Lab Chip, 2020, 20,1441-1448
DOI: 10.1039/D0LC00028K, Paper

Open Access

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Yoshiki Soda, Kye J. Robinson, Thomas J. Cherubini, Eric Bakker
A pixel-level colorimetric absorbance analysis can measure the total quantity of dye on paper, irrespective of shape and size.
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Lab Chip, 2020, 20,1461-1471
DOI: 10.1039/C9LC01097A, Paper

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Mario Rothbauer, Gregor Höll, Christoph Eilenberger, Sebastian R. A. Kratz, Bilal Farooq, Patrick Schuller, Isabel Olmos Calvo, Ruth A. Byrne, Brigitte Meyer, Birgit Niederreiter, Seta Küpcü, Florian Sevelda, Johannes Holinka, Oliver Hayden, Sandro F. Tedde, Hans P. Kiener, Peter Ertl
We demonstrate that the integration of complex human synovial organ cultures in a lab-on-a-chip provides reproducible and reliable information on how systemic stress factors affect synovial tissue architectures using light scatter biosensing.
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Lab Chip, 2020, 20,1398-1409
DOI: 10.1039/C9LC01103J, Paper

Open Access

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Kartik Totlani, Jan-Willem Hurkmans, Walter M. van Gulik, Michiel T. Kreutzer, Volkert van Steijn
We developed a microfluidic droplet on-demand (DoD) generator that enables the production of droplets with a volume solely governed by the geometry of the generator for a range of operating conditions.
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Lab Chip, 2020, 20,1318-1357
DOI: 10.1039/C9LC00775J, Critical Review

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Masoud Madadelahi, Luis F. Acosta-Soto, Samira Hosseini, Sergio O. Martinez-Chapa, Marc J. Madou
This paper focuses on theory and computational modelling of lab-on-a-disc devices of relevance for novel applications discovery and optimal designs.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01028A, Paper

Open Access

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Yan Jiang, Theodore Feldman, Julia A. M. Bakx, Darren Yang, Wesley P. Wong
High-speed hydrodynamic trapping enables combined surface-free force spectroscopy and fluorescence imaging of single DNA molecules at extreme forces.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01209E, Paper

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J. A. Crowe, A. El-Tamer, D. Nagel, A. V. Koroleva, J. Madrid-Wolff, O. E. Olarte, S. Sokolovsky, E. Estevez-Priego, A.-A. Ludl, J. Soriano, P. Loza-Alvarez, B. N. Chichkov, E. J. Hill, H. R. Parri, E. U. Rafailov
We identified photopolymers for 2-photon polymerisation with biocompatibility for human iPSC-derived neural network development. Generation of microscale scaffold topologies enabled neurite guidance, demonstrating use in reproducing aligned networks.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01192G, Paper

Roman Mikhaylov, Fangda Wu, Hanlin Wang, Aled Clayton, Chao Sun, Zhihua Xie, Dongfang Liang, Yinhua Dong, Fan Yuan, Despina Moschou, Zhenlin Wu, Ming Hong Shen, Jian Yang, Yongqing Fu, Zhiyong Yang, Christian Burton, Rachel J. Errington, Marie Wiltshire, Xin Yang
We demonstrate a novel SAW device fabrication technique by mechanically clamping interdigital electrodes (IDEs) on the printed circuit board (PCB) to a LiNbO₃ wafer. The novel PCB-SAW device is capable of performing all the functions of standard SAW devices.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00263A, Paper

Jaime L. Korner, Elanna B. Stephenson, Katherine S. Elvira
A new type of pharmacokinetic compartment model using artificial cell membranes that predicts intestinal absorption three times more accurately than the current state of the art.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00122H, Paper

N. Garg, R. Tona, P. Martin, P. M. Martin-Soladana, G. Ward, N. Douillet, D. Lai
A microfluidic approach to seeded crystallization has been demonstrated using abacavir hemisulfate, a nucleoside analog reverse transcriptase inhibitor, in droplet reactors to control polymorphism and produce particles with a low particle size distribution.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00059K, Paper

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Christian G. M. van Dijk, Maarten M. Brandt, Nikolaos Poulis, Jonas Anten, Matthijs van der Moolen, Liana Kramer, Erik F. G. A. Homburg, Laura Louzao-Martinez, Jiayi Pei, Merle M. Krebber, Bas W. M. van Balkom, Petra de Graaf, Dirk J. Duncker, Marianne C. Verhaar, Regina Luttge, Caroline Cheng
We present a microfluidic vascular device. Vascular cells in a 3D-ECM environment support hemodynamic flow and enable monocyte interaction.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00302F, Paper

Christopher Dixon, Julian Lamanna, Aaron R. Wheeler
The integration of 3D porous membranes in a digital microfluidic device enables the generation of cell-free plasma from finger-stick volumes of blood with in-line, on-chip analysis.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00001A, Paper

