rom Serial killer spotted on the night train from Newcastle By go.theregister.co.uk Published On :: Thu, 07 May 2020 08:15:08 GMT Remember when all we had to complain about were crappy rail services? Bork!Bork!Bork! Welcome to another in The Register's inexplicably long-lived series of digital signage suffering the odd public whoopsie.… Full Article
rom As coronavirus catches tech CEOs with their pants down, IBM's Ginni Rometty warns of IT's new role post-pandemic By go.theregister.co.uk Published On :: Thu, 07 May 2020 18:35:05 GMT Middle management is about to learn just how necessary they are Last night, one of the most senior figures in the IT industry from one of the biggest companies gave the strongest indication that when COVID-19 lockdowns gradually begin to lift, people will not return to the jobs they once had. That means both tech jobs, and how technology supports other business roles.… Full Article
rom GitHub Codespaces: VS Code was 'designed from the get-go' for this, says Microsoft architect By go.theregister.co.uk Published On :: Thu, 07 May 2020 20:21:08 GMT A compelling addition to repo house – but is the Redmond flavour too strong? GitHub had a lot to say about its plans at its virtual Satellite event yesterday, but the most far-reaching was the advent of Codespaces, the ability to edit code online, integrated into the GitHub user interface.… Full Article
rom Bored at home? Cisco has just the thing: A shed-load of security fixes to install, from a Kerberos bypass to crashes By go.theregister.co.uk Published On :: Thu, 07 May 2020 23:13:21 GMT Switchzilla issues a whopping 30+ patches in time for the long UK weekend Cisco has emitted a fresh round of software updates to address nearly three dozen security holes in its products.… Full Article
rom India’s Jio Platforms scores third US cash injection in three weeks - this time $1.5bn from Vista Equity Partners By go.theregister.co.uk Published On :: Fri, 08 May 2020 04:59:13 GMT It's like three buses showing up at once carrying $8bn India’s largest mobile carrier, Jio, has just scored a third new investor in three weeks!… Full Article
rom Source code for seminal adventure game Zork circa-1977 exhumed from MIT tapes, plonked on GitHub By go.theregister.co.uk Published On :: Fri, 08 May 2020 06:58:08 GMT Revisit what it’s like to run a PDP-10 and be eaten by a grue Source code for seminal adventure game Zork, dating back to 1977 and recovered from MIT tapes, was published this week on GitHub.… Full Article
rom 10/1/17 - No one from the future By www.tinyghosts.com Published On :: Monday, 02 Oct 2017 Full Article
rom Distant Worlds: music from FINAL FANTASY JIRITSU By www.gamemp3s.net Published On :: Fri, 22 Mar 2019 21:15:00 +0000 -Album Details- Title: Distant Worlds: music from FINAL FANTASY JIRITSU Publisher: Square Enix Music Catalog Number: SQEX-10659~60 Release Date: September 20th, 2018 Ripped by: dancey -Info- Nothing new or revelatory here other than it was only available at TGS2018, enjoy nonetheless. Full Article new releases
rom Featured - Career Advice from a Rock Star of Science By www.labspaces.net Published On :: Mon, 04 Apr 2011 22:53:32 -0500 I walked past the mini-conference room area that AACR set up in the middle of the exhibit hall and my eyes immediately zeroed in on the name of one of my science idols: Elizabeth Blackburn. She was going to be speaking about careers to young scientists and allow them to ask her questions. I noted the day and time. It wouldn’t matter to me what she was talking about. I would be there. ; (read more) Source: Suzy - Discipline: Careers Full Article
rom From Riches to Rags By www.funnyandjokes.com Published On :: Thu, 14 Nov 2013 12:33:00 +0000 A wealthy Catholic man travels to the Vatican City to see the Bishop of Rome in person, and hopes to meet this leader of the worldwide Catholic Church. Wearing his finest suit, he prays to God that he might be able to meet the Holy Father. During the morning’s Papal procession, he manages to work […] The post From Riches to Rags appeared first on Funny & Jokes. Full Article Jokes Religious Jokes
rom Exosome-mediated protection of auditory hair cells from ototoxic insults By www.jci.org Published On :: Hearing loss caused by the death of sensory hair cells of the inner ear is an unfortunate side effect for many patients treated with aminoglycoside antibiotics or platinum-containing chemotherapy agents. In animal models, induction of heat shock confers substantial otoprotection against aminoglycoside- and cisplatin-induced hair cell death. In this issue of the JCI, Breglio et al. demonstrate that inner ear tissue released exosomes carrying heat shock protein 70 (HSP70) in response to heat stress. HSP70 acted by a paracrine mechanism that engaged the Toll-like receptor 4 (TLR4) on hair cells to protect them from death. Exosomes and the HSP70/TLR4 pathway could thus provide treatment targets for the protection of hair cells from chemically induced death or from other insults, such as noise. Full Article
