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Construction and analysis of safe, secure, and interoperable smart devices [electronic resource] : second international workshop, CASSIS 2005, Nice, France, March 8-11, 2005 : revised selected papers / Gilles Barthe [and others] (eds.)

Berlin ; New York : Springer, [2006]




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Construction and analysis of safe, secure, and interoperable smart devices [electronic resource] : international workshop, CASSIS 2004, Marseille, France, March 10-14, 2004 : revised selected papers / Gilles Barthe [and others] (eds.)

Berlin ; New York : Springer, [2005]




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Portal launched for Lakshadweep islanders

The Lakshadweep Administration has launched a portal on its website where people who are stranded in Kerala and Mangaluru, and on islands away from th




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Long walk home ends in tragedy: Goods train mows down 16 migrants

Migrants fell asleep on railway track in Maharashtra




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Aarogya Setu most downloaded healthcare app in the world, says Amitabh Kant

Aarogya Setu is currently available on iOS and Android, and nearly 9 crore users have already downloaded the app




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Coronavirus LIVE: Testing scaled up to 95,000 per day, says Harsh Vardhan

Coronavirus India update: Stay tuned with Business Standard for latest news on COVID-19, world death toll, and cases across the world and in India




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OCI card holders' entry in India to remain suspended during lockdown: Govt

The government has kept in abeyance multiple-entry life-long visas given to OCI card holders till the time international travel resumes




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Aurangabad train accident: Raised an alarm but to no avail, says eyewitness

As many as 16 migrant labourers were killed and five others injured when a freight train ran over them between Jalna and Aurangabad on Friday




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Lockdown impact: Fuel demand in India plunged to historic lows in April

In its latest report, the International Energy Agency has said India's annual fuel consumption will decline 5.6 per cent in 2020




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Former Chhattisgarh CM Ajit Jogi hospitalised after cardiac arrest

Citing the information provided by family members of Ajit Jogi, the hospital said he fell unconscious at his residence here in the morning




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Microfabricated electrochemical sensing devices

Lab Chip, 2020, 20,1358-1389
DOI: 10.1039/C9LC01112A, Critical Review
Fumihiro Sassa, Gokul Chandra Biswas, Hiroaki Suzuki
Electrochemistry provides possibilities to realize smart microdevices of the next generation with high functionalities.
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Optically-controlled closable microvalves for polymeric centrifugal microfluidic devices

Lab Chip, 2020, 20,1426-1440
DOI: 10.1039/C9LC01187K, Paper
M. Shane Woolf, Leah M. Dignan, Hannah M. Lewis, Christopher J. Tomley, Aeren Q. Nauman, James P. Landers
Microvalving is a pivotal component in many microfluidic lab-on-a-chip platforms and micro-total analysis systems (μTAS).
The content of this RSS Feed (c) The Royal Society of Chemistry




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A liquid biopsy-guided drug release system for cancer theranostics: integrating rapid circulating tumor cell detection and precision tumor therapy

Lab Chip, 2020, 20,1418-1425
DOI: 10.1039/D0LC00149J, Paper
Chun-Miao Xu, Man Tang, Jiao Feng, Hou-Fu Xia, Ling-Ling Wu, Dai-Wen Pang, Gang Chen, Zhi-Ling Zhang
A system integrating diagnostic and therapeutic functions for cancer is presented using magnetically controlled microfluidics.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Colorimetric absorbance mapping and quantitation on paper-based analytical devices

Lab Chip, 2020, 20,1441-1448
DOI: 10.1039/D0LC00028K, Paper
Open Access
Yoshiki Soda, Kye J. Robinson, Thomas J. Cherubini, Eric Bakker
A pixel-level colorimetric absorbance analysis can measure the total quantity of dye on paper, irrespective of shape and size.
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Advanced 96-microtiter plate based bioelectrochemical platform reveals molecular short cut of electron flow in cytochrome P450 enzyme

