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Chaldean Patriarchate to restore ancient manuscripts, rebuil...

By www.atour.com
Published On :: Tue, 09 Jul 2013 01:21:00 UT

Chaldean Patriarchate to restore ancient manuscripts, rebuild Christian future


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Assyro-Chaldeans with their Syriac Churches formed a Civiliz...

By www.atour.com
Published On :: Fri, 06 Dec 2019 06:03:00 UT

Assyro-Chaldeans with their Syriac Churches formed a Civilization


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Comprehensive Mideast Peace Plan

By www.atour.com
Published On :: Fri, 05 Oct 2018 12:42:00 UT

Comprehensive Mideast Peace Plan


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  • Perspective: Editorials | Guest-Editorials | Letters
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WMX Americas closes doors after two days of super-charged debate, collaboration and deal-making

By postandparcel.info
Published On :: Wed, 21 Feb 2024 14:19:09 +0000

WMX Americas closed its doors after a successful two days. One clear key message from the conference was there has to be a better focus on the customer. Customer experience, customer journey and customer feedback were all key takeaways.


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ZigZag Survey proves that customers can come round to the idea of paid returns

By postandparcel.info
Published On :: Mon, 30 Sep 2024 10:21:27 +0000

Returns specialist ZigZag has published the results of a survey which indicates that one-off fees for returns are preferable to price rises on items among consumers.


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The Biology Of Why Coronavirus Is So Deadly

By scienceblogs.com
Published On :: Thu, 02 Apr 2020 18:02:27 +0000

The Biology Of Why Coronavirus Is So Deadly

COVID-19 is caused by a coronavirus called SARS-CoV-2. Coronaviruses belong to a group of viruses that infect animals, from peacocks to whales. They’re named for the bulb-tipped spikes that project from the virus’s surface and give the appearance of a corona surrounding it.

A coronavirus infection usually plays out one of two ways: as an infection in the lungs that includes some cases of what people would call the common cold, or as an infection in the gut that causes diarrhea. COVID-19 starts out in the lungs like the common cold coronaviruses, but then causes havoc with the immune system that can lead to long-term lung damage or death.

SARS-CoV-2 is genetically very similar to other human respiratory coronaviruses, including SARS-CoV and MERS-CoV. However, the subtle genetic differences translate to significant differences in how readily a coronavirus infects people and how it makes them sick.

 

SARS-CoV-2 virus particles (pink dots) on a dying cell. National Institute of Allergy and Infectious Diseases, NIH

 

SARS-CoV-2 has all the same genetic equipment as the original SARS-CoV, which caused a global outbreak in 2003, but with around 6,000 mutations sprinkled around in the usual places where coronaviruses change. Think whole milk versus skim milk.

Compared to other human coronaviruses like MERS-CoV, which emerged in the Middle East in 2012, the new virus has customized versions of the same general equipment for invading cells and copying itself. However, SARS-CoV-2 has a totally different set of genes called accessories, which give this new virus a little advantage in specific situations. For example, MERS has a particular protein that shuts down a cell’s ability to sound the alarm about a viral intruder. SARS-CoV-2 has an unrelated gene with an as-yet unknown function in that position in its genome. Think cow milk versus almond milk.

 

How the virus infects

 

Every coronavirus infection starts with a virus particle, a spherical shell that protects a single long string of genetic material and inserts it into a human cell. The genetic material instructs the cell to make around 30 different parts of the virus, allowing the virus to reproduce. The cells that SARS-CoV-2 prefers to infect have a protein called ACE2 on the outside that is important for regulating blood pressure.

The infection begins when the long spike proteins that protrude from the virus particle latch on to the cell’s ACE2 protein. From that point, the spike transforms, unfolding and refolding itself using coiled spring-like parts that start out buried at the core of the spike. The reconfigured spike hooks into the cell and crashes the virus particle and cell together. This forms a channel where the string of viral genetic material can snake its way into the unsuspecting cell.

