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JAMA Cardiology : Effect of 1 or 2 Doses of Inclisiran on Low-Density Lipoprotein Cholesterol Levels

Interview with Kausik K. Ray, MD, author of Effect of 1 or 2 Doses of Inclisiran on Low-Density Lipoprotein Cholesterol Levels: One-Year Follow-up of the ORION-1 Randomized Clinical Trial, and Maarten JG. Leening, MD, PhD, author of Safety and Tolerability of Sustained Lipid-Lowering Therapy: Trial Data and Public Perception in a World Where Vaccines and Statins Are About to Collide




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JAMA Cardiology : Longitudinal Associations Between Income Changes and Incident Cardiovascular Disease

Interview with Scott David Solomon, MD, and Stephen Yishu Wang, BS, authors of Longitudinal Associations Between Income Changes and Incident Cardiovascular Disease: The Atherosclerosis Risk in Communities Study, and Edward P. Havranek, MD, author of The Influence of Social and Economic Factors on Heart Disease






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Equity flows dip 47% in Apr despite mkts seeing sharpest run-up since 2009

Debt categories continued to see redemptions. Credit risk funds saw a bulk of the outflows at Rs 19,238 crore, registering the worst month for the category in 13 months




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Indian origin UK doctors evince interest in investing in Bihar



  • DO NOT USE Indians Abroad
  • World

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Income Splitting: Opportunities and Pitfalls

In this webinar, the tax lawyers of Minden Gross LLP will provide a practical overview of income splitting strategies available today. This webinar will review in detail the various attribution rules devised to thwart income planning, and guide participants to strategies still available for safe and effective income splitting.

Available Sessions for this Seminar:

ipwebinar.aspx?tab=1&smid=1669, May 12, 2015




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Income Taxation of Employment Benefits

Join Jayne Pong of PwC for an insightful overview of the income tax implications of benefits and allowances employers provided to their employees, including those who are owner-managers. The webinar will provide payroll administrators, small to medium-sized business owners and their advisors with a general understanding of when employment benefits are taxable, how to determine the value of these benefits, and when sales taxes and payroll deductions are applicable to these benefits. Understanding the tax consequences of employment benefits will assist in deciding the types of benefits to offer in compensation strategies.

Available Sessions for this Seminar:

ipwebinar.aspx?tab=1&smid=1525, January 28, 2015




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Revised Goa University circular includes six other courses

The revised terms for the new academic year 2019-20 issued by Goa University on May 5 will also be applicable for the bachelor of education, bachelor of physical education, bachelor of performing art, bachelor of social work, master of education and master of performing art programmes.




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Principles and priorities

I think about design principles a lot. I’m such a nerd for design principles, I even have a collection. I’m not saying all of the design principles in the collection are good—far from it! I collect them without judgement.

As for what makes a good design principle, I’ve written about that before. One aspect that everyone seems to agree on is that a design principle shouldn’t be an obvious truism. Take this as an example:

Make it usable.

Who’s going to disagree with that? It’s so agreeable that it’s practically worthless as a design principle. But now take this statement:

Usability is more important than profitability.

Ooh, now we’re talking! That’s controversial. That’s bound to surface some disagreement, which is a good thing. It’s now passing the reversability test—it’s not hard to imagine an endeavour driven by the opposite:

Profitability is more important than usability.

In either formulation, what makes these statements better than the bland toothless agreeable statements—“Usability is good!”, “Profitability is good!”—is that they introduce the element of prioritisation.

I like design principles that can be formulated as:

X, even over Y.

It’s not saying that Y is unimportant, just that X is more important:

Usability, even over profitability.

Or:

Profitability, even over usability.

Design principles formulated this way help to crystalise priorities. Chris has written about the importance of establishing—and revisiting—priorities on any project:

Prioritisation isn’t and shouldn’t be a one-off exercise. The changing needs of your customers, the business environment and new opportunities from technology mean prioritisation is best done as a regular activity.

I’ve said it many times, but one on my favourite design principles comes from the HTML design principles. The priority of consitituencies (it’s got “priorities” right there in the name!):

In case of conflict, consider users over authors over implementors over specifiers over theoretical purity.