Lab Chip, 2020, 20,1449-1460
DOI: 10.1039/C9LC01220F, Paper
Ronny Frank, Christoph Prönnecke, Ronny Azendorf, Heinz-Georg Jahnke, Annette G. Beck-Sickinger, Andrea A. Robitzki
We developed a novel 96-well microtiter plate based bioelectrochemical platform with a vertical divided cell three-electrode architecture and a 96-multipotentiostat to perform fully parallelised bioelectrocatalytic screenings on redox enzymes.
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Scalable microfluidic droplet on-demand generator for non-steady operation of droplet-based assays

Lab Chip, 2020, 20,1398-1409
DOI: 10.1039/C9LC01103J, Paper
Open Access
Kartik Totlani, Jan-Willem Hurkmans, Walter M. van Gulik, Michiel T. Kreutzer, Volkert van Steijn
We developed a microfluidic droplet on-demand (DoD) generator that enables the production of droplets with a volume solely governed by the geometry of the generator for a range of operating conditions.
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Rapid lipolytic oscillations in ex vivo adipose tissue explants revealed through microfluidic droplet sampling at high temporal resolution

Lab Chip, 2020, 20,1503-1512
DOI: 10.1039/D0LC00103A, Paper
Juan Hu, Xiangpeng Li, Robert L. Judd, Christopher J. Easley
High temporal resolution sampling and quantitative detection of glycerol secretion dynamics from adipose tissue using our automated, droplet-based microfluidic system.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Contact lens-based lysozyme detection in tear using a mobile sensor

Lab Chip, 2020, 20,1493-1502
DOI: 10.1039/C9LC01039D, Paper
Zachary Ballard, Sarah Bazargan, Diane Jung, Shyama Sathianathan, Ashley Clemens, Daniel Shir, Saba Al-Hashimi, Aydogan Ozcan
A rapid and cost-effective method for monitoring proteins in tear-fluid is reported, which enables biomarker monitoring using contact lenses toward personalized mobile-health applications.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Fluorescence-based sorting of Caenorhabditis elegans via acoustofluidics

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00051E, Paper
Jinxin Zhang, Jessica H. Hartman, Chuyi Chen, Shujie Yang, Qi Li, Zhenhua Tian, Po-Hsun Huang, Lin Wang, Joel N. Meyer, Tony Jun Huang
Acoustofluidic sorting of Caenorhabditis elegans in a high throughput manner.
To cite this article before page numbers are assigned, use the DOI form of citation above.
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Nanoplasmon-enhanced drop-screen for high throughput single-cell nucleocytoplasmic miRNA profiling

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01226E, Paper
Jia Liu, Guoyun Sun, Shih-Chung Wei, Song Guo, Weikang Nicholas Lin, Chia-Hung Chen
Nanoplasmon-enhanced drop screen is developed to measure single-cell multiple miRNAs with high sensitivity of 0.1 nM, addressing cell nucleocytoplasmic profile in a throughput ∼100 cells per minute.
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ECM-based microchannel for culturing in vitro vascular tissues with simultaneous perfusion and stretch

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00254B, Paper
Azusa Shimizu, Wei Huang Goh, Shun Itai, Michinao Hashimoto, Shigenori Miura, Hiroaki Onoe
A perfusable and stretchable gelatin-based microfluidic system that can apply both simultaneous fluidic shear stress and stretch stress to in vitro endothelial 3D tissues is presented.
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Development of two-photon polymerised scaffolds for optical interrogation and neurite guidance of human iPSC-derived cortical neuronal networks

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01209E, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
J. A. Crowe, A. El-Tamer, D. Nagel, A. V. Koroleva, J. Madrid-Wolff, O. E. Olarte, S. Sokolovsky, E. Estevez-Priego, A.-A. Ludl, J. Soriano, P. Loza-Alvarez, B. N. Chichkov, E. J. Hill, H. R. Parri, E. U. Rafailov
We identified photopolymers for 2-photon polymerisation with biocompatibility for human iPSC-derived neural network development. Generation of microscale scaffold topologies enabled neurite guidance, demonstrating use in reproducing aligned networks.
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Seeded droplet microfluidic system for small molecule crystallization

