A proteomics perspective on 2 years of high-intensity training in horses: a pilot study  Nature.com

Native-state proteomics of Parvalbumin interneurons identifies unique molecular signatures and vulnerabilities to early Alzheimer’s pathology  Nature.com

Plasma proteomic and polygenic profiling improve risk stratification and personalized screening for colorectal cancer  Nature.com

Proteomics identifies potential immunological drivers of postinfection brain atrophy and cognitive decline  Nature.com

Imputation of label-free quantitative mass spectrometry-based proteomics data using self-supervised deep learning  Nature.com

Novel FFPE proteomics method suggests prolactin induced protein as hormone induced cytoskeleton remodeling spatial biomarker | Communications Biology  Nature.com

EXCRETE workflow enables deep proteomics of the microbial extracellular environment | Communications Biology  Nature.com

A multi-species benchmark for training and validating mass spectrometry proteomics machine learning models  Nature.com

Deep Plasma Proteomics with Data-Independent Acquisition: Clinical Study Protocol Optimization with a COVID-19 Cohort  ACS Publications

Overnight Work for CTA’s Red-Purple Lines: Between W. Montrose Avenue and Wilson Station for track work.

The Chicago Transit Authority (CTA) today announced the rail stations that will receive repairs and improvements in fall 2024 as part of its ongoing, cyclical station improvement program Refresh & Renew.

Overnight Work, CTA’s Red-Purple Lines: South End of Wilson Station for track work.

Ride with CTA to all the exciting festivities happening around town. Customers can save money by purchasing an unlimited rides pass, either the 1-Day ($5) – far more economical and convenient than the price of gas and parking - or the 3-Day ($15) pass – a real budget-saving move.

Intermittent Daily and Nightly Street Closures at W. Ardmore Avenue at the CTA Tracks for Material Delivery for Trackwork.

Overnight Work Construction lot east of 5343 N. Broadway (Jewel-Osco) for Material Delivery & Crane Lifts.

The Chicago Transit Authority (CTA) announced the launch of an agency-wide strategic planning process to determine the strategic direction for the agency over the next several years. “Powering Our Transit Future” marks the agency’s first-ever comprehensive, long-term strategic planning effort.

CTA will be providing added capacity, so whether you plan to run or cheer on the runners, take a train or bus to avoid the headaches of traffic and parking near the route of the 2024 Bank of America Chicago Marathon and Abbott Health and Fitness Expo at McCormick Place. For details about marathon service, you can find it here on CTA’s dedicated Bank of America Chicago Marathon webpage.

Overnight Street Closures W. Lawrence Avenue at the CTA Tracks for Track Structure Segment Installation.

An unoccupied property at 354 W 109th St will be used by Chicago Fire personnel for firefighter training exercises.

Chicago Fire personnel will use the unoccupied property at 409 W. 103rd St. for firefighter training exercises.

Afghanistan's economy changed — almost overnight — after the Taliban retook control of the country | Subscribe to our weekly newsletter here.

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The 40 hour work week has been the standard for 80 years. What will it take to lower that? | Subscribe to our weekly newsletter here.

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We look at a hidden form of inflation affecting our economy — we're calling it "skimpflation." The Indicator tells a spooky tale about the inflation demon. | Subscribe to our weekly newsletter here.

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How one man's quest to dominate the onion market changed commodities trading, and potentially how much you pay at the grocery store, forever. | Subscribe to Planet Money+ in Apple Podcasts or at plus.npr.org/planetmoney.

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On today's show: the Watergate scandal you haven't heard about – that led directly to Citizens United and multi-billion dollar elections. | Subscribe to our weekly newsletter here.

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Texas's energy grid is largely disconnected from the rest of the U.S. That led to disastrous consequences last year when the state's grid was overloaded during a winter storm. Back in the 1970s, one company attempted to change the system in a secret, middle-of-the-night operation.
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Inflation is making prices go up, except not for...sports tickets? So, we set out on a daylong sporting event marathon to learn why.

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It's the thrilling conclusion to our three-part series on AI — the world premiere of the first episode of Planet Money written by AI. In Part 1 of this series, we taught AI how to write an original Planet Money script by feeding it real research and interviews. In Part 2, we used AI to clone the voice of our former colleague Robert Smith.

Now, we've put everything together into a 15-minute Planet Money episode. And we've gathered some of our co-hosts to listen along.

So, how did the AI do? You'll have to listen to learn what went surprisingly well, where it fell short, and hear reactions from the real-life hosts whose jobs could be at risk of being replaced by the machines.

This episode was produced by Emma Peaslee and Willa Rubin. It was engineered by James Willetts and fact-checked by Sierra Juarez. Keith Romer edited this series and Jess Jiang is our acting executive producer.

In the radio play, Mary Childs voiced Ethel Kinney; Willa Rubin voiced Alice; and Kenny Malone voiced Dr. Jones and Dial Doom 5000.