rom Posttreatment Lyme disease syndromes: distinct pathogenesis caused by maladaptive host responses By www.jci.org Published On :: Full Article
rom Targetable ERBB2 mutations identified in neurofibroma/schwannoma hybrid nerve sheath tumors By www.jci.org Published On :: BACKGROUND Neurofibroma/schwannoma hybrid nerve sheath tumors (N/S HNSTs) are neoplasms associated with larger nerves that occur sporadically and in the context of schwannomatosis or neurofibromatosis type 2 or 1. Clinical management of N/S HNSTs is challenging, especially for large tumors, and established systemic treatments are lacking.METHODS We used next-generation sequencing and array-based DNA methylation profiling to determine the clinically actionable genomic and epigenomic landscapes of N/S HNSTs.RESULTS Whole-exome sequencing within a precision oncology program identified an activating mutation (p.Asp769Tyr) in the catalytic domain of the ERBB2 receptor tyrosine kinase in a patient with schwannomatosis-associated N/S HNST, and targeted treatment with the small-molecule ERBB inhibitor lapatinib led to prolonged clinical benefit and a lasting radiographic and metabolic response. Analysis of a multicenter validation cohort revealed recurrent ERBB2 mutations (p.Leu755Ser, p.Asp769Tyr, p.Val777Leu) in N/S HNSTs occurring in patients who met diagnostic criteria for sporadic schwannomatosis (3 of 7 patients), but not in N/S HNSTs arising in the context of neurofibromatosis (6 patients) or outside a tumor syndrome (1 patient), and showed that ERBB2-mutant N/S HNSTs cluster in a distinct subgroup of peripheral nerve sheath tumors based on genome-wide DNA methylation patterns.CONCLUSION These findings uncover a key biological feature of N/S HNSTs that may have important diagnostic and therapeutic implications.FUNDING This work was supported by grant H021 from DKFZ-HIPO, the University Cancer Center Frankfurt, and the Frankfurt Research Funding Clinician Scientist Program. Full Article
rom The lymph node stromal laminin α5 shapes alloimmunity By www.jci.org Published On :: Lymph node stromal cells (LNSCs) regulate immunity through constructing lymphocyte niches. LNSC-produced laminin α5 (Lama5) regulates CD4+ T cells but the underlying mechanisms of its functions are poorly understood. Here we show that depleting Lama5 in LNSCs resulted in decreased Lama5 protein in the LN cortical ridge (CR) and around high endothelial venules (HEVs). Lama5 depletion affected LN structure with increased HEVs, upregulated chemokines, and cell adhesion molecules, and led to greater numbers of Tregs in the T cell zone. Mouse and human T cell transendothelial migration and T cell entry into LNs were suppressed by Lama5 through the receptors α6 integrin and α-dystroglycan. During immune responses and allograft transplantation, depleting Lama5 promoted antigen-specific CD4+ T cell entry into the CR through HEVs, suppressed T cell activation, and altered T cell differentiation to suppressive regulatory phenotypes. Enhanced allograft acceptance resulted from depleting Lama5 or blockade of T cell Lama5 receptors. Lama5 and Lama4/Lama5 ratios in allografts were associated with the rejection severity. Overall, our results demonstrated that stromal Lama5 regulated immune responses through altering LN structures and T cell behaviors. This study delineated a stromal Lama5–T cell receptor axis that can be targeted for immune tolerance modulation. Full Article
rom Parental metabolic syndrome epigenetically reprograms offspring hepatic lipid metabolism in mice By www.jci.org Published On :: The prevalence of nonalcoholic fatty liver disease (NAFLD) is increasing worldwide. Although gene-environment interactions have been implicated in the etiology of several disorders, the impact of paternal and/or maternal metabolic syndrome on the clinical phenotypes of offspring and the underlying genetic and epigenetic contributors of NAFLD have not been fully explored. To this end, we used the liver-specific insulin receptor knockout (LIRKO) mouse, a unique nondietary model manifesting 3 hallmarks that confer high risk for the development of NAFLD: hyperglycemia, insulin resistance, and dyslipidemia. We report that parental metabolic syndrome epigenetically reprograms members of the TGF-β family, including neuronal regeneration–related protein (NREP) and growth differentiation factor 15 (GDF15). NREP and GDF15 modulate the expression of several genes involved in the regulation of hepatic lipid metabolism. In particular, NREP downregulation increases the protein abundance of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) and ATP-citrate lyase (ACLY) in a TGF-β receptor/PI3K/protein kinase B–dependent manner, to regulate hepatic acetyl-CoA and cholesterol synthesis. Reduced hepatic expression of NREP in patients with NAFLD and substantial correlations between low serum NREP levels and the presence of steatosis and nonalcoholic steatohepatitis highlight the clinical translational relevance of our findings in the context of recent preclinical trials implicating ACLY in NAFLD progression. Full Article
