al Nanomolar-scale, high throughput chemical synthesis of drug-like molecules By feeds.nature.com Published On :: 2014-12-18 A high throughput, miniaturized chemical synthesis platform could enable rapid discovery of lead compounds. Full Article
al Angiopoietin 2 (ANG2; ANGPT2); placental growth factor (PGF; PlGF); tissue inhibitor of metalloproteinases 3 (TIMP3) By feeds.nature.com Published On :: 2014-12-18 Mouse studies suggest inhibiting PGF could help treat hypertension. Full Article
al c-jun N-terminal kinase (JNK); MAP kinase 1 (MAPK1; ERK-2); MAPK3 (ERK-1) By feeds.nature.com Published On :: 2014-12-18 In vitro and rodent studies suggest ophiopogonin D could help prevent doxorubicin-induced cardiotoxicity. Full Article
al Epidermal growth factor receptor 1 (EGFR1; ErbB1; HER1); HER2 (EGFR2; ErbB2; neu); HER3 (EGFR3; ErbB3); VEGF By feeds.nature.com Published On :: 2014-12-18 Tumor cell and mouse studies suggest tetravalent antibodies that target four different antigens could help treat cancers resistant to HER-targeted therapies. Full Article
al Cyclin dependent kinase 7 (CDK7); v-myc myelocytomatosis viral related oncogene neuroblastoma derived (MYCN; NMYC) By feeds.nature.com Published On :: 2014-12-18 In vitro and mouse studies suggest THZ1, a covalent CDK7 inhibitor, could help treat neuroblastoma and other cancers driven by MYCN and other c-MYC (MYC)-family oncoproteins. Full Article
al Genocea's mark on malaria By feeds.nature.com Published On :: 2014-12-18 Genocea has identified an immunological imprint in patients with malaria and is using a $1.2 million grant from the Gates Foundation to turn the findings into a vaccine. Full Article
al Translational tidbits By feeds.nature.com Published On :: 2014-12-18 Yabao and MRC Technology partner in PD; charities form Neuro-MAP to insource pharma's abandoned compounds; Singapore creates a diagnostic hub; a roundup of public-private partnerships. Full Article
al Translational balance By feeds.nature.com Published On :: 2014-12-18 Moving discoveries from academia to industry requires a delicate balance of risk, reward, skill sets and personalities, according to a translational panel held at BIO-Europe's partnering conference. Full Article
al Neutralizing the negatives of RNAi By feeds.nature.com Published On :: 2014-12-18 The siRNN technology that Solstice licensed from UCSD could take RNAi-based therapies to tissues outside the liver and expand their use to a host of new diseases. Full Article
al Pac1/LIS1 stabilizes an uninhibited conformation of dynein to coordinate its localization and activity By feeds.nature.com Published On :: 2020-04-27 Full Article
al Tissue-resident ductal macrophages survey the mammary epithelium and facilitate tissue remodelling By feeds.nature.com Published On :: 2020-04-27 Full Article
al Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis By feeds.nature.com Published On :: 2020-05-04 Full Article
al MicroRNA binding site polymorphism in inflammatory genes associated with colorectal cancer: literature review and bioinformatics analysis By feeds.nature.com Published On :: 2020-03-23 Full Article
al In vivo antitumor activity by dual stromal and tumor-targeted oncolytic measles viruses By feeds.nature.com Published On :: 2020-03-31 Full Article
al TMB: a promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials By feeds.nature.com Published On :: 2020-04-28 Full Article
al High-purity orbital angular momentum states from a visible metasurface laser By feeds.nature.com Published On :: 2020-04-27 Full Article
al Two-dimensional optical edge detection By feeds.nature.com Published On :: 2020-04-28 Full Article
al Cardamonin protects against lipopolysaccharide-induced myocardial contractile dysfunction in mice through Nrf2-regulated mechanism By feeds.nature.com Published On :: 2020-04-21 Full Article
al Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization By feeds.nature.com Published On :: 2020-04-23 Full Article
al Nanomedicines based on nanoscale metal-organic frameworks for cancer immunotherapy By feeds.nature.com Published On :: 2020-04-30 Full Article
