nes Glucose availability but not changes in pancreatic hormones sensitizes hepatic AMPK activity during nutritional transition in rodents [Metabolism] By www.jbc.org Published On :: 2020-05-01T00:06:09-07:00 The cellular energy sensor AMP-activated protein kinase (AMPK) is a metabolic regulator that mediates adaptation to nutritional variations to maintain a proper energy balance in cells. We show here that suckling-weaning and fasting-refeeding transitions in rodents are associated with changes in AMPK activation and the cellular energy state in the liver. These nutritional transitions were characterized by a metabolic switch from lipid to glucose utilization, orchestrated by modifications in glucose levels and the glucagon/insulin ratio in the bloodstream. We therefore investigated the respective roles of glucose and pancreatic hormones on AMPK activation in mouse primary hepatocytes. We found that glucose starvation transiently activates AMPK, whereas changes in glucagon and insulin levels had no impact on AMPK. Challenge of hepatocytes with metformin-induced metabolic stress strengthened both AMPK activation and cellular energy depletion under limited-glucose conditions, whereas neither glucagon nor insulin altered AMPK activation. Although both insulin and glucagon induced AMPKα phosphorylation at its Ser485/491 residue, they did not affect its activity. Finally, the decrease in cellular ATP levels in response to an energy stress was additionally exacerbated under fasting conditions and by AMPK deficiency in hepatocytes, revealing metabolic inflexibility and emphasizing the importance of AMPK for maintaining hepatic energy charge. Our results suggest that nutritional changes (i.e. glucose availability), rather than the related hormonal changes (i.e. the glucagon/insulin ratio), sensitize AMPK activation to the energetic stress induced by the dietary transition during fasting. This effect is critical for preserving the cellular energy state in the liver. Full Article
nes New guidelines for treating the sickest COVID-19 patients By www.eurekalert.org Published On :: Mon, 04 May 2020 00:00:00 EDT (University of Houston) A new set of recommendations for health care workers on the front lines, to help them make decisions on how to treat the most critical COVID-19 patients, those with severe lung or heart failure, has been published. Full Article
nes Balancing Act: Consumers Are Willing to Sacrifice Privacy to See Fewer Digital Ads, According to New Columbia Business School Research By www8.gsb.columbia.edu Published On :: Mon, 17 Feb 2020 18:01:28 +0000 Business Economics and Public Policy Marketing Media and Technology Tuesday, February 4, 2020 - 12:45 NEW YORK – In the era of online surveillance, consumers continually express concerns about how their digital footprint is being tracked and their privacy compromised. Full Article
nes Researchers Answer a Diversity Puzzle: Why Chinese Americans but not Indian Americans are Underrepresented in Leadership Positions By www8.gsb.columbia.edu Published On :: Thu, 20 Feb 2020 16:26:43 +0000 Leadership Thursday, February 20, 2020 - 11:15 New studies identify the boundary and causes of the “Bamboo Ceiling” Full Article
nes Same Old Tune: Columbia Business School Research Shows Bias Against Women in the Music Industry By www8.gsb.columbia.edu Published On :: Fri, 28 Feb 2020 21:54:41 +0000 Leadership Operations Thursday, February 27, 2020 - 16:45 NEW YORK – In 2018, the Grammy Awards faced criticism when male artists swept the most prestigious music awards – prompting Recording Academy president Neil Portnow to say the solution is for women to “step up.” But the truth is women artists have been stepping up for decades, according to research from Columbia Business School’s Professor of Business Michael Mauskapf and Associate Professor of Organizational Behavior Noah Askin. Full Article
nes Research from Columbia Business School Suggests Hypersensitivity to Coronavirus News Is Driving Market Reactions – and Vice Versa By www8.gsb.columbia.edu Published On :: Fri, 03 Apr 2020 02:46:58 +0000 Business Economics and Public Policy Capital Markets and Investments Healthcare Media and Technology Friday, April 10, 2020 - 22:45 NEW YORK – On March 11th, the Dow Jones Industrial Average plunged 1,485 points, ending the longest bull-market run in history, and sending the market into nosedive the likes of which has not been witnessed since the Great Recession. While it could take years to fully understand all of the factors that led to this recent crash, a consensus has emerged that fear of an economic downturn brought on by the coronavirus has played a large role. Full Article
nes New Research from Columbia Business School Shows Radical Changes in Household Spending Habits During COVID-19 Epidemic By www8.gsb.columbia.edu Published On :: Tue, 28 Apr 2020 18:37:51 +0000 Business Economics and Public Policy Operations Risk Management Tuesday, April 28, 2020 - 14:30 Study provides first real-time view into household consumption during outbreak in U.S., showing an initial sharp increase in key categories, followed by a sharp decrease in overall spending Full Article
nes Lockdown Losses: Lack of Government Transparency during COVID-19 Pandemic Holds Back Businesses from Taking Risks, Making Financial Decisions By www8.gsb.columbia.edu Published On :: Wed, 29 Apr 2020 18:19:09 +0000 Business Economics and Public Policy Operations Risk Management Strategy Thursday, April 30, 2020 - 14:15 NEW YORK – Since the coronavirus outbreak began, states across the U.S. have implemented stay-at-home orders, disrupting businesses and causing many to shut down. In addition, almost half of U.S. states from New York to Oregon have extended their lockdown orders beyond the original end date. These extensions of lockdown policy, while clearly beneficial to address public health concerns, can damage the economy beyond their immediate impact on business closures and layoffs. Full Article
nes New Research: Entrepreneurship, New Business Creation are Critical to COVID-19 Economic Recovery By www8.gsb.columbia.edu Published On :: Tue, 05 May 2020 13:02:07 +0000 Business Economics and Public Policy Entrepreneurship Tuesday, May 5, 2020 - 09:00 Working Paper from Columbia Business School Emphasizes the Need to Accelerate New Businesses, Not Just Protect Existing Ones, to Restore the U.S. Economy Full Article
nes How small chromosomes compete with big ones for a cell's attention By www.eurekalert.org Published On :: Wed, 06 May 2020 00:00:00 EDT (Memorial Sloan Kettering Cancer Center) Scientists at the Sloan Kettering Institute have solved the puzzle of how small chromosomes ensure that they aren't skipped over during meiosis, the process that makes sperm and egg. Full Article
nes AI tool speeds up search for COVID-19 treatments and vaccines By www.eurekalert.org Published On :: Mon, 04 May 2020 00:00:00 EDT (Northwestern University) Northwestern University researchers are using artificial intelligence (AI) to speed up the search for COVID-19 treatments and vaccines. The AI-powered tool makes it possible to prioritize resources for the most promising studies -- and ignore research that is unlikely to yield benefits. Full Article
nes New study examines which galaxies are best for intelligent life By www.eurekalert.org Published On :: Fri, 01 May 2020 00:00:00 EDT (University of Arkansas) Giant elliptical galaxies are not as likely as disk-shaped galaxies, such as our own Milky Way, to be cradles of technological civilizations, according to a recent paper by a University of Arkansas astrophysicist. Full Article
nes The story of three African slaves during Spanish colonialism, as told by their bones By www.eurekalert.org Published On :: Thu, 30 Apr 2020 00:00:00 EDT (Cell Press) In a study appearing April 30 in the journal Current Biology, scientists tell the story of three 16th century African slaves identified from a mass burial site in Mexico City. Using a combination of genetic, osteological, and isotope analyses, the scientists determined from where in Africa they were likely captured, the physical hardships they experienced as slaves, and what novel pathogens they may have carried with them across the Atlantic. Full Article
nes New freeze-resistant trichinella species discovered in wolverines By www.eurekalert.org Published On :: Wed, 06 May 2020 00:00:00 EDT (US Department of Agriculture - Agricultural Research Service) A new freeze-resistant Trichinella species has been discovered in wolverines by Agricultural Research Service scientists and their colleagues. Trichinella are parasites that cause the disease trichinosis (formally referred to as trichinellosis), which people can get by eating raw or undercooked meat from infected animals. Full Article
nes University of Tennessee extension forester named 2020 Forester of the Year By www.eurekalert.org Published On :: Thu, 07 May 2020 00:00:00 EDT (University of Tennessee Institute of Agriculture) David Mercker, an Extension forestry specialist with the University of Tennessee Department of Forestry, Wildlife and Fisheries, has been named 2020 Extension Forester of the Year by the Forest Landowners Association (FLA). FLA is a national organization that promotes and protects the interests of private forest landowners and bestows this award annually as determined by its board of directors. Full Article
nes Algae in the oceans often steal genes from bacteria By www.eurekalert.org Published On :: Wed, 29 Apr 2020 00:00:00 EDT (Rutgers University) Algae in the oceans often steal genes from bacteria to gain beneficial attributes, such as the ability to tolerate stressful environments or break down carbohydrates for food, according to a Rutgers co-authored study. Full Article
nes Study: Climate change has been influencing where tropical cyclones rage By www.eurekalert.org Published On :: Mon, 04 May 2020 00:00:00 EDT (NOAA Headquarters) While the global average number of tropical cyclones each year has not budged from 86 over the last four decades, climate change has been influencing the locations of where these deadly storms occur, according to new NOAA-led research published in Proceedings of the National Academy of Science. Full Article
nes Frontier Airlines becomes first U.S. airline to announce passenger temperature checks By news.yahoo.com Published On :: Thu, 07 May 2020 18:36:43 -0400 The budget carrier will begin conducting temperature checks via touchless thermometers on June 1. Passengers have to start wearing masks Friday. Full Article
