CES 2019, LAS VEGAS – JANUARY 7, 2019 – Today’s discerning audio consumer is seeking sophisticated design and innovative technology that seamlessly blends with their daily lives. When it comes to a multi-room speaker system that means: ease of use, form...

At this year’s North American International Auto Show (NAIAS) in Detroit, HARMAN and its automotive partners brought the latest evolution of premium in-car experiences that reflect and seamlessly connect with your lifestyle. Ensuring users are...

Companies across the globe are focused on delivering voice-enabled products to their customers. However, voice technology is a nascent, complicated one that few companies can develop internally, without any collaboration. Enter, HARMAN Embedded Audio. A...

HARMAN is gearing up to present its best-in-class audio technologies and solutions for many of the world’s foremost automotive OEMs at IAA 2019 from September 12-22 in Frankfurt/Main. Now in its 68th edition, IAA is the world’s largest motor show as well...

CES 2020 – LAS VEGAS, NV – JANUARY 6, 2020 – Following the Harman Kardon Citation Series announcement last year, the brand has expanded its wireless speaker series with additional form factors for every room and living space. Outfitted with Harman...

This week, watch as Westworld breaks out of the park and into LA, discover why vision is so important and listen as a drama exploits the weirdness of sound

CES 2020, LAS VEGAS – JANUARY 6, 2020 – Harman International, a wholly-owned subsidiary of Samsung Electronics Co., Ltd. focused on connected technologies for automotive, consumer and enterprise markets, today announced its EV Plus+ Solutions, a new...

Two more firms are eyeing a share of Reliance Industries Ltd's $65-billion digital unit Jio Platforms, according to Bloomberg News, setting them up to be a part of a growing list of firms that have recently invested in the Indian company.

Background

Water and solute transport across epithelia can occur via the transcellular or paracellular pathways. Tight junctions play a key role in mediating paracellular ion reabsorption in the kidney. In the renal collecting duct, which is a typical absorptive tight epithelium, coordination between transcellular sodium reabsorption and paracellular permeability may prevent the backflow of reabsorbed sodium to the tubular lumen along a steep electrochemical gradient.

An exceptionally well-preserved specimen of the articulated rhodophyte Permocalculus, compared with P. tenellus sensu Elliott, 1955, is described from fine-grained Upper Permian limestones of the Khuff Formation of Saudi Arabia. Longitudinal medullary and sheaf-like cortical filaments extend through the uniserial series of elongate-globular, concave- and convex-terminating, interlocking segments for which they are interpreted to have functioned in articulation. The filaments tend to splay and branch laterally into the cortex where they terminate at the pores. At the terminal aperture, the filaments extend as bifurcating and possibly trifurcating branches and may serve as the origin of a new segment. Numerous elongate-globular chambers, up to five in each row and intimately involved with the filaments, are developed in the outer medulla and are considered to represent reproductive sporangia. The specimen is considered to have occupied predominantly low-energy, normal to slightly elevated salinity, shallow conditions within the subtidal regime of a lagoon.

Approximately 40% of patients with diabetic macular edema (DME) are resistant to anti–vascular endothelial growth factor (VEGF) therapy (rDME). Here, we demonstrate that significant correlations between inflammatory cytokines and VEGF, as observed in naive DME, are lost in patients with rDME. VEGF overexpression in the mouse retina caused delayed inflammatory cytokine upregulation, monocyte/macrophage infiltration (CD11b⁺ Ly6C⁺ CCR2⁺ cells), macrophage/microglia activation (CD11b⁺ CD80⁺ cells), and blood-retinal barrier disruption due to claudin-5 redistribution, which did not recover with VEGF blockade alone. Phosphorylated protein analysis of VEGF-overexpressed retinas revealed rho-associated coiled-coil–containing protein kinase (ROCK) activation. Administration of ripasudil, a selective ROCK inhibitor, attenuated retinal inflammation and claudin-5 redistribution. Ripasudil also contributed to the stability of claudin-5 expression by both transcriptional enhancement and degradation suppression in inflammatory cytokine–stimulated endothelium. Notably, the anti-VEGF agent and the ROCK inhibitor were synergic in suppressing cytokine upregulation, monocyte/macrophage infiltration, macrophage/microglia activation, and claudin-5 redistribution. Furthermore, in vitro analysis confirmed that claudin-5 redistribution depends on ROCK2 but not on ROCK1. This synergistic effect was also confirmed in human rDME cases. Our results suggest that ROCK-mediated claudin-5 redistribution by inflammation is a key mechanism in the anti-VEGF resistance of DME.

