tal Human conflict and ecosystem services: finding the environmental price of warfare By feedproxy.google.com Published On :: Wed, 02 Jul 2014 10:57:18 +0000 2 July 2014 , Volume 90, Number 4 Robert A. Francis and Krishna Krishnamurthy Full Article
tal Valuing Vital Resources in India: Potential for Integrated Approaches to Water, Energy and Agricultural Sustainability By feedproxy.google.com Published On :: Tue, 06 Jan 2015 11:15:01 +0000 Invitation Only Research Event 16 January 2015 - 9:00am to 2:00pm The India Habitat Centre, New Delhi, India Event participants Dr Ashwini Swain, Fellow, CUTS Institute for Regulation and CompetitionGlada Lahn, Senior Research Fellow, Energy, Environment and Resources, Chatham HouseDr Gareth Price, Senior Research Fellow, Asia Programme, Chatham House As part of the international dialogue on Valuing Vital Resources, this seminar will convene policy-makers, scholars, technical practitioners, NGOs, multilateral agencies and the media to discuss recommendations for new policy approaches in India to reorient energy and water use in agriculture. The aim is to gain input to practical policy proposals and identify the work now needed to make them robust. Attendance is by invitation only. Please note this event is held in New Delhi, all times are local. This event is organized together with the CUTS Institute for Regulation & Competition (CIRC). Event attributes External event Department/project Energy, Environment and Resources Programme, Valuing Vital Resources Glada Lahn Senior Research Fellow, Energy, Environment and Resources Programme, Chatham House Email Full Article
tal The Economics of Natural Capital By feedproxy.google.com Published On :: Mon, 13 Apr 2015 09:15:02 +0000 Members Event 24 June 2015 - 1:00pm to 2:00pm Chatham House, London Transcriptpdf | 120.49 KB Transcript: Q&Apdf | 135.64 KB Event participants Professor Dieter Helm CBE, Professor of Energy Policy, University of OxfordChair: David Shukman, Science Editor, BBC News As the global population and economy continues to grow, the international community faces the challenge of accommodating significant growth over the coming decades without a major loss of biodiversity and natural capital, the world’s stock of natural resources. Presenting an economic analysis of these natural assets, Dieter Helm will argue that natural capital and environmental concerns should be placed at the core of economic policy. He will set out a framework for sustainable growth, outlining key measures that could help to preserve the environment while also enabling economic growth. Members Events Team Email Full Article
tal The Elements of Power: Gadgets, Guns and the Struggle for a Sustainable Future in the Rare Metal Age By feedproxy.google.com Published On :: Fri, 29 Apr 2016 14:30:01 +0000 Invitation Only Research Event 19 May 2016 - 5:00pm to 6:30pm Chatham House, London, UK At this session, the speaker will argue that our future hinges on a set of elements that receive scant attention even from those whose fortunes rely upon them. The speaker will outline why our electronic gadgets, the most powerful armies and indeed the fate of our planet depend on producing sustainable supplies of rare metals. He will outline some of the new environmental, economic, and geopolitical consequences of supply chains and discuss the dynamics of the rare metal markets which are vastly different than traditional commodities traded on open exchanges. The speaker will also address some of the security of supply issues arising from China's role as the dominant consumer and producer of most of the world’s minor metals. Finally, the discussion will also include what countries and companies can do to ensure resilient supply lines.Attendance at this event is by invitation only. Department/project Energy, Environment and Resources Programme Owen Grafham Manager, Energy, Environment and Resources Programme +44 (0)20 7957 5708 Email Full Article
tal D-backs add mental skills dept. to aid players By mlb.mlb.com Published On :: Fri, 1 Feb 2019 15:05:06 EDT In an effort to help develop their players on and off the field, the D-backs have added a mental skills department to their baseball operations staff. Full Article