rom TGF-β–induced epigenetic deregulation of SOCS3 facilitates STAT3 signaling to promote fibrosis By www.jci.org Published On :: Fibroblasts are key effector cells in tissue remodeling. They remain persistently activated in fibrotic diseases, resulting in progressive deposition of extracellular matrix. Although fibroblast activation may be initiated by external factors, prolonged activation can induce an “autonomous,” self-maintaining profibrotic phenotype in fibroblasts. Accumulating evidence suggests that epigenetic alterations play a central role in establishing this persistently activated pathologic phenotype of fibroblasts. We demonstrated that in fibrotic skin of patients with systemic sclerosis (SSc), a prototypical idiopathic fibrotic disease, TGF-β induced the expression of DNA methyltransferase 3A (DNMT3A) and DNMT1 in fibroblasts in a SMAD-dependent manner to silence the expression of suppressor of cytokine signaling 3 (SOCS3) by promoter hypermethylation. Downregulation of SOCS3 facilitated activation of STAT3 to promote fibroblast-to-myofibroblast transition, collagen release, and fibrosis in vitro and in vivo. Reestablishment of the epigenetic control of STAT3 signaling by genetic or pharmacological inactivation of DNMT3A reversed the activated phenotype of SSc fibroblasts in tissue culture, inhibited TGF-β–dependent fibroblast activation, and ameliorated experimental fibrosis in murine models. These findings identify a pathway of epigenetic imprinting of fibroblasts in fibrotic disease with translational implications for the development of targeted therapies in fibrotic diseases. Full Article
rom Bacterial CagA protein compromises tumor suppressor mechanisms in gastric epithelial cells By www.jci.org Published On :: Approximately half of the world’s population is infected with the stomach pathogen Helicobacter pylori. Infection with H. pylori is the main risk factor for distal gastric cancer. Bacterial virulence factors, such as the oncoprotein CagA, augment cancer risk. Yet despite high infection rates, only a fraction of H. pylori–infected individuals develop gastric cancer. This raises the question of defining the specific host and bacterial factors responsible for gastric tumorigenesis. To investigate the tumorigenic determinants, we analyzed gastric tissues from human subjects and animals infected with H. pylori bacteria harboring different CagA status. For laboratory studies, well-defined H. pylori strain B128 and its cancerogenic derivative strain 7.13, as well as various bacterial isogenic mutants were employed. We found that H. pylori compromises key tumor suppressor mechanisms: the host stress and apoptotic responses. Our studies showed that CagA induces phosphorylation of XIAP E3 ubiquitin ligase, which enhances ubiquitination and proteasomal degradation of the host proapoptotic factor Siva1. This process is mediated by the PI3K/Akt pathway. Inhibition of Siva1 by H. pylori increases survival of human cells with damaged DNA. It occurs in a strain-specific manner and is associated with the ability to induce gastric tumor. Full Article
rom Moving from transplant as a treatment to transplant as a cure By www.jci.org Published On :: Immunosuppression continues to be a necessary component of transplantation, despite its association with a multitude of adverse effects. Numerous efforts have been made to circumvent the need for immunosuppression by using various techniques to achieve donor hyporesponsiveness. In this issue of the JCI, Morath et al. take this endeavor forward. Prior to transplantation, the researchers infused recipients with donor-modified immune cells and achieved immunologic hyporesponsiveness. This successful phase I trial also provides a possible avenue for achieving transplantation without the requisite immunosuppression. Full Article
rom Local microvascular leakage promotes trafficking of activated neutrophils to remote organs By www.jci.org Published On :: Increased microvascular permeability to plasma proteins and neutrophil emigration are hallmarks of innate immunity and key features of numerous inflammatory disorders. Although neutrophils can promote microvascular leakage, the impact of vascular permeability on neutrophil trafficking is unknown. Here, through the application of confocal intravital microscopy, we report that vascular permeability–enhancing stimuli caused a significant frequency of neutrophil reverse transendothelial cell migration (rTEM). Furthermore, mice with a selective defect in microvascular permeability enhancement (VEC-Y685F-ki) showed reduced incidence of neutrophil rTEM. Mechanistically, elevated vascular leakage promoted movement of interstitial chemokines into the bloodstream, a response that supported abluminal-to-luminal neutrophil TEM. Through development of an in vivo cell labeling method we provide direct evidence for the systemic dissemination of rTEM neutrophils, and showed them to exhibit an activated phenotype and be capable of trafficking to the lungs where their presence was aligned with regions of vascular injury. Collectively, we demonstrate that increased microvascular leakage reverses the localization of directional cues across venular walls, thus causing neutrophils engaged in diapedesis to reenter the systemic circulation. This cascade of events offers a mechanism to explain how local tissue inflammation and vascular permeability can induce downstream pathological effects in remote organs, most notably in the lungs. Full Article