Twitch is doubling down on esports in this new era of social distancing as a number of traditional sporting events have been cancelled. The company this week introduced a new esports directory on its site that will make it easier for viewers to find live matches, information on players, games with active competition leagues, a […]

Alec Baldwin also returned to the 'SNL' stage as Donald Trump in the cold open.

"Deepfakes" have received a lot of attention as a way to potentially spread misleading or false information and influence public opinion. But two specialists say that might not be a huge concern.

Three deals in three weeks injected a combined $8 billion in the group and help it pare its debt.

Show has been praised for its representation of consensual sex

The show is due to return in September

Too many connection drop-outs, too many missed cues: at least phone calls are intimate

This week, a parcel presumed lost arrived. It was from my mum. Inside was a mask she’d sewn; sunflower seeds to plant; an Easter egg and a card: “To my lovely daughter, I miss you so much!” it read. “Absence truly makes the heart grow fonder. But indifference doesn’t. Video call me. Mum xx”

My mum and I are very close. We speak most days and would usually visit weekly; if it were up to her, it would be more. Her dream is to have all her children, our partners and someday grandchildren living under the same roof. One big happy family, bonded by love, loyalty, south Asian melodrama and unsolicited comments about weight.

The Thor star was thankful to finally be on a well-deserved break from his hectic schedule.

Newcastle United are in danger of being used as a "PR tool" by Saudi Arabia if the club's proposed takeover goes through, according to Amnesty International UK.

Amnesty International has written to the Premier League saying it "risks becoming a patsy" unless it takes a serious look at Saudi Arabia's human rights record with regard to the takeover of Newcastle United.

The Premier League has been asked to consider blocking a Saudi-backed consortium's attempt to purchase Newcastle United by one of the league's major broadcast partners.

The Government is not likely to intervene in the proposed Saudi Arabia-led takeover of Newcastle United, according to Culture Secretary Oliver Dowden​.

Investors in Saudi Arabia were considering a bid for Manchester United as recently as October – before the Gulf state pressed ahead with the buyout of Newcastle United.

An interview with former Leicester City manager Claudio Ranieri encountered a rather odd technical difficulty on Thursday - with the feed cutting to his unsuspecting wife Rosanna.

With the NFL heading into its next round of broadcasting negotiations, it could not afford to release a schedule full of unsightly seams and untenable sacrifices.

While the 2020 NFL season faces some uncertainties because of the coronavirus, the league leaned on a familiar road map in constructing the season schedule.

The first press briefing in more than a year was a rehash of a play we’ve seen before. But the president and his base should be pleased.

An employee of a Sewell, N.J., company that provided temporary electrical utilities pleaded guilty today to participating in a fraud conspiracy at an Environmental Protection Agency (EPA)-designated Superfund site in New Jersey.

A former Department of Veterans Affairs (VA) social work associate was convicted yesterday by a jury on four counts of honest services mail fraud, violating the criminal conflict of interest statute and making a false statement to agency officials.

Invista will pay a $1.7 million civil penalty and spend up to an estimated $500 million to correct self-reported environmental violations discovered at facilities in seven states. The company disclosed more than 680 violations of water, air, hazardous waste, emergency planning and preparedness, and pesticide regulations to EPA after auditing 12 facilities it acquired from DuPont in 2004.