An illustration of the SARS-CoV-2 spike protein shown from the side (left) and top. The protein latches onto human lung cells. 5-HT2AR/Wikimedia

SARS-CoV-2 spreads from person to person by close contact. The Shincheonji Church outbreak in South Korea in February provides a good demonstration of how and how quickly SARS-CoV-2 spreads. It seems one or two people with the virus sat face to face very close to uninfected people for several minutes at a time in a crowded room. Within two weeks, several thousand people in the country were infected, and more than half of the infections at that point were attributable to the church. The outbreak got to a fast start because public health authorities were unaware of the potential outbreak and were not testing widely at that stage. Since then, authorities have worked hard and the number of new cases in South Korea has been falling steadily.

 

How the virus makes people sick

 

SARS-CoV-2 grows in type II lung cells, which secrete a soap-like substance that helps air slip deep into the lungs, and in cells lining the throat. As with SARS, most of the damage in COVID-19, the illness caused by the new coronavirus, is caused by the immune system carrying out a scorched earth defense to stop the virus from spreading. Millions of cells from the immune system invade the infected lung tissue and cause massive amounts of damage in the process of cleaning out the virus and any infected cells.

Each COVID-19 lesion ranges from the size of a grape to the size of a grapefruit. The challenge for health care workers treating patients is to support the body and keep the blood oxygenated while the lung is repairing itself.

 

How SARS-CoV-2 infects, sickens and kills people

 

SARS-CoV-2 has a sliding scale of severity. Patients under age 10 seem to clear the virus easily, most people under 40 seem to bounce back quickly, but older people suffer from increasingly severe COVID-19. The ACE2 protein that SARS-CoV-2 uses as a door to enter cells is also important for regulating blood pressure, and it does not do its job when the virus gets there first. This is one reason COVID-19 is more severe in people with high blood pressure.

SARS-CoV-2 is more severe than seasonal influenza in part because it has many more ways to stop cells from calling out to the immune system for help. For example, one way that cells try to respond to infection is by making interferon, the alarm signaling protein. SARS-CoV-2 blocks this by a combination of camouflage, snipping off protein markers from the cell that serve as distress beacons and finally shredding any anti-viral instructions that the cell makes before they can be used. As a result, COVID-19 can fester for a month, causing a little damage each day, while most people get over a case of the flu in less than a week.

At present, the transmission rate of SARS-CoV-2 is a little higher than that of the pandemic 2009 H1N1 influenza virus, but SARS-CoV-2 is at least 10 times as deadly. From the data that is available now, COVID-19 seems a lot like severe acute respiratory syndrome (SARS), though it’s less likely than SARS to be severe.

 

What isn’t known

 

There are still many mysteries about this virus and coronaviruses in general – the nuances of how they cause disease, the way they interact with proteins inside the cell, the structure of the proteins that form new viruses and how some of the basic virus-copying machinery works.

Another unknown is how COVID-19 will respond to changes in the seasons. The flu tends to follow cold weather, both in the northern and southern hemispheres. Some other human coronaviruses spread at a low level year-round, but then seem to peak in the spring. But nobody really knows for sure why these viruses vary with the seasons.

What is amazing so far in this outbreak is all the good science that has come out so quickly. The research community learned about structures of the virus spike protein and the ACE2 protein with part of the spike protein attached just a little over a month after the genetic sequence became available. I spent my first 20 or so years working on coronaviruses without the benefit of either. This bodes well for better understanding, preventing and treating COVID-19.

By Benjamin Neuman, Professor of Biology, Texas A&M University-Texarkana. This article is republished from The Conversation under a Creative Commons license. Read the original article.

The Conversation Thu, 04/02/2020 - 14:02
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Life Sciences


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Genetically Rescued Organism: Toward A Solution For Sudden Oak Death

By scienceblogs.com
Published On :: Mon, 08 Nov 2021 22:47:18 +0000

Genetically Rescued Organism: Toward A Solution For Sudden Oak Death

Sudden oak death, caused by the pathogen Phythophthora ramorum, is one of the most ecologically devastating forest diseases in North America, responsible for the deaths of millions of oaks and tanoaks along the coast.