rom Maps from Isolation By www.maproomblog.com Published On :: Wed, 22 Apr 2020 14:53:03 +0000 Full Article Art 2019-nCoV CityLab coronavirus COVID-19 hand-drawn
rom A U.S. Army Film from 1971: ‘Mapping a Better Tomorrow’ By www.maproomblog.com Published On :: Thu, 23 Apr 2020 13:21:52 +0000 Full Article Cartography GIS history of cartography military military cartography Moon topo maps U.S. Army
rom Lifeguard romance out now! By www.keiraandrews.com Published On :: Thu, 19 Sep 2019 14:59:05 +0000 It’s release day for my new MM romance! My last release was Christmas 2018, so I’m very excited to finally have a new book for you. When I was in Australia earlier this year, I got hooked on Bondi Rescue, and this (completely fictional!) romance between a trainee and an older, very closeted lifeguard was born. […] Full Article blog action/adventure age difference coming out contemporary gay romance first time friends to lovers hurt/comfort kindle unlimited new release
rom Holiday romance deal! By www.keiraandrews.com Published On :: Sat, 09 Nov 2019 22:56:27 +0000 You can grab four steamy and sweet MM holiday romances in one box set for a major discount! This new collection is only $6.99 or you can borrow it in KU. I’m also very excited that these novellas are available in print for the first time! ???? Buy the ebook box set exclusively at Amazon […] Full Article blog age difference bdsm book deals christmas romance coming out contemporary gay romance first time friends to lovers holiday romance hurt/comfort kindle unlimited new adult gay romance new release virgin
rom New holiday romance! By www.keiraandrews.com Published On :: Sat, 16 Nov 2019 01:50:37 +0000 “Looking for a fun and sweet holiday romance with dual POV, some heat, a humorous caper, and a wonderful HEA ending? Look no further!” ~ Gay Book Reviews Fa-la-la-la-la! My new holiday romance is now available to buy or borrow in KU! You’ve got fake boyfriends, bisexual exploration, found family, a single dad in desperate need […] Full Article blog bisexual romance christmas romance coming out contemporary gay romance first time friends to lovers holiday romance hurt/comfort kindle unlimited make the yuletide gay new release
rom New (old) title for my figure skating romance By www.keiraandrews.com Published On :: Sun, 12 Jan 2020 18:26:10 +0000 My figure skating romance has a new (old) title! Misha and Dev’s story was originally two novellas published through Loose Id called Cold War and Holding the Edge. I later combined them into one volume to give you more bang for your buck. To avoid confusion, I called the book The Winning Edge. However, Cold War is frankly just a much better […] Full Article blog coming out contemporary gay romance enemies to lovers figure skating figure skating romance hate to love kindle unlimited news sports
rom Deals: Refurbished 15-Inch MacBook Pro Notebooks on Sale at Woot From $1,580 ($800+ Off) By www.macrumors.com Published On :: Fri, 08 May 2020 08:35:35 PDT Woot is ending the week with a refurbished sale on the 15-inch MacBook Pro, available in multiple storage sizes and colors. The sale starts with the 256GB SSD model (16GB RAM, Intel Core i7) for $1,579.99. Note: MacRumors is an affiliate partner with Woot. When you click a link and make a purchase, we may receive a small payment, which helps us keep the site running. For more storage, the 512GB SSD model (16GB RAM, Intel Core i9) is on sale for $1,849.99. Woot's refurbished sales are offering more than $800 in savings when compared to the original prices of these notebooks, which began at $2,399.00 when they launched in May 2019. Similar to previous Woot sales, each MacBook Pro comes with a One Year Limited Woot Warranty. Each device has been refurbished and is ensured to be in full working condition. When shipped, they are packaged in a generic white box. You can find even more discounts on new MacBooks by visiting our Best Deals guide for MacBook Pro and MacBook Air. In this guide we track the steepest discounts for the newest MacBook models every week, so be sure to bookmark it and check back often if you're shopping for a new Apple notebook.Related Roundup: Apple DealsThis article, "Deals: Refurbished 15-Inch MacBook Pro Notebooks on Sale at Woot From $1,580 ($800+ Off)" first appeared on MacRumors.comDiscuss this article in our forums Full Article Deals