nes Benefits of higher doses of certain medicines fail to justify costs and risks, study shows By www.eurekalert.org Published On :: Tue, 05 May 2020 00:00:00 EDT (Oregon State University) Clinical trial data behind drug dose recommendations for elevated cholesterol and chronic obstructive pulmonary disease illustrate how larger doses may not be worth the extra costs for many types of patients. Full Article
nes Police stop fewer black drivers at night when a 'veil of darkness' obscures their race By www.eurekalert.org Published On :: Wed, 06 May 2020 00:00:00 EDT (Stanford School of Engineering) After analyzing 95 million traffic stop records, filed by officers with 21 state patrol agencies and 35 municipal police forces from 2011 to 2018, a Stanford-led research team concluded that 'police stops and search decisions suffer from persistent racial bias.' Full Article
nes Blood Glucose Awareness Training: What Is It, Where Is It, and Where Is It Going? By spectrum.diabetesjournals.org Published On :: 2006-01-01 Daniel J. CoxJan 1, 2006; 19:43-49Feature Articles Full Article
nes Group Education in Diabetes: Effectiveness and Implementation By spectrum.diabetesjournals.org Published On :: 2003-04-01 Carolé R. MensingApr 1, 2003; 16:Articles Full Article
nes Kaay Jones: The Jamaican who joins region in singing ‘We Got This’ By jamaica-star.com Published On :: Wed, 06 May 2020 05:01:07 -0500 Up-and-coming recording artiste Kaay Jones says she did not know she was becoming part of a transformational music project that would connect her to a wide cross section of talent in the Caribbean. Jones carries Jamaica's flag in a unified... Full Article
nes Bars may have to remove stools and tables - Holness hints at measures that could accompany reopening of pubs By jamaica-star.com Published On :: Thu, 07 May 2020 05:01:26 -0500 It is possible that the next time you walk into a bar you may find that there is only standing room, and you are among a handful of persons allowed inside. Prime Minister Andrew Holness said that in addition to having a specific gathering rule,... Full Article
nes Small business owner looks for silver lining By jamaica-star.com Published On :: Fri, 08 May 2020 05:01:52 -0500 Deborah Fearon is a bar owner who also has a small chicken business. She depends on both for a living. Before the COVID-19 outbreak she was doing well, and had plans of completing her house this year. However, she has been hit hard by the economic... Full Article
nes Fitness freak promotes sperm smoothie By jamaica-star.com Published On :: Fri, 08 May 2020 05:01:30 -0500 Eyes popped and mouths dropped wide open this week when it was reported in this newspaper that a British woman is using sperm smoothies to build her immune system. Tracy Kiss, 32, said she takes the sperm straight from the source - her boyfriend... Full Article
nes Quick Earthquake Messages M6.7 [7.0S, 130.0E] in Tanimbar Islands Region, Indonesia (21:54 HKT 06/05/2020) By openstreetmap.org Published On :: Wed, 06 May 2020 22:01:16 +0800 Earthquake: 2020-05-06 21:54HKT M6.7 [7.0S, 130.0E] in Tanimbar Islands Region, Indonesia http://openstreetmap.org/?mlat=-7&mlon=130. Full Article
nes Columbia-Harlem Small Business Development Center Is a Lifeline for Business Owners By www8.gsb.columbia.edu Published On :: Tue, 28 Apr 2020 00:00:00 -0400 The SBDC offers resources and guidance to Harlem’s small businesses amidst the COVID-19 crisis. Full Article
nes Virtual Wellness Offerings Are Pivotal in the Age of Remote Work By www8.gsb.columbia.edu Published On :: Wed, 06 May 2020 00:00:00 -0400 Liz Wilkes ’13, CEO of Exubrancy, knows mental and physical well-being is more important now than ever before. Full Article
nes Recommitting to International Criminal Justice and Human Rights in Indonesia By feedproxy.google.com Published On :: Fri, 06 Apr 2018 15:19:11 +0000 6 April 2018 Agantaranansa Juanda Academy Associate, International Law Programme LinkedIn Jason Naselli Senior Digital Editor LinkedIn Agantaranansa Juanda speaks to Jason Naselli about the promises the government has made and the steps that still need to be taken for the country to deliver justice for past violations of human rights. 2018-04-06-Jokowi.jpg Indonesian PM Joko Widodo. Photo: Getty Images. Does the Indonesian government adequately protect human rights?It does and it does not; it really depends on the context. Indonesia looks good among its neighbours in Southeast Asia in terms of protection of civil and political rights, and to some extent economic, social and cultural rights, although room for improvements exists.But one of the promises of the current president, Joko Widodo, during his 2014 campaign was about international criminal justice, which involves rights for many victims of past cases of human rights abuses in Indonesia. In that sense, it does not protect these rights, including the rights to justice, truth, reparations or guarantees of non-recurrence.For example, in the case of the conflict over independence for East Timor in 1999, there were many gross violations of human rights. However, there has never been any sort of effective judicial process to address gross violations of human rights, and crimes against humanity in particular.In 1965–66, during the government’s violent anti-communist operations, 500,000 people or more were killed. Indonesia’s National Commission on Human Rights was tasked with conducting an investigation into this period within its limited mandate, but it led to nothing; there have never been any prosecutions relating to these crimes.The election promise of the current president was to deal with a number of these past human rights cases, and this promise has not been met at all. His opponent in 2014, Prabowo Subianto, was a former military general involved in alleged past human rights abuses, so it was politically expedient to make such a promise. But it has not been pursued in office.In 2000, Indonesia established its own Human Rights Court. What is your assessment of its record?Some human rights activists suggested that the establishment of the Human Rights Court took place under international pressure following the independence of East Timor. To avoid international scrutiny, for example the creation of an ad hoc international tribunal, the government established this court.Based on the report of the International Commission of Inquiry on East Timor in 2000, it was indeed recommended that an international human rights tribunal be set up. Indonesian government rejected the proposal with strong assurances that it would provide justice for atrocities committed by its nationals. So it is fair for some to see the establishment of Indonesia’s Human Rights Court as a political move by the government at that time, in order to avoid scrutiny by the international community.When it comes to performance, the Human Rights Court actually investigated and prosecuted cases relating to atrocities in East Timor. There were around 100 suspects identified, and 18 were put on trial. Out of these 18, only one trial, of Eurico Guterres, ended in a conviction for crimes against humanity. However, the Indonesian Supreme Court cleared Guterres of all charges in 2008. So the Human Rights Court did take steps, but the net result amounted to essentially nothing. Impunity remains.So it has not lived up to its mandate, but there is another factor, which is that the founding law of the Human Rights Court does not accommodate international standards of criminal justice. It only covers two of the four categories of crime as outlined in the Rome Statute – crimes against humanity and genocide. It also does not provide adequate protection for victims and witnesses. So there are issues not only with the performance of the Human Rights Court but also with the legislation establishing it.Why hasn’t Indonesia become a party to the Rome Statute to join the ICC?The main opposition came from the military, because they were afraid of being targeted by the ICC. There was also a lot of discussion about Indonesia’s ‘sovereign right to prosecute’.But what those opposing failed to understand is that the ICC is bound by temporal and territorial boundaries, meaning that it will not intervene if the state in question is able and willing to prosecute. So I think accession to the Rome Statute has not taken place because of this misunderstanding.I think another factor since this was initially raised is there is a focus on other issues. Indonesia is an emerging country economically; there is a focus on building infrastructure. So many in government feel like they are done with the past. But for the millions of victims of past crimes and their families, the past is not done.So it’s very important at this point in the country’s history to revisit the commitment to international criminal justice to be able to contribute to sustainable peace and development.What steps could the Indonesian government take to improve how it handles these issues?The establishment of the Human Rights Court was an important starting point, but clearly there has to be significant reform, both in terms of the substantive law underpinning it and its procedures.Clearly the domestic laws need to be reformed, but also, an effort needs to be made to improve the courts capacity in terms of manpower and logistical support. This is why the government needs to restart the discussion about becoming a party to the Rome Statute. Through the outreach programme of the ICC, this would give the Human Rights Court the capacity, in terms of manpower and logistical support, to tackle past human rights violations in Indonesia, which the Human Rights Court is currently lacking.Only if these two steps are taken – reforming the domestic Human Rights Court and restarting discussion about becoming a party to the Rome Statute – will the Indonesian government be able to say it has made progress on international criminal justice.The Indonesian government is actually running for a seat on the UN Security Council for the period of 2019–20. So I think it is an urgent discussion that the Indonesian government needs to have before it makes another pledge to contribute to the maintenance of international peace and security. It is difficult to have sustainable peace without justice. Full Article