tal Covid-19: Nightingale hospitals set to shut down after seeing few patients By feeds.bmj.com Published On :: 2020-05-07T06:50:46-07:00 The mothballing of Britain’s Nightingale hospitals, some of which have yet to treat a single covid-19 patient, has raised questions about whether resources to fight the pandemic were... Full Article
tal Opioid agonist treatment and risk of mortality during opioid overdose public health emergency: population based retrospective cohort study By feeds.bmj.com Published On :: Tuesday, March 31, 2020 - 09:36 Full Article
tal Use of electronic medical records in development and validation of risk prediction models of hospital readmission: systematic review By feeds.bmj.com Published On :: Wednesday, April 8, 2020 - 09:41 Full Article
tal Association between maternal and paternal mental illness and risk of injuries in children and adolescents: nationwide register based cohort study in Sweden By feeds.bmj.com Published On :: Wednesday, April 8, 2020 - 22:31 Full Article
tal FTC puts Total gas market share at 30% - Sees no threat to competition from Epping deal By jamaica-gleaner.com Published On :: Fri, 08 May 2020 00:08:14 -0500 THE ACQUISITION of Epping resulted in Total Jamaica controlling nearly a third of the retail gasolene market, but that’s not enough to lessen competition, the Fair Trading Commission, FTC, has found. “The acquisition is unlikely to have either the... Full Article
tal Digital Jamaica throws sales lifeline to furniture companies By jamaica-gleaner.com Published On :: Fri, 08 May 2020 00:18:42 -0500 DESPITE TUMBLING sales and challenges with hire-purchase accounts, two of the largest retailers of home furniture and appliances, Courts Jamaica and Singer Jamaica, have found glimmers of hope during the COVID-19 pandemic. That’s because work-from... Full Article
tal Healthcare comes to standstill in east Aleppo as last hospitals are destroyed By feeds.bmj.com Published On :: Wednesday, November 23, 2016 - 13:46 Full Article
tal Covid-19: UK death toll overtakes Italy’s to become worst in Europe By feeds.bmj.com Published On :: Wednesday, May 6, 2020 - 13:37 Full Article
tal Atomic force microscopy-based characterization of the interaction of PriA helicase with stalled DNA replication forks [DNA and Chromosomes] By feedproxy.google.com Published On :: 2020-05-01T00:06:09-07:00 In bacteria, the restart of stalled DNA replication forks requires the DNA helicase PriA. PriA can recognize and remodel abandoned DNA replication forks, unwind DNA in the 3'-to-5' direction, and facilitate the loading of the helicase DnaB onto the DNA to restart replication. Single-stranded DNA–binding protein (SSB) is typically present at the abandoned forks, but it is unclear how SSB and PriA interact, although it has been shown that the two proteins interact both physically and functionally. Here, we used atomic force microscopy to visualize the interaction of PriA with DNA substrates with or without SSB. These experiments were done in the absence of ATP to delineate the substrate recognition pattern of PriA before its ATP-catalyzed DNA-unwinding reaction. These analyses revealed that in the absence of SSB, PriA binds preferentially to a fork substrate with a gap in the leading strand. Such a preference has not been observed for 5'- and 3'-tailed duplexes, suggesting that it is the fork structure that plays an essential role in PriA's selection of DNA substrates. Furthermore, we found that in the absence of SSB, PriA binds exclusively to the fork regions of the DNA substrates. In contrast, fork-bound SSB loads PriA onto the duplex DNA arms of forks, suggesting a remodeling of PriA by SSB. We also demonstrate that the remodeling of PriA requires a functional C-terminal domain of SSB. In summary, our atomic force microscopy analyses reveal key details in the interactions between PriA and stalled DNA replication forks with or without SSB. Full Article
tal A Path to Citizenship for 1.8 Million DREAMERs? Despite Talk, No Proposal Would Do So By www.migrationpolicy.org Published On :: Thu, 15 Feb 2018 15:54:34 -0500 Even as the 1.8 million number swirls in the discussion of how many DREAMers would be placed on a path to citizenship, proposals debated in the Senate in February 2018 would have resulted in the legalization of smaller numbers, as this commentary explains. It offers estimates of potential beneficiaries of several Senate proposals, including one backed by the White House, and analysis of key criteria. Full Article