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In 1978, a young man named Mike Shanks started a moving business in the north end of Seattle. It was just him and a truck — a pretty small operation. Things were going great. Then one afternoon, he was pulled over and cited for moving without a permit.

The investigators who cited him were part of a special unit tasked with enforcing utilities and transportation regulations. Mike calls them the furniture police. To legally be a mover, Mike needed a license. Otherwise, he'd face fines — and even potentially jail time. But soon he'd learn that getting that license was nearly impossible.

Mike is the kind of guy who just can't back down from a fight. This run-in with the law would set him on a decade-long crusade against Washington's furniture moving industry, the furniture police, and the regulations themselves. It would turn him into a notorious semi-celebrity, bring him to courtrooms across the state, lead him to change his legal name to 'Mike The Mover,' and send him into the furthest depths of Washington's industrial regulations.

The fight was personal. But it drew Mike into a much larger battle, too: An economic battle about regulation, and who it's supposed to protect.

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How do you get the best deal? How do you know you're getting the best deal? Whether you're talking down the price of a car or talking up your salary, you don't have to be a jerk to get what you want. Negotiations can be win-win – if you know what to ask for and how to grow the pie.

We have three stories in today's episode about how to negotiate tactically. First, a hostage negotiator tries to buy a car. Will he get far? Then, one man's encounter at the airline ticket booth may inform how you respond to your next job offer. Finally, how to avoid a food fight and make a deal that benefits everybody.

We'll learn about something called BATNA, or best alternative to a negotiated agreement, which can tell you when to stand firm and when to walk away. We'll find out how to shift our thinking about what success can look like in a negotiation, and shift your counterpart's thinking too.

Come learn the techniques of expert negotiators in the penultimate episode of Planet Money Summer School, MBA edition. Next week: Graduation! So, you have one week to negotiate the cost of your cap and gown.

Our Summer School series is hosted by Robert Smith and produced by Max Freedman. Our project manager is Julia Carney. This episode was edited by our executive producer, Alex Goldmark, and engineered by James Willetts. The show was fact-checked by Sierra Juarez.

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In China, data on the economy is sometimes difficult to come by. The Chinese government has put a pause on releasing some of its official economic data. But many of the stories emerging from the country paint a clear picture: the second largest economy in the world is struggling.

Today, our friends at The Indicator share some of their recent reporting on China. First up, it's a special edition of the Beigie Awards focused entirely on China. What can the approach of the Federal Reserve's Beige Book - i.e. looking at anecdotes that tell us something about where the economy is headed - show us about China's economy?

Then, we take a deep dive into one of the most alarming indicators in China: the skyrocketing urban youth unemployment rate.

This episode was hosted by Darian Woods, Wailin Wong, and Robert Smith. The original Indicator episodes were produced by Corey Bridges with engineering by Robert Rodriguez. They were fact-checked by Cooper Katz McKim and Sierra Juarez. They were edited by Paddy Hirsch and Kate Concannon.

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Union membership in the U.S. has been declining for decades. But, in 2022, support for unions among Americans was the highest it's been in decades. This dissonance is due, in part, to the difficulties of one important phase in the life cycle of a union: setting up a union in the first place. One place where that has been particularly clear is at the Volkswagen plant in Chattanooga, Tennessee.

Back in 2008, Volkswagen announced that they would be setting up production in the United States after a 20-year absence. They planned to build a new auto manufacturing plant in Chattanooga.

Volkswagen has plants all over the world, all of which have some kind of worker representation, and the company said that it wanted that for Chattanooga too. So, the United Auto Workers, the union that traditionally represents auto workers, thought they would be able to successfully unionize this plant.

They were wrong.

In this episode, we tell the story of the UAW's 10-year fight to unionize the Chattanooga plant. And, what other unions can learn from how badly that fight went for labor.

This episode was hosted by Amanda Aronczyk and Nick Fountain. It was produced by Willa Rubin. It was engineered by Josephine Nyounai, fact-checked by Sierra Juarez, and edited by Keith Romer. Alex Goldmark is our executive producer.

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Picture the Pacific Ocean of the 16th century. Spanish Galleons sail the wide open seas, carrying precious cargo like silver, porcelain, and textiles. The waters are dangerous; ship logs show concerns over pirates. But pirates are not to blame for a mysterious event that keeps happening.

For, you see, one in five of the ships leaving from the port of Manila didn't make it to Acapulco. It's a shipwrecking rate much higher than rates for other routes of the time. And the mystery of the serial shipwrecking Spanish ships remains unsolved, until today.

Everyone involved with these Spanish ships were aligned in a goal: Don't wreck the Spanish ships. And yet, wreck they did. Three economists took a look at the incentives for profit and risk at the time, and found the key to unlocking this ancient booty (of knowledge).