nes Responsible Business 2019 By feedproxy.google.com Published On :: Tue, 04 Sep 2018 08:40:01 +0000 Conference Priorities, practices and principles in a digital age 28 February 2019 - 9:30am to 5:00pm Chatham House, London Book now Book now Book now Overview Agenda Speakers Pricing and booking information Sponsors Media partners and supporting organizations Venue and accommodation Press registration Contact us Ever-increasing consumer, investor and employee awareness continues to drive the business case for responsible behaviour, and recent events have highlighted the growing need for corporate accountability and transparency from C-suite behaviour to global supply chain management. But what exactly are these expectations across different sectors, as the acceleration of the digital age continues to present new risks, opportunities and concerns? How can the right behaviours be encouraged? Furthermore, ongoing political transitions and regulatory stances over the last two years have shone a light on companies’ potential and realized impact on society. With trust in political institutions low, many are calling upon businesses not only to reflect their values but to actively bridge the governance gap on issues such as equality, sustainability and human rights, in their own business operations and beyond. But what role should business be adopting, and what are the consequences of this trend? What are the perceived trade-offs? The past year has seen examples of technology leaders being held to account for the mishandling of data, global corporations taking a proactive stance on contentious political issues and executive behaviour directly impacting share price. It is critical that policy-makers and business leaders re-evaluate their priorities, practices and principles as technology and politics continue to reshape the landscape. The third annual Chatham House Responsible Business conference will explore key questions, including:Who will lead the corporate responsibility agenda? What is driving responsible behaviour? To what extent has there been a policy retreat in this space? What has been the response to this, and what does it mean for different roles and responsibilities? What are the new priorities for responsible business in a digital age? How have recent events demonstrated a shift in expectations? How can policy-makers and companies foster the integration of human rights across global supply chains, international trade and regional business operations?What is the role of corporate governance and leadership in setting standards and promoting responsible business? Is this a new era of corporate activism? The Chatham House RuleTo enable as open a debate as possible, this conference will be held under the Chatham House Rule.Twitter@CH_Events#CHBusiness Thursday 28 February0920Welcome and chair's opening remarksDr Robin Niblett, Director, Chatham HouseKeynote addressSimon Thompson, Chairman, Rio TintoQuestions and discussionSession One | Leaders and Drivers1000-1115This opening session will examine the status of corporate leadership in responsible business, evolving policy environments and stakeholder expectations, and how they continue to shape roles and responsibilities. How are expectations for responsible business evolving? Where has this been most apparent in the past 18 months, and what is driving these shifts? Do policy and regulation continue to be effective at encouraging responsible business behaviour? Where is regulation most effective in this space? Given current political sentiments and levels of trust, what role should business play in creating a sustainable economy and a more equal society? What are the implications of this? What can business leaders learn from existing examples of corporate activism? Does a trade-off exist between responsible practices and economic competitiveness, or do commercial drivers incentivize better behaviours? How does this differ across different markets and regions?ChairTamzin Booth, European Business Editor, The EconomistSpeakersHelena Morrissey, Head of Personal Investing, Legal & General Investment Management, and Founder of the 30% ClubIoannis Ioannou, Associate Professor of Strategy and Entrepreneurship, London Business SchoolPhil Bloomer, Executive Director, Business & Human Rights Resource CentreSue Garrard, EVP Sustainable Business and Communications, Unilever (2014-18)Questions and discussion1115-1145 RefreshmentsSession Two | Practices and Transparency1145-1300This session will address regulatory frameworks and economic incentives governing responsible business conduct, as well as human rights and business operations across global supply chains. How prominent are business and human rights issues on national policy agendas? To what extent has this influenced business behaviours across different sectors and regions? What progress has been made with regards to the UN Guiding Principles for Business and Human Rights? What has most effectively driven their integration? To what extent can public opinion and public awareness help narrow the governance gap? How can investors actively promote and enforce better governance practices? Does transparency necessarily lead to accountability, and in turn increase consumer and investor trust? What are the implications of this? How can due diligence and reporting be made more efficient to enhance accountability as well as transparency across supply chains and investments? Can digital solutions be employed to achieve social and environmental best practice?ChairBennett Freeman, Deputy Assistant Secretary for Democracy, Human Rights and Labor, US Department of State (1999–2001)SpeakersGillian Caldwell, CEO, Global WitnessMadelaine Tuininga, Head of Unit, DG Trade, European CommissionSharan Burrow, General Secretary, International Trade Union Confederation Guus Houttuin, Trade Adviser, European External Action Service, and Chair, the OECD Multi-stakeholder Steering Group Questions and discussion1300-1400 LunchSession Three | Responsibility in the Digital Age1400-1515This session will examine the risks and opportunities presented by digitization and other technological developments for responsible business practices. What have events over the past year indicated regarding stakeholder concerns accompanying specific technologies and business practices? How have different sectors and companies responded? What are the responsible business issues that accompany the transition to a digital-first society? What can be learned from the challenges of regulating tech titans?How can businesses ensure data privacy and help customers with digital access to maintain trust and maximize benefits from digital transformation? To what extent is the proliferation of information through technology already enhancing corporate accountability and transparency? What are the risks here? ChairJohn Thornhill, Innovation Editor, Financial TimesSpeakersNuala O’Connor, President and CEO of the Center for Democracy and TechnologySimon McDougall, Executive Director, Technology Policy and Innovation, Information Commissioner’s OfficeRebecca MacKinnon, Director, Ranking Digital Rights, New AmericaSarah Drinkwater, Director, Tech and Society Solutions Lab, Omidyar NetworkQuestions and discussion1515-1545 Afternoon refreshmentsSession Four | Governance1545-1700This closing session will explore the role of corporate governance in setting standards and leading responsible business practices, including diversity and inclusion as well as C-suite accountability and transparency. How are businesses responding to expectations of good corporate governance and leadership in the digital age? Are businesses equipped to maintain high standards of accountability and transparency in the era of open data and social media?Do business leaders have a responsibility to embody as well as promote high standards of responsible business and ethical leadership? What lessons can be learnt from corporate governance failings? What role should business leaders play in the broader political environment? Is corporate activism part of responsible governance, and what are the risks?What are the best strategies to empower diversity and foster inclusion in a rapidly changing global economy? Should diversity and inclusion begin in the boardroom?ChairAris Vrettos, Director of Open Programmes and International Markets, Cambridge Institute for Sustainability LeadershipSpeakersCatherine Howarth, CEO, ShareAction Jane Ellis, Director, GoodCorporationMo Ibrahim, Founder, Mo Ibrahim Foundation Alison Cottrell, CEO, Banking Standards BoardQuestions and discussion1700 Close of conference and drinks reception © The Royal Institute of International Affairs 2019 Keynote Speaker Simon Thompson Chairman, Rio Tinto Speakers Phil Bloomer Executive Director, Business & Human Rights Resource Centre Tamzin Booth Business Editor, The Economist Sharan Burrow General Secretary, International Trade Union Confederation Gillian Caldwell CEO, Global Witness Alison Cottrell CEO, Banking Standards Board Sarah Drinkwater Director, Tech and Society Solutions Lab, Omidyar Network Jane Ellis Director, GoodCorporation Bennett Freeman Deputy Assistant Secretary for Democracy, Human Rights and Labor, United States (1999-2001) Sue Garrard EVP Sustainable Business and Communications, Unilever (2014-18) Guus Houttuin Trade Adviser, European External Action Service, and Chair, the OECD Multi-stakeholder Steering Group Catherine Howarth CEO, ShareAction Mo Ibrahim Founder, Mo Ibrahim Foundation Ioannis Ioannou Associate Professor of Strategy and Entrepreneurship, London Business School Rebecca MacKinnon Director, Ranking Digital Rights, New America Simon McDougall Executive Director, Technology Policy and Innovation, Information Commissioner's Office Dame Helena Morrissey Head of Personal Investing, Legal & General Investment Management; Founder, 30% Club Dr Robin Niblett CMG Director, Chatham House Nuala O'Connor President and CEO, Center for Democracy & Technology John Thornhill Innovation Editor, Financial Times Madelaine Tuininga Head of Unit, DG Trade, European Commission Aris Vrettos Director of Open Programmes and International Markets, Cambridge Institute for Sustainability Leadership Ways to book:Online: Click here to complete the online registration formPhone: Call Boudicca Georgii Hellberg on +44 (0) 20 7314 2785Email/Post: Download a PDF registration form, complete and return to Boudicca Georgii Hellberg via email or post: Chatham House, 10 St. James Square, London, SW1Y 4LECheck if your organization is a member of Chatham