rom MacRumors Giveaway: Win an Apple-Themed Plush Pillow From Throwboy By www.macrumors.com Published On :: Fri, 08 May 2020 11:01:17 PDT For this week's giveaway, we've once again teamed up with Throwboy to offer MacRumors readers a chance to win one of Throwboy's plushes modeled after classic Apple products and icons. Throwboy makes a whole range of different plush pillow options priced at $30 to $40, with each one designed to look like an Apple product of some kind, including classic Macs, the iPod, the iPhone, and more. Each pillow features detailed embroidery and careful construction to highlight each component and to accurately represent Apple's designs. The 1998 pillow, for example, is modeled after Apple's original iMac with its bright Bondi Blue design, while the 2001 pillow modeled after the original iPod comes complete with a screen and click wheel embroidery. The 2007 pillow looks like the original iPhone with black bezels and a silver backing, and the Icon Pillow looks like Apple's classic happy Finder icon. There's even a rainbow-colored Spinning Wheel Pillow that's designed to look like the dreaded spinning pinwheel that the cursor morphs into when an application is busy. All of Throwboy's plushes are soft, squishy, huggable, and the perfect accent piece for an Apple fan. Each pillow is the ideal size to be used as a comfortable throw pillow for a couch or a chair. Photos of the pillows in action can be seen on Throwboy's Instagram account. We have 10 of Throwboy's pillows to give away to MacRumors readers, and each winner will be able to pick their favorite pillow: iMac, iPod, classic iPhone, Finder Icon, or Spinning Wheel. To enter to win our giveaway, use the Gleam.io widget below and enter an email address. Email addresses will be used solely for contact purposes to reach the winners and send the prizes. You can earn additional entries by subscribing to our weekly newsletter, subscribing to our YouTube channel, following us on Twitter, following us on Instagram, or visiting the MacRumors Facebook page. Due to the complexities of international laws regarding giveaways, only U.S. residents who are 18 years or older and Canadian residents (excluding Quebec) who have reached the age of majority in their province or territory are eligible to enter. To offer feedback or get more information on the giveaway restrictions, please refer to our Site Feedback section, as that is where discussion of the rules will be redirected. Throwboy GiveawayThe contest will run from today (May 8) at 11:00 a.m. Pacific Time through 11:00 a.m. Pacific Time on May 15. The winners will be chosen randomly on May 15 and will be contacted by email. The winners will have 48 hours to respond and provide a shipping address before new winners are chosen.Tag: giveawayThis article, "MacRumors Giveaway: Win an Apple-Themed Plush Pillow From Throwboy" first appeared on MacRumors.comDiscuss this article in our forums Full Article No AMP giveaway
rom Apple Preparing Retail Employees to Return to Work With Tips From South Korea Reopening By www.macrumors.com Published On :: Fri, 08 May 2020 11:48:25 PDT Apple in mid-April reopened Apple Garosugil, its lone store in South Korea, located in the Seoul's Gangnam District. Apple's South Korea reopening has served as a test ground for further store reopenings, and Apple created an instructional video on reopening practices that's now being shared with other retail employees around the world as they prepare to reopen stores. We're not able to share the video, but it provides a good overview of the measures Apple is putting in place to safely operate retail locations. Retail employees are following a strict set of guidelines that very heavily emphasize social distancing of two meters (or six feet in the United States). Apple is taking the following measures: Prior to when work starts, all employees undergo a health screening complete with a temperature check, with the results logged in a daily spreadsheet. Daily briefings are done in the mornings in the Forum area at Apple Stores, with employees making sure to sit at least two meters apart. Prior to being allowed in the store, customers are also given a temperature check. All Apple Stores are providing hand sanitizer, which customers are encouraged to use. Stores are limiting the number of people inside, forming lines with customers waiting at least two meters apart. Products purchased by customers or returned after repair are delivered from the back in a relay system, being handed off from employee to employee to allow each person to stay in a separated zone without back and forth. Product specialists and Genius Bar staff are positioning themselves across tables away from customers in order to maintain distance. In the forum area, employees sit one cube away from customers they're interacting with. Employees are encouraged to communicate with one another through the Talk app to cut down on unnecessary movement within the store. Half of the workstations in the back are empty, with employees working at alternating workstations to keep more distance between them. Tables have been rearranged to put products on corners