Science to the rescue? After the success of genetically modified organisms in things like insulin and food, a recent trend is Genetically Rescued Organisms. These GROs would use science to create natural resistance, like a vaccine for plants, and reduce the impact of altered species composition, released carbon pools, and greater fire risk the deaths bring.

Before that can happen, scientists need to better understand the basic biology of Phythophthora ramorum, including how well it sporulates on common plants.


Image by RegalShave from Pixabay

Scientists at the University of California, Davis, set out to investigate the sporulation potential of this pathogen on common California plant species. They collected leaves from 13 common plant hosts in the Big Sur-region and inoculated them with the causal pathogen. They found that most of the species produced spores, though there was a ride range, with bay laurel and tanoak producing significantly more sporangia than the other species. They also observed an inconsistent relationship between sporulation and lesion size, indicating that visual symptoms are not a reliable metric of sporulation potential.

 “Our study is the first to investigate the sporulation capacity on a wide range of common coastal California native plant species and with a large enough sample size to statistically distinguish between species," explained first author Dr. Lisa Rosenthal. "It largely confirms what was previously reported in observational field studies – that tanoak and bay laurel are the main drivers of sudden oak death infections—but also indicates that many other hosts are capable of producing spores.”

Citation: Lisa M. Rosenthal, Sebastian N. Fajardo, and David M. Rizzo, Sporulation Potential of Phytophthora ramorum Differs Among Common California Plant Species in the Big Sur Region, Plant Disease 17 Aug 2021 https://doi.org/10.1094/PDIS-03-20-0485-RE

sb admin Mon, 11/08/2021 - 17:47
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Life Sciences


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L.A. County reports first West Nile virus death this year

By www.latimes.com
Published On :: Fri, 27 Sep 2024 10:00:26 GMT

A San Fernando Valley resident is the first person in L.A. County to die this year from West Nile virus, a mosquito-transmitted illness that can cause lethal inflammation in the brain.


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'More serious than we had hoped': Bird flu deaths mount among California dairy cows

By www.latimes.com
Published On :: Fri, 4 Oct 2024 17:47:31 GMT

Although California dairy farmers anticipated a bird flu mortality rate of less than 2%, some say between 10% and 15% of infected cattle are dying.


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As bird flu outbreaks rise, piles of dead cattle become shocking Central Valley tableau

By www.latimes.com
Published On :: Sun, 20 Oct 2024 10:00:44 GMT

Although California dairy farmers had heard about the H5N1 bird flu before it hit, none was prepared for the devastation it would cause in some herds.


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Health groups call for suspending state plan on maternal deaths, saying it burdens patients

By www.latimes.com
Published On :: Tue, 29 Oct 2024 10:00:55 GMT

Maternal health organizations and advocates are urging the California surgeon general to suspend the rollout of a plan aimed at reducing maternal mortality.


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Jim Williams: Second-screen options draw U.S. Open to ESPN deal

By www.washingtonexaminer.com
Published On :: Sat, 18 May 2013 04:00:00 GMT

On Thursday, the USTA announced a new 11-year multiplatform broadcast deal with ESPN. The deal will start in 2015 and will make the network the exclusive home of all U.S. Open tennis tournament coverage.


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Off-duty California deputy shot dead by police on golf course

By www.washingtonexaminer.com
Published On :: Thu, 17 Aug 2023 07:16:48 GMT

An off-duty Los Angeles County Sheriff's Department deputy was shot and killed by police at a golf course on Tuesday after he allegedly started shooting his gun following a domestic situation.


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Jon Rahm jumping from PGA Tour to LIV with over $300 million deal: Report

By www.washingtonexaminer.com
Published On :: Thu, 07 Dec 2023 23:03:19 GMT

Golfer Jon Rahm is reportedly jumping from the PGA Tour to the Saudi-backed LIV Golf and is expected to receive a lucrative payday for his move.