tal Lack of Opportunities and Family Pressures Drive Unaccompanied Minor Migration from Albania to Italy By www.migrationpolicy.org Published On :: Tue, 16 Jul 2019 14:38:33 -0400 Faced with a lack of employment opportunities and recurrent poverty, Albanian youth migrate to Italy alone in the hopes of improving their educational prospects or making money for their families. Yet upon arrival, they face many vulnerabilities. While some protections for unaccompanied minors exist in the Italy, the system is greatly fragmented and challenges, including how to return them to Albania, remain persistent. Full Article
tal Chasing the Dubai Dream in Italy: Bangladeshi Migration to Europe By www.migrationpolicy.org Published On :: Tue, 03 Oct 2017 13:02:31 -0400 Bangladeshis in 2017 suddenly emerged as one of the top migrant groups entering Europe illegally. While Europe is a new destination, Bangladeshi labor migration has been an important part of the country's development since the 1970s, with growing numbers heading abroad, largely to the Gulf Cooperation Council countries. This article explores and contextualizes the new phenomenon of Bangladeshi migration to Europe. Full Article
tal Migration and Environmental Change: Assessing the Developing European Approach By www.migrationpolicy.org Published On :: Wed, 01 May 2013 00:00:00 -0400 This policy brief explores the relationship between environmental change and migration to Europe in light of recent scholarship challenging the notion that environmental change triggers mass migration. It presents an overview of European policy response in this area and summarizes the spectrum of proposed solutions. Full Article
tal Environmental Change and Migration: What We Know By www.migrationpolicy.org Published On :: Sun, 01 Sep 2013 00:00:00 -0400 Environmental change is likely to affect global migration flows in a number of ways. Both long-term trends such as increased flooding and the increasing scarcity of resources as well as shorter term trends like severe weather are likely to contribute to displacement and increased migration for individuals already in vulnerable situations. While often viewed as a negative outcome of climate change, planned migration can also serve as a strategy for mitigating its impact. Full Article
tal Human Rights, Climate Change, Environmental Degradation and Migration: A New Paradigm By www.migrationpolicy.org Published On :: Fri, 14 Mar 2014 14:27:50 -0400 Discussion at launch of this MPI-IOM Issue in Brief, Human Rights, Climate Change, Environmental Degradation and Migration: A New Paradigm, which focuses on the vulnerability of environmental migrants and how the international legal framework can better ensure their protection, particularly in the Asia-Pacific region. Full Article
tal Human Rights, Climate Change, Environmental Degradation and Migration: A New Paradigm By www.migrationpolicy.org Published On :: Wed, 19 Mar 2014 12:19:19 -0400 This issue brief addresses the rights of migrants whose movement is induced by environmental degradation or climate change, particularly in the highly vulnerable Asia-Pacific region. The brief evaluates the current international legal framework, identifies gaps in the framework and its implementation, and reviews options available to the international community. Full Article
tal Human Rights, Climate Change, Environmental Degradation and Migration: A New Paradigm By www.migrationpolicy.org Published On :: Wed, 23 Apr 2014 15:44:22 -0400 This MPI event, in partnership with the International Organization for Migration (IOM), discusses the critical issue of climate-related displacement in the Asia-Pacific region, focusing on the vulnerability of environmental migrants and how the international legal framework can better ensure their protection. Full Article