Kiing S. Wong, William T. H. Lim, Chien W. Ooi, Leslie Y. Yeo, Ming K. Tan
We demonstrate an efficient technique for in situ production and application of plasma-activated aerosols for surface disinfection.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC90036B, Correction

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Ewa Guzniczak, Oliver Otto, Graeme Whyte, Nicholas Willoughby, Melanie Jimenez, Helen Bridle
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Lab Chip, 2020, Advance Article
DOI: 10.1039/C9LC01268K, Paper

Bohee Maeng, Hyung-kwan Chang, Jungyul Park
A powerless smart contact lens enabling to monitor intraocular pressure (IOP) by checking the visual color change in photonic crystal structure with a microhydraulic amplification system has been realized.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00069H, Paper

W. Hampton Henley, Nathan A. Siegfried, J. Michael Ramsey
Encoded beads carrying primer pairs for nucleic acid targets are used for sample preparation and multiplexed-in-space digital PCR quantification.
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Lab Chip, 2020, Advance Article
DOI: 10.1039/D0LC00280A, Communication

Amin Mansoorifar, Anthony Tahayeri, Luiz E. Bertassoni
We proposed a novel concept for reconfiguration of hydrogel microfluidic devices, where multiple fluidic pathways could be generated via reversible manipulation of magnetic inks.
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Lab Chip, 2020, 20,1577-1585
DOI: 10.1039/D0LC00024H, Paper

Jingjing Guo, Li Lin, Kaifeng Zhao, Yanling Song, Mengjiao Huang, Zhi Zhu, Leiji Zhou, Chaoyong Yang
An automated ligand binding affinity evaluation platform using digital microfluidics with a bidirectional magnetic separation method that reduces the bead loss.
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Lab Chip, 2020, 20,1601-1611
DOI: 10.1039/D0LC00115E, Paper

Veasna Soum, Sooyong Park, Albertus Ivan Brilian, Jae-Youl Choi, Yongwoo Lee, Wonjung Kim, Oh-Sun Kwon, Kwanwoo Shin
A precise, simple, and inexpensive method for controlling fluid flow in a photo-paper-based microfluidic device was reported.
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Lab Chip, 2020, 20,1687-1693
DOI: 10.1039/C9LC01021A, Paper

Zongdai Liu, Dan Luo, Kun-Lin Yang
The concentration of toluene vapor is obtained based on polymer-stabilized liquid crystals by viewing a colourful gamut under a polarized optical microscope.
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Lab Chip, 2020, 20,1544-1553
DOI: 10.1039/C9LC01230C, Communication

Jeffrey C. Y. Chiu, Joyce A. Teodoro, Jeong Hyun Lee, Kerryn Matthews, Simon P. Duffy, Hongshen Ma
Inverse gelation of methylcellulose enables hydrogel micropatterning to selectively propagate cells identified by microscopy.
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Lab Chip, 2020, 20,1676-1686
DOI: 10.1039/D0LC00244E, Paper

Open Access

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Andreas Kleiber, Anuradha Ramoji, Günter Mayer, Ute Neugebauer, Jürgen Popp, Thomas Henkel
The control of the focus plane allows multi-directional imaging flow cytometry.
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Lab Chip, 2020, 20,1586-1600
DOI: 10.1039/D0LC00099J, Paper

Karina M. Lugo-Cintrón, José M. Ayuso, Bridget R. White, Paul M. Harari, Suzanne M. Ponik, David J. Beebe, Max M. Gong, María Virumbrales-Muñoz
Lymphatic organotypic in vitro model allows the examination of components of the tumor microenvironment (e.g., ECM density, cancer cells) in lymphatic vessel biology in the context of cancer, providing insights into potential therapeutic targets.
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Lab Chip, 2020, 20,1621-1627
DOI: 10.1039/D0LC00304B, Paper

Fu Sun, Anurup Ganguli, Judy Nguyen, Ryan Brisbin, Krithika Shanmugam, David L. Hirschberg, Matthew B. Wheeler, Rashid Bashir, David M. Nash, Brian T. Cunningham
A 30-minute nucleic acid test for equine respiratory virus from nasal swab material, detected with a smartphone.
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Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00153H, Paper

Zhening Su, Jinxu He, Peipei Zhou, Lu Huang, Jianhua Zhou
Crystallization of active pharmaceutical ingredients (APIs) is a crucial process in the pharmaceutical industry due to its great impact in drug efficacy. However, conventional approaches for screening the optimal crystallization...
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Lab Chip, 2020, Accepted Manuscript
DOI: 10.1039/D0LC00096E, Paper

Hanfei Shen, Tony Liu, Jesse Cui, Piyush Borole, Ari Benjamin, Konrad Kording, David Issadore
Liquid biopsy (LB) technologies continue to improve in sensitivity, specificity, and multiplexing and can measure an ever growing library of disease biomarkers. However, clinical interpretation of the increasingly large sets...
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DOI: 10.1021/acs.jcim.9b01103

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