A method is disclosed for preparing a soft tissue site, and augmenting the soft tissue site, such as the breast(s), scar, depression, or other defect, of a subject through use of devices that exert a distractive force on the breast(s) and grafting of autologous fat tissue such as domes with sealing rims for surrounding each of the soft tissue site and a regulated pump. The method for preparing the soft tissue site, and enhancing fat graft results, entails application of the distracting force to the targeted soft tissue site at least intermittently for some period of time and preferably several weeks prior to the graft procedure. A related aspect of the invention includes following the preparation steps by transfer of fat from other areas of the subject to the subject's soft tissue site, and then reapplication of the distractive force to the soft tissue site that received the autologous fat graft. Alternatively, fat from genetically related sources may be used, and the fat may be further processed prior to injection. Substantial soft tissue augmentation, high rates of graft survival and negligible graft necrosis (data demonstrating 80% survival and only 20% necrosis is presented) or calcification result from the practice of these methods.

The invention is directed to an adhesive strip, particularly an adhesive strip or bandage for use in periodontal treatments. The biocompatible adhesive strip comprises a flexible barrier with a biocompatible adhesive for use in an oral environment, wherein the adhesive is in a non-tacky state when dry and becomes adherent upon contact with liquids.

A hydrogel tissue adhesive formed by reacting an aldehyde-functionalized polysaccharide containing pendant aldehyde groups with a water-dispersible, multi-arm amine is described. The hydrogel may be useful as a tissue adhesive or sealant for medical applications that require a more rapid degradation time, such as the prevention of undesired tissue-to tissue adhesions resulting from trauma or surgery.

A hydrogel tissue adhesive having decreased gelation time and decreased degradation time is described. The hydrogel tissue adhesive is formed by reacting an oxidized polysaccharide containing aldehyde groups with a water-dispersible, multi-arm amine in the presence of a thiol additive. The thiol additive accelerates the process to form the hydrogel and accelerates the degradation of the hydrogel formed. The hydrogel may be useful as a tissue adhesive or sealant for medical applications, such as a hemostat sealant or to prevent undesired tissue-to-tissue adhesions resulting from trauma or surgery.

An implant for marking an area within a living body includes a matrix material and a marking material. The implant is formable to fit the shape and size of a cavity in the human body. The implant is configured to support tissue surrounding the cavity and to allow in-growth of fibrous tissue into and replace at least a portion of the matrix material.

The invention pertains to methods of producing artificial composite tissue constructs that permit coordinated motion. Biocompatable structural matrices having sufficient rigidity to provide structural support for cartilage-forming cells and bone-forming cells are used. Biocompatable flexible matrices seeded with muscle cells are joined to the structural matrices to produce artificial composite tissue constructs that are capable of coordinated motion.

The present invention is related to the use of secretagogue peptides repeatedly administered as part of a pharmaceutical composition that prevent and eradicate the deposition of pathological fibrotic material in parenchymal tissues of internal organs like the liver, lungs, esophagus, small intestine, kidneys, blood vessels, joints, and other systemic forms of cutaneous fibrosis of any etiopathogenesis. Additionally, these peptides prevent and eradicate deposition of amiloid and hyaline materials in any of their correspondent chemical forms and tissue manifestations in the brain, cerebellum, blood vessels, liver, intestines, kidneys, spleen, pancreas, joints and the skin, among others. By this way, cellular, tissular and organ dysfunctions generated by these depositions are corrected. The peptides of the present invention are infiltrated or topically applied, contributing to prevent and eradicate keloids and hypertrophic scars in the skin, derived as sequelae of burns and other cutaneous trauma.

Methods and devices for ophthalmic tissue closure and fixation of ophthalmic prostheses are provided. In accordance with some embodiments, devices for both grasping and clipping a plurality of ocular tissue and ocular prostheses are provided. Various device embodiments are provided for both malleable clips and delivery of normally closed clips (i.e. shape memory). The device may accommodate a plurality of clips which include, but are not limited to: malleable metals, absorbable, shape memory, drug-eluting, and adhesive dispensing. The clips may be pigmented to match the colors of associated tissue (cornea, iris, conjunctiva, sclera, retina) to serve to camouflage fixation clips for healing duration or permanently. According to one aspect, shallow angle access to anatomy may be provided by specialized angulation of device shaft and closure jaws that are intended to access the eye through a small self-healing cornea incision and/or any ocular tissue.

