tam Padres pitcher Craig Stammen buys Coronado home close to Petco Park By www.latimes.com Published On :: Thu, 30 Apr 2020 13:12:37 -0400 In the resort city of Coronado, Padres pitcher Craig Stammen recently shelled out $3.7 million for a home right across the bay from Petco Park. Full Article
tam Review: Smartly scripted 'Tammy's Always Dying' pits mother and daughter in toxic cycle By www.latimes.com Published On :: Thu, 30 Apr 2020 16:40:07 -0400 "Tammy's Always Dying" is a low-key, insightful comic drama about a striving woman and her albatross-like mother, played by Felicity Huffman. Full Article
tam Celtic boss Neil Lennon warns Leigh Griffiths over behaviour after stamp flashpoint By www.express.co.uk Published On :: Mon, 03 Feb 2020 07:01:00 +0000 Celtic boss Neil Lennon has issued a stern warning to Leigh Griffiths about his behaviour after a ‘stamp' incident overshadowed their win over Hamilton. Full Article
tam Co-op recalls Sliced Pepperoni because of contamination with E. coli By www.food.gov.uk Published On :: Tue, 14 Apr 2020 00:00:00 +0100 Co-op is recalling Co-op Sliced Pepperoni because E. coli O157 has been found in the product. Full Article
tam Tòa Việt Nam: 'Có tam quyền phân lập mới hết được án oan sai!' By www.bbc.com Published On :: Thu, 07 May 2020 22:18:50 GMT Có tam quyền phân lập, có tư pháp độc lập liệu mới mong giảm hay chấm dứt được các vụ án xét xử oan sai, theo bình luận của luật sư Nguyễn Văn Đài. Full Article
tam Coronavírus: por que alguns pacientes já recuperados voltam a ter teste positivo para covid-19, segundo OMS By www.bbc.com Published On :: Tue, 05 May 2020 10:43:51 GMT Infectologista da organização explica que células mortas expelidas do pulmão fazem exames darem positivo mais de uma vez — mas não necessariamente quer dizer que a pessoa voltou a ficar infectada pelo coronavírus. Full Article
tam 'Coronavírus pode acabar com minha oportunidade de ser mãe': mulheres sofrem com suspensão de tratamento de fertilidade By www.bbc.com Published On :: Mon, 04 May 2020 10:01:43 GMT Casais com problemas de fertilidade que estavam passando por processo de fertilização in vitro no Brasil temem perder chance de ter filhos por causa da pandemia. Full Article
tam 'Se encontrá-las, corra e nos chame!': cientistas nos EUA alertam para chegada de 'vespas assassinas' By www.bbc.com Published On :: Tue, 05 May 2020 09:00:26 GMT Segundo estudos, insetos liberam toxina tão potente que pode causar a morte de uma pessoa que tiver levado várias picadas. Full Article
tam Coronavírus: os sete tipos de pessoas que inventam e disseminam fake news By www.bbc.com Published On :: Thu, 07 May 2020 21:49:46 GMT Investigamos centenas de histórias enganosas durante a pandemia. Isso nos deu uma ideia sobre quem está por trás da desinformação - e o que os motiva. Aqui estão sete tipos de pessoas que iniciam e espalham falsidades. Full Article
tam Destruição de armas apreendidas cai no primeiro ano do governo Bolsonaro, aponta levantamento By www.bbc.com Published On :: Wed, 06 May 2020 16:29:20 GMT Desde 2017, a intenção do poder público vinha sendo acelerar destruições, que evitam que armas caiam nas mãos do crime; órgãos públicos não sabem explicar a razão da queda. Full Article
tam 'Não quero morrer sem revê-la': as mães que doaram seus filhos no passado e hoje lutam para reencontrá-los By www.bbc.com Published On :: Sat, 09 May 2020 10:41:09 GMT Mulheres que doaram os filhos décadas atrás relatam angústia e tristeza em busca de respostas sobre paradeiros das crianças. Full Article
tam Tamika Catchings to face Mike Conley in NBA HORSE competition By rssfeeds.indystar.com Published On :: Thu, 09 Apr 2020 14:13:23 +0000 Mike Conley is Tamika Catchings' first-round opponent in the NBA's HORSE event on ESPN; competitors will remain separated Full Article
tam Family shares Mexican tradition of tamales By rssfeeds.indystar.com Published On :: Sun, 23 Dec 2018 01:06:12 +0000 The Vasquez family makes tamales to sell at the Carmel Farmer's Market Full Article
