k Organotypic human skin culture models constructed with senescent fibroblasts show hallmarks of skin aging By feeds.nature.com Published On :: 2020-03-06 Full Article
k High rate of durable remissions post autologous stem cell transplantation for core-binding factor acute myeloid leukaemia in second complete remission By feeds.nature.com Published On :: 2020-05-06 Full Article
k Phase I trial of maintenance selinexor after allogeneic hematopoietic stem cell transplantation for patients with acute myeloid leukemia and myelodysplastic syndrome By feeds.nature.com Published On :: 2020-05-06 Full Article
k Donor-derived DNA variability in fingernails of acute myeloid leukemia patients after allogeneic hematopoietic stem cell transplantation detected by direct PCR By feeds.nature.com Published On :: 2020-05-09 Full Article
k Differential effectiveness of tyrosine kinase inhibitors in 2D/3D culture according to cell differentiation, p53 status and mitochondrial respiration in liver cancer cells By feeds.nature.com Published On :: 2020-05-07 Full Article
k QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism By feeds.nature.com Published On :: 2020-05-07 Full Article
k NF-kappa B interacting long noncoding RNA enhances the Warburg effect and angiogenesis and is associated with decreased survival of patients with gliomas By feeds.nature.com Published On :: 2020-05-07 Full Article
k MicroRNA let-7c (MIRLET7C; let-7c), miR-99a and miR-125b as prognostic markers of luminal breast cancer By feeds.nature.com Published On :: 2014-12-18 Studies in patient samples and cell culture suggest let-7c, miR-99a and miR-125b could serve as prognostic markers in patients with estrogen receptor–positive luminal breast cancers. Full Article
k Chromosome 11 open reading frame 30 (C11orf30), calpain small subunit 1 (CAPNS1; CAPN4), signal transducer and activator of transcription 6 (STAT6) and ankyrin repeat domain 27 (ANKRD27) as diagnostic markers for eosinophilic esophagitis (EoE) By feeds.nature.com Published On :: 2014-12-18 Genomewide association studies identified four genes that could serve as diagnostic markers and/or therapeutic targets for EoE. Full Article
k Nanomolar-scale, high throughput chemical synthesis of drug-like molecules By feeds.nature.com Published On :: 2014-12-18 A high throughput, miniaturized chemical synthesis platform could enable rapid discovery of lead compounds. Full Article
k c-jun N-terminal kinase (JNK); MAP kinase 1 (MAPK1; ERK-2); MAPK3 (ERK-1) By feeds.nature.com Published On :: 2014-12-18 In vitro and rodent studies suggest ophiopogonin D could help prevent doxorubicin-induced cardiotoxicity. Full Article
k K-Ras (KRAS) By feeds.nature.com Published On :: 2014-12-18 In vitro and mouse studies suggest rapamycin plus a bisphosphonate could help treat KRAS-mutant NSCLC. Full Article
k Cyclin dependent kinase 7 (CDK7); v-myc myelocytomatosis viral related oncogene neuroblastoma derived (MYCN; NMYC) By feeds.nature.com Published On :: 2014-12-18 In vitro and mouse studies suggest THZ1, a covalent CDK7 inhibitor, could help treat neuroblastoma and other cancers driven by MYCN and other c-MYC (MYC)-family oncoproteins. Full Article
k Estrogen receptor; LYN kinase (LYN); phosphoinositide 3-kinase (PI3K) By feeds.nature.com Published On :: 2014-12-18 Studies in mice and human samples suggest inhibiting LYN could help treat estrogen receptor–positive breast cancers resistant to anti-estrogen therapy. Full Article
k Genocea's mark on malaria By feeds.nature.com Published On :: 2014-12-18 Genocea has identified an immunological imprint in patients with malaria and is using a $1.2 million grant from the Gates Foundation to turn the findings into a vaccine. Full Article
k Differentiation of transplanted haematopoietic stem cells tracked by single-cell transcriptomic analysis By feeds.nature.com Published On :: 2020-05-04 Full Article
k TMB: a promising immune-response biomarker, and potential spearhead in advancing targeted therapy trials By feeds.nature.com Published On :: 2020-04-28 Full Article
k Nintedanib inhibits keloid fibroblast functions by blocking the phosphorylation of multiple kinases and enhancing receptor internalization By feeds.nature.com Published On :: 2020-04-23 Full Article
