent Warren Cornwell about how a company came up with a replacement for the popular can lining material bisphenol A and then recruited knowledgeable critics to test its safety. Sarah is also joined by Beate Escher of the Helmholtz Centre for Environmental Research and the University of Tübingen to discuss ways to trace complex mixtures of humanmade chemicals in the environment. They talk about how new technologies can help detect these mixtures, understand their toxicity, and eventually connect their effects on the environment, wildlife, and people. Read more in the special issue on chemicals for tomorrow’s Earth. This week’s episode was edited by Podigy. Listen to previous podcasts. About the Science Podcast Download a transcript (PDF)

On this week’s show, host Joel Goldberg gets an update on the coronavirus pandemic from Senior Correspondent Jon Cohen. In addition, Cohen gives a rundown of his latest feature, which highlights the relationship between diseases and changing seasons—and how this relationship relates to a potential coronavirus vaccine. Also this week, from a recording made at this year’s AAAS annual meeting in Seattle, host Meagan Cantwell speaks with Alexandra Maertens, director of the Green Toxicology initiative at Johns Hopkins University, Baltimore, about the importance of incorporating nonanimal testing methods to study the adverse effects of chemicals. This week’s episode was produced with help from Podigy. Download a transcript (PDF) Listen to previous podcasts. About the Science Podcast [Image: Let Ideas Compete/Flickr; Music: Jeffrey Cook]