tam Greenwood Christian AD Sue Tameling dies from apparent heart attack: 'She very much loved GCA.' By rssfeeds.indystar.com Published On :: Tue, 07 Apr 2020 17:06:57 +0000 Sue Tameling was in her role as Greenwood Christian AD for less than two years, but she left an impression as a mentor, teacher and a friend. Full Article
tam Coronavirus: Should I start taking vitamin D? By www.bbc.co.uk Published On :: Thu, 23 Apr 2020 01:34:35 GMT Some people might want to consider it during the pandemic. Here's why. Full Article
tam ‘Wattam’: A game best left for the kids By www.washingtonpost.com Published On :: Fri, 20 Dec 2019 14:36:33 +0000 The game teeters over the line between childlike and childish. Full Article
tam Republicans are all about boosting economic growth — except when it comes to food stamps By www.washingtonpost.com Published On :: Thu, 05 Dec 2019 23:34:35 +0000 Kicking people off food stamps this late in the business cycle makes no sense. Full Article
tam AT#305 - Travel to Tampa, Florida By usa.amateurtraveler.com Published On :: Sat, 03 Dec 2011 19:43:41 +0000 The Amateur Traveler talks to Shannon Martin from Two Who Travel about her hometown of Tampa Bay (and St Petersburg) Florida. Shannon recommends the Tamp Bay area for a beach vacation, possible combined with a trip to Walt Disney World in Orlando. Full Article
tam Inhibition of the erythropoietin-producing receptor EPHB4 antagonizes androgen receptor overexpression and reduces enzalutamide resistance [Molecular Bases of Disease] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 Prostate cancer (PCa) cells heavily rely on an active androgen receptor (AR) pathway for their survival. Enzalutamide (MDV3100) is a second-generation antiandrogenic drug that was approved by the Food and Drug Administration in 2012 to treat patients with castration-resistant prostate cancer (CRPC). However, emergence of resistance against this drug is inevitable, and it has been a major challenge to develop interventions that help manage enzalutamide-resistant CRPC. Erythropoietin-producing human hepatocellular (Eph) receptors are targeted by ephrin protein ligands and have a broad range of functions. Increasing evidence indicates that this signaling pathway plays an important role in tumorigenesis. Overexpression of EPH receptor B4 (EPHB4) has been observed in multiple types of cancer, being closely associated with proliferation, invasion, and metastasis of tumors. Here, using RNA-Seq analyses of clinical and preclinical samples, along with several biochemical and molecular methods, we report that enzalutamide-resistant PCa requires an active EPHB4 pathway that supports drug resistance of this tumor type. Using a small kinase inhibitor and RNAi-based gene silencing to disrupt EPHB4 activity, we found that these disruptions re-sensitize enzalutamide-resistant PCa to the drug both in vitro and in vivo. Mechanistically, we found that EPHB4 stimulates the AR by inducing proto-oncogene c-Myc (c-Myc) expression. Taken together, these results provide critical insight into the mechanism of enzalutamide resistance in PCa, potentially offering a therapeutic avenue for enhancing the efficacy of enzalutamide to better manage this common malignancy. Full Article
tam Extending the Limits of Quantitative Proteome Profiling with Data-Independent Acquisition and Application to Acetaminophen-Treated Three-Dimensional Liver Microtissues By feedproxy.google.com Published On :: 2015-05-01 Roland BrudererMay 1, 2015; 14:1400-1410Research Full Article