Or put another way:

  • Users, even over authors.
  • Authors, even over implementors.
  • Implementors, even over specifiers.
  • Specifiers, even over theoretical purity.

When it comes to evaluating technology for the web, I think there are a number of factors at play.

First and foremost, there’s the end user. If a technology choice harms the end user, avoid it. I’m thinking here of the kind of performance tax that a user has to pay when developers choose to use megabytes of JavaScript.

Mind you, some technologies have no direct effect on the end user. When it comes to build tools, version control, toolchains …all the stuff that sits on your computer and never directly interacts with users. In that situation, the wants and needs of developers can absolutely take priority.

But as a general principle, I think this works:

User experience, even over developer experience.

Sadly, I think the current state of “modern” web development reverses that principle. Developer efficiency is prized above all else. Like I said, that would be absolutely fine if we’re talking about technologies that only developers are exposed to, but as soon as we’re talking about shipping those technologies over the network to end users, it’s negligent to continue to prioritise the developer experience.

I feel like personal websites are an exception here. What you do on your own website is completely up to you. But once you’re taking a paycheck to make websites that will be used by other people, it’s incumbent on you to realise that it’s not about you.

I’ve been talking about developers here, but this is something that applies just as much to designers. But I feel like designers go through that priority shift fairly early in their career. At the outset, they’re eager to make their mark and prove themselves. As they grow and realise that it’s not about them, they understand that the most appropriate solution for the user is what matters, even if that’s a “boring” tried-and-tested pattern that isn’t going to wow any fellow designers.

I’d like to think that developers would follow a similar progression, and I’m sure that some do. But I’ve seen many senior developers who have grown more enamoured with technologies instead of honing in on the most appropriate technology for end users. Maybe that’s because in many organisations, developers are positioned further away from the end users (whereas designers are ideally being confronted with their creations being used by actual people). If a lead developer is focused on the productivity, efficiency, and happiness of the dev team, it’s no wonder that their priorities end up overtaking the user experience.

I realise I’m talking in very binary terms here: developer experience versus user experience. I know it’s not always that simple. Other priorities also come into play, like business needs. Sometimes business needs are in direct conflict with user needs. If an online business makes its money through invasive tracking and surveillance, then there’s no point in having a design principle that claims to prioritise user needs above all else. That would be a hollow claim, and the design principle would become worthless.

Because that’s the point with design principles. They’re there to be used. They’re not a nice fluffy exercise in feeling good about your work. The priority of constituencies begins, “in case of conflict” and that’s exactly when a design principle matters—when it’s tested.

Suppose someone with a lot of clout in your organisation makes a decision, but that decision conflicts with your organisations’s design principles. Instead of having an opinion-based argument about who’s right or wrong, the previously agreed-upon design principles allow you to take ego out of the equation.

Prioritisation isn’t easy, and it gets harder the more factors come into play: user needs, business needs, technical constraints. But it’s worth investing the time to get agreement on the priority of your constituencies. And then formulate that agreement into design principles.




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Integrated principles of zoology / Cleveland P. Hickman, Jr., Washington and Lee University, Susan L. Keen, University of California-Davis, David J. Eisenhour, Morehead State University, Allan Larson, Washington University, Helen I' Anson, Washington

Hickman, Cleveland P., Jr., author




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Prediction of ternary fluorooxoborates with coplanar triangular units [BOxF3−x]x− from first-principles

Dalton Trans., 2020, 49,5424-5428
DOI: 10.1039/D0DT00160K, Communication
Zhonglei Wei, Wenyao Zhang, Hao Zeng, Hao Li, Zhihua Yang, Shilie Pan
From first-principles prediction, we got all the basic structural units of fluorooxoborates, namely, tetrahedral elements [BOxF4−x] (x = 1,2,3) like [BO4] and triangular elements [BOxF3−x] (x = 1,2) like [BO3].
The content of this RSS Feed (c) The Royal Society of Chemistry




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Dehydrogenation of amines in aryl-amine functionalized pincer-like nitrogen-donor redox non-innocent ligands via ligand reduction on a Ni(II) template