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LIV-PGA agreement deadline expected to be extended: Report

By www.washingtonexaminer.com
Published On :: Fri, 29 Dec 2023 20:11:01 GMT

A deal between the PGA Tour and LIV Golf is not expected by Dec. 31, but the deadline is expected to be extended as the two entities reportedly appear within sight of making a deal.


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Apple announces deal with OpenAI. Will it be a game-changer?

By www.latimes.com
Published On :: Mon, 10 Jun 2024 19:28:54 GMT

Apple announced new artificial intelligence-powered tools, including a partnership with OpenAI that allows Siri to surface answers from ChatGPT.


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Elon Musk blasts Apple's OpenAI deal over alleged privacy issues. Does he have a point?

By www.latimes.com
Published On :: Wed, 12 Jun 2024 20:37:19 GMT

The Tesla and SpaceX leader's beef with OpenAI flared up again after Apple unveiled its plans to use ChatGPT to support some of its AI features. Apple said privacy is a key component of its entry into the space.


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Will Google strike a deal with California news outlets to fund journalism?

By www.latimes.com
Published On :: Wed, 26 Jun 2024 00:43:53 GMT

California news publishers and Big Tech companies appear to be inching toward compromise on legislation requiring digital platforms to pay news outlets.


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Deal reached in feud between California news outlets and Google: $250 million to support journalism but no new law

By www.latimes.com
Published On :: Wed, 21 Aug 2024 21:25:18 GMT

Lawmakers agree to shelve the California Journalism Preservation Act, which aimed to revive the struggling news business by forcing Google to pay for news content it distributes.


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How AI might help researchers make esophageal cancer less deadly

By www.latimes.com
Published On :: Mon, 16 Sep 2024 10:00:29 GMT

To improve survival for esophageal cancer patients, researchers are using artificial intelligence to improve screening for the disease.


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AI? New jobs? California's local news deal with Google leaves lots of unanswered questions

By www.latimes.com
Published On :: Fri, 20 Sep 2024 10:00:25 GMT

Weeks after California announced a $250 million public-private partnership with Google to fund local news outlets and develop AI, many aspects of the deal remain uncertain.


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Sensual Mystique Bandeau top sectioned suit.

By www.newlook.com.sg
Published On :: Wed, 5 Sep 2007 16:11:51 GMT

Bandeau top sectioned suit with rings down center front. Sensual and sexy in soft and comfortable fabric. Designed in USA. Black color only. Sizes S-M and M-LXL. See Sizechart. Price: USD19.54


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Intimidea Repose 40.

By www.newlook.com.sg
Published On :: Sun, 11 Dec 2011 16:11:53 GMT

Relaxing tights with graduated compression in 40 deniers from Intimidea. Helps to relief tired legs and reduce leg swelling. Ideal for user who stands or sits for long period. Matt semi-sheer look. Reinforced body and reinforced toe for durability. With gusset for hygiene and convenience. See Sizechart. Price: USD8.22


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Intimidea Cotton Hipster Short.

By www.newlook.com.sg
Published On :: Mon, 6 Feb 2012 16:11:53 GMT

Fashion YOU&ME cotton high leg hipster short from Intimedia. Natural comfort on the skin. See Sizechart. Price: USD9.73


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New collection: Intimidea Ice-Land Legging 120d

By www.newlook.com.sg
Published On :: Fri, 29 May 2009 00:31:18 +0800

Sensational Italian made ultra-opaque (120 denier) legging in comfort microfibre, from Intimidea®.

Ankle long leggings (footless tights) in soft comfort waistband. With cotton gusset for comfort.

See sizechart at:
http://www.newlook.com.sg/sizechart.asp?style=ND92018


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New collection: Intimidea Legging Treccia/Costa Montana Fashion 70d

By www.newlook.com.sg
Published On :: Fri, 29 May 2009 00:34:04 +0800

Sensational Italian made opaque legging in plait/rib pattern. 70 denier, from Intimidea®.

Sheer to waist. Calf long leggings (footless tights) in soft comfort waistband. With flat seams and cotton gusset for comfort.