House here. RATE (+VAT):Partners and major corporate members All organizations£595Standard corporate members Commercial organizations£1,180Government departments/agencies/intergovernmental organizations£700NGOs/academic institutions/associations (including not for profits and registered charities)£460Non-members Commercial organizations£1,295Government departments/agencies/intergovernmental organizations£750NGOs/academic insitutions/associations (including not for profits and registered charities)£510 Your delegate pass includes:DocumentationLunch and refreshmentsTravel and accommodation are not included. If you are interested in becoming a sponsor for this event, please contact Olivia Lewis on +44 (0)20 7957 5732 If you are interested in partnering with Chatham House on this event, please contact Ayesha Arif on +44 (0)20 7957 5753 Chatham House10 St James's SquareLondonSW1Y 4LEUKconferences@chathamhouse.orgTelephone: +44 (0)20 7957 5643Fax: +44 (0)20 7957 5710If you wish to book the venue for your own event please phone +44 (0)20 7314 2764DirectionsThe nearest tube station is Piccadilly Circus which is on the Piccadilly and the Bakerloo Underground lines. From Piccadilly follow Regent Street southwards towards Pall Mall and take the first road on the right called Jermyn Street. Duke of York Street is the second road on the left and leads to St James's Square. Chatham House is immediately on your right.MapAccommodationAlthough we cannot book accommodation for delegates, we have arranged a reduced rate at some nearby hotels, where you can book your own accommodation. Please inform the hotel that you will be attending a conference at Chatham House (The Royal Institute of International Affairs) to qualify for the Institute's reduced rate.Please note all rates are subject to availability.Flemings Mayfair13 Half Moon StreetMayfairLondon - W1J 7BHTel: + 44 (0)20 7499 2964Fax: + 44 (0)20 7499 1817reservations@flemings.co.ukClassic Double without breakfast: £195 +VATThe Cavendish London81 Jermyn StreetLondon - SW1U 6JFTel: + 44 (0)20 7930 2111Fax: + 44 (0)20 7839 2125enquiry.cavendish@the-ascott.com Classic Room without breakfast: £195 +VATBook The Cavendish onlineThe Stafford London St James's PlaceLondon - SW1A 1NJTel: 020 7493 0111Fax: 020 7493 7121reservations@thestaffordlondon.comClassic Queen without breakfast: £247 +VATQuote Chatham House This conference will be held under the Chatham House Rule. Information for journalists.Press can request a press pass. For enquiries relating to the conference agenda or sponsorship please call Olivia Lewis on +44 (0) 20 7957 5732For registration enquiries please call Boudicca Georgii Hellberg on +44 (0) 20 7314 2785For general enquiries please email conferences@chathamhouse.org Department/project International Law Programme Full Article
nes Exploring Public International Law and the Rights of Individuals with Chinese Scholars - Part One By feedproxy.google.com Published On :: Mon, 29 Oct 2018 16:37:47 +0000 17 April 2014 As part of a roundtable series, Chatham House and China University of Political Science and Law (CUPL) jointly organized this four-day meeting at Chatham House for international lawyers to discuss a wide range of issues related to public international law and the rights of individuals. Download PDF Sonya Sceats Associate Fellow, International Law Programme @SonyaSceats 20140624ChinaHumanRights.jpg The Representative of China at the 19th Session of the Human Rights Council, Palais des Nations, Geneva. 27 February 2012. Photo: UN Photo Geneva/Violaine Martin. The specific objectives were to:create a platform for Chinese international law academics working on international human rights law issues to present their thinking and exchange ideas with counterparts from outside China;build stronger understanding within the wider international law community of intellectual debates taking place in China about the international human rights system and China's role within it;support networking between Chinese and non-Chinese academics working on international human rights and related areas of international law.The roundtable forms part of a wider Chatham House project exploring China's impact on the international human rights system and was inspired by early discussions with a burgeoning community of Chinese academics thinking, writing (mainly in Chinese) and teaching about international human rights law.For China University of Political Science and Law, one of the largest and most prestigious law schools in China and perhaps the only university in the world with an entire faculty of international law, the initiative is part of a drive to forge partnerships beyond China in the international law field.The roundtable had a total of 22 participants, 10 Chinese (from universities and other academic institutions in Beijing and Shanghai) and 12 non-Chinese (from Australia, Germany, the Netherlands, Switzerland, the United Kingdom and the United States).All discussions were held in English under the Chatham House Rule. Department/project International Law Programme, China and the Future of the International Legal Order Full Article
nes Exploring Public International Law and the Rights of Individuals with Chinese Scholars - Part Two By feedproxy.google.com Published On :: Tue, 30 Oct 2018 08:46:37 +0000 15 November 2014 As part of a roundtable series, Chatham House and China University of Political Science and Law (CUPL) held a two-day roundtable meeting in Beijing on public international law and the rights of individuals. Download PDF Sonya Sceats Associate Fellow, International Law Programme @SonyaSceats 20140624ChinaHumanRights.jpg The Representative of China at the 19th Session of the Human Rights Council, Palais des Nations, Geneva. 27 February 2012. Photo: UN Photo Geneva/Violaine Martin. The specific objectives were to:create a platform for Chinese international law academics working on international human rights law issues to present their thinking and exchange ideas with counterparts from outside China;build stronger understanding within the wider international law community of intellectual debates taking place in China about the international human rights system and China's role within it;support networking between Chinese and non-Chinese academics working on international human rights and related areas of international law.The roundtable forms part of a wider Chatham House project exploring China's impact on the international human rights system and was inspired by early discussions with a burgeoning community of Chinese academics thinking, writing (mainly in Chinese) and teaching about international human rights law.For CUPL, one of the largest and most prestigious law schools in China and perhaps the only university in the world with an entire faculty of international law, the initiative is part of a drive to forge partnerships beyond China in the international law field.The meeting in Beijing was hosted by CUPL and involved 20 participants, 10 Chinese (from universities and other academic institutions in Beijing) and 10 non-Chinese (from Australia, the Netherlands, South Africa, Switzerland, the United Kingdom and the United States).To ensure continuity while also expanding the experts network being built, the second meeting included a mix of participants from the first meeting and some new participants.All discussions were held in English under the Chatham House Rule. Department/project International Law Programme, China and the Future of the International Legal Order Full Article
nes Exploring Public International Law and the Rights of Individuals with Chinese Scholars - Part Three By feedproxy.google.com Published On :: Tue, 30 Oct 2018 08:55:48 +0000 6 March 2016 As part of a roundtable series, Chatham House, China University of Political Science and Law (CUPL) and the Graduate Institute Geneva held a two-day roundtable meeting in Geneva on public international law and the rights of individuals. Download PDF Sonya Sceats Associate Fellow, International Law Programme @SonyaSceats 20140624ChinaHumanRights.jpg The Representative of China at the 19th Session of the Human Rights Council, Palais des Nations, Geneva. 27 February 2012. Photo: UN Photo Geneva/Violaine Martin. The specific objectives were to:create a platform for Chinese international law academics working on international human rights law issues to present their thinking and exchange ideas with counterparts from outside China;build stronger understanding within the wider international law community of intellectual debates taking place in China about the international human rights system and China's role within it;support networking between Chinese and non-Chinese academics working on international human rights and related areas of international law.The roundtable forms part of a wider Chatham House project exploring China's impact on the international human rights system and was inspired by early discussions with a burgeoning community of Chinese academics thinking, writing (mainly in Chinese) and teaching about international human rights law.For CUPL, one of the largest and most prestigious law schools in China and perhaps the only university in the world with an entire faculty of international law, the initiative is part of a drive to forge partnerships beyond China in the international law field.The meeting in Geneva was co-hosted by the Graduate Institute Geneva and involved 19 participants, 9 Chinese (from six research institutions in Beijing and Shanghai) and 11 non-Chinese (from eight research institutions in Australia, Germany, the Netherlands, Switzerland, the United Kingdom and the United States).To ensure continuity while also expanding the expert network being built, the third meeting included a mix of participants from the first two meetings and some new participantsAll discussions were held in English under the Chatham House Rule. Department/project International Law Programme, China and the Future of the International Legal Order Full Article