Dalton Trans., 2020, Advance Article
DOI: 10.1039/D0DT00466A, Paper
Manas Khatua, Bappaditya Goswami, Subhas Samanta
A Ni(II)-template directed dehydrogenative imine formation reaction via ligand reduction leading to the formation of new pincer-like azo imine ligands is described.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry




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Selenotungstates incorporating organophosphonate ligands and metal ions: synthesis, characterization, magnetism and catalytic efficiency in Knoevenagel condensation reaction

Dalton Trans., 2020, Accepted Manuscript
DOI: 10.1039/D0DT00444H, Paper
Jingyang Niu, Hui Kong, Peipei He, Zongfei Yang, Qiaofei Xu, Jiawei Wang, Ran Ban, Pengtao Ma, Jingping Wang
Three sandwich-type TM-containing (TM = transition metal) organophosphonate-based polyoxotungstate clusters, [TM(H2O)4(SeW6O21)2{Co(OOCCH2NCH2PO3)2}3]12– (TM = Co, Ni), have been successfully synthesized, which is the first reported TMs-containing organophosphonate-based selenotungstates. They were structurally...
The content of this RSS Feed (c) The Royal Society of Chemistry




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International migration law / Vincent Chetail

Dewey Library - K3275.C44 2019




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Law and development: balancing principles and values / Piotr Szwedo, Richard Peltz-Steele, Dai Tamada, editors

Online Resource




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Governing infrastructure regulators in fragile environments: principles and implementation manual.

Online Resource




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International taxation of trust income / Mark Brabazon

Dewey Library - K4536.T78 B73 2019




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The Cambridge handbook of the law of the sharing economy / edited by Nestor M. Davidson, Fordham Law School ; Michèle Finck, University of Oxford ; John J. Infranca, Suffolk University Law School

Dewey Library - K1318.C36 2018




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Energy law and policy / Lincoln L. Davies, Alexandra B. Klass, Hari M. Osofsky, Joseph P. Tomain, Elizabeth J. Wilson

Dewey Library - KF2120.D38 2018




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Street vendors demand inclusion in relief package

Street vendors are unhappy that they have been left out from the list of people in different sectors that will receive compensation from the State. Th






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Enterprising China : business, economic, and legal developments since 1979 / Linda Yueh

Yueh, Linda Y. (Linda Yi-Chuang)




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Mediation : principles process practice / Laurence Boulle, Teh Hwee Hwee

Boulle, Laurence, 1949-




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The power of inclusive exclusion : anatomy of Israeli rule in the occupied Palestinian territories / edited by Adi Ophir, Michal Givoni, and Sari Hanafi




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[ASAP] Distinct Quality Changes of Garlic Bulb during Growth by Metabolomics Analysis

Journal of Agricultural and Food Chemistry
DOI: 10.1021/acs.jafc.0c01120




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Zinc Batteries: Basics, Developments, and Applications


 

Battery technology is constantly changing, and the concepts and applications of these changes are rapidly becoming increasingly more important as more and more industries and individuals continue to make “greener” choices in their energy sources.  As global dependence on fossil fuels slowly wanes, there is a heavier and heavier importance placed on cleaner power sources and methods for storing and transporting that power.  Battery technology is a



Read More...




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Groups sue US military to stop PFAS incineration

Activists say contracts with companies violate federal law




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Biogen bets big on Sangamo's zinc fingers to treat Alzheimer's

Biogen will pay the biotech firm $350 million upfront and get rights to its therapies for up to 12 neurological diseases




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Groups sue US military to stop PFAS incineration

Activists say contracts with companies violate federal law




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Biogen to develop zinc finger therapies with Sangamo




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Merck and Princeton scientists create method to map cell-surface microenvironments

The technique, called MicroMapping, identifies potential protein interactions on and between cells




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US stimulus bill includes funding for coronavirus research

The National Institutes of Health receives the vast majority of the support




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US stimulus bill includes funding for coronavirus research

The National Institutes of Health receives the vast majority of the support




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Incinerators may spread, not break down PFAS

Preliminary data show soil and water near New York facility are contaminated




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Incinerators may spread, not break down, PFAS

Preliminary data show soil and water near New York facility are contaminated




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Google Inc makes Meet app free for all users