tam A kainate receptor-selective RNA aptamer [Neurobiology] By feedproxy.google.com Published On :: 2020-05-08T03:41:14-07:00 Kainate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are two major, closely related receptor subtypes in the glutamate ion channel family. Excessive activities of these receptors have been implicated in a number of central nervous system diseases. Designing potent and selective antagonists of these receptors, especially of kainate receptors, is useful for developing potential treatment strategies for these neurological diseases. Here, we report on two RNA aptamers designed to individually inhibit kainate and AMPA receptors. To improve the biostability of these aptamers, we also chemically modified these aptamers by substituting their 2'-OH group with 2'-fluorine. These 2'-fluoro aptamers, FB9s-b and FB9s-r, were markedly resistant to RNase-catalyzed degradation, with a half-life of ∼5 days in rat cerebrospinal fluid or serum-containing medium. Furthermore, FB9s-r blocked AMPA receptor activity. Aptamer FB9s-b selectively inhibited GluK1 and GluK2 kainate receptor subunits, and also GluK1/GluK5 and GluK2/GluK5 heteromeric kainate receptors with equal potency. This inhibitory profile makes FB9s-b a powerful template for developing tool molecules and drug candidates for treatment of neurological diseases involving excessive activities of the GluK1 and GluK2 subunits. Full Article
tam Vitamin E does not prevent Western diet-induced NASH progression and increases metabolic flux dysregulation in mice [Research Articles] By feedproxy.google.com Published On :: 2020-05-01T00:05:27-07:00 Fatty liver involves ectopic lipid accumulation and dysregulated hepatic oxidative metabolism, which can progress to a state of elevated inflammation and fibrosis referred to as nonalcoholic steatohepatitis (NASH). The factors that control progression from simple steatosis to NASH are not fully known. Here, we tested the hypothesis that dietary vitamin E (VitE) supplementation would prevent NASH progression and associated metabolic alterations induced by a Western diet (WD). Hyperphagic melanocortin-4 receptor-deficient (MC4R–/–) mice were fed chow, chow+VitE, WD, or WD+VitE starting at 8 or 20 weeks of age. All groups exhibited extensive hepatic steatosis by the end of the study (28 weeks of age). WD feeding exacerbated liver disease severity without inducing proportional changes in liver triglycerides. Eight weeks of WD accelerated liver pyruvate cycling, and 20 weeks of WD extensively upregulated liver glucose and oxidative metabolism assessed by 2H/13C flux analysis. VitE supplementation failed to reduce the histological features of NASH. Rather, WD+VitE increased the abundance and saturation of liver ceramides and accelerated metabolic flux dysregulation compared with 8 weeks of WD alone. In summary, VitE did not limit NASH pathogenesis in genetically obese mice, but instead increased some indicators of metabolic dysfunction. Full Article
tam A kainate receptor-selective RNA aptamer [Neurobiology] By feedproxy.google.com Published On :: 2020-05-08T03:41:14-07:00 Kainate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are two major, closely related receptor subtypes in the glutamate ion channel family. Excessive activities of these receptors have been implicated in a number of central nervous system diseases. Designing potent and selective antagonists of these receptors, especially of kainate receptors, is useful for developing potential treatment strategies for these neurological diseases. Here, we report on two RNA aptamers designed to individually inhibit kainate and AMPA receptors. To improve the biostability of these aptamers, we also chemically modified these aptamers by substituting their 2'-OH group with 2'-fluorine. These 2'-fluoro aptamers, FB9s-b and FB9s-r, were markedly resistant to RNase-catalyzed degradation, with a half-life of ∼5 days in rat cerebrospinal fluid or serum-containing medium. Furthermore, FB9s-r blocked AMPA receptor activity. Aptamer FB9s-b selectively inhibited GluK1 and GluK2 kainate receptor subunits, and also GluK1/GluK5 and GluK2/GluK5 heteromeric kainate receptors with equal potency. This inhibitory profile makes FB9s-b a powerful template for developing tool molecules and drug candidates for treatment of neurological diseases involving excessive activities of the GluK1 and GluK2 subunits. Full Article