See sizechart at:
http://www.newlook.com.sg/sizechart.asp?style=ND92057


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New collection: Intimidea Ice-Land 100 Vita Bassa 100d

By www.newlook.com.sg
Published On :: Sun, 31 May 2009 13:29:06 +0800

Beautifully made Italian ultra-opaque low waist woman tights in comfort microfibre.

Sheer to waist. Matt. Soft waistband with cotton gusset for comfort.

See sizechart at:
http://www.newlook.com.sg/sizechart.asp?style=ND92015


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New collection: Intimidea Effect 70 Collant

By www.newlook.com.sg
Published On :: Sun, 31 May 2009 23:28:51 +0800

Sensational Italian made graduated compression tights in 70 denier. Gives you a relaxing feeling and benefits from the anti-tiring effect with tonic and massage action.

Control top with in soft comfort waistband. With cotton gusset for comfort.

See sizechart at:
http://www.newlook.com.sg/sizechart.asp?style=ND92011


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New collection: Intimidea Elegance 8 collant

By www.newlook.com.sg
Published On :: Tue, 2 Jun 2009 04:13:30 +0800

Sensational Italian made ultra-sheer tights in 8 denier. Sheer to waist with invisible toe.

Flat seams for comfort. Cotton gusset for convenience. Semi-matt.

See sizechart at:
http://www.newlook.com.sg/sizechart.asp?style=ND92019


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New collection: Intimidea Fitness Cyclist Pants

By www.newlook.com.sg
Published On :: Wed, 3 Jun 2009 01:31:51 +0800

Sensational Italian made fitness cyclist short pants. Knitted with containing special techno fibre with "X-Force" to provide high resistance and durability.

Made with precious soft microfibre for extra comfort and support. Cotton gusset for added protection and comfort.

See sizechart at:
http://www.newlook.com.sg/sizechart.asp?style=ND61007


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New collection: Intimidea Fascia Bandeau

By www.newlook.com.sg
Published On :: Fri, 5 Jun 2009 01:05:01 +0800

Beautifully made Italian lingerie - bandeau in comfort microfibre. Anotomic with light support.

Strapless for the sensational look and feel.

See sizechart at:
http://www.newlook.com.sg/sizechart.asp?style=ND11317


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New collection: Intimidea Reggiseno Beverly Hills

By www.newlook.com.sg
Published On :: Fri, 5 Jun 2009 01:06:39 +0800

Beautifully made Italian lingerie - Beverly Hills bra in comfort microfibre. Anotomic with light support.

Fine straps for the sensational look and feel.

See sizechart at:
http://www.newlook.com.sg/sizechart.asp?style=ND11147


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New collection: Intimidea Fitness Reggiseno T-back

By www.newlook.com.sg
Published On :: Fri, 5 Jun 2009 01:07:16 +0800

Sensational fitness T-back bra from Italy. Special techno fibre with "X-Force", providing high resistance and durability.

Made with precious soft microfibre for extra comfort and support.

See sizechart at:
http://www.newlook.com.sg/sizechart.asp?style=ND11192


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New collection: Intimidea T-Shirt Roundneck Valencia

By www.newlook.com.sg
Published On :: Fri, 12 Jun 2009 15:07:00 +0800

Stylish Italian made round neck T-Shirt, half sleeves "raglan". Luxurious T-Shirt in soft microfibre for extra comfort.

See sizechart at:
http://www.newlook.com.sg/sizechart.asp?style=ND21845


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New collection: Intimidea Body Saint Michel

By www.newlook.com.sg
Published On :: Fri, 19 Jun 2009 02:21:57 +0800

Sensational Italian made teddy with V neckline and long sleeves in laced trim.

Seamless in soft microfibre for comfort. Eye-and-hook crotch area for convenience.