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00122H, Paper
N. Garg, R. Tona, P. Martin, P. M. Martin-Soladana, G. Ward, N. Douillet, D. Lai
A microfluidic approach to seeded crystallization has been demonstrated using abacavir hemisulfate, a nucleoside analog reverse transcriptase inhibitor, in droplet reactors to control polymorphism and produce particles with a low particle size distribution.
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SLOCK (sensor for circadian clock): passive sweat-based chronobiology tracker

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00134A, Paper
Sayali Upasham, Shalini Prasad
SLOCK is a sweat based platform for monitoring circadian relevant biomarkers-cortisol and DHEA, using electrochemical detection modality.
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Microfluidic device for high-throughput affinity-based isolation of extracellular vesicles

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01190K, Paper
Ting-Wen Lo, Ziwen Zhu, Emma Purcell, Daniel Watza, Joyful Wang, Yoon-Tae Kang, Shruti Jolly, Deepak Nagrath, Sunitha Nagrath
Immunoaffinity based EV isolation technologies use antibodies targeting surface markers on EVs to provide higher isolation specificity and purity compared to existing approaches.
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In situ generation of plasma-activated aerosols via surface acoustic wave nebulization for portable spray-based surface bacterial inactivation

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00001A, Paper
Kiing S. Wong, William T. H. Lim, Chien W. Ooi, Leslie Y. Yeo, Ming K. Tan
We demonstrate an efficient technique for in situ production and application of plasma-activated aerosols for surface disinfection.
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Correction: Deformability-induced lift force in spiral microchannels for cell separation

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC90036B, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Ewa Guzniczak, Oliver Otto, Graeme Whyte, Nicholas Willoughby, Melanie Jimenez, Helen Bridle
To cite this article before page numbers are assigned, use the DOI form of citation above.
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A new polymer lab-on-a-chip (LOC) based on a microfluidic capillary flow assay (MCFA) for detecting unbound cortisol in saliva

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00071J, Paper
Vinitha T. U., Sthitodhi Ghosh, Alexander Milleman, Thinh Nguyen, Chong H. Ahn
A new polymer lab-on-a-chip with on-chip dried reagents for microfluidic capillary flow assay (MCFA) detection of unbound cortisol in saliva.
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Photonic crystal-based smart contact lens for continuous intraocular pressure monitoring

Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01268K, Paper
Bohee Maeng, Hyung-kwan Chang, Jungyul Park
A powerless smart contact lens enabling to monitor intraocular pressure (IOP) by checking the visual color change in photonic crystal structure with a microhydraulic amplification system has been realized.
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Spatially isolated reactions in a complex array: using magnetic beads to purify and quantify nucleic acids with digital and quantitative real-time PCR in thousands of parallel microwells

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00069H, Paper
W. Hampton Henley, Nathan A. Siegfried, J. Michael Ramsey
Encoded beads carrying primer pairs for nucleic acid targets are used for sample preparation and multiplexed-in-space digital PCR quantification.
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Multiplexed homogeneous digital immunoassay based on single-particle motion analysis

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00079E, Paper
Kenji Akama, Hiroyuki Noji
Homogeneous digital immunoassay is a powerful analytical method for highly sensitive biomarker detection with a simple protocol. By using this method, we demonstrated the simultaneous multiple protein detection.
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Acoustic separation of living and dead cells using high density medium

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00175A, Paper
Open Access
Karl Olofsson, Björn Hammarström, Martin Wiklund
A novel, simple and robust route for binary separation of viable and dead cells using a density modified medium which takes advantage of the compromised cell membrane of dead cells.
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Bioinspired reconfiguration of 3D printed microfluidic hydrogels via automated manipulation of magnetic inks