tal Reaching a “Fair Deal” on Talent: Emigration, Circulation, and Human Capital in Countries of Origin By www.migrationpolicy.org Published On :: Tue, 02 Feb 2016 10:39:57 -0500 While skilled migration brings widely acknowledged economic benefits for destination countries and migrants, its impact on countries of origin has been the subject of more debate. Despite a growing consensus that origin countries can benefit from emigration and the circulation of skills, enabling this potential to be fully exploited remains a challenge. This report examines initiatives that develop skills and human capital. Full Article
tal Intellectual Disability in KATP Channel Neonatal Diabetes By care.diabetesjournals.org Published On :: 2020-02-20T11:55:29-08:00 OBJECTIVE Neonatal diabetes has been shown to be associated with high neuropsychiatric morbidity in a genotype-phenotype–dependent manner. However, the specific impact of different mutations on intellectual functioning is still insufficiently characterized. Specifically, only a small number of subjects with developmental delay have been comprehensively assessed, creating a knowledge gap about patients carrying the heaviest burden. RESEARCH DESIGN AND METHODS We assessed the intellectual functioning and mental health of the complete Norwegian population with KATP channel neonatal diabetes. Eight sulfonylurea-treated children (five with the p.V59M genotype [KCNJ11]) were assessed using age-matched control subjects with type 1 diabetes. The investigations included a physical and motor developmental examination, cerebral MRI, psychometrical examination, and questionnaires assessing intellectual capabilities and psychiatric morbidity. RESULTS A strong genotype-phenotype correlation was found, revealing the p.V59M genotype as highly associated with substantial intellectual disability, with no significant correlation with the time of sulfonylurea initiation. Consistent with previous studies, other genotypes were associated with minor cognitive impairment. Cerebral MRI verified normal brain anatomy in all but one child. CONCLUSIONS We here presented a comprehensive assessment of intellectual functioning in the largest cohort of p.V59M subjects to date. The level of intellectual disability revealed not only changes the interpretation of other psychological measures but downplays a strong protective effect of sulfonylurea. Within the scope of this study, we could not find evidence supporting an early treatment start to be beneficial, although a weaker effect cannot be ruled out. Full Article
tal Brooks Koepka learned not to smack talk Michael Jordan on golf course By www.upi.com Published On :: Thu, 07 May 2020 08:12:10 -0400 PGA Tour star Brooks Koepka said he'll no longer smack talk Michael Jordan on the golf course after he lost a round to the basketball legend. Full Article
tal Peyton Manning trash talks Tom Brady before May 24 golf match By www.upi.com Published On :: Fri, 08 May 2020 07:59:36 -0400 Former star quarterback Peyton Manning delivered some trash talk to Tampa Bay Buccaneers star Tom Brady while they promoted their May 24 charity golf match. Full Article
tal Korea's K-League soccer returns with rules against spitting, talking By www.upi.com Published On :: Fri, 08 May 2020 10:49:47 -0400 K-League soccer resumed with a game behind closed doors Friday in South Korea, with players prohibited from spitting and talking. Full Article
tal Mortality Implications of Prediabetes and Diabetes in Older Adults By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE Diabetes in older age is heterogeneous, and the treatment approach varies by patient characteristics. We characterized the short-term all-cause and cardiovascular mortality risk associated with hyperglycemia in older age. RESEARCH DESIGN AND METHODS We included 5,791 older adults in the Atherosclerosis Risk in Communities Study who attended visit 5 (2011–2013; ages 66–90 years). We compared prediabetes (HbA1c 5.7% to <6.5%), newly diagnosed diabetes (HbA1c ≥6.5%, prior diagnosis <1 year, or taking antihyperglycemic medications <1 year), short-duration diabetes (duration ≥1 year but <10 years [median]), and long-standing diabetes (duration ≥10 years). Outcomes were all-cause and cardiovascular mortality (median follow-up of 5.6 years). RESULTS Participants were 58% female, and 24% had prevalent cardiovascular