nes Exploring Public International Law Issues with Chinese Scholars – Part Four By feedproxy.google.com Published On :: Tue, 30 Oct 2018 09:01:59 +0000 3 June 2018 As part of a roundtable series, Chatham House and the China University of Political Science and Law (CUPL) held a two-day roundtable in Beijing on emerging issues of public international law. Download PDF Harriet Moynihan Senior Research Fellow, International Law Programme @HarrietMoyniha9 20140624ChinaHumanRights.jpg The Representative of China at the 19th Session of the Human Rights Council, Palais des Nations, Geneva. 27 February 2012. Photo: UN Photo Geneva/Violaine Martin. The specific objectives were to:create a platform for Chinese international law academics working on international human rights law issues to present their thinking and exchange ideas with counterparts from outside China;build stronger understanding within the wider international law community of intellectual debates taking place in China about the international human rights system and China's role within it;support networking between Chinese and non-Chinese academics working on international human rights and related areas of international law.The roundtable forms part of a wider Chatham House project exploring China's impact on the international human rights system and was inspired by early discussions with a burgeoning community of Chinese academics thinking, writing (mainly in Chinese) and teaching about international human rights law.For CUPL, one of the largest and most prestigious law schools in China and perhaps the only university in the world with an entire faculty of international law, the initiative is part of a drive to forge partnerships beyond China in the international law field.The meeting was co-hosted with CUPL and involved 28 participants, consisting of 19 Chinese participants (from six leading research institutions in Beijing and Shanghai) and nine nonChinese participants (from eight leading research institutions in Australia, the Netherlands, the UK, Switzerland, Canada and Singapore).To ensure continuity while also expanding the expert network being built, the fifth meeting included a mix of participants from the previous meetings and some new participants.All discussions were held in English under the Chatham House Rule. Department/project International Law Programme, China and the Future of the International Legal Order Full Article
nes Kate Jones By feedproxy.google.com Published On :: Mon, 24 Feb 2020 12:00:38 +0000 Associate Fellow, International Law Programme Biography Kate focuses on cyber and human rights law issues, and is author of Chatham House’s research paper on Online Disinformation and Political Discourse: Applying a Human Rights Framework.Kate is based at the University of Oxford, where she is a member of the Law Faculty and directs the Diplomatic Studies Programme, a set of postgraduate courses for diplomats. She gained much of her experience in human rights law and public international law as a lawyer at the UK Foreign and Commonwealth Office, both in London and overseas as Legal Adviser at the UK Mission to the United Nations in Geneva and then Deputy Permanent Representative at the UK Delegation to the Council of Europe in Strasbourg. She took her undergraduate and postgraduate degrees in law at the University of Oxford, and qualified as a solicitor at Norton Rose. Areas of expertise Cyber and human rights law (disinformation, elections, social media platforms, etc)Human rights lawPublic international lawDiplomatic skills and training Past experience 2015 - presentDirector, Diplomatic Studies Programme; Member of University Law Faculty; Fellow of Kellogg College, University of Oxford2014-15Research and Outreach Specialist, UK Foreign and Commonwealth Office2011-14Deputy Permanent Representative, UK Delegation to Council of Europe2008-11Legal Adviser, UK Mission to the United Nations2002-07Assistant Legal Adviser, UK Foreign and Commonwealth Office1997-2001Trainee, then Assistant Solicitor, Norton Rose1999Judicial Assistant, Court of Appeal (secondment) Email @katejones77 LinkedIn Full Article
nes Deletion of fatty acid transport protein 2 (FATP2) in the mouse liver changes the metabolic landscape by increasing the expression of PPAR{alpha}-regulated genes [Lipids] By feedproxy.google.com Published On :: 2020-04-24T06:08:45-07:00 Fatty acid transport protein 2 (FATP2) is highly expressed in the liver, small intestine, and kidney, where it functions in both the transport of exogenous long-chain fatty acids and the activation of very-long-chain fatty acids. Here, using a murine model, we investigated the phenotypic impacts of deleting FATP2, followed by a transcriptomic analysis using unbiased RNA-Seq to identify concomitant changes in the liver transcriptome. WT and FATP2-null (Fatp2−/−) mice (5 weeks) were maintained on a standard chow diet for 6 weeks. The Fatp2−/− mice had reduced weight gain, lowered serum triglyceride, and increased serum cholesterol levels and attenuated dietary fatty acid absorption. Transcriptomic analysis of the liver revealed 258 differentially expressed genes in male Fatp2−/− mice and a total of 91 in female Fatp2−/− mice. These genes mapped to the following gene ontology categories: fatty acid degradation, peroxisome biogenesis, fatty acid synthesis, and retinol and arachidonic acid metabolism. Targeted RT-quantitative PCR verified the altered expression of selected genes. Of note, most of the genes with increased expression were known to be regulated by peroxisome proliferator–activated receptor α (PPARα), suggesting that FATP2 activity is linked to a PPARα-specific proximal ligand. Targeted metabolomic experiments in the Fatp2−/− liver revealed increases of total C16:0, C16:1, and C18:1 fatty acids; increases in lipoxin A4 and prostaglandin J2; and a decrease in 20-hydroxyeicosatetraenoic acid. We conclude that the expression of FATP2 in the liver broadly affects the metabolic landscape through PPARα, indicating that FATP2 provides an important role in liver lipid metabolism through its transport or activation activities. Full Article
nes The transcriptional regulator MEIS2 sets up the ground state for palatal osteogenesis in mice [Gene Regulation] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 Haploinsufficiency of Meis homeobox 2 (MEIS2), encoding a transcriptional regulator, is associated with human cleft palate, and Meis2 inactivation leads to abnormal palate development in mice, implicating MEIS2 functions in palate development. However, its functional mechanisms remain unknown. Here we observed widespread MEIS2 expression in the developing palate in mice. Wnt1Cre-mediated Meis2 inactivation in cranial neural crest cells led to a secondary palate cleft. Importantly, about half of the Wnt1Cre;Meis2f/f mice exhibited a submucous cleft, providing a model for studying palatal bone formation and patterning. Consistent with complete absence of palatal bones, the results from integrative analyses of MEIS2 by ChIP sequencing, RNA-Seq, and an assay for transposase-accessible chromatin sequencing identified key osteogenic genes regulated directly by MEIS2, indicating that it plays a fundamental role in palatal osteogenesis. De novo motif analysis uncovered that the MEIS2-bound regions are highly enriched in binding motifs for several key osteogenic transcription factors, particularly short stature homeobox 2 (SHOX2). Comparative ChIP sequencing analyses revealed genome-wide co-occupancy of MEIS2 and SHOX2 in addition to their colocalization in the developing palate and physical interaction, suggesting that SHOX2 and MEIS2 functionally interact. However, although SHOX2 was required for proper palatal bone formation and was a direct downstream target of MEIS2, Shox2 overexpression failed to rescue the palatal bone defects in a Meis2-mutant background. These results, together with the fact that Meis2 expression is associated with high osteogenic potential and required for chromatin accessibility of osteogenic genes, support a vital function of MEIS2 in setting up a ground state for palatal osteogenesis. Full Article
nes The testis-specific LINC component SUN3 is essential for sperm head shaping during mouse spermiogenesis [Cell Biology] By feedproxy.google.com Published On :: 2020-05-08T03:41:14-07:00 Sperm head shaping is a key event in spermiogenesis and is tightly controlled via the acrosome–manchette network. Linker of nucleoskeleton and cytoskeleton (LINC) complexes consist of Sad1 and UNC84 domain–containing (SUN) and Klarsicht/ANC-1/Syne-1 homology (KASH) domain proteins and form conserved nuclear envelope bridges implicated in transducing mechanical forces from the manchette to sculpt sperm nuclei into a hook-like shape. However, the role of LINC complexes in sperm head shaping is still poorly understood. Here we assessed the role of SUN3, a testis-specific LINC component harboring a conserved SUN domain, in spermiogenesis. We show that CRISPR/Cas9-generated Sun3 knockout male mice are infertile, displaying drastically reduced sperm counts and a globozoospermia-like phenotype, including a missing, mislocalized, or fragmented acrosome, as well as multiple defects in sperm flagella. Further examination revealed that the sperm head abnormalities are apparent at step 9 and that the sperm nuclei fail to elongate because of the absence of manchette microtubules and perinuclear rings. These observations indicate that Sun3 deletion likely impairs the ability of the LINC complex to transduce the cytoskeletal force to the nuclear envelope, required for sperm head elongation. We also found that SUN3 interacts with SUN4 in mouse testes and that the level of SUN4 proteins is drastically reduced in Sun3-null mice. Altogether, our results indicate that SUN3 is essential for sperm head shaping and male fertility, providing molecular clues regarding the underlying pathology of the globozoospermia-like phenotype. Full Article
nes A cross-linking mass spectrometry approach defines protein interactions in yeast mitochondria By feedproxy.google.com Published On :: 2020-04-24 Andreas LindenApr 24, 2020; 0:RA120.002028v1-mcp.RA120.002028Research Full Article
nes Mathematical light shines blindly on us By blogs.ams.org Published On :: Mon, 09 Dec 2019 18:57:58 +0000 By William Yslas Vélez Professor Emeritus University of Arizona “When I go to a Mexican restaurant I would gladly pay the musicians to stop playing.” John (not his real name) did not like the noise level. This statement came up … Continue reading → Full Article Changing Graduate Programs General Uncategorized
