Inhibition of BET protein bromodomains BD1 and BD2 produces unique phenotypes in disease models.

A new method called MicroMapping can identify nanoscale protein–protein interactions on live cells.

Mismatch repair (MMR)–deficient tumors exhibit proteome-wide protein instability and aggregation.

Maintenance of the proteome, ensuring the proper locations, proper conformations, appropriate concentrations, etc., is essential to preserve the health of an organism in the face of environmental insults, infectious diseases, and the challenges associated with aging. Maintaining the proteome is even more difficult in the background of inherited mutations that render a given protein and others handled by the same proteostasis machinery misfolding prone and/or aggregation prone. Maintenance of the proteome or maintaining proteostasis requires the orchestration of protein synthesis, folding, trafficking, and degradation by way of highly conserved, interacting, and competitive proteostasis pathways. Each subcellular compartment has a unique proteostasis network compromising common and specialized proteostasis maintenance pathways. Stress-responsive signaling pathways detect the misfolding and/or aggregation of proteins in specific subcellular compartments using stress sensors and respond by generating an active transcription factor. Subsequent transcriptional programs up-regulate proteostasis network capacity (i.e., ability to fold and degrade proteins in that compartment). Stress-responsive signaling pathways can also be linked by way of signaling cascades to nontranscriptional means to reestablish proteostasis (e.g., by translational attenuation). Proteostasis is also strongly influenced by the inherent kinetics and thermodynamics of the folding, misfolding, and aggregation of individual proteins, and these sequence-based attributes in combination with proteostasis network capacity together influence proteostasis. In this review, we will focus on the growing body of evidence that proteostasis deficits leading to human pathology can be reversed by pharmacologic adaptation of proteostasis network capacity through stress-responsive signaling pathway activation. The power of this approach will be exemplified by focusing on the ATF6 arm of the unfolded protein response stress responsive-signaling pathway that regulates proteostasis network capacity of the secretory pathway.

Lab-grown ‘meat’ often uses gelatin produced in slaughterhouses to give artificial beef a meat-like texture – but substituting soya protein can achieve that without killing animals

An AI-powered application lets you create real-time deepfakes during video calls, making you appear to be speaking as anyone from Albert Einstein to the Mona Lisa

Alison Roman’s latest comments about Marie Kondo have not sparked joy.

In an interview with The New Consumer about her increased popularity and the avenues she might pursue to capitalize on it, the popular food columnist discussed her hesitance to put her name on a product line—citing the Japanese organization maven and Chrissy Teigen as examples of what she did not foresee in her own future.

“I have a collaboration coming out with [the cookware startup] Material, a capsule collection,” Roman said. “It’s limited edition, a few tools that I designed that are based on tools that I use that aren’t in production anywhere—vintage spoons and very specific things that are one-offs that I found at antique markets that they have made for me.”

Read more at The Daily Beast.

A team of researchers say they have discovered a protein molecule inside a meteorite, the first extraterrestrial example ever found, but others are sceptical

A star that swoops close to the Milky Way’s supermassive black hole has a strange, looping orbit that proves Einstein was right about the gravity of black holes

“I didn’t ‘sell out’ by making my dreams come true.”

Ed Pilkington looks ahead to Weinstein’s court battle where he faces charges of rape and sexual assault, which he denies. And Jamie Grierson on why counter-terror police have listed Extinction Rebellion as a ‘key threat’

The film producer Harvey Weinstein will stand trial this week in New York City accused of five charges, including rape and sexual assault. Weinstein denies all allegations. The trial, expected to last about six weeks, will focus on the witness accounts of two alleged victims who claim they were assaulted by Weinstein.

The Guardian’s Ed Pilkington has been in court for the jury selection process in which 2,000 potential jurors were whittled down to 12 who will decide Weinstein’s fate. He tells Anushka Asthana that the case will cause a sensation in the US and around the world, but that it should not be seen as #MeToo on trial.

Like dozens of women in the entertainment industry, the actor, model and writer Zoë Brock has claimed she had a traumatic encounter with the film producer Harvey Weinstein. Now she is faced with a settlement offer that she believes would allow him to escape blame for the alleged assaults. Also today: Lily Kuo on the spread of the deadly coronavirus in China

The actor, model and writer Zoë Brock was on a retreat in the New Zealand bush in 2017 when an email pinged into her inbox. It was from a friend sending a link to a breaking news story of allegations against Harvey Weinstein. The claims from several women against the film producer were eerily familiar to an incident that Brock alleges happened to her.

This week, Weinstein goes on trial charged with rape and sexual assault. But for dozens of women with claims against him, their only recourse is to civil courts. Brock tells Anushka Asthana that while she is part of the class action suit against Weinstein, she is deeply unhappy with the terms of the proposed settlement, which she believes would allow him to accept no blame for the allegations.