disease. All-cause mortality rates, per 1,000 person-years, were 21.2 (95% CI 18.7, 24.1) among those without diabetes, 23.7 (95% CI 20.8, 27.1) for those with prediabetes, 33.8 (95% CI 25.2, 45.5) among those with recently diagnosed diabetes, 29.6 (95% CI 25.0, 35.1) for those with diabetes of short duration, and 48.6 (95% CI 42.4, 55.7) for those with long-standing diabetes. Cardiovascular mortality rates, per 1,000 person-years, were 5.8 (95% CI 4.6, 7.4) among those without diabetes, 6.6 (95% CI 5.2, 8.5) for those with prediabetes, 11.5 (95% CI 7.0, 19.1) among those with recently diagnosed diabetes, 8.2 (95% CI 5.9, 11.3) for those with diabetes of short duration, and 17.3 (95% CI 13.8, 21.7) for those with long-standing diabetes. After adjustment for other cardiovascular risk factors, prediabetes and newly diagnosed diabetes were not significantly associated with a higher risk of all-cause mortality (hazard ratio [HR] 1.03 [95% CI 0.85, 1.23] and HR 1.31 [95% CI 0.94, 1.82], respectively) or cardiovascular mortality (HR 1.00 [95% CI 0.70, 1.43] and HR 1.35 [95% CI 0.74, 2.49], respectively). Excess mortality risk was primarily concentrated among those with long-standing diabetes (all-cause: HR 1.71 [95% CI 1.40, 2.10]; cardiovascular: HR 1.72 [95% CI 1.18, 2.51]). CONCLUSIONS In older adults, long-standing diabetes has a substantial and independent effect on short-term mortality. Older individuals with prediabetes remained at low mortality risk over a median 5.6 years of follow-up. Full Article
tal Clinical Outcomes in Patients With Isolated or Combined Diabetic Ketoacidosis and Hyperosmolar Hyperglycemic State: A Retrospective, Hospital-Based Cohort Study By care.diabetesjournals.org Published On :: 2020-01-20T12:00:30-08:00 OBJECTIVE Many patients with hyperglycemic crises present with combined features of diabetic ketoacidosis (DKA) and hyperosmolar hyperglycemic state (HHS). The implications of concomitant acidosis and hyperosmolality are not well known. We investigated hospital outcomes in patients with isolated or combined hyperglycemic crises. RESEARCH DESIGN AND METHODS We analyzed admissions data listing DKA or HHS at two academic hospitals. We determined 1) the frequency distributions of HHS, DKA, and combined DKA-HHS (DKA criteria plus elevated effective osmolality); 2) the relationship of markers of severity of illness and clinical comorbidities with 30-day all-cause mortality; and 3) the relationship of hospital complications associated with insulin therapy (hypoglycemia and hypokalemia) with mortality. RESULTS There were 1,211 patients who had a first admission with confirmed hyperglycemic crises criteria, 465 (38%) who had isolated DKA, 421 (35%) who had isolated HHS, and 325 (27%) who had combined features of DKA-HHS. After adjustment for age, sex, BMI, race, and Charlson Comorbidity Index score, subjects with combined DKA-HHS had higher in-hospital mortality compared with subjects with isolated hyperglycemic crises (adjusted odds ratio [aOR] 2.7; 95% CI 1.4, 4.9; P = 0.0019). In all groups, hypoglycemia (<40 mg/dL) during treatment was associated with a 4.8-fold increase in mortality (aOR 4.8; 95% CI 1.4, 16.8). Hypokalemia ≤3.5 mEq/L was frequent (55%). Severe hypokalemia (≤2.5 mEq/L) was associated with increased inpatient mortality (aOR 4.9; 95% CI 1.3, 18.8; P = 0.02). CONCLUSIONS Combined DKA-HHS is associated with higher mortality compared with isolated DKA or HHS. Severe hypokalemia and severe hypoglycemia are associated with higher hospital mortality in patients with hyperglycemic crises. Full Article
tal Impact of Treating Oral Disease on Preventing Vascular Diseases: A Model-Based Cost-effectiveness Analysis of Periodontal Treatment Among Patients With Type 2 Diabetes By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE Previous randomized trials found that treating periodontitis improved glycemic control in patients with type 2 diabetes (T2D), thus lowering the risks of developing T2D-related microvascular diseases and cardiovascular disease (CVD). Some payers in the U.S. have started covering nonsurgical periodontal treatment for those with chronic conditions, such as diabetes. We sought to identify the cost-effectiveness of