See sizechart at:
http://www.newlook.com.sg/sizechart.asp?style=ND51079


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New collection: Intimidea Elegance 20 Collant

By www.newlook.com.sg
Published On :: Mon, 19 Apr 2010 19:08:58 +0800

Beautifully Italian made 20den semi-matt woman pantyhose. Sheer to waist with flat seam. Soft waistband with cotton gusset for comfort. See sizechart: http://www.newlook.com.sg/nd/sizechart5.jpg


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New collection: Intimidea Elegance 20 Vita Bassa Collant

By www.newlook.com.sg
Published On :: Tue, 20 Apr 2010 01:43:24 +0800

Beautifully Italian made 20den semi-matt woman pantyhose in low waist>. Sheer to waist with flat seam. Soft waistband with cotton gusset for comfort. See sizechart: http://www.newlook.com.sg/nd/sizechart3.jpg


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New collection: Intimidea Ice-Land 100 Collant

By www.newlook.com.sg
Published On :: Thu, 22 Apr 2010 23:18:52 +0800

Beautifully Italian made 100den opaque pantyhose in comfort microfibre.

Sheer to waist. Matt. Soft waistband with cotton gusset for comfort. Nero color only. Sizes 1/2, 3, 4 and 5.

See sizechart:
http://www.newlook.com.sg/nd/sizechart5.jpg


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New collection: Intimidea Collant 20 Line

By www.newlook.com.sg
Published On :: Tue, 27 Apr 2010 04:33:53 +0800

Beautifully Italian made highly stretchable sheer 20den pantyhose with backseam by Intimidea. Sheer to waist with nude toe. Soft waistband with cotton gusset for comfort. Semimatt look. See sizechart: http://www.newlook.com.sg/nd/sizechart3.jpg


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New collection: Intimidea Elegance 20 Autoreggente

By www.newlook.com.sg
Published On :: Fri, 30 Apr 2010 06:20:00 +0800

Sensational Italian made highly stretchable sheer stayups stockings in 20den by Intimidea®. Comfort silicone lace band. Semi-matt look. See sizechart: http://www.newlook.com.sg/nd/sizechart2.jpg


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New collection: Intimidea Essential 15 Collant

By www.newlook.com.sg
Published On :: Wed, 12 May 2010 12:06:38 +0800

Sensational Italian made pantyhose highly stretchable sheer women pantyhose in 15den from Intimidea®. Matt look. Reinforced panty area. See sizechart: http://www.newlook.com.sg/nd/sizechart5.jpg


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New collection: Intimidea Essential 15 Collant XL

By www.newlook.com.sg
Published On :: Tue, 18 May 2010 02:15:58 +0800

Sensational Italian made pantyhose highly stretchable sheer women pantyhose in 15den size 5 (XL) from Intimidea®. Matt look. Reinforced panty area. See sizechart: http://www.newlook.com.sg/nd/sizechart5.jpg


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New collection: Intimidea Line 20 Autoreggente

By www.newlook.com.sg
Published On :: Thu, 19 May 2011 18:35:43 +0800

Sensational Italian made stayup stockings with black backseam in 20den by Intimidea®.

Comes with precious silicone lace band in distinctive stripes pattern. Boarded with foot shape for the better fitting and extra comfort.

See sizechart: http://www.newlook.com.sg/nd/sizechart2.jpg


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New collection: Intimidea Attraction Rete Collant

By www.newlook.com.sg
Published On :: Sun, 5 Jun 2011 23:23:27 +0800

Sensational Italian made Fishnet tights from Intimidea®.

Knitted in thick durable fibre with more spandex for greater stretchability. With highly elastic comfort waistband. Comes with cotton gusset.

See sizechart: http://www.newlook.com.sg/nd/sizechart2.jpg


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New collection: Intimidea Jegging Denim

By www.newlook.com.sg
Published On :: Mon, 28 Nov 2011 08:25:57 +0800

Seasons fashion jegging denim from Intimidea®, combining leggings and jeans into one. Microfibre leggings with jeans effect and orange stitches.

Contains breathable microfiber which is highly comfortable. Seamless for additional comfort.

See sizechart: http://www.newlook.com.sg/nd/sizechartg2.jpg


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Stock replenishment: Intimidea

By www.newlook.com.sg
Published On :: Sun, 30 Dec 2012 01:54:44 +0800

Stock replenishment for the following styles of Intimidea® collection:


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