to prevent customers from being near one another. Products on tables have been reduced. Communal tables and couches have been removed from employee break rooms and have been replaced with individual chairs evenly spaced about the room. Operating hours are reduced. Employees are all wearing face masks. After opening its South Korea store on April 16, Apple has reopened its sole store in Vienna, Austria, and 21 stores located in Australia. Stores in Germany will begin reopening on May 11, and all of the newly opened locations are following many of the same guidelines listed above to keep both customers and employees safe. There's no word yet on when Apple retail stores in the United States will start to reopen, but Apple CEO Tim Cook last week said that stores in North America will begin reopening starting in the month of May. Apple plans to evaluate data and make reopening decisions on a city by city, county by county basis, following local guidelines and recommendations before opening up a store.Related Roundup: Apple StoresTag: Apple retailThis article, "Apple Preparing Retail Employees to Return to Work With Tips From South Korea Reopening" first appeared on MacRumors.comDiscuss this article in our forums Full Article Apple Store Apple retail
rom 'Sonic the Hedgehog' movie garners a fresh rating from Rotten Tomatoes By www.flayrah.com Published On :: Sun, 23 Feb 2020 01:52:53 +0000 On Wednesday, May 1, 2019, Flayrah contributor 2cross2affliction wrote in the article 'Sonic the Hedgehog' ... the movie ... the trailer: Fun fact: no movie directly adapted from a video game has ever scored as "fresh" on the review aggregate site Rotten Tomatoes. [...] But, a new challenger approaches! [...] The question of whether this movie is going to be any good, perhaps unfairly, has mostly already been answered by the Internet. The answer so far has been no. No. Just no. Okay, maybe Jim Carrey? But otherwise, why? Why the human teeth? Why ten times? Whoops. Turns out Sonic the Hedgehog somehow, against the odds, is rated Fresh by Rotten Tomatoes, with a score of 64% positive reviews from 175 professional opinions, as of this writing. read more Full Article computer games movies reviews Rotten Tomatoes Sonic the Hedgehog
rom Obituary: Rick May, voice of Peppy Hare from 'Star Fox 64' By www.flayrah.com Published On :: Wed, 15 Apr 2020 22:50:56 +0000 Rick May, best known to furries and non-furries alike as the voice of Peppy Hare in the English version of the game Star Fox 64 passed away April 13, 2020 due to COVID-19. May was born September 21, 1940 (with the full name of Richard J. May), meaning he would have turned 80 later this year. May had also recently suffered a stroke in February, making him even more vulnerable to the disease caused by the novel coronavirus. May will forever be known as the man who originally uttered the memetic line "Do a barrel roll! (Z or R twice.)" in Star Fox 64, explaining to players how to perform what is technically an aileron roll in order to deflect enemy attacks. May also played the villain of Star Fox 64, Andross. Outside of furry video games, May is probably best known for voicing the Soldier of Team Fortress 2; furries might also recognize his voice behind the villainous Dr. M from the third Sly Cooper game. In addition to voice work for video games, May has had a long history of working both on and for the stage as both a director and actor, beginning with USO shows while stationed in Japan. His part in a Renton, Washington production of Cotton Patch Gospel featured a combination of his voice and stage work, as he used different voices to portray 21 characters in what was reportedly his favorite stage role. read more Full Article coronavirus obituaries Star Fox
rom Ranking every furry skin in Fortnite from worst to best By www.flayrah.com Published On :: Sun, 19 Apr 2020 15:32:48 +0000 Fortnite Battle Royale (or just Fortnite) is a “battle royale” shooter that has been around since 2017, and while its getting a bit long in the tooth, it’s still hanging around and still free to play. Last year, the game finally implemented skill-based matchmaking, which means for casual and new players, it’s never been easier to get into. In many ways, it is comparable to Nintendo properties such as Super Smash Bros. or Mario Kart, taking a more traditionally “hardcore” video game genre and making it more accessible with gimmicky gameplay, goofy items, cartoony visuals and massive amounts of RNG. Of course, the game isn’t exactly furry in and of itself, but the game makes its money selling cosmetic upgrades to player’s in game characters, and quite a few of them feature either characters in animal costumes, or, more recently, straight up anthropomorphic animals. In the time-honored tradition of clickbait listicals, here is my ranking of those skins. read more Full Article animals wearing party hats art computer games Fortnite opinion