expanding periodontal treatment coverage among patients with T2D. RESEARCH DESIGN AND METHODS A cost-effectiveness analysis was conducted to estimate lifetime costs and health gains using a stochastic microsimulation model of oral health conditions, T2D, T2D-related microvascular diseases, and CVD of the U.S. population. Model parameters were obtained from the nationally representative National Health and Nutrition Examination Survey (NHANES) (2009–2014) and randomized trials of periodontal treatment among patients with T2D. RESULTS Expanding periodontal treatment coverage among patients with T2D and periodontitis would be expected to avert tooth loss by 34.1% (95% CI –39.9, –26.5) and microvascular diseases by 20.5% (95% CI –31.2, –9.1), 17.7% (95% CI –32.7, –4.7), and 18.4% (95% CI –34.5, –3.5) for nephropathy, neuropathy, and retinopathy, respectively. Providing periodontal treatment to the target population would be cost saving from a health care perspective at a total net savings of $5,904 (95% CI –6,039, –5,769) with an estimated gain of 0.6 quality-adjusted life years per capita (95% CI 0.5, 0.6). CONCLUSIONS Providing nonsurgical periodontal treatment to patients with T2D and periodontitis would be expected to significantly reduce tooth loss and T2D-related microvascular diseases via improved glycemic control. Encouraging patients with T2D and poor oral health conditions to receive periodontal treatment would improve health outcomes and still be cost saving or cost-effective. Full Article
tal Dietary Nonheme, Heme, and Total Iron Intake and the Risk of Diabetes in Adults: Results From the China Health and Nutrition Survey By care.diabetesjournals.org Published On :: 2020-03-20T11:50:34-07:00 OBJECTIVE Excessive iron intake has been linked to diabetes risk. However, the evidence is inconsistent. This study examined the association between dietary heme and nonheme iron intake and diabetes risk in the Chinese population. RESEARCH DESIGN AND METHODS We included 17,026 adults (8,346 men and 8,680 women) who were part of the China Health and Nutrition Survey (1991–2015) prospective cohort. Dietary intake was measured by three consecutive 24-h dietary recalls combined with a household food inventory. Diabetes cases were identified through a questionnaire. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% CIs. RESULTS A total of 547 men and 577 women developed diabetes during 202,138 person-years of follow-up. For men, the adjusted HRs (95% CIs) for quintiles of nonheme iron intake were 1.00, 0.77 (0.58–1.02), 0.72 (0.54–0.97), 0.63 (0.46–0.85), and 0.87 (0.64–1.19) (P-nonlinearity = 0.0015). The corresponding HRs (95% CIs) for women were 1.00, 0.63 (0.48–0.84), 0.57 (0.43–0.76), 0.58 (0.43–0.77), and 0.67 (0.49–0.91) (P-nonlinearity < 0.0001). The dose-response curves for the association between nonheme iron and total iron intake and diabetes followed a reverse J shape in men and an L shape in women. No significant associations were observed between heme iron intake and diabetes risk. CONCLUSIONS Total iron and nonheme iron intake was associated with diabetes risk, following a reverse J-shaped curve in men and an L-shaped curve in women. Sufficient intake of nonheme or total iron might be protective against diabetes, while excessive iron intake might increase the risk of diabetes among men. Full Article
tal Watch: Driver accidentally reverses onto two parked cars outside Florida bank By www.upi.com Published On :: Wed, 06 May 2020 10:31:58 -0400 A Florida sheriff's office said a driver reversing out of a bank parking lot accidentally ended up backing up onto two other cars. Full Article
tal Prevalence of Hyper- and Hypoglycemia Among Inpatients With Diabetes: A national survey of 44 U.S. hospitals By care.diabetesjournals.org Published On :: 2007-02-01 Deborah J. WexlerFeb 1, 2007; 30:367-369BR Epidemiology/Health Services/Psychosocial Research Full Article
tal In-Hospital Prognosis of Ppatients With Fasting Hyperglycemia After First Myocardial Infarction By care.diabetesjournals.org Published On :: 1991-08-01 John J O'SullivanAug 1, 1991; 14:758-760Short Report Full Article