A device for deploying a tissue fixation apparatus of the type including first and second tissue anchors coupled together by an adjustable suture assembly. The device comprises a handle mechanism and a needle cartridge assembly releasably coupled to the handle mechanism. The needle cartridge assembly includes a needle cannula with a side opening through which a tissue anchor can be loaded into an internal chamber of the needle cannula. A push rod is disposed in the needle cannula and is operable between an extended position in which the push rod prevents the tissue anchor from entering the chamber through the side opening, and a retracted configuration in which the tissue anchor can be pushed into the chamber under the action of a resilient band positioned over the side opening.

A microwave ablation system includes an energy source adapted to generate microwave energy and a power splitting device having an input adapted to connect to the energy source and a plurality of outputs. The plurality of outputs are configured to be coupled to a corresponding plurality of energy delivery devices. The power splitting device is configured to selectively divide energy provided from the energy source between the plurality of energy devices.

A method and device for controlling the compression of tissue include clamping tissue between a first clamping member and a second clamping member by driving at least one of the clamping members with an electric motor toward a predetermined tissue gap between the clamping members and, during the clamping, monitoring a parameter of the electric motor indicative of a clamping force exerted to the tissue by the clamping members. The method and device include, during the clamping, controlling the electric motor, based on the monitored parameter, to limit the clamping force to a predetermined maximum limit.

The present disclosure relates to surgical fastener applying apparatus and the application of variable compression to tissue. More specifically, the presently disclosed surgical fastener applying apparatus act to limit the flow of blood through tissue immediately adjacent a cut-line formed therein to effectuate hemostasis, while maximizing the flow of blood through tissue more removed from the cut-line to limit unnecessary necrosis. In one embodiment, a surgical fastener applying apparatus is disclosed having a tool assembly coupled to a distal end thereof with first and second jaws respectively including an anvil and a surgical fastener cartridge. The surgical fastener cartridge includes, among other things, angled pushers that engage surgical fasteners of varying lengths.

Devices for attaching a sheet-like implant to a target tissue include a sheath and a staple push rod. The sheath has a distal end configured to be pressed against the target tissue. The staple push rod is disposed within at least a portion of the sheath and is slidable relative thereto. The staple push rod includes a pair of stakes. Each stake is dimensioned to abut a surface of a staple to apply pushing forces thereto. The stakes are biased to assume a bow-like shape such that an intermediate portion of a staple extends tautly between the first stake and the second stake when the stakes are extending beyond the distal end of the tubular member. Methods for attaching a sheet-like implant to a target tissue are also disclosed.

A device for attaching a sheet-like implant to a target tissue. The device includes a fastener push rod including a first portion, a second portion and a force limiting mechanism operably coupled between the first portion and the second portion. A fastener is carried by the second portion of the fastener push rod. The force limiting mechanism transmits longitudinal movement of the first portion to the second portion while the forces applied to the fastener by the fastener push rod are less than a predetermined value such that longitudinal movement of the first portion of the fastener push rod causes substantially equivalent longitudinal movement of the second portion. The force limiting mechanism allows relative longitudinal motion between the first and second portions while the forces applied to the fastener are equal to or greater than the predetermined value such that the application of undue forces to the fastener is prevented.

Circular stapling instruments and anvil assemblies. The anvil assemblies may have collapsible anvil support members that may be inserted through an opening in a patient and then expanded to be attached to an anvil plate assembly that has a staple-forming surface thereon. The anvil support member is attachable to the anvil plate assembly in such a way that when the anvil assembly is coupled to the stapling head of a circular stapler, the staple-forming surface is in substantial registry with the staples supported in the stapling head. A variety of different anvil support members and anvil plate assemblies are disclosed. Various embodiments have a tissue-piercing feature.

A system and process is described for producing spirally wound products. According to the process of the present disclosure, two or more webs are conveyed together in a superimposed relationship. The webs are then separated such that one web goes to a first winding module while a second web goes to a second winding module, etc. In this manner, at least two spirally wound products can be produced simultaneously. The process and system of the present disclosure are particularly well suited for processing tissue webs, such as paper towels and bath tissue. The process of the present disclosure can effectively at least double throughput on existing winding systems.