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00280A, Communication
Amin Mansoorifar, Anthony Tahayeri, Luiz E. Bertassoni
We proposed a novel concept for reconfiguration of hydrogel microfluidic devices, where multiple fluidic pathways could be generated via reversible manipulation of magnetic inks.
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Capacitive Sensing of Triglyceride Film Reactions: A Proof-of-Concept Demonstration for Sensing in Simulated Duodenal Contents with Gastrointestinal Targeting Capsule System

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00133C, Paper
George Banis, Luke Beardslee, Justin Stine, Rajendra Mayavan Sathyam, Reza Ghodssi
Ingestible capsule systems continue evolving to overcome drawbacks associated with traditional gastrointestinal (GI) diagnostic and therapeutic processes, such as location restrictions or insufficient sensitivity measures when obtaining information on local...
The content of this RSS Feed (c) The Royal Society of Chemistry




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Catalytic exchange of hydrogen isotopes intensified by two-phase stratified flow in wettability designable microchannels

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00250J, Paper
Yuexiao Song, Feng Xin, Yongsheng Xu
This work develops a reliable method to achieve stratified flow in squared cross-section microchannels by endowing the four channel walls with very different wettabilities. The gas–liquid flows are studied experimentally...
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PRESCIENT: platform for the rapid evaluation of antibody success using integrated microfluidics enabled technology

Lab Chip, 2020, 20,1628-1638
DOI: 10.1039/C9LC01165J, Paper
Jose A. Wippold, Han Wang, Joseph Tingling, Julian L. Leibowitz, Paul de Figueiredo, Arum Han
Identifying antibodies (Abs) that neutralize infectious agents is the first step for developing therapeutics, vaccines, and diagnostic tools for these infectious agents.
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Auto-affitech: an automated ligand binding affinity evaluation platform using digital microfluidics with a bidirectional magnetic separation method

Lab Chip, 2020, 20,1577-1585
DOI: 10.1039/D0LC00024H, Paper
Jingjing Guo, Li Lin, Kaifeng Zhao, Yanling Song, Mengjiao Huang, Zhi Zhu, Leiji Zhou, Chaoyong Yang
An automated ligand binding affinity evaluation platform using digital microfluidics with a bidirectional magnetic separation method that reduces the bead loss.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Quantitatively controllable fluid flows with ballpoint-pen-printed patterns for programmable photo-paper-based microfluidic devices

Lab Chip, 2020, 20,1601-1611
DOI: 10.1039/D0LC00115E, Paper
Veasna Soum, Sooyong Park, Albertus Ivan Brilian, Jae-Youl Choi, Yongwoo Lee, Wonjung Kim, Oh-Sun Kwon, Kwanwoo Shin
A precise, simple, and inexpensive method for controlling fluid flow in a photo-paper-based microfluidic device was reported.
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Monitoring the two-dimensional concentration profile of toluene vapors by using polymer-stabilized nematic liquid crystals in microchannels

Lab Chip, 2020, 20,1687-1693
DOI: 10.1039/C9LC01021A, Paper
Zongdai Liu, Dan Luo, Kun-Lin Yang
The concentration of toluene vapor is obtained based on polymer-stabilized liquid crystals by viewing a colourful gamut under a polarized optical microscope.
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Electrostatically gated nanofluidic membrane for ultra-low power controlled drug delivery

Lab Chip, 2020, 20,1562-1576
DOI: 10.1039/D0LC00121J, Paper
Open Access
Nicola Di Trani, Antonia Silvestri, Antons Sizovs, Yu Wang, Donald R. Erm, Danilo Demarchi, Xuewu Liu, Alessandro Grattoni
Control of molecular diffusion through nanofluidic channels using electrostatic gating.
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Hybrid paper and 3D-printed microfluidic device for electrochemical detection of Ag nanoparticle labels