tam SUS vai oferecer aparelho de última geração para tipo de perda auditiva até então sem tratamento By saudeprospera.com.br Published On :: Mon, 30 Oct 2017 18:43:53 +0000 Prótese auditiva ancorada em osso não emite um som como o aparelho convencional. Seu diferencial é vibrar o osso da cabeça. The post SUS vai oferecer aparelho de última geração para tipo de perda auditiva até então sem tratamento appeared first on Saúde Próspera. Full Article Dicas de Saúde
tam Candidíase – Conheça as causas, sintomas e tratamentos By saudeprospera.com.br Published On :: Fri, 10 Nov 2017 12:13:02 +0000 O que é Candidíase? Candidíase, é uma infecção sistêmica causada pelo fungos da Candida albicans. A Candida albicans é um tipo de fungo (levedura) que vive em harmonia no organismo,… The post Candidíase – Conheça as causas, sintomas e tratamentos appeared first on Saúde Próspera. Full Article Dicas de Saúde
tam CBD Communiqué: The Beauty and Variety of Life on Earth Captured in Postage Stamps. By www.cbd.int Published On :: Mon, 12 Jul 2010 00:00:00 GMT Full Article
tam Soldo supports COVID-19 'digital foodstamps' response By www.techworld.com Published On :: Thu, 23 Apr 2020 07:00:00 GMT The London-headquartered fintech startup Soldo has repurposed its spend management tools for local authorities in Italy to support its COVID-19 emergency response measures Full Article
tam Select Vitamins and Minerals in the Management of Diabetes By spectrum.diabetesjournals.org Published On :: 2001-08-01 Belinda S. OConnellAug 1, 2001; 14:Articles Full Article
tam Vitamin D Deficiency and Type 2 Diabetes in African Americans: The Common Denominators By spectrum.diabetesjournals.org Published On :: 2011-08-01 Shani V. DavisAug 1, 2011; 24:148-153Feature Article/Vitamin D in African Americans Full Article
tam Vitamin D and Diabetes By spectrum.diabetesjournals.org Published On :: 2011-05-01 Teresa MartinMay 1, 2011; 24:113-118Pharmacy and Therapeutics Full Article
tam Inhibition of the erythropoietin-producing receptor EPHB4 antagonizes androgen receptor overexpression and reduces enzalutamide resistance [Molecular Bases of Disease] By www.jbc.org Published On :: 2020-04-17T00:06:05-07:00 Prostate cancer (PCa) cells heavily rely on an active androgen receptor (AR) pathway for their survival. Enzalutamide (MDV3100) is a second-generation antiandrogenic drug that was approved by the Food and Drug Administration in 2012 to treat patients with castration-resistant prostate cancer (CRPC). However, emergence of resistance against this drug is inevitable, and it has been a major challenge to develop interventions that help manage enzalutamide-resistant CRPC. Erythropoietin-producing human hepatocellular (Eph) receptors are targeted by ephrin protein ligands and have a broad range of functions. Increasing evidence indicates that this signaling pathway plays an important role in tumorigenesis. Overexpression of EPH receptor B4 (EPHB4) has been observed in multiple types of cancer, being closely associated with proliferation, invasion, and metastasis of tumors. Here, using RNA-Seq analyses of clinical and preclinical samples, along with several biochemical and molecular methods, we report that enzalutamide-resistant PCa requires an active EPHB4 pathway that supports drug resistance of this tumor type. Using a small kinase inhibitor and RNAi-based gene silencing to disrupt EPHB4 activity, we found that these disruptions re-sensitize enzalutamide-resistant PCa to the drug both in vitro and in vivo. Mechanistically, we found that EPHB4 stimulates the AR by inducing proto-oncogene c-Myc (c-Myc) expression. Taken together, these results provide critical insight into the mechanism of enzalutamide resistance in PCa, potentially offering a therapeutic avenue for enhancing the efficacy of enzalutamide to better manage this common malignancy. Full Article