A toilet tissue roll holder is provided having a telescoping structure that is attachable to a wall surface for providing replacement toilet tissue to a dispenser and shrouding unused rolls prior to deployment. The device includes a lowermost housing having a base surface, rounded sidewalls, an interior volume, and an open front. The lowermost housing connects to a first upstanding sidewall thereabove, which in turn supports a plurality of telescoping sidewalls that form individual toilet tissue roll containers extending upward. A viewing window is provided through at least one of the device sidewalls above the lowermost housing to allow an administrator to visualize whether a minimum number of reserve toilet paper rolls are still available. The structure is expanded and contracted depending on the number of rolls therein, while the lowermost housing and first upstanding sidewall provide the base structure that is secured to a support wall.

A radio-frequency (RF) amplifier having a direct response to an arbitrary signal source to output one or more electrosurgical waveforms within an energy activation request, is disclosed. The RF amplifier includes a phase compensator coupled to an RF arbitrary source, the phase compensator configured to generate a reference signal as a function of an arbitrary RF signal from the RF arbitrary source and a phase control signal; at least one error correction amplifier coupled to the phase compensator, the at least one error correction amplifier configured to output a control signal at least as a function of the reference signal; and at least one power component coupled to the at least one error correction amplifier and to a high voltage power source configured to supply high voltage direct current thereto, the at least one power component configured to operate in response to the control signal to generate at least one component of the at least one electrosurgical waveform.

A tissue fastener production method of clamping two living tissues together by bringing the two living tissues into close contact includes the following steps: fixing one end of a wire material made of a metal to a shaft body, and winding the wire material around an outer periphery of the shaft body while twisting the wire material round an axis of the wire material, thereby forming a coil on which a predetermined force is exerted in the winding direction; heat treating the wire material to impart superelasticity thereto; and deforming the wire material to which the superelasticity is imparted in a range in which the wire material is elastically deformable, and reversing the winding direction of the coil in a direction reverse to the winding direction of the coil wound in the step of forming the coil so as to obtain an initial tension corresponding to the predetermined force.

Apparatuses, systems, and methods for applying reduced pressure to a tissue site on a foot are provided. An apparatus may include an insole and a tissue contacting surface covering at least a portion of the insole. At least one portion of the tissue contacting surface is removable to form a void. The apparatus may also include a reduced-pressure interface for receiving reduced pressure from a reduced-pressure source, and at least one flow channel fluidly coupled to the reduced-pressure interface and the void.

A modular engineered tissue construct includes a plurality of fused self-assembled, scaffold-free, high-density cell aggregates. At least one cell aggregate includes a plurality of cells and a plurality of biocompatible and biodegradable nanoparticles and/or microparticles that are incorporated within the cell aggregates. The nanoparticles and/or microparticles acting as a bulking agent within the cell aggregate to increase the cell aggregate size and/or thickness and improve the mechanical properties of the cell aggregate as well as to deliver bioactive agents.

The present invention provides a modified cellulosic fiber having reduced hydrogen bonding capabilities. The modified fiber formed in accordance with the present invention may be useful in the production of tissue products having improved bulk and softness. More importantly, the modified fiber is adaptable to current tissue making processes and may be incorporated into a tissue product to improve bulk and softness without an unsatisfactory reduction in tensile.

Methods and systems for preserving tissues in situ using critical point drying are disclosed. Such methods and systems are particularly applicable to the preservation of a deceased body, such as a deceased person or animal, with or without removal of internal tissues or organs. A fixative can be perfused through the vascular system of the body while blood is removed from the body. The exterior of the body can also be immersed in a bath of fixative. The fixative in the vascular system and the bath can be replaced by subsequent washes of buffer, de-ionized water, and/or alcohol. The alcohol-infused and fixated body can be disposed in a pressure chamber and subjected to a critical point drying process using carbon dioxide. After the critical point drying process, the body is in a preserved state.