Three Saudi nationals were transferred today from the detention facility at Guantanamo Bay to the Kingdom of Saudi Arabia under appropriate security measures.

The co-owner of a Martinsville, N.J., landscaping company pleaded guilty to participating in a fraud conspiracy at the Environmental Protection Agency (EPA)-designated Superfund site, Federal Creosote, located in Manville, N.J. Frederick Landgraber pleaded guilty in the U.S. District Court of New Jersey today to one count of conspiracy to defraud the EPA from approximately March 2002 until approximately June 2005 at the Federal Creosote site.

A federal jury in Los Angeles convicted a physician assistant late yesterday for his role in a $7.7 million Medicare fraud scheme.

Two demolition and salvage companies and three of their respective owners and supervisors were indicted today by a federal grand jury in Chattanooga, Tenn. The indictment describes a year-long scheme in which the former Standard Coosa Thatcher plant in Chattanooga was illegally demolished while still containing large amounts of asbestos.

Febe Durango-Rueda, 52, a Colombian national, pleaded guilty on Nov. 20, 2009, to participating in a scheme to defraud the Export-Import Bank of the United States (Ex-Im Bank) of more than $1 million.

Anthony Mowl, the former assistant vice president of business development for Viable Communications Inc. (Viable), and Donald Tropp, the former human resources manager for Viable, pleaded guilty today to engaging in a conspiracy to defraud the Federal Communications Commission’s (FCC) Video Relay Service (VRS) program of more than $2.5 million, announced Assistant Attorney General Lanny A. Breuer of the Criminal Division.

Irma Azrelyant and Joshua Finkle, the former co-owners of New York and New Jersey-based Deaf and Hard of Hearing Interpreting Services Inc. (DHIS), pleaded guilty today to engaging in a conspiracy to defraud the Federal Communications Commission’s (FCC) Video Relay Service (VRS) program of more than $7 million.

Four former owners and employees of three different video relay service companies pleaded guilty today and yesterday to engaging in conspiracies to defraud the Federal Communications Commission’s (FCC) Video Relay Service (VRS) program of more than $2.5 million.

Three former owners and employees of two different video relay service companies pleaded guilty today to conspiring to defraud the Federal Communications Commission’s (FCC) Video Relay Service (VRS) program of more than $2.5 million.

Innospec Inc., a Delaware corporation, pleaded guilty today to defrauding the United Nations (UN), to violating the Foreign Corrupt Practices Act (FCPA) and to violating the U.S. embargo against Cuba.

The Health Alliance of Greater Cincinnati and one of its former member hospitals, The Christ Hospital, have agreed to pay the United States $108 million to settle claims that they violated the Anti-Kickback Statute and the False Claims Act by paying unlawful remuneration to doctors in exchange for referring cardiac patients to The Christ Hospital in a pay-to-play scheme.

Robert D. Hearn, 55, was charged in a five-count indictment in the Southern District of Texas with wire fraud and conversion stemming from a scheme to defraud the United States and Iraq.

Jonathan Feeney is charged with using the U.S. mails to execute a scheme involving fraudulent invoices to defraud the U. S. Department of Defense.

An owner of two Houston health care companies pleaded guilty today in connection with a $6.3 million Medicare fraud scheme, announced the Departments of Justice and Health and Human Services (HHS).

A Virginia man was sentenced today to 18 months in prison in connection with a scheme to defraud the U.S. Department of Defense of more than $450,000.

John T.C. Yeh, the owner of Viable Communications Inc., and his brother, Joseph Yeh, the former vice president for corporate strategy and second in charge for Viable, pleaded guilty today to engaging in a conspiracy to defraud the Federal Communications Commission’s Video Relay Service program.

Marc Velasquez pleaded guilty today to engaging in a conspiracy to defraud the Federal Communications Commission’s (FCC) Video Relay Service (VRS) program.