Jameela Jamil also came to Teigen and Kondo's defense, calling Roman "distasteful" and "cliche" for criticizing women of color for being successful in business.

An analysis and structural modeling of the SARS-CoV-2 spike protein, the area of the virus that facilitates entry into a cell, reveals a unique feature that could explain why the COVID-19-causing coronavirus is so transmissible between people. The study also shows that, aside from primates, cats, ferrets and minks are the animal species apparently most [...]

Does a cell surface protein explain why the coronavirus is more likely to kill people with diabetes or heart disease? Researchers are trying to find out

A protein shredder that occurs in cell membranes of brain cells apparently also indirectly regulates the fat metabolism. The shredder, known as gamma-secretase, is considered a possible target for drugs against cancer and Alzheimer's disease. However, the results suggest that such agents may have long-range effects that need to be watched closely.

Harvey Weinstein has been charged with a new count of sexual assault, prosecutors in Los Angeles have said.

More than a century ago, Einstein predicted how much the star's orbit changes, and now the data collected by scientists exactly matches his theory.

Sex offender Jeffrey Epstein visited Harvard University dozens of times after his conviction - and was even given his own office.

A couple of days ago Alison Roman, critic and food enthusiast gave an interview directly trashing Chrissy Teigen’s approach to business. “What Chrissy Teigen has done is so crazy to me. She had a successful cookbook. And then it was like Boom, the line at Target. Boom, now she has an Instagram page that has […]

The post Alison Roman Is Eating Her Words, Apologizing To Chrissy Teigen appeared first on Chart Attack.

Move over, Martha Stewart and Gwyneth Paltrow. There's a new feud brewing between two leaders in the lifestyle industry. Best-selling cookbook author Alison Roman has caught the...

'I truly do wonder what's going on inside of her brain,' one outraged tweeter wrote

'For years before Time's Up women had to put up with harassment and still do on a regular basis'

The former assistant to the jailed producer talks to Olivia Petter about her attempted rape allegation against Harvey Weinstein, why his lawyers must be held to account, and the damaging myths we attach to rape survivors and perpetrators

Food writer Alison Roman accused Teigen of having people 'run a content farm' for her

The Booksmart actress was concerned that she wasn't a good fit for the British-based story.

Move over, Martha Stewart and Gwyneth Paltrow. There's a new feud brewing between two leaders in the lifestyle industry. Best-selling cookbook author Alison Roman has caught the...

A protein shredder that occurs in cell membranes of brain cells apparently also indirectly regulates the fat metabolism. This is shown by a recent study by the University of Bonn. The shredder, known as gamma-secretase, is considered a possible target for drugs against cancer and Alzheimer's disease. However, the results suggest that such agents may have long-range effects that need to be watched closely. The study has now been published in "Life Science Alliance".

Move over, Martha Stewart and Gwyneth Paltrow. There's a new feud brewing between two leaders in the lifestyle industry. Best-selling cookbook author Alison Roman has caught the...

Beanie Feldstein stars

"The department has organized itself to ensure that we are in a position to aggressively investigate and prosecute cyber crime wherever it occurs," said Deputy Assistant Attorney General Weinstein.

"One of the Department of Justice’s core missions is protecting the privacy of Americans and prosecuting criminals who violate that privacy," said Deputy Assistant Attorney General Weinstein.

Kathryn Keneally, the Assistant Attorney General for the Tax Division of the Department of Justice, Preet Bharara, the U.S. Attorney for the Southern District of New York and Richard Weber, the Chief of the Internal Revenue Service, Criminal Investigation (IRS-CI), announced today that Liechtensteinische Landesbank AG, a bank based in Vaduz, Liechtenstein (LLB-Vaduz), has agreed to pay more than $23.8 million to the United States and entered into a non-prosecution agreement (NPA) with the U.S. Attorney’s Office for the Southern District of New York.

Temple University researchers discovered that boosting levels of a protein called Lin28 in injured spinal cords of mice prompts the regrowth of axons and repairs communication between the brain and body. They believe the discovery could be used to develop new treatments for both spinal cord and optic nerve injuries.

The recommended daily allowance of protein may be inadequate to support maintenance of muscle in young women and eating protein from the humble potato can help to maintain muscle, according to research from McMaster University funded by the Alliance for Potato Research & Education.

A novel combination of two Lactobacillus paracasei strains may increase absorption of key amino acids in plant proteins, according to a new placebo-controlled, randomized, double-blind, multicenter, crossover study.

npj Microgravity, Published online: 23 April 2020; doi:10.1038/s41526-020-0102-3