Earlier, the premium video conferencing app was available only for paid enterprise users of the GSuite. This is the first time that a product designed for enterprise use is being extended to individual users, Smita Hashim, Director, Product Management, Google Cloud told ET




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Increased work hours, action against workers not reporting to duty, among CII’s recommendations to Labour Minister

The CII representatives had a meeting with Labour and Employment Minister Santosh Kumar Gangwar on Friday




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Drug targeting [electronic resource] : strategies, principles, and applications / edited by G.E. Francis and Cristina Delgado

Totowa, N.J. : Humana Press, [2000]




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Diseases of the heart, chest & breast [electronic resource] : diagnostic imaging and interventional techniques / 39th International Diagnostic Course in Davos (IDKD), Davos, March 25-30, 2007, including the Pediatric Satellite Course "Kangaroo&qu

Milan ; New York : Springer, [2007]




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Danno vascolare e tromboemostasi [electronic resource] : fisiopatologia e patologia clinica / Vincenzo Sica, Claudio Napoli ; presentazione a cura di Giovanni Delrio

Milano : Springer, 2007




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Big 4 audit firms look to increase women in leadership roles

The Big Four employ about 200,000 in India. On average, around 40% are women. Clients of the Big Four are pressing for better diversity at workplaces to make them future-ready, a senior partner with a Big Four firm said. However, women in leadership roles cannot be increased overnight, countered another senior executive.




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PwC deferring promotions, increments and bonuses of India employees, partners to take 25% pay cut

PwC India is deferring promotions, increments and bonuses for all its employees in India due to Covid impact.




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Five in 10 organisations across industries keeping their salary increment budgets unchanged: Survey

According to the survey, five in 10 companies have deferred or suspended their promotion schedule; at the same time a downward trend on promotions numbers across all job levels was observed wherein 33% of organisations admitted to having reduced it. However, most organisations in IT/ITES, life sciences/pharma and retail sector have refrained from any downwards trend in overall promotion cycle.




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One in three Indian professionals now have decreased income: LinkedIn survey

IT, media, and manufacturing employees think their firms will do worse in the next 6 months. However, they’re confident about long-term growth - 77% of manufacturing professionals, 67% of media professionals, and 65% of IT professionals thought their companies would pick up in the next 2 years.




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Simultaneous ozonation of 90 organic micropollutants including illicit drugs and their metabolites in different water matrices

Environ. Sci.: Water Res. Technol., 2020, Accepted Manuscript
DOI: 10.1039/D0EW00260G, Paper
Open Access
Garyfalia A. Zoumpouli, Fernanda Siqueira Souza, Bruce Petrie, Liliana Féris, Barbara Kasprzyk-Hordern, Jannis Wenk
The ozonation of 90 chemically diverse organic micropollutants (OMPs) including four classes of illicit drugs and their metabolites was studied in pure buffered water, tap water and wastewater effluent at...
The content of this RSS Feed (c) The Royal Society of Chemistry




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News from the John W. Kluge Center: Don’t miss out: 30 Years Since the Fall of the Berlin Wall

Get your free tickets here.


This week, on Thursday, December 5, at 4pm in room LJ-119 of the Thomas Jefferson Building, the John W. Kluge Center will hold a discussion marking the 30th anniversary of the fall of the Berlin Wall.


Hope M. Harrison and Constanze Stelzenmüller will take part in a discussion moderated by Kluge Center Director John Haskell on the history of the wall itself, why it fell, and how German reunification impacts today’s politics and the future of democracy.


The event is free, but due to expected demand, tickets are recommended. Tickets are available on a first-come, first-served basis. Visit the event ticketing site for more information and to secure your ticket. Entry is not guaranteed.

Register for a ticket here.


Questions? Please contact (202) 707-9219 or scholarly@loc.gov

 




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Ram Janambhoomi Teertha Kshetra put under section 80G; donations to trust exempted from income tax

The Shri Ram Janambhoomi Teerth Kshetra Trust has been created for the construction of the Ram temple in Ayodhya. The 15-member trust was constituted by the Modi government, after the Supreme Court's verdict on November 9 settled the Ram Janmabhoomi-Babri Masjid case.