tam Vitamin D linked to low virus death rate -- Study By www.eurekalert.org Published On :: Thu, 07 May 2020 00:00:00 EDT (Anglia Ruskin University) A new study has found an association between low average levels of vitamin D and high numbers of COVID-19 cases and mortality rates across 20 European countries. Full Article
tam Select Vitamins and Minerals in the Management of Diabetes By spectrum.diabetesjournals.org Published On :: 2001-08-01 Belinda S. OConnellAug 1, 2001; 14:Articles Full Article
tam The effects of monosodium glutamate on PSMA radiotracer uptake in men with recurrent prostate cancer: a prospective, randomized, double-blind, placebo-controlled intra-individual imaging study. By jnm.snmjournals.org Published On :: 2020-05-08T13:18:58-07:00 The prostate-specific membrane antigen (PSMA) is an excellent target for theranostic applications in prostate cancer (PCa). However, PSMA-targeted radioligand therapy can cause undesirable effects due to high accumulation of PSMA radiotracers in salivary glands and kidneys. This study assessed orally administered monosodium glutamate (MSG) as a potential means of reducing kidney and salivary gland radiation exposure using a PSMA targeting radiotracer. Methods: This prospective, double-blind, placebo-controlled study enrolled 10 biochemically recurrent PCa patients. Each subject served as his own control. [18F]DCFPyl PET/CT imaging sessions were performed 3 – 7 days apart, following oral administration of either 12.7 g of MSG or placebo. Data from the two sets of images were analyzed by placing regions of interest on lacrimal, parotid and submandibular glands, left ventricle, liver, spleen, kidneys, bowel, urinary bladder, gluteus muscle and malignant lesions. The results from MSG and placebo scans were compared by paired analysis of the ROI data. Results: A total of 142 pathological lesions along with normal tissues were analyzed. As hypothesized a priori, there was a significant decrease in maximal standardized uptake values corrected for lean body mass (SULmax) on images obtained following MSG administration in the parotids (24 ± 14%, P = 0.001), submandibular glands (35 ± 11%, P<0.001) and kidneys (23 ± 26%, P = 0.014). Significant decreases were also observed in lacrimal glands (49 ± 13%, P<0.001), liver (15 ± 6%, P<0.001), spleen (28 ± 13%, P = 0.001) and bowel (44 ± 13%, P<0.001). Mildly lower blood pool SULmean was observed after MSG administration (decrease of 11 ± 13%, P = 0.021). However, significantly lower radiotracer uptake in terms of SULmean, SULpeak, and SULmax was observed in malignant lesions on scans performed after MSG administration compared to the placebo studies (SULmax median decrease 33%, range -1 to 75%, P<0.001). No significant adverse events occurred and vital signs were stable following placebo or MSG administration. Conclusion: Orally administered MSG significantly decreased salivary gland, kidney and other normal organ PSMA radiotracer uptake in human subjects, using [18F]DCFPyL as an exemplar. However, MSG caused a corresponding reduction in tumor uptake, which may limit the benefits of this approach for diagnostic and therapeutic applications. Full Article
tam Bisretinoid phospholipid and vitamin A aldehyde: Shining a light [Thematic Reviews] By feedproxy.google.com Published On :: 2020-05-05T13:30:26-07:00 Vitamin A aldehyde covalently bound to opsin protein is embedded in a phospholipid-rich membrane that supports photon absorption and phototransduction in photoreceptor cell outer segments. Following absorption of a photon, the 11-cis-retinal chromophore of visual pigment in photoreceptor cells isomerizes to all-trans-retinal. To maintain photosensitivity 11-cis-retinal must be replaced. At the same time, however, all-trans-retinal has to be handled so as to prevent nonspecific aldehyde activity. Some molecules of retinaldehyde upon release from opsin are efficiently reduced to retinol. Other molecules are released into the lipid phase of the disc membrane where they form a conjugate (N-retinylidene-PE, NRPE) through a Schiff base