A seed sampling system is provided having an automated seed loading assembly including a seed bin and being operable to singulate seeds from a plurality of seeds within the seed bin. The system also includes an automated seed sampling assembly operable to remove tissue samples from the singulated seeds, and an automated seed transport assembly operable to transfer the singulated seeds from the seed loading assembly to the seed sampling assembly. The seed transport assembly includes multiple retention members. Each of the retention members is movable relative to the seed loading assembly and to the seed sampling assembly. The seed transport assembly is operable to position one of the multiple retention members adjacent to the seed loading assembly for engaging one of the singulated seeds, while positioning another of the retention members adjacent to the seed sampling assembly for presenting another of the singulated seeds to the seed sampling assembly.

The present document describes an electrophoretic tissue clearing chamber comprising an electrophoresis channel, configured to receive a clarification fluid therethrough; a first clarification fluid inlet, in fluid communication with the electrophoresis channel, configured to be connected to a source of the clarification fluid; a tissue sample holder in fluid communication with the electrophoresis channel, configured to receive a tissue sample to be clarified, and pressurize and homogenously apply the clarification fluid onto the tissue sample; a clarification fluid outlet, in fluid communication with the tissue sample holder, for exit of the clarification fluid from the electrophoretic tissue clearing chamber; and first and a second electrode, opposite one another in the electrophoresis channel, for transmission of an electric field therethrough.

The present disclosure relates to use of high-concentration aldehyde-based fixatives to fix tissue samples. Aldehyde concentrations are selected that significantly increase rate of diffusion of the fixative solution into the tissue. When combined in the cold-temperature step of a two-temperature fixation, a substantial improvement in the preservation of post-translationally modified proteins is achieved.

To provide a method of producing scented tissue paper. The problem is solved by performing shrink wrapping in which a tissue paper housing obtained by carrying fragrance-containing microcapsules on an inner surface of a housing box using a binder is covered with a shrink film and the shrink film is exposed to hot air W so as to be attached to the tissue paper housing, causing the fragrance-containing microcapsules to be detached from the binder by heating the tissue paper housing at the time of the shrink wrapping, and providing the scent for plural sheets of tissue papers.

They have been allowed to wander free for centuries and as such have attracted thousands upon thousands of visitors.

It's always a treat when a lady with true southern charm makes an appearance on the Friday Feature Interview of the Week. WNCW welcomed back Our State Magazine Editor-in-chief Elizabeth Hudson to talk about the upcoming May issue titled 'The Hiking Issue.' Page by page, Hudson takes us on a tour, mostly across Western North Carolina, to look at topics featured in this issue, from great trails, to views, to good eats. Hudson also talks about how the popular magazine has been affected by the COVID-19 pandemic. This segment first aired April 24, 2020. Posted by Host and Producer of WNCW's Friday Feature- Paul Foster, Senior Producer, News Director, and Morning Edition Regional Host

The Ohio School Boards Association says voters Tuesday approved a smaller percentage of school tax issues on the primary ballot than in the previous primary election.

It's been forecast that this spring will be quite wet. That could bring flooding to portions of Washtenaw County. Washtenaw County Water Resources Commissioner Evan Pratt joined WEMU's David Fair to discuss planning for such issues and the proactive nature of work already underway on this week's "Issues of the Environment."

Bank signs up to help magazine during coronavirus crisis.

It's so easy... a child can do it!

Draft maps have today been published, outlining which roads are set to be covered by the city’s 20 is Plenty scheme.

Under the e-token system, customers are given specific time for purchasing alcohol so that there is no violation of social distancing norms by people queuing up outside liquor stores.

Thanks to philanthropic support — and your readership — we will spend the next two years examining tribes in Arizona and the Southwest.

Under the e-token system, customers are given specific time for purchasing alcohol so that there is no violation of social distancing norms by people queuing up outside liquor stores.

Hanung Toys and Textile Ltd owes Rs 2,300 crore from a consortium of 15 lenders led by state-owned PNB, which alone has exposure of Rs 599 crore.

Even at locations open to deliveries, e-commerce players are facing manpower crunch due to travel restrictions on delivery partners.

"The total sanitiser licenses issued in the state is 48 and production ramped up to 50,000 litres per day," Additional Chief Secretary, Information, Awanish Awasthi, told reporters.

Three Republicans made their cases for why they deserve their party's nomination for the 17th Congressional District this March.