tal A Mathematical Model for the Determination of Total Area Under Glucose Tolerance and Other Metabolic Curves By care.diabetesjournals.org Published On :: 1994-02-01 Mary M TaiFeb 1, 1994; 17:152-154Short Report Full Article
tal Periodontal Disease: The sixth complication of diabetes mellitus By care.diabetesjournals.org Published On :: 1993-01-01 Harald LöeJan 1, 1993; 16:329-334Supplement 1: Diabetes in Native Americans Full Article
tal Coronary Heart Disease Incidence and Cardiovascular Mortality in Busselton with Reference to Glucose and Insulin Concentrations By care.diabetesjournals.org Published On :: 1979-03-01 T A WelbornMar 1, 1979; 2:154-160Proceedings of the Kroc Foundation International Conference on Epidemiology of Diabetes and its Macrovascular Complications Full Article
tal Gestational Diabetes Mellitus and Diet: A Systematic Review and Meta-analysis of Randomized Controlled Trials Examining the Impact of Modified Dietary Interventions on Maternal Glucose Control and Neonatal Birth Weight By care.diabetesjournals.org Published On :: 2018-07-01 Jennifer M. YamamotoJul 1, 2018; 41:1346-1361Reconsidering Pregnancy With Diabetes Full Article
tal Diabetes Technology Update: Use of Insulin Pumps and Continuous Glucose Monitoring in the Hospital By care.diabetesjournals.org Published On :: 2018-08-01 Guillermo E. UmpierrezAug 1, 2018; 41:1579-1589Diabetes Care Symposium Full Article
tal Vasodilatory Actions of Glucagon-Like Peptide 1 Are Preserved in Skeletal and Cardiac Muscle Microvasculature but Not in Conduit Artery in Obese Humans With Vascular Insulin Resistance By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE Obesity is associated with microvascular insulin resistance, which is characterized by impaired insulin-mediated microvascular recruitment. Glucagon-like peptide 1 (GLP-1) recruits skeletal and cardiac muscle microvasculature, and this action is preserved in insulin-resistant rodents. We aimed to examine whether GLP-1 recruits microvasculature and improves the action of insulin in obese humans. RESEARCH DESIGN AND METHODS Fifteen obese adults received intravenous infusion of either saline or GLP-1 (1.2 pmol/kg/min) for 150 min with or without a euglycemic insulin clamp (1 mU/kg/min) superimposed over the last 120 min. Skeletal and cardiac muscle microvascular blood volume (MBV), flow velocity and blood flow, brachial artery diameter and blood flow, and pulse wave velocity (PWV) were determined. RESULTS Insulin failed to change MBV or flow in either skeletal or cardiac muscle, confirming the presence of microvascular insulin resistance. GLP-1 infusion alone increased MBV by ~30% and ~40% in skeletal and cardiac muscle, respectively, with no change in flow velocity, leading to a significant increase in microvascular blood flow in both skeletal and cardiac muscle. Superimposition of insulin to GLP-1 infusion did not further increase MBV or flow in either skeletal or cardiac muscle but raised the steady-state glucose infusion rate by ~20%. Insulin, GLP-1, and GLP-1 + insulin infusion did not alter brachial artery diameter and blood flow or PWV. The vasodilatory actions of GLP-1 are preserved in both skeletal and cardiac muscle microvasculature, which may contribute to improving metabolic insulin responses and cardiovascular outcomes. CONCLUSIONS In obese humans with microvascular insulin resistance, GLP-1’s vasodilatory actions are preserved in both skeletal and cardiac muscle microvasculature, which may contribute to improving metabolic insulin responses and cardiovascular outcomes. Full Article
tal Association of Urine Haptoglobin With Risk of All-Cause and Cause-Specific Mortality in Individuals With Type 2 Diabetes: A Transethnic Collaborative Work By care.diabetesjournals.org Published On :: 2020-02-20T11:55:30-08:00 OBJECTIVE Haptoglobin is an acute-phase reactant with pleiotropic functions. We aimed to study whether urine haptoglobin may predict risk of mortality in people with type 2 diabetes. RESEARCH DESIGN AND METHODS We employed a transethnic approach with a cohort of Asian origin (Singapore) (N = 2,061) and a cohort of European origin (France) (N = 1,438) included in the study. We used survival analyses to study the association of urine haptoglobin with risk of all-cause and cause-specific mortality. RESULTS A total of 