Our show today was produced by James Sneed, edited by Jess Jiang, fact-checked by Sierra Juarez, and engineered by Cena Loffredo. Alex Goldmark is Planet Money's executive producer.

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There's this fundamental question in economics that has proven really hard to answer: What's a good way to help people out of poverty? The old-school way was to fund programs that would support very particular things, like buying cows for a village, giving people business training, or building schools.

But over the past few decades, there has been a new idea: Could you help people who don't have money by ... just giving them money? We covered this question in a segment of This American Life that originally ran in 2013. Economists who studied the question found that giving people cash had positive effects on recipients' economic and psychological well-being. Maybe they bought a cow that could earn them money each week. Maybe they could replace their grass roofs with metal roofs that didn't need fixing every so often.

The success of just giving people in poverty cash has spawned a whole set of new questions that economists are now trying to answer. Like, if we do just give money, what's the best way to do that? Do you just give it all at once? Or do you dole it out over time? And it turns out... a huge new study on giving cash was just released and it's got a lot of answers.

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(Note: This episode originally ran in 2023.)

Union membership in the U.S. has been declining for decades. But, in 2022, support for unions among Americans was the highest it's been in decades. This dissonance is due, in part, to the difficulties of one important phase in the life cycle of a union: setting up a union in the first place. One place where that has been particularly clear is at the Volkswagen plant in Chattanooga, Tennessee.

Back in 2008, Volkswagen announced that they would be setting up production in the United States after a 20-year absence. They planned to build a new auto manufacturing plant in Chattanooga.

Volkswagen has plants all over the world, all of which have some kind of worker representation, and the company said that it wanted that for Chattanooga too. So, the United Auto Workers, the union that traditionally represents auto workers, thought they would be able to successfully unionize this plant.

They were wrong.

In this episode, we tell the story of the UAW's 10-year fight to unionize the Chattanooga plant. And, what other unions can learn from how badly that fight went for labor.

This episode was hosted by Amanda Aronczyk and Nick Fountain. It was produced by Willa Rubin. It was engineered by Josephine Nyounai, fact-checked by Sierra Juarez, and edited by Keith Romer. Alex Goldmark is our executive producer.

Help support Planet Money and get bonus episodes by subscribing to Planet Money+ in Apple Podcasts or at plus.npr.org/planetmoney.

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At the core of most of the electronics we use today are some very tiny, very powerful chips. Semiconductor chips. And they are mighty: they help power our phones, laptops, and cars. They enable advances in healthcare, military systems, transportation, and clean energy. And they're also critical for artificial intelligence, providing the hardware needed to train complex machine learning.

On today's episode, we're bringing you two stories from our daily show The Indicator, diving into the two most important semiconductor chip companies, which have transformed the industry over the past 40 years.

First, we trace NVIDIA's journey from making niche graphics cards for gaming to making the most advanced chips in the world — and briefly becoming the world's biggest company. Next, we see how the Taiwan Semiconductor Manufacturing Company's decision to manufacture chips for its competition instead of itself flipped the entire industry on its head, and moved the vast majority of the world's advanced chip production to Taiwan.

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This season on the StoryCorps Podcast from NPR, eight stories about eight moments that changed everything.

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A true 'Master' mechanic is intimately familiar with the intricate workings of innumerable makes and models of cars, right? Yeah, but can they help Emma from Montana figure out which 'thingie' to put the blue liquid into? Let's all find out on this episode of the Best of Car Talk.
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The New York-based folk rock band perform songs from their latest album, Valley of Abandoned Songs.

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The Australian musician talks about the motivation and meaning behind Wild God, a new album with his band The Bad Seeds.

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The Los Angeles-based musician was inspired by the dark side of state's mythology in the making of her fourth studio album.

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The funk, soul and R&B band from Seattle explores the more complicated side of love on their latest album, Love Direction.

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This English indie rock band formed while studying at the Leeds Conservatoire in 2020. Four years laters, they won the Mercury Prize.

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The Montreal-based band blends together different influences, from japanese folk to J-Pop and Brazilian surf rock.

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The alternative rock pioneers perform an exclusive set ahead of the release of their latest album.

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The record producer and composer sought inspiration from his beginnings in Sacramento for his latest record.

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The saxophonist has spent his life developing his unique, physically demanding performance style.

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With many of us stuck at home right now, it's natural to feel bored and listless. But our new host Manoush Zomorodi is kind of an expert in boredom - she wrote a book and gave a TED Talk on the topic - and she says it doesn't have to be so bad. In 2018, Guy Raz interviewed Manoush for our episode "Attention Please." Listen to why we might actually need to feel bored in order to jump-start our creativity.

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From prehistoric cave art to today's social media feeds, to design is to be human. This hour, designer Debbie Millman guides us through a world made and remade—and helps us design our own paths.

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From prehistoric cave art to today's social media feeds, to design is to be human. This hour, designer Debbie Millman guides us through a world made and remade—and helps us design our own paths.

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