As the Illinois primary election draws closer, college students are preparing to cast their votes. Some for the first time. As part of our series, "You're the Boss," we asked several NIU voters at campus voter registration events about their most important issues in the election, and what questions they would ask candidates and current officeholders directly if they had the chance. Here's what they had to say: Salvador Meza, electrical and computer engineering major, Chicago “Well, on a national level, there seems to be a lot of division within the country. It would be nice to have a candidate that can united on both sides, see both sides of the matter. That would be the primary thing. Definitely immigration. Right now immigration is a big thing for me at least. On the state level, definitely taxes. Taxes need to get a little bit sorted on what’s going on, but what’s new in Illinois, right?” “I’d definitely ask them what would be their plan for immigration for not only the DACA

Lights On G1 are calling for donations of tinned food, washing powder and soap.

Rangers vice-chairman John Bennett has criticised the SPFL for their 'cynical tactics' over their labelling of the club's dossier as a "smoking gun" - and insists the issue is not merely Gers vs the governing body.

Select Family Law Issues: Host Jeffrey Hayden welcomes family law specialists certified by the California Board of Legal Specialization -- Janet Frankel, whose office is in San Francisco; B J Fadem, with office in San Jose. Both are members of the Family Law Section of the California Lawyers Association. Questions for BJ and Janet? Please call toll-free 866-798-8255. Also, this evening is our once-a-month Call-A-Lawyer Night. The number to call for Call-A-Lawyer is (800) 525-9917. While Your Legal Rights broadcasts 7 'til 8pm PDT, 91.7 FM (online kalw.org), attorneys are available off-the-air as well on the same number: 800-525-9917, for private no-fee consultation on a variety of legal questions. Plus, Thursday, May 31st, Leon Bayer, Certified Specialist in Bankruptcy Law, will take calls on Bankruptcy: 800-477-3111, 9am 'til Noon, for Mr Bayer's no-obligation public service to KALW listeners.

Landlord/Tenant -- Host Jeff Hayden welcomes Sal Timpano to consider issues, laws & initiatives as Elections loom, November 6th. Ballot propositions borrowed here from a round-up by Capital Public Radio's Emily Zentner: Allowing Local Authorities to Enact Rent Control measures, Prop 10 would give Cali localities freedom to enact rent controls. On this November's ballot, Proposition 10 would repeal the Costa-Hawkins Rental Housing Act and its ban on certain types of rent control [http://www.capradio.org/articles/2018/06/20/rent-control-is-coming-to-californias-november-ballot-heres-whats-at-stake/], including protections for tenants of single-family homes, condos and apartments built after 1995. Also check Liza Veale's KALW capsule on Prop 10 Other props pertinent to housing are 1, 2 & 5. Recently, San Franciscans voting in June 2018, enacted Prop F. As described in National Low Income Housing Coalition (NLIHC) report leads off: "During the California state primary election on

Pollution found in our air and water can lead to serious health issues. A new report from the Children’s Environmental Health Network explored such risks, especially for children. Michigan Environmental Council program director Tina Reynolds discusses the report with WEMU's David Fair in this week's "Issues of the Environment."

The 1,4 dioxane plume emanating from the old Gelman Sciences facility on Wagner Road in Scio Township continues to expand through groundwater in the greater Ann Arbor area. At a recent public forum, the federal Environmental Protection Agency said it would take decades to get the contamination designated as a Superfund site and clean-up could take decades beyond that. In this week's "Issues of the Environment," WEMU's David Fair talks to Washtenaw County Board of Commissioners chair Jason Morgan about what is happening now to better address the environmental threat.

PFAS contamination continues to threaten Michigan's environment, as well as the health of its citizens. Over the past month, action at the state level has been taken to fight this problem. In this week's "Issues of the Environment," Rebecca Esselman, executive director of the Huron River Watershed Council, discusses progress and challenges with WEMU's David Fair.

By all accounts, electric vehicles are the future. Right now, EV’s comprise a small percentage of the automotive marketplace. A new study from the Ecology Center in Ann Arbor shows the electric vehicles owners are paying far more in taxes and fees and that can serve as a disincentive to purchase. The center’s Charles Griffith joined WEMU’s David Fair for this week’s "Issues of the Environment" to share the study’s findings and discuss the need to create policy that will create tax parity for EV vehicles.