365 and 525 deaths were registered in the Singapore cohort (median follow-up 7.5 years [interquartile range 3.5–12.8]) and French SURDIAGENE cohort (median follow-up 6.8 years [interquartile range 4.3–10.5], respectively. Singapore participants with urine haptoglobin in quartiles 2 to 4 had higher risk for all-cause mortality compared with quartile 1 (unadjusted hazard ratio [HR] 1.47 [95% CI 1.02–2.11], 2.28 [1.62–3.21], and 4.64 [3.39–6.35], respectively). The association remained significant in quartile 4 after multiple adjustments (1.68 [1.15–2.45]). Similarly, participants in the French cohort with haptoglobin in quartile 4 had significantly higher hazards for all-cause mortality compared with quartile 1 (unadjusted HR 2.67 [2.09–3.42] and adjusted HR 1.49 [1.14–1.96]). In both cohorts, participants in quartile 4 had a higher risk of mortality attributable to cardiovascular disease and infection but not malignant tumor. CONCLUSIONS Urine haptoglobin predicts risk of mortality independent of traditional risk factors, suggesting that it may potentially be a novel biomarker for risk of mortality in patients with type 2 diabetes. Full Article
tal Stony Brook University opens Center for Implant and Digital Technology By www.ada.org Published On :: Thu, 02 Jan 2020 15:06:00 -0600 Stony Brook School of Dental Medicine opened Dec. 5 its Center for Implant and Digital Technology, which will serve as a state-of-the-art space for digital dentistry-focused education, patient care and research. Full Article
tal ADA seeks nominations for representation on Dental Quality Alliance By www.ada.org Published On :: Fri, 10 Jan 2020 13:01:00 -0600 The ADA is calling for nominations for two seats to represent the Association in the Dental Quality Alliance. Full Article
tal Dental schools, industry team up to create innovation centers By www.ada.org Published On :: Fri, 17 Jan 2020 10:44:00 -0600 The Center for Research & Education in Technology is encouraging dental schools to find out how to participate in its program and learn about the benefits to the school and its students. Full Article
tal Dental sealant webinar to stream Feb. 6 By www.ada.org Published On :: Fri, 17 Jan 2020 13:12:00 -0600 The ADA will present a free webinar Feb. 6 on dental sealants, especially designed to help dental providers in communities that do not yet have sealant programs in place. Full Article
tal Texas A&M dental school opens new clinic, education building By www.ada.org Published On :: Tue, 21 Jan 2020 10:14:00 -0600 Texas A&M College of Dentistry announced Jan. 17 it opened it’s a new 160,000-square-foot, nine-story clinic, which enables the dental school to increase underserved patients’ access to care. Full Article
tal Special Olympics athletes get dental help thanks to ADA member dentist By www.ada.org Published On :: Tue, 21 Jan 2020 11:15:00 -0600 As the world gets ready for the Special Olympics Sweden Invitational Games in February, one of the ADA’s member dentists will be watching as the Special Smiles program he founded will be used to screen and attend to the dental needs of the competing athletes. Full Article
tal Tufts University program provides homeless veterans with advanced dental care By www.ada.org Published On :: Tue, 28 Jan 2020 11:29:00 -0600 Service With A Smile was among 10 programs from nine universities to receive funding this year through the ADA Foundation’s E. “Bud” Tarrson Dental School Student Community Leadership Awards. Full Article
tal National Children’s Dental Health Month highlights optimally fluoridated water By www.ada.org Published On :: Wed, 29 Jan 2020 09:30:00 -0600 This year the February observance of National Children’s Dental Health Month honors the 75th anniversary of community water fluoridation with its theme, “Fluoride in water prevents cavities! Get it from the tap!” Full Article
tal Dental Quality Alliance to help dentists make connection between everyday dentistry, quality measures By www.ada.org Published On :: Wed, 29 Jan 2020 11:15:00 -0600 The Dental Quality Alliance will help dentists learn more about how quality measure domains can be best used to drive quality improvement at the practice level through a free webinar in March. Full Article