Lab Chip, 2020, 20,1648-1657
DOI: 10.1039/D0LC00276C, Paper
Charuksha Walgama, Michael P. Nguyen, Lisa M. Boatner, Ian Richards, Richard M. Crooks
A hybrid paper/plastic microfluidic device for detection of Ag nanoparticle labels at concentrations as low as 12 pM.
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Selective cell propagation via micropatterning of a thermally-activated hydrogel

Lab Chip, 2020, 20,1544-1553
DOI: 10.1039/C9LC01230C, Communication
Jeffrey C. Y. Chiu, Joyce A. Teodoro, Jeong Hyun Lee, Kerryn Matthews, Simon P. Duffy, Hongshen Ma
Inverse gelation of methylcellulose enables hydrogel micropatterning to selectively propagate cells identified by microscopy.
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High-sensitivity microliter blood pressure sensors based on patterned micro-nanostructure arrays

Lab Chip, 2020, 20,1554-1561
DOI: 10.1039/D0LC00063A, Communication
Nianzuo Yu, Yongshun Liu, Bai Ji, Shuli Wang, Yunyun Chen, Tianmeng Sun, Junhu Zhang, Bai Yang
Blood pressure sensors are proposed to measure the value of central venous pressure, and diagnose the severity of hypertension, hypotension and arterial thrombosis.
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Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract

Lab Chip, 2020, 20,1621-1627
DOI: 10.1039/D0LC00304B, Paper
Fu Sun, Anurup Ganguli, Judy Nguyen, Ryan Brisbin, Krithika Shanmugam, David L. Hirschberg, Matthew B. Wheeler, Rashid Bashir, David M. Nash, Brian T. Cunningham
A 30-minute nucleic acid test for equine respiratory virus from nasal swab material, detected with a smartphone.
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Microfluidic assessment of red blood cell mediated microvascular occlusion

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00112K, Paper
Yuncheng Man, Erdem Kucukal, Ran An, Quentin Watson, Jürgen Bosch, Peter A. Zimmerman, Jane A Little, Umut A. Gurkan
Abnormal red blood cells (RBC) deformability contributes to hemolysis, thrombophilia, inflammation, and microvascular occlusion in various circulatory diseases. A quantitative and objective assessment of microvascular occlusion mediated by RBCs with...
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Particle/cell separation using sheath-free deterministic lateral displacement arrays with inertially focused single straight input

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00354A, Paper
Naotomo Tottori, Takasi Nisisako
We propose sheath-free microfluidic deterministic lateral displacement devices with inertially focused single straight input.
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A high-throughput system combining microfluidic hydrogel droplets with deep learning for screening the antisolvent-crystallization conditions of active pharmaceutical ingredient

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00153H, Paper
Zhening Su, Jinxu He, Peipei Zhou, Lu Huang, Jianhua Zhou
Crystallization of active pharmaceutical ingredients (APIs) is a crucial process in the pharmaceutical industry due to its great impact in drug efficacy. However, conventional approaches for screening the optimal crystallization...
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Evaluation of intercellular communication between breast cancer cells and adipose-derived stem cells via passive diffusion in a two-layer microfluidic device

Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00142B, Paper
Sharif M. Rahman, Joshua M. Campbell, Rachael N. Coates, Katie M. Render, C. Ethan Byrne, Elizabeth C. Martin, Adam T. Melvin
Breast cancer cells co-cultured with adipose-derived stem cells (ASCs) in a microfluidic device exhibited enhanced growth, a more aggressive morphology and polarization towards the ASCs, and increased drug resistance.
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A Web-based Automated Machine Learning Platform to Analyze Liquid Biopsy Data

Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00096E, Paper
Hanfei Shen, Tony Liu, Jesse Cui, Piyush Borole, Ari Benjamin, Konrad Kording, David Issadore
Liquid biopsy (LB) technologies continue to improve in sensitivity, specificity, and multiplexing and can measure an ever growing library of disease biomarkers. However, clinical interpretation of the increasingly large sets...
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PM Narendra Modi’s day at the Red Fort through 10 Express photos