linkage with phosphatidylethanolamine (PE). The reversible formation of NRPE serves as a transient sink for retinaldehyde that is intended to return retinaldehyde to the visual cycle. However, if instead of hydrolyzing to PE and retinaldehyde, NRPE reacts with a second molecule of retinaldehyde a synthetic pathway is initiated that leads to the formation of multiple species of unwanted bisretinoid fluorophores. We report on recently identified members of the bisretinoid family some of which differ with respect to the acyl chains associated with the glycerol backbone. We discuss processing of the lipid moieties of these fluorophores in lysosomes of retinal pigment epithelial (RPE) cells, their fluorescence characters and new findings related to light and iron-associated oxidation of bisretinoids. Full Article
tam Vitamin E does not prevent Western diet-induced NASH progression and increases metabolic flux dysregulation in mice [Research Articles] By feedproxy.google.com Published On :: 2020-05-01T00:05:27-07:00 Fatty liver involves ectopic lipid accumulation and dysregulated hepatic oxidative metabolism, which can progress to a state of elevated inflammation and fibrosis referred to as nonalcoholic steatohepatitis (NASH). The factors that control progression from simple steatosis to NASH are not fully known. Here, we tested the hypothesis that dietary vitamin E (VitE) supplementation would prevent NASH progression and associated metabolic alterations induced by a Western diet (WD). Hyperphagic melanocortin-4 receptor-deficient (MC4R–/–) mice were fed chow, chow+VitE, WD, or WD+VitE starting at 8 or 20 weeks of age. All groups exhibited extensive hepatic steatosis by the end of the study (28 weeks of age). WD feeding exacerbated liver disease severity without inducing proportional changes in liver triglycerides. Eight weeks of WD accelerated liver pyruvate cycling, and 20 weeks of WD extensively upregulated liver glucose and oxidative metabolism assessed by 2H/13C flux analysis. VitE supplementation failed to reduce the histological features of NASH. Rather, WD+VitE increased the abundance and saturation of liver ceramides and accelerated metabolic flux dysregulation compared with 8 weeks of WD alone. In summary, VitE did not limit NASH pathogenesis in genetically obese mice, but instead increased some indicators of metabolic dysfunction. Full Article
tam Acute Hyperglycemia Increases Brain Pregenual Anterior Cingulate Cortex Glutamate Concentrations in Type 1 Diabetes Mellitus By diabetes.diabetesjournals.org Published On :: 2020-04-24T14:58:49-07:00 The brain mechanisms underlying the association of hyperglycemia with depressive symptoms are unknown. We hypothesized that disrupted glutamate metabolism in pregenual anterior cingulate cortex (ACC) in type 1 diabetes (T1D) without depression affects emotional processing. Using proton magnetic resonance spectroscopy (MRS), we measured glutamate concentrations in ACC and occipital cortex (OCC) in 13 T1D without major depression (HbA1c=7.1±0.7% [54±7mmol/mol]) and 11 healthy non-diabetic controls (HbA1c=5.5±0.2% [37±3mmol/mol]) during fasting euglycemia (EU) followed by a 60-minute +5.5mmol/l hyperglycemic clamp (HG). Intrinsic neuronal activity was assessed using resting-state blood oxygen level dependent functional MRI to measure the fractional amplitude of low frequency fluctuations in slow-band 4 (fALFF4). Emotional processing and depressive symptoms were assessed using emotional tasks (Emotional-Stroop, Self-Referent-Encoding-Task SRET) and clinical ratings (HAM-D, SCL-90-R), respectively. During HG, ACC glutamate increased (1.2mmol/kg, +10%, p=0.014) while ACC fALFF4 was unchanged (-0.007, -2%, p=0.449) in T1D; in contrast, glutamate was unchanged (-0.2mmol/kg, -2%, p=0.578) while fALFF4 decreased (-0.05, -13%, p=0.002) in controls. OCC glutamate and fALFF4 were unchanged in both groups. T1D had longer SRET negative-word response-times (p=0.017) and higher depression-rating