al Head-to-head trials in inflammatory bowel disease: past, present and future By feeds.nature.com Published On :: 2020-04-17 Full Article
al Microbiota and colorectal cancer: colibactin makes its mark By feeds.nature.com Published On :: 2020-04-21 Full Article
al Colons or semi-colons: punctuating the regional variation of intestinal microbial–immune interactions By feeds.nature.com Published On :: 2020-04-22 Full Article
al Universal screening for hepatitis C virus infection should be linked to universal treatment access By feeds.nature.com Published On :: 2020-04-29 Full Article
al Author Correction: Management of IBD during the COVID-19 outbreak: resetting clinical priorities By feeds.nature.com Published On :: 2020-05-06 Full Article
al A novel multidimensional reinforcement task in mice elucidates sex-specific behavioral strategies By feeds.nature.com Published On :: 2020-05-06 Full Article
al A roadmap for development of neuro-oscillations as translational biomarkers for treatment development in neuropsychopharmacology By feeds.nature.com Published On :: 2020-05-06 Full Article
al Correction: Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression By feeds.nature.com Published On :: 2020-05-06 Full Article
al Evaluating the impact of trauma and PTSD on epigenetic prediction of lifespan and neural integrity By feeds.nature.com Published On :: 2020-05-07 Full Article
al Δ<sup>9</sup>-Tetrahydrocannabinol (THC) impairs visual working memory performance: a randomized crossover trial By feeds.nature.com Published On :: 2020-05-09 Full Article
al Nuclear receptor crosstalk — defining the mechanisms for therapeutic innovation By feeds.nature.com Published On :: 2020-04-17 Full Article
al Obesity affects skeletal muscle ketone oxidation By feeds.nature.com Published On :: 2020-04-20 Full Article
al Obesity and impaired metabolic health in patients with COVID-19 By feeds.nature.com Published On :: 2020-04-23 Full Article
al Sweet signals — gut–brain circuit for sugar identified By feeds.nature.com Published On :: 2020-04-28 Full Article
al New insights into K<sub>ATP</sub> channel gene mutations and neonatal diabetes mellitus By feeds.nature.com Published On :: 2020-05-06 Full Article
al Probing nanoscale fluctuation of ferromagnetic meta-atoms with a stochastic photonic spin Hall effect By feeds.nature.com Published On :: 2020-04-27 Full Article
al Author Correction: Vitamin lipid nanoparticles enable adoptive macrophage transfer for the treatment of multidrug-resistant bacterial sepsis By feeds.nature.com Published On :: 2020-04-28 Full Article
al Publisher Correction: Optomechanical detection of vibration modes of a single bacterium By feeds.nature.com Published On :: 2020-04-29 Full Article
al Nonoperative treatment of traumatic spinal injuries in Tanzania: who is not undergoing surgery and why? By feeds.nature.com Published On :: 2020-04-29 Full Article
al Incidence of acute spinal cord injury in South Korea does not reflect a sizable number of traumatic spinal cord injuries By feeds.nature.com Published On :: 2020-04-30 Full Article
al A more accurate incidence of acute spinal cord injury in South Korea can be estimated by the national health insurance system By feeds.nature.com Published On :: 2020-04-30 Full Article
al Development of a skin temperature map for dermatomes in individuals with spinal cord injury: a cross-sectional study By feeds.nature.com Published On :: 2020-05-05 Full Article
al Impact of COVID-19 outbreak on spinal pathology: single center first impression By feeds.nature.com Published On :: 2020-05-05 Full Article
al Recovery after traumatic thoracic- and lumbar spinal cord injury: the neurological level of injury matters By feeds.nature.com Published On :: 2020-05-05 Full Article
al Supporting sexual adjustment from the perspective of men living with spinal cord injury By feeds.nature.com Published On :: 2020-05-07 Full Article
al Age influences structural brain restoration during weight gain therapy in anorexia nervosa By feeds.nature.com Published On :: 2020-05-04 Full Article
al Rodent models of post-traumatic stress disorder: behavioral assessment By feeds.nature.com Published On :: 2020-05-06 Full Article