nes Strengthening Urban Preparedness and Resilience Against Biological Threats in Accra By feedproxy.google.com Published On :: Wed, 23 Jan 2019 17:40:01 +0000 Invitation Only Research Event 1 March 2019 - 10:30am to 2 March 2019 - 3:00pm Chatham House, London Capacity to contain and respond to biological threats varies considerably across the world. Yet such preparedness is vital for prevention, impact-reduction and resilience in the face of biological events, whether they be natural or deliberate outbreaks.Chatham House is conducting a series of meetings to strengthen urban preparedness for, and resilience against, biological threats in African countries. This meeting will examine the preparedness and prevention mechanisms in Accra, reviewing the comprehensiveness of city-level preparedness. This meeting will focus on the formation and implementation of city-level action plans in the context of preparedness for managing biological threats. It will also explore how local authorities are contributing to this effort with their knowledge and expertise.Attendance at this event is by invitation only. Department/project International Security Programme, Strengthening Urban Preparedness and Resilience against Biological Threats Nilza Amaral Project Manager, International Security Programme Email Full Article
nes The Future of EU–US Cooperation in Space Traffic Management and Space Situational Awareness By feedproxy.google.com Published On :: Mon, 19 Aug 2019 10:09:54 +0000 29 August 2019 As more space activities develop, there is an increasing requirement for comprehensive space situational awareness (SSA). This paper provides an overview of the current landscape in SSA and space traffic management as well as possible scenarios for EU–US cooperation in this area. Read online Download PDF Alexandra Stickings Research Fellow for Space Policy and Security, RUSI 2019-08-19-SpaceTrafficManagement.jpg Deployment of the NanoRacks-Remove Debris Satellite from the International Space Station. Photo: Getty Images. SummarySpace situational awareness (SSA) and space traffic management (STM) are essential for sustainable near-Earth orbit. International cooperation in SSA and STM is vital with the growing number of satellite operators and the increasingly complex space environment.The various definitions of SSA and STM are ambiguous. Understanding the activities that fall under each term can better assist in finding areas for cooperation and collaboration.SSA has historically been a military activity, leading to an incomplete public catalogue of its use and barriers to sharing information with other states and the commercial sector. The rise in private space actors has increased the number of commercial STM providers and, with plans in the US to move responsibility for STM to civilian control, there will likely be more opportunities for international collaboration, particularly through the EU Space Surveillance and Tracking (SST) programme.Individual EU member states possess developed STM capabilities, but overall these are still some way behind those of allies such as the US. Further investment in STM infrastructure and programmes is required for the EU and individual European states to be an essential partner to the US and add value to the global effort.There are worldwide challenges, both political and technical, to providing STM coverage, which may lead to a lack of collaboration and gaps in understanding of activities in orbit. Existing sensors have limitations in terms of the size of objects that can be detected and the precision with which their movements can be predicted. These capability gaps represent opportunities for the EU to contribute.The EU can build on its tradition of support for openness and civil society by creating a system that fosters an environment of cooperation and collaboration involving industry, commercial STM providers and the wider international community.Although collaboration in STM is vital, the EU should also aim to tackle issues within the wider definition of SSA including space weather, intelligence and the security of ground stations.The EU is well placed to become a global leader in SSA and STM. However, it needs to take into consideration the current political and technical landscape when making decisions regarding investment in capabilities and the pursuit of international partnerships. Department/project International Security Programme, Cyber and Space Full Article
nes Legal Provision for Crisis Preparedness: Foresight not Hindsight By feedproxy.google.com Published On :: Tue, 21 Apr 2020 17:03:31 +0000 21 April 2020 Dr Patricia Lewis Research Director, Conflict, Science & Transformation; Director, International Security Programme @PatriciaMary COVID-19 is proving to be a grave threat to humanity. But this is not a one-off, there will be future crises, and we can be better prepared to mitigate them. 2020-04-21-Nurse-COVID-Test Examining a patient while testing for COVID-19 at the Velocity Urgent Care in Woodbridge, Virginia. Photo by Chip Somodevilla/Getty Images. A controversial debate during COVID-19 is the state of readiness within governments and health systems for a pandemic, with lines of the debate drawn on the issues of testing provision, personal protective equipment (PPE), and the speed of decision-making.President Macron in a speech to the nation admitted French medical workers did not have enough PPE and that mistakes had been made: ‘Were we prepared for this crisis? We have to say that no, we weren’t, but we have to admit our errors … and we will learn from this’.In reality few governments were fully prepared. In years to come, all will ask: ‘how could we have been better prepared, what did we do wrong, and what can we learn?’. But after every crisis, governments ask these same questions.Most countries have put in place national risk assessments and established processes and systems to monitor and stress-test crisis-preparedness. So why have some countries been seemingly better prepared?Comparing different approachesSome have had more time and been able to watch the spread of the disease and learn from those countries that had it first. Others have taken their own routes, and there will be much to learn from comparing these different approaches in the longer run.Governments in Asia have been strongly influenced by the experience of the SARS epidemic in 2002-3 and - South Korea in particular - the MERS-CoV outbreak in 2015 which was the largest outside the Middle East. Several carried out preparatory work in terms of risk assessment, preparedness measures and resilience planning for a wide range of threats.Case Study of Preparedness: South KoreaBy 2007, South Korea had established the Division of Public Health Crisis Response in Korea Centers for Disease Control and Prevention (KCDC) and, in 2016, the KCDC Center for Public Health Emergency Preparedness and Response had established a round-the-clock Emergency Operations Center with rapid response teams.KCDC is responsible for the distribution of antiviral stockpiles to 16 cities and provinces that are required by law to hold and manage antiviral stockpiles.And, at the international level, there are frameworks for preparedness for pandemics. The International Health Regulations (IHR) - adopted at the 2005 World Health Assembly and binding on member states - require countries to report certain disease outbreaks and public health events to the World Health Organization (WHO) and ‘prevent, protect against, control and provide a public health response to the international spread of disease in ways that are commensurate with and restricted to public health risks, and which avoid unnecessary interference with international traffic and trade’.Under IHR, governments committed to a programme of building core capacities including coordination, surveillance, response and preparedness. The UN Sendai Framework for Disaster Risk highlights disaster preparedness for effective response as one of its main purposes and has already incorporated these measures into the Sustainable Development Goals (SDGs) and other Agenda 2030 initiatives. UN Secretary-General António Guterres has said COVID-19 ‘poses a significant threat to the maintenance of international peace and security’ and that ‘a signal of unity and resolve from the Council would count for a lot at this anxious time’.Case Study of Preparedness: United StatesThe National Institutes of Health (NIH) and the Center for Disease Control (CDC) established PERRC – the Preparedness for Emergency Response Research Centers - as a requirement of the 2006 Pandemic and All-Hazards Preparedness Act, which required research to ‘improve federal, state, local, and tribal public health preparedness and response systems’.The 2006 Act has since been supplanted by the 2019 Pandemic and All-Hazards Preparedness and Advancing Innovation Act. This created the post of Assistant Secretary for Preparedness and Response (ASPR) in the Department for Health and Human Services (HHS) and authorised the development and acquisitions of medical countermeasures and a quadrennial National Health Security Strategy.The 2019 Act also set in place a number of measures including the requirement for the US government to re-evaluate several important metrics of the Public Health Emergency Preparedness cooperative agreement and the Hospital Preparedness Program, and a requirement for a report on the states of preparedness and response in US healthcare facilities.This pandemic looks set to continue to be a grave threat to humanity. But there will also be future pandemics – whether another type of coronavirus or a new influenza virus – and our species will be threatened again, we just don’t know when.Other disasters too will befall us – we already see the impacts of climate change arriving on our doorsteps characterised by increased numbers and intensity of floods, hurricanes, fires, crop failure and other manifestations of a warming, increasingly turbulent atmosphere and we will continue to suffer major volcanic eruptions, earthquakes and tsunamis. All high impact, unknown probability events.Preparedness for an unknown future is expensive and requires a great deal of effort for events that may not happen within the preparers’ lifetimes. It is hard to imagine now, but people will forget this crisis, and revert to their imagined projections of the future where crises don’t occur, and progress follows progress. But history shows us otherwise.Preparations for future crises always fall prey to financial cuts and austerity measures in lean times unless there is a mechanism to prevent that. Cost-benefit analyses will understandably tend to prioritise the urgent over the long-term. So governments should put in place legislation – or strengthen existing legislation – now to ensure their countries are as prepared as possible for whatever crisis is coming.Such a legal requirement would require governments to report back to parliament every year on the state of their national preparations detailing such measures as:The exact levels of stocks of essential materials (including medical equipment)The ability of hospitals to cope with large influx of patientsHow many drills, exercises and simulations had been organised – and their findingsWhat was being done to implement lessons learned & improve preparednessIn addition, further actions should be taken:Parliamentary committees such as the UK Joint Committee on the National Security Strategy should scrutinise the government’s readiness for the potential threats outlined in the National Risk register for Civil Emergencies in-depth on an annual basis.Parliamentarians, including ministers, with responsibility for national security and resilience should participate in drills, table-top exercises and simulations to see for themselves the problems inherent with dealing with crises.All governments should have a minister (or equivalent) with the sole responsibility for national crisis preparedness and resilience. The Minister would be empowered to liaise internationally and coordinate local responses such as local resilience groups.There should be ring-fenced budget lines in annual budgets specifically for preparedness and resilience measures, annually reported on and assessed by parliaments as part of the due diligence process.And at the international level:The UN Security Council should establish a Crisis Preparedness Committee to bolster the ability of United Nations Member States to respond to international crisis such as pandemics, within their borders and across regions. The Committee would function in a similar fashion as the Counter Terrorism Committee that was established following the 9/11 terrorist attacks in the United States.States should present reports on their level of preparedness to the UN Security Council. The Crisis Preparedness Committee could establish a group of experts who would conduct expert assessments of each member state’s risks and preparedness and facilitate technical assistance as required.Regional bodies such as the OSCE, ASEAN and ARF, the AU, the OAS, the PIF etc could also request national reports on crisis preparedness for discussion and cooperation at the regional level.COVID-19 has been referred to as the 9/11 of crisis preparedness and response. Just as that shocking terrorist attack shifted the world and created a series of measures to address terrorism, we now recognise our security frameworks need far more emphasis on being prepared and being resilient. Whatever has been done in the past, it is clear that was nowhere near enough and that has to change.Case Study of Preparedness: The UKThe National Risk Register was first published in 2008 as part of the undertakings laid out in the National Security Strategy (the UK also published the Biological Security Strategy in July 2018). Now entitled the National Risk Register for Civil Emergencies it has been updated regularly to analyse the risks of major emergencies that could affect the UK in the next five years and provide resilience advice and guidance.The latest edition - produced in 2017 when the UK had a Minister for Government Resilience and Efficiency - placed the risk of a pandemic influenza in the ‘highly likely and most severe’ category. It stood out from all the other identified risks, whereas an emerging disease (such as COVID-19) was identified as ‘highly likely but with moderate impact’.However, much preparatory work for an influenza pandemic is the same as for COVID-19, particularly in prepositioning large stocks of PPE, readiness within large hospitals, and the creation of new hospitals and facilities.One key issue is that the 2017 NHS Operating Framework for Managing the Response to Pandemic Influenza was dependent on pre-positioned ’just in case’ stockpiles of PPE. But as it became clear the PPE stocks were not adequate for the pandemic, it was reported that recommendations about the stockpile by NERVTAG (the New and Emerging Respiratory Virus Threats Advisory Group which advises the government on the threat posed by new and emerging respiratory viruses) had been subjected to an ‘economic assessment’ and decisions reversed on, for example, eye protection.The UK chief medical officer Dame Sally Davies, when speaking at the World Health Organization about Operation Cygnus – a 2016 three-day exercise on a flu pandemic in the UK – reportedly said the UK was not ready for a severe flu attack and ‘a lot of things need improving’.Aware of the significance of the situation, the UK Parliamentary Joint Committee on the National Security Strategy launched an inquiry in 2019 on ‘Biosecurity and human health: preparing for emerging infectious diseases and bioweapons’ which intended to coordinate a cross-government approach to biosecurity threats. But the inquiry had to postpone its oral hearings scheduled for late October 2019 and, because of the general election in December 2019, the committee was obliged to close the inquiry. Full Article
nes Lebanese Women and the Politics of Disruption By feedproxy.google.com Published On :: Thu, 30 Apr 2020 11:00:01 +0000 Research Event 6 May 2020 - 1:00pm to 2:00pm Event participants Carmen Geha, Assistant Professor of Public Administration, Leadership and Organisational Development, American University of BeirutModerator: Lina Khatib, Director, Middle East and North Africa Programme, Chatham House Lebanese women have been at the forefront of the protest movement that has shaken Lebanon since October 2019. The active participation by women and their visibility in Lebanon's protest movement has challenged the gender norms prevalent in Lebanese society and politics. However, the COVID-19 pandemic and the nationwide lockdown that ensued has disrupted women's ability to organize, and is threatening the fragile progress towards female inclusion in the political process. In a recent article, Carmen Geha discussed the politics of representation in the context of women's participation in public life in Lebanon and argued that the country's political system is maintained through tightly-knit informal power relations among sectarian politicians, making women's participation in politics virtually impossible. The article explained how the October 2019 revolution challenged that norm by creating inclusive spaces where women activists could confront politicians and thus, transform the way women participate in politics and public life. In this webinar, part of the Chatham House project on the future of the state in the Middle East and North Africa, the article's author will discuss how women's activism in Lebanon has been affected by the coronavirus-induced lockdown. The speaker will consider how, under current circumstances, women activists can speak up collectively and bring back a movement to contest gender norms in order to build an alternative political model that can better represent women's priorities. You can express your interest in attending by following this link. You will receive a Zoom confirmation email should your registration be successful. Alternatively, you can watch the event live on the MENA Programme Facebook page. Department/project Middle East and North Africa Programme, The Future of the State in the Middle East Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email Full Article
Reni Zhelyazkova Programme Coordinator, Middle East and North Africa Programme +44 (0)20 7314 3624 Email
nes COVID-19 Crisis – Business as Usual for Gaza? By feedproxy.google.com Published On :: Wed, 06 May 2020 14:48:14 +0000 6 May 2020 Mohammed Abdalfatah Asfari Foundation Academy Fellow @mhalabi258 LinkedIn The COVID-19 pandemic has brought unprecedented challenges, economic collapse and strict lockdowns in many parts of the world. For the people of Gaza, this reality is nothing new. 2020-05-06-covid-19-gaza.jpg Palestinians light fireworks above the rubble during the Muslim holy month of Ramadan amid concerns about the spread of the coronavirus disease (COVID-19), in Gaza City , 30 April 2020. Photo by Majdi Fathi/NurPhoto via Getty Images. In August 2012, when the UN released its report Gaza in 2020: A liveable place?, they could not have imagined what the world would look like in 2020: cities under lockdown, restrictions on movement, border closures, widespread unemployment, economic collapse, fear and anxiety and, above all, uncertainty about what the future holds.For Gaza’s population of 2 million people this reality is nothing new. The conditions that the rest of the world are currently experiencing as a result of the COVID-19 pandemic is similar to the tight blockade Gaza has been living under ever since Hamas took over in 2007. Israel has imposed severe restrictions on the movement of people and goods, youth unemployment has reached 60 per cent, and over 80 per cent of Gaza’s population are now dependent on international aid.The people of Gaza are having to face the COVID-19 crisis already at a disadvantage, with poor infrastructure, limited resources and a shortage of the most basic services, such as water and power supply. It also has a fragile health system, with hospitals lacking essential medical supplies and equipment, as well as the capacity to deal with the outbreak as there are only 84 ICU beds and ventilators available. Meanwhile, intra-Palestinian divisions have persisted and were evident in the initial reaction to the pandemic. When President Mahmoud Abbas announced a state of emergency, it took two days for the Hamas-led government in Gaza to follow suit and shut down schools and universities. They later made a separate emergency appeal to address the crisis and prepare for a COVID-19 response in Gaza. This lack of coordination is typical of the way the Palestinian Authority and Hamas approach crisis situations.After the initial uncoordinated response, Hamas, as the de-facto ruler of Gaza, has asserted its ability to control Gaza’s borders by putting in place quarantine measures for everyone who enters the strip, whether through the Erez checkpoint with Israel or the Rafah border with Egypt. They have also assigned 21 hospitals, hotels, and schools as compulsory quarantine centres for all arrivals from abroad, who have to stay in quarantine for 21 days. In