k Nanomedicines based on nanoscale metal-organic frameworks for cancer immunotherapy By feeds.nature.com Published On :: 2020-04-30 Full Article
k Microbiota and colorectal cancer: colibactin makes its mark By feeds.nature.com Published On :: 2020-04-21 Full Article
k Universal screening for hepatitis C virus infection should be linked to universal treatment access By feeds.nature.com Published On :: 2020-04-29 Full Article
k Author Correction: Management of IBD during the COVID-19 outbreak: resetting clinical priorities By feeds.nature.com Published On :: 2020-05-06 Full Article
k Effects of acute and repeated treatment with methocinnamox, a mu opioid receptor antagonist, on fentanyl self-administration in rhesus monkeys By feeds.nature.com Published On :: 2020-05-06 Full Article
k A novel multidimensional reinforcement task in mice elucidates sex-specific behavioral strategies By feeds.nature.com Published On :: 2020-05-06 Full Article
k Cannabinoid CB<sub>2</sub> receptors mediate the anxiolytic-like effects of monoacylglycerol lipase inhibition in a rat model of predator-induced fear By feeds.nature.com Published On :: 2020-05-06 Full Article
k A roadmap for development of neuro-oscillations as translational biomarkers for treatment development in neuropsychopharmacology By feeds.nature.com Published On :: 2020-05-06 Full Article
k Correction: Ketamine metabolites, clinical response, and gamma power in a randomized, placebo-controlled, crossover trial for treatment-resistant major depression By feeds.nature.com Published On :: 2020-05-06 Full Article
k Nesfatin-1 puts the brakes on reward-based feeding By feeds.nature.com Published On :: 2020-05-06 Full Article
k Δ<sup>9</sup>-Tetrahydrocannabinol (THC) impairs visual working memory performance: a randomized crossover trial By feeds.nature.com Published On :: 2020-05-09 Full Article
k Nuclear receptor crosstalk — defining the mechanisms for therapeutic innovation By feeds.nature.com Published On :: 2020-04-17 Full Article
k Obesity affects skeletal muscle ketone oxidation By feeds.nature.com Published On :: 2020-04-20 Full Article
k New insights into K<sub>ATP</sub> channel gene mutations and neonatal diabetes mellitus By feeds.nature.com Published On :: 2020-05-06 Full Article
k Incidence of acute spinal cord injury in South Korea does not reflect a sizable number of traumatic spinal cord injuries By feeds.nature.com Published On :: 2020-04-30 Full Article
k A more accurate incidence of acute spinal cord injury in South Korea can be estimated by the national health insurance system By feeds.nature.com Published On :: 2020-04-30 Full Article
k Development of a skin temperature map for dermatomes in individuals with spinal cord injury: a cross-sectional study By feeds.nature.com Published On :: 2020-05-05 Full Article
k Impact of COVID-19 outbreak on spinal pathology: single center first impression By feeds.nature.com Published On :: 2020-05-05 Full Article
k Reduction of depression-like behavior in rat model induced by ShRNA targeting norepinephrine transporter in locus coeruleus By feeds.nature.com Published On :: 2020-05-04 Full Article
k Phosphorylation of cGAS by CDK1 impairs self-DNA sensing in mitosis By feeds.nature.com Published On :: 2020-04-28 Full Article
k Expert opinion—management of chronic myeloid leukemia after resistance to second-generation tyrosine kinase inhibitors By feeds.nature.com Published On :: 2020-05-04 Full Article
k Erythrocytosis with <i>JAK2</i> GGCC_46/1 haplotype and without <i>JAK2</i> V617F mutation is associated with <i>CALR</i> rs1049481_G allele By feeds.nature.com Published On :: 2020-05-04 Full Article
k SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia By feeds.nature.com Published On :: 2020-05-07 Full Article
k High-risk additional chromosomal abnormalities at low blast counts herald death by CML By feeds.nature.com Published On :: 2020-05-07 Full Article
k Multilevel omics for the discovery of biomarkers and therapeutic targets for stroke By feeds.nature.com Published On :: 2020-04-22 Full Article
k An update on blood-based biomarkers for non-Alzheimer neurodegenerative disorders By feeds.nature.com Published On :: 2020-04-22 Full Article
k Parkinson disease and the immune system — associations, mechanisms and therapeutics By feeds.nature.com Published On :: 2020-04-24 Full Article