rom President Obama says that he cannot change Washington from the inside By www.cpa-connecticut.com Published On :: Mon, 05 Nov 2012 01:05:05 +0000 After being elected in 2008 on "hope and change", "change you can believe in", and "change the way Washington works", President Obama now says that he cannot change Washington from the inside? Then why should we re-elect him in 2012? Continue reading → Full Article Accountants CPA Hartford Articles Cenk Uygur change the way Washington works change you can believe in Hope and change President Obama says that he cannot change Washington from the inside The Young Turks
rom TurboTax accounts hacked, delaying tax refunds, compromising personal information, impairing credit rating By www.cpa-connecticut.com Published On :: Sat, 07 Mar 2015 01:28:09 +0000 Online criminals have been systematically targeting TurboTax, filing fraudulent tax returns of individuals, and diverting their tax refunds to prepaid debit, cards, stealing their personal information, and using and impairing their credit ratings. Continue reading → Full Article Accountants CPA Hartford Articles credit rating fraudulent tax returns hackers Internal Revenue Service internet security Intuit Julie Magee Minnesota Department of Revenue online tax filing personal information scammers Shane MacDougall tax fraud tax refunds tax refunds stolen tax-return identity theft TurboTax TurboTax accounts hacked delaying tax refunds compromising personal information impairing credit rating TurboTax fraudulent filing Utah Tax Commission whistleblower compaint to SEC Intuit Turbotax
rom Make an Offer that the IRS Can’t Refuse: How to calculate an offer in compromise acceptable to the”Don” By www.cpa-connecticut.com Published On :: Sun, 28 Jun 2015 18:57:05 +0000 An Offer in Compromise is an agreement between the taxpayer and the government that settles a tax liability for payment of less than the full amount owed. The Internal Revenue Service will generally accept an Offer in Compromise when it … Continue reading → Full Article Accountants CPA Hartford Articles Cenk Uygur Current TV December 7 2011 Collection Information Statement Consigliere of Goombas to the IRS Disposal Income Form 433-A Internal Revenue Service It is what it is Luca Brasi Make an Offer that the IRS Can't Refuse: How to calculate an offer in compromise acceptable to the"Don" Monetary Assets Monthly Income Necessary Living Expenses Non-Monetary Assets offer in compromise Realizable Value Reasonable Collection Potential swim with the fishes The Don has spoken
rom Berlin Connecticut needs candidates from a third political party to stop the strict partisan voting on the Town Council By www.cpa-connecticut.com Published On :: Sun, 05 Jul 2015 17:21:15 +0000 Berlin needs an independent candidate on its Town Council to counter and prevent the dominance of a major political party from unilaterally imposing its agenda and will on the citizens of Berlin. Our Town Council has been voting along strict party lines on key issues even though members pledged to reach across the aisle. It has dismissed or circumvented the results of referendums, reducing them to mere dog-and-pony shows. Berlin has more unaffiliated voters than those of the two major parties. Let's petition, nominate, and place on the ballot an independent candidate to represent these citizens and prevent the control of our Town by the dominant party on the Town Council. If interested, please contact us: berlinctpropertyownersassn@gmail.com. Continue reading → Full Article Accountants CPA Hartford Articles Berlin Connecticut Berlin Connecticut needs candidates from a third political party to stop the strict partisan voting on the Town Council Berlin Town Council democracy Democratic Party independent candidates independent party partisan politics Republican party special interests voting along strict party line
rom Bernie Sanders on fight against ISIS: “We have got to learn the lessons from Iraq” By www.cpa-connecticut.com Published On :: Sun, 06 Dec 2015 18:00:16 +0000 December 6, 2015, 10:50 AM|Senator Bernie Sanders, I-Vermont, believes there must be an international coalition led by Arab nations in the fight against ISIS. Continue reading → Full Article Accountants CPA Hartford Articles believes there must be an international coalition led by Arab nations in the fight against ISIS. Bernie Sanders on fight against ISIS: “We have got to learn the lessons from Iraq” December 6 2015 Dickerson Face the Nation I-Vermont interview Senator Bernie Sanders transcript video
rom Green Party’s Jill Stein — What We Fear from Donald Trump We Have Already Seen from Hillary Clinton By www.cpa-connecticut.com Published On :: Thu, 09 Jun 2016 21:29:30 +0000 Green Party's Jill Stein says that what we Fear from Donald Trump is what we have already seen from Hillary Clinton. Continue reading → Full Article Accountants CPA Hartford Articles Amy Goodman Democracy Now Donald Trump Green Party's Jill Stein -- What We Fear from Donald Trump We Have Already Seen from Hillary Clinton Green Party's Jill Stein says that what we Fear from Donald Trump is what we have already seen from Hillary Clinton Hillary Clinton Jill Stein