comparison, there are 20 quarantine centres in the West Bank. These strict measures have prevented the spread of the virus in the community and confined it to the quarantine centres, with only 20 confirmed cases of COVID-19 as of 6 May. Gaza’s de-facto authorities have also been able to monitor markets and prices to ensure the availability of essential goods.Faced with a major crisis, Al-Qassam Brigades – the armed wing of Hamas – have tried to play the role of a national army by participating in efforts to fight the pandemic. They have relatively good logistical capacity and have contributed to the construction of two quarantine facilities with a total capacity of 1,000 units to prepare for more arrivals into Gaza. At the local level, municipalities have been disinfecting public spaces and facilities in addition to disseminating information about the virus and related preventative and protective measures. Other precautionary measures put in place include closing the weekly open markets, and restricting social gatherings like weddings and funerals.Despite COVID-19, it’s business as usual when it comes to international dealings with Gaza. The key parties in the conflict – Israel, Hamas and the Palestinian Authority – along with the main external actors – Egypt, the United Nations and Qatar – have continued to stick to their policies aimed at keeping the security situation under control and preventing further escalation. Although Israel has allowed entry of pharmaceutical supplies and medical equipment into Gaza during the pandemic, it has kept its restrictions on the movement of goods and people in place, while keeping a close eye on the development of the COVID-19 outbreak in Gaza – a major outbreak here would be a nightmare scenario for Israel.Meanwhile, Qatar has continued to address the humanitarian and economic needs of Gaza in an attempt to ease the pressure and prevent further escalation. It has pledged $150 million over the next six months to help families in Gaza from poorer backgrounds. Gaza has also been discussed by the Middle East Quartet, as Nickolay Mladenov, the UN special coordinator for the Middle East Peace Process, expressed his concern about the risk of a disease outbreak in Gaza during a call with the members of the Quartet.Amid the pandemic, threats are still being exchanged between Israel and Hamas. The Israeli defence minister, Naftali Bennett, requested that in return for providing humanitarian aid to Gaza, Hamas agrees to return the remains of two Israeli soldiers killed in the 2014 war. While openly rejecting Bennett's statement, the leader of Hamas in Gaza, Yahya Sinwar, has offered to move forward with a prisoner swap deal if Israel agrees to release elderly prisoners and detainees in addition to detained women and children. Though dealing with its own COVID-19 outbreak, Egypt has started to mediate between the two parties in an attempt to stabilize the situation and reach a prisoner swap deal.In the wake of this pandemic, lessons should be learned and policies should be examined, by all parties. Firstly, Israel should re-evaluate its security measures towards Gaza by easing restrictions on movement and trade which would have a positive impact on living conditions for Gaza’s population. The current measures have proven to be unsustainable and have contributed to the endless cycle of violence. Secondly, the intra-Palestinian division should end, to save Palestinians from contradictory policies and insufficient capacity on both sides. In fact, all previous attempts have failed to end this self-destructive division and this is due to the absence of political will on both sides. Elections seem to be the only viable path towards unity. Finally, efforts by the international community should go beyond stabilizing the security situation and ongoing crisis inside Gaza, where disruption of normal life is the norm.While the world has reacted to this pandemic with a whole host of new policies and emergency measures, it has remained business as usual when dealing with Gaza. Should COVID-19 spread in Gaza, its people – who have already paid the price of a continuous blockade and intra-Palestinian division for 13 years – will pay a heavy price yet again. However, this time it is not a crisis that they alone will have to face. Full Article
nes 18F-Fluorodeoxyglucose Positron Emission Tomography / Computed Tomography in Left-Ventricular Assist Device Infection: Initial Results Supporting the Usefulness of Image-Guided Therapy By jnm.snmjournals.org Published On :: 2019-12-05T10:37:41-08:00 Background: Accurate definition of the extent and severity of left-ventricular assist device (LVAD) infection may facilitate therapeutic decision making and targeted surgical intervention. Here, we explore the value of 18F-fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) for guidance of patient management. Methods: Fifty-seven LVAD-carrying patients received 85 whole-body 18F-FDG PET/CT scans for the work-up of device infection. Clinical follow-up was obtained over a period of up to two years. Results: PET/CT showed various patterns of infectious involvement of the 4 LVAD components: driveline entry point (77% of cases), subcutaneous driveline path (87%), pump pocket (49%) and outflow tract (58%). Driveline smears revealed staphylococcus or pseudomonas strains as the underlying pathogen in a majority of cases (48 and 34%, respectively). At receiver-operating characteristics analysis, an 18F-FDG standardized uptake value (SUV) >2.5 was most accurate to identify smear-positive driveline infection. Infection of 3 or all 4 LVAD components showed a trend towards lower survival vs infection of 2 or less components (P = 0.089), while involvement of thoracic lymph nodes was significantly associated with adverse outcome (P = 0.001 for nodal SUV above vs below median). Finally, patients that underwent early surgical revision within 3 months after PET/CT (n = 21) required significantly less inpatient hospital care during follow-up when compared to those receiving delayed surgical revision (n = 11; p<0.05). Conclusion: Whole-body 18F-FDG PET/CT identifies the extent of LVAD infection and predicts adverse outcome. Initial experience suggests that early image-guided surgical intervention may facilitate a less complicated subsequent course. Full Article
nes Intraoperative 68Gallium-PSMA Cerenkov Luminescence Imaging for surgical margins in radical prostatectomy - a feasibility study By jnm.snmjournals.org Published On :: 2020-02-14T14:01:21-08:00 Objective: To assess the feasibility and accuracy of Cerenkov Luminescence Imaging (CLI) for assessment of surgical margins intraoperatively during radical prostatectomy (RPE). Methods: A single centre feasibility study included 10 patients with high-risk primary prostate cancer (PC). 68Ga-PSMA PET/CT scans were performed followed by RPE and intraoperative CLI of the excised prostate. In addition to imaging the intact prostate, in the first two patients the prostate gland was incised and imaged with CLI to visualise the primary tumour. We compared the tumour margin status on CLI to postoperative histopathology. Measured CLI intensities were determined as tumour to background ratio (TBR). Results: Tumour cells were successfully detected on the incised prostate CLI images as confirmed by histopathology. 3 of 10 men had histopathological positive surgical margins (PSMs), and 2 of 3 PSMs were accurately detected on CLI. Overall, 25 (72%) out of 35 regions of interest (ROIs) proved to visualize a tumour signal according to standard histopathology. The median tumour radiance in these areas was 11301 photons/s/cm2/sr (range 3328 - 25428 photons/s/cm2/sr) and median TBR was 4.2 (range 2.1 – 11.6). False positive signals were seen mainly at the prostate base with PC cells overlaid by benign tissue. PSMA-immunohistochemistry (PSMA-IHC) revealed strong PSMA staining of benign gland tissue, which impacts measured activities. Conclusion: This feasibility showed that 68Ga-PSMA CLI is a new intraoperative imaging technique capable of imaging the entire specimen’s surface to detect PC tissue at the resection margin. Further optimisation of the CLI protocol, or the use of lower-energetic imaging tracers such as 18F-PSMA, are required to reduce false positives. A larger study will be performed to assess diagnostic performance. Full Article
nes Amyloid PET in Dementia Syndromes: A Chinese Multicenter Study By jnm.snmjournals.org Published On :: 2020-05-08T13:18:58-07:00 Cerebral β-amyloid deposits and regional glucose metabolism assessed by positron emission tomography (PET) are used to distinguish between Alzheimer's disease (AD) and other dementia syndromes. In the present multicenter study, we estimated the prevalence of β-amyloid deposits on PET imaging in a wide variety of dementia syndromes and mild cognitive impairment (MCI) within a memory clinic population. Methods: Of the 1193 consecutive patients with cognitive impairment (CI) who received combined 18F-AV45 and/or 11C-PIB PET, 960 were diagnosed with AD, 36 with frontotemporal dementia (FTD), 5 with dementia with Lewy bodies (DLB), 144 with MCI, 29with vascular dementia (VaD), 4 with corticobasal syndrome (CBS) and 15 with unclassifiable dementia. Baseline clinical diagnoses were independently established without access to PET imaging results. ApoE genotype analysis was performed in CI patients and 231 gender- and age-matched controls. Results: Of the 1193 CI patients, 860 (72.1%) were amyloid-positive. The prevalence of amyloid positivity in AD and MCI patients was 86.8% (833/960) and 9.7% (14/144), respectively. In FTD patients, the prevalence of β-amyloid deposits was 5.6% (2/36). In the 4 CBS patients, two were amyloid-positive. Three of the 5 DLB patients showed amyloid positivity, as did 6 of the 29 VaD (20.7%) patients. The ApoE4 allele frequency was significantly increased in amyloid-positive CI patients (30.5%) as compared with other amyloid-negative CI patients (14%) or controls (7.3%). Conclusion: Amyloid imaging may potentially be the most helpful parameter for differential diagnosis in dementia, particularly to distinguish between AD and FTD. Amyloid PET can be used in conjunction with the ApoE4 allele genetic risk test for amyloid deposits. Full Article
nes Discussions with Leaders: A Conversation Between Johnese Spisso and Johannes Czernin By jnm.snmjournals.org Published On :: 2020-05-08T13:18:58-07:00 Full Article