Systemic study of pathogenic pathways and interrelationships underlying genes associated with Alzheimer's disease (AD) facilitates the identification of new targets for effective treatments. Recently available large-scale multiomics datasets provide opportunities to use computational approaches for such studies. Here, we devised a novel disease gene identification (digID) computational framework that consists of a semi-supervised deep learning classifier to predict AD-associated genes and a protein–protein interaction (PPI) network-based analysis to prioritize the importance of these predicted genes in AD. digID predicted 1,529 AD-associated genes and revealed potentially new AD molecular mechanisms and therapeutic targets including GNAI1 and GNB1, two G-protein subunits that regulate cell signaling, and KNG1, an upstream modulator of CDC42 small G-protein signaling and mediator of inflammation and candidate coregulator of amyloid precursor protein (APP). Analysis of mRNA expression validated their dysregulation in AD brains but further revealed the significant spatial patterns in different brain regions as well as among different subregions of the frontal cortex and hippocampi. Super-resolution STochastic Optical Reconstruction Microscopy (STORM) further demonstrated their subcellular colocalization and molecular interactions with APP in a transgenic mouse model of both sexes with AD-like mutations. These studies support the predictions made by digID while highlighting the importance of concurrent biological validation of computationally identified gene clusters as potential new AD therapeutic targets.

Why the American Ingenuity Award winner believes higher education should be a basic human right

Koshik, an elephant in a South Korean zoo, learned to say five different Korean words (Still: iStock/ROMAOSLO)

Primatologist Tetsuro Matsuzawa studies chimps in hopes of uncovering how they learn and communicate

Lindow Man, believed to be a victim of human sacrifice, remains one of the best preserved ancient bodies in all of Europe. The level of detail on his face is staggering—not bad for a 2,000-year-old mummy

Julie Montagu, the American-born Viscountess Hinchingbrooke, is meeting up with an expert on 18th century dance. Her aim is to learn about the dances performed in that era.

The technology, enabled by thorium atoms, could keep time more accurately than atomic clocks and enable new discoveries about gravity, gravitational waves and dark matter

The grassroots organization, Nihon Hidankyo, was lauded for "demonstrating through witness testimony that nuclear weapons must never be used again"

Malloree Enoch alleges she was sexually coerced by former Whitecaps coach Hubert Busby Jr., who was recently reinstated as head coach of the Jamaican women's national team.

Some educators are giving history classes new relevance by teaching students to be junior historians: offering engaging entry points into Canada's past and inspiring connections to the world today.

Sir Richard Branson, Jeff Ray, Jon Hirschtick, and World-Class Companies to Shine at World’s Largest Annual SolidWorks Gathering

Expanded 3D CAD curriculum gives instructors more time for individual instruction and special projects

3D CAD software helps U.K. retail display company compete on creativity, time to market

Off-Campus, Around-the-Clock Access and Integrated Simulation are Big Advantages for Students

OMer Richard Sharp teaches practical and relevant methods of sharing the Gospel with Portuguese young people at a youth camp.

A Transform 2012 Dancelink team in Mondim, Portugal, clears the way for a Transform Transit team to see the Gospel bear fruit four months later.

OMers work with a Hungarian church to invest in relationships through every season.

OMer Patrick shares his biggest takeaways from serving in sports ministry in Hungary for two years.

Paul and Vivienne, volunteers from the UK, recently visited a centre for asylum seekers in one of Sweden’s large cities and share about their experiences.

A French couple attended the Off The GRID discipleship programme in New Zealand, where they learned about missions and God.

A testimony of change in a Malawian village

Fazeen is a graduate of OM's training programme, through which God changed her life's perspective and direction.

Long-term worker teaches Transform seminar about loving Muslim women, encouraging two participants to deepen relationships with Muslim friends back home.

A News24 Business reader has to pay R500 to receive a debt clearance certificate but is currently unemployed.

The answer is unclear but "the threat is real," English-language-learner advocacy groups say. The advocates say the Education Department has evaded their questions about the future of the office of English-language acquisition.

Education needs to stop going around in circles, writes Stanford’s Thomas S. Dee.

With schools unable to conduct in-person evaluations, schools must find new ways to determine if students need English-language-learner support services.

New sheets outlines how districts can support English-learner students, but concedes that "schools may not be able to provide all services in the same manner they are typically provided."

The selection of Lorena Orozco McElwain as director of the office of English language acquisition shakes up a long-standing tradition.

Native-language assessments may more fully reflect what English-language learners know and can do academically after months away from school. But not all states offer them.

A new report urges districts to pay close attention to how they choose and use technology for students who are not yet fluent in English.

A new database offers a state-by-state look at guidance on supporting English-learner students and their families amid the global pandemic.

Would measurement approaches based on "learning growth" resolve some of the concerns over NCLB?

Should school time be expanded to accommodate new demands? And if so, How?

A more deliberate approach to curriculum, instruction, assessment, and teacher professional development this fall could mean a better experience for students; the lack of one could turn equity gaps into chasms.

The strategy of reinforcing good behavior with praise is the least likely to be taught in teacher-prep programs, an analysis finds.

Support for in-person teaching is rising, but hybrid approaches to instruction remain the most popular, an EdWeek Research Center survey finds.

A pair of multidisciplinary faculty members at Penn State Shenango received an Advancing Equity and Inclusion Grant from the Schreyer Institute for Teaching Excellence to help fund a series of four online workshops focused on project-based learning. 

High-quality professional learning is difficult to provide in education, principal Jasmine Kullar writes. Here's a solution.

A veteran teacher shares how he puts the latest research on growth mindset into action for his students in this guest blog by Jamie M. Carroll and David Yeager.

Teaching and Learning with Technology (TLT), part of Penn State University Libraries, has announced the Teaching and Learning Technologies Faculty Advisory Committee for the 2024-25 academic year. The committee is pivotal in guiding TLT on integrating technology within teaching and learning at Penn State.

Linda M. Gojak and Sara Delano Moore, two of the co-authors of "Visible Learning For Mathematics: What Works Best to Optimize Student Learning", agreed to answer a few questions about the book.

Keisha Oliver, who is pursuing a dual-title doctoral degree in art education and African American and diaspora studies, was named a fall 2024 artist-in-residence at the Penn State College of Engineering’s Learning Factory.

Stefano Terlizzi joined the Ken and Mary Alice Lindquist Department of Nuclear Engineering as the John and Jean M. Brennan Clean Energy Early Career Professor on July 22. In this Q&A, Terlizzi talks about his research background and interests, why he chose Penn State and more.

As teacher strikes sweep the nation, Marc Tucker compares the trajectory of teaching to that of the nursing profession, one of high standards of entry and rigorous preparation.

Public libraries are moving deeper into digital learning, often in partnership with schools and other institutions, to help prepare students for the skills they'll need for college and careers.

U.S. Department of Education money will help public television develop projects promoting math and literacy for children ages 2 to 8.

Summer programs that use multimedia may improve student literacy, numeracy, phonics skills, and math vocabulary, according to a study released by WestEd, a nonprofit education research organization. The report examines the Electric Company's Summer Learning Program, which is sponsored by the Sesame

A new professional development course explores how Penn State faculty members and staff can help the parents, guardians and spouses of online learners while following federal and University privacy policies.