rom Donald Trump sells out supporters by selecting executives from Goldman Sachs for key cabinet posts to regulate our economy By www.cpa-connecticut.com Published On :: Mon, 12 Dec 2016 20:38:33 +0000 Donald Trump sold out his supporters and the 99% by selecting Wall Streeters and war mongers for his top cabinet positions. Continue reading → Full Article Accountants CPA Hartford Articles cabinet Chuck Todd Donald Trump Donald Trump sells out supporters by selecting executives from Goldman Sachs for key cabinet posts to regulate our economy Goldman Sachs Goldman Sachs executives selected by Trump for cabinet posts to regulate our economy Kellyanne Conway
rom Lobbyists are buying our government out from under us By www.cpa-connecticut.com Published On :: Thu, 17 May 2018 07:46:48 +0000 Lobbyists are buying our government out from under us Continue reading → Full Article Accountants CPA Hartford Articles Lobbyists are buying our government out from under us Lobbyists are corrupting our government
rom Watch Clips From Tonight’s ‘NCIS’ & ‘NCIS:NOLA’ By www.csifiles.com Published On :: Tue, 03 Jan 2017 22:25:45 +0000 NCIS and NCIS: New Orleans will air the first new episodes of 2017 tonight. You can find sneak peeks, tweets and photos... Full Article NCIS NCIS: NOLA Guest stars Henry Kerkovich Silber Video
rom Check Out ‘Criminal Minds’ Ratings, Links & Promo By www.csifiles.com Published On :: Thu, 05 Jan 2017 22:37:45 +0000 Criminal Minds aired the ninth episode of season twelve last night at 9:00pm ET/PT. “Profiling 202” pulled in 7.25 million viewers and... Full Article Criminal Minds Bring Gupton Hatchitt Ratings Video Williams
rom Watch Clips From Tonight’s ‘NCIS:LA’ By www.csifiles.com Published On :: Sun, 08 Jan 2017 23:16:30 +0000 NCIS: Los Angeles will air the first new episode of 2017 tonight. “Kulinda” is scheduled to start at 8:00pm ET/PT. (If anything... Full Article NCIS: LA Cambor Harimoto LL Cool J Video
rom ‘NCIS:LA’ Ratings, Links & Promo Are Available By www.csifiles.com Published On :: Mon, 09 Jan 2017 22:12:53 +0000 NCIS: Los Angeles aired the twelfth episode of season eight last night. “Kulinda” pulled in 10.35 million viewers at 8:00pm, earning a... Full Article NCIS: LA Guest stars Kousakis Mckiernan Ratings Video
rom Theresa May seeks third Brexit vote Friday after promising to resign By www.business-standard.com Published On :: Thu, 28 Mar 2019 23:34:00 +0530 European Union leaders have offered Britain a Brexit extension until May 22. Full Article
rom Видео: Супруги Райкконен в новой рекламе Alfa Romeo By www.f1news.ru Published On :: Sat, 09 May 2020 14:36:00 +0300 В Италии жизнь понемногу возвращается в нормальное русло, и не случайно именно в эти дни компания Alfa Romeo представила новый рекламный ролик, посвящённый флагманскому кроссоверу Stelvio Quadrifoglio, где в главной роли мы видим Кими Райкконена... Full Article
rom The Weather Company, an IBM Business, to Integrate Global Flight Tracking Data from FlightAware By www.ibm.com Published On :: Wed, 16 Aug 2017 01:01:11 GMT The Weather Company, an IBM Business announced today that it is enhancing its global flight operations solution WSI Fusion, with live flight tracking data from FlightAware. WSI Fusion provides early insight into changing flight, airport and airspace conditions, enabling aviation providers to carefully plan and track flights, optimize operations and reduce the impacts of disruptive events. With the addition of FlightAware’s data, including its private network of over 12,000 Automatic Dependent Surveillance – Broadcast (ADS-B) ground stations in over 160 countries, WSI Fusion customers will have access to enhanced flight following capabilities worldwide. Full Article Travel & Transportation
rom IBM, Packet Clearing House and Global Cyber Alliance Collaborate to Protect Businesses and Consumers from Internet Threats By www.ibm.com Published On :: Thu, 16 Nov 2017 11:30:38 GMT IBM Security, Packet Clearing House (PCH) and The Global Cyber Alliance (GCA) today launched a free service designed to give consumers and businesses added privacy and security protection as they access the internet. The new Quad9 Domain Name System (DNS) service helps protect users from accessing millions of malicious internet sites known to steal personal information, infect users with ransomware and malware, or conduct fraudulent activity. Full Article IBM Security
rom IBM Announces Planned Acquisition of Promontory to Transform Regulatory Compliance with Watson By www.ibm.com Published On :: Thu, 29 Sep 2016 03:01:01 GMT IBM today announced plans to acquire Promontory Financial Group, a global market-leading risk management and regulatory compliance consulting firm. Upon close, the capabilities of Promontory combined with IBM's deep industry expertise and Watson’s cognitive capabilities will directly address the massive operational effort and manual cost of escalating regulation and risk management requirements. Full Article Global Financing