scores (HAM-D p=0.020; SCL-90-R-depression p=0.008). Higher glutamate change tended to associate with longer Emotional-Stroop response-times in T1D only. Brain glutamate must be tightly controlled during hyperglycemia due to the risk for neurotoxicity with excessive levels. Results suggest that ACC glutamate control mechanisms are disrupted in T1D, which affects glutamatergic neurotransmission related to emotional or cognitive processing. Increased prefrontal glutamate during acute hyperglycemic episodes could explain our previous findings of associations between chronic hyperglycemia, cortical thinning and depressive symptoms in T1D. Full Article
tam Inhibition of the erythropoietin-producing receptor EPHB4 antagonizes androgen receptor overexpression and reduces enzalutamide resistance [Molecular Bases of Disease] By feedproxy.google.com Published On :: 2020-04-17T00:06:05-07:00 Prostate cancer (PCa) cells heavily rely on an active androgen receptor (AR) pathway for their survival. Enzalutamide (MDV3100) is a second-generation antiandrogenic drug that was approved by the Food and Drug Administration in 2012 to treat patients with castration-resistant prostate cancer (CRPC). However, emergence of resistance against this drug is inevitable, and it has been a major challenge to develop interventions that help manage enzalutamide-resistant CRPC. Erythropoietin-producing human hepatocellular (Eph) receptors are targeted by ephrin protein ligands and have a broad range of functions. Increasing evidence indicates that this signaling pathway plays an important role in tumorigenesis. Overexpression of EPH receptor B4 (EPHB4) has been observed in multiple types of cancer, being closely associated with proliferation, invasion, and metastasis of tumors. Here, using RNA-Seq analyses of clinical and preclinical samples, along with several biochemical and molecular methods, we report that enzalutamide-resistant PCa requires an active EPHB4 pathway that supports drug resistance of this tumor type. Using a small kinase inhibitor and RNAi-based gene silencing to disrupt EPHB4 activity, we found that these disruptions re-sensitize enzalutamide-resistant PCa to the drug both in vitro and in vivo. Mechanistically, we found that EPHB4 stimulates the AR by inducing proto-oncogene c-Myc (c-Myc) expression. Taken together, these results provide critical insight into the mechanism of enzalutamide resistance in PCa, potentially offering a therapeutic avenue for enhancing the efficacy of enzalutamide to better manage this common malignancy. Full Article
tam A Bivariate Genome-Wide Approach to Metabolic Syndrome: STAMPEED Consortium By diabetes.diabetesjournals.org Published On :: 2011-04-01 Aldi T. KrajaApr 1, 2011; 60:1329-1339Genetics Full Article
tam Vitamin D Receptor Overexpression in {beta}-Cells Ameliorates Diabetes in Mice By diabetes.diabetesjournals.org Published On :: 2020-05-01 Meritxell MorróMay 1, 2020; 69:927-939Islet Studies Full Article
tam Tamborine By kolembo.wordpress.com Published On :: Tue, 22 Mar 2016 03:51:26 +0000 They shot the cheese cake. High heels, Eye-liner, Battle-ship, Village people, Purple tortoise Yelling, The light of day, Grey, The road, Dim, Muddy, Single lane, Wet, Pools reflecting torch-light, Forest in sillouette, Trees in moonlight, Going home now, Finished now, Homeward bound. Full Article Poetry age death family humor life love NHS
tam Tambourine By kolembo.wordpress.com Published On :: Thu, 25 May 2017 10:21:05 +0000 They shot the cheese cake. High heels, Eye-liner, Battle-ship, Village people, Purple tortoises Yelling, The light of day, Grey, The road, Dim, Muddy, Single lane, Wet, Pools reflecting torch-light, Forest in sillouette, Trees in moonlight, Going home now, Finished now, Homeward bound. For Betty Valdez-Ogembo ♦♦*photo* – self♦♦ Full Article Poetry ancestors death family love poem poetry
tam Evidence for vitamin D supplimentation By feeds.bmj.com Published On :: Fri, 25 Nov 2016 16:15:14 +0000 Despite high quality systematic reviews reporting ineffectiveness, many guideline groups continue to recommend vitamin D supplementation (with or without calcium) for fall or fracture prevention. Recently Public Health England recommended that everyone needs vitamin D equivalent to an average daily intake of 10 μg (400 IU) to protect bone and... Full Article
tam Talk evidence - Vitamin D, Oxygen and ethics By feeds.bmj.com Published On :: Fri, 16 Nov 2018 11:30:56 +0000 Welcome to this, trial run, of a new kind of BMJ podcast - here we’re going to be focusing on all things EBM. Duncan Jarvies, Helen Macdonald and Carl Heneghan - and occasional guests- will be back every month to discuss what's been happening in the world of evidence. We'll bring you our Verdict on what you should start or stop doing, geek out... Full Article
tam Vitamin C in Human Health and Disease: Effects, Mechanisms of Action, and New Guidance on Intake By jnm.snmjournals.org Published On :: 2020-04-01T06:00:28-07:00 Full Article
tam Preoperative Localization of Adenomas in Primary Hyperparathyroidism: The Value of 11C-Choline PET/CT in Patients with Negative or Discordant Findings on Ultrasonography and 99mTc-Sestamibi SPECT/CT By jnm.snmjournals.org Published On :: 2020-04-01T06:00:28-07:00 We aimed to assess the value of 11C-choline PET in patients with primary hyperparathyroidism and negative or discordant results on 99mTc-sestamibi imaging and neck ultrasound. Methods: Eighty-seven such patients were assessed and subsequently underwent parathyroidectomy. PET/CT image data were analyzed semiquantitatively using SUVmax and SUV ratios (target to contralateral thyroid gland and carotid artery). A positive PET/CT result was defined as focal uptake significantly higher than regular thyroid tissue. Ectopic foci were also considered positive. Inconclusive PET/CT cases were defined as a lesion with uptake equal to normal thyroid tissue. If no prominent or ectopic uptake was detectable, the PET/CT result was considered negative. Results: When dichotomizing the 11C-choline PET/CT imaging results by defining lesions with both positive and inconclusive uptake as positive, we found 84 of 92 lesions (91.3%) to have true-positive uptake whereas 8 lesions (8.7%) had false-positive uptake. One lesion showed false-negative uptake; the sensitivity was 98.8%. The corresponding positive predictive value for lesions was 91.3%. The mean SUVmax was 6.15 ± 4.92 in 72 lesions with positive uptake (70 patients) and 2.96 ± 2.32 in 20 lesions with inconclusive uptake (18 patients). Conclusion: These results in a large group of patients indicate that 11C-choline PET/CT is a promising tool for parathyroid adenoma localization when ultrasound and 99mTc-sestamibi imaging yield negative or discordant results. Full Article
tam Vitamin E Reduction of Protein Glycosylation in Diabetes: New Prospect for Prevention of Diabetic Complications? By care.diabetesjournals.org Published On :: 1991-01-01 Antonio CerielloJan 1, 1991; 14:68-72Short Report Full Article
tam Serum 25-Hydroxyvitamin D3 Concentrations and Prevalence of Cardiovascular Disease Among Type 2 Diabetic Patients By care.diabetesjournals.org Published On :: 2006-03-01 Massimo CigoliniMar 1, 2006; 29:722-724BR Cardiovascular and Metabolic Risk Full Article
tam Concentrations of Serum Vitamin D and the Metabolic Syndrome Among U.S. Adults By care.diabetesjournals.org Published On :: 2005-05-01 Earl S. FordMay 1, 2005; 28:1228-1230BR Metabolic Syndrome/Insulin Resistance Syndrome/Pre-Diabetes Full Article
tam Tampa Bay Lightning team dentist puts players’ mouths back together again By www.ada.org Published On :: Thu, 27 Feb 2020 09:54:00 -0600 When Dr. Gil Rivera became a dentist, he had no idea his career would take him to the bloodied and bruised front lines of the NHL, but nearly 18 years later, he continues to treat the ravaged mouths of professional hockey players as the team dentist of the Tampa Bay Lightning. Full Article