In sporadic Alzheimer's disease, neurofibrillary lesion formation is preceded by extensive post-translational modification of the microtubule associated protein tau. Immunoassays have been developed recently that detect tau in biological specimens, thus providing a means for pre-mortem diagnosis of Alzheimer's disease, which has remained elusive. These assays have been improved by the analysis of relevant post-translational modifications, such as phosphorylation, however opportunity for improvement remains. The present invention addresses this issue by disclosing synthetic methylated peptides derived from the tau protein of paired helical filaments and non-diseased control brain. Alzheimer's disease specificity is provided by the presence or absence of methyl moieties on lysine residues and differences between mono-, di-, and tri-methylation. The methylated peptide is useful as an antigen and a binding partner for identifying compounds that interact with the peptide and the methylated tau protein, including antibodies that can distinguish non-diseased brain from that affected by Alzheimer's disease. The resulting antibodies are useful diagnostically and therapeutically. The compounds that specifically bind to methylated tau proteins are useful for eliminating abnormally methylated tau.

The present disclosure provides robust, high-throughput, and clinically applicable methods for simultaneously separating and quantifying the biologically active forms of Vitamin B1 (TPP) and Vitamin B6 (PLP) from human whole blood.

Oakland's alaMar Kitchen & Bar is about to start serving 1,500 free meals per week to restaurant workers who have been displaced and derailed by the coronavirus outbreak.

Located at 100 Grand Ave., chef Nelson German's popular seafood restaurant has just issued this announcement:

"We are here for you, Oakland! ...…

The owners of Oakland's Homestead Restaurant have just debuted a new business concept that is meant to outlast the Covid-19 crisis.

Currently operating at the restaurant's 4029 Piedmont Ave. space Tuesdays through Saturdays from 10 a.m. to 6 p.m. via curbside pickup and Caviar or Doordash delivery, The Humble Sandwich comprises a selection of classic deli sandos made with the same high-quality ingredients for which the seven-year-old restaurant is revered.…

HE MAY NOT be held in the highest regard by the public but there’s something to love about Piers Morgan on Good Morning Britain.

The present invention relates to a delayed fluorescence-quantum dot (QD) electroluminescent diode, the delayed fluorescence-quantum dot electroluminescent diode includes an anode, a cathode, and a light emitting layer located between the anode and the cathode, and the light emitting layer includes a QD and a delayed fluorescence material which supplies energy to the QD.

In one embodiment, a plant control apparatus is configured to control a power generating plant that includes a gas turbine configured to be driven by a gas, an exhaust heat recovery boiler configured to generate steam by using heat of an exhaust gas from the gas turbine, a temperature reducing apparatus configured to cool, through a cooling medium, the steam generated by the exhaust heat recovery boiler, and a steam turbine configured to be driven by the steam cooled by the temperature reducing apparatus. The plant control apparatus includes an output controller configured to control output of the gas turbine, and a temperature reduction controller configured to control a cooling operation of the steam by the temperature reducing apparatus while the output controller controls the output of the gas turbine.

A system includes a gas turbine system having a turbine combustor, a turbine driven by combustion products from the turbine combustor, and an exhaust gas compressor driven by the turbine. The exhaust gas compressor is configured to compress and supply an exhaust gas to the turbine combustor. The gas turbine system also has an exhaust gas recirculation (EGR) system. The EGR system is configured to recirculate the exhaust gas along an exhaust recirculation path from the turbine to the exhaust gas compressor. The system further includes a main oxidant compression system having one or more oxidant compressors. The one or more oxidant compressors are separate from the exhaust gas compressor, and the one or more oxidant compressors are configured to supply all compressed oxidant utilized by the turbine combustor in generating the combustion products.

A variable refrigerant package air conditioner is shown that is easy to install in new construction with a unique base that causes collected mixture that overflows to drain outside the building. A control system is shown that has motors and compressor that are pulse width modulated so the air conditioner is infinitely variable while maintaining the highest possible power factor. Dehumidification of outside air occurs as it is mixed with inside air. By gradually approaching a temperature set point and even reheating after dehumidification, moisture is removed from the room.

An apparatus for separating and storing liquid refrigerant in a refrigerant circuit including a housing configured as a refrigerant collection container, the housing having a refrigerant outflow line disposed therein. The refrigerant outflow line extending from an inlet opening, which is disposed in a gas refrigerant region and above a level of the liquid refrigerant, via a liquid refrigerant region to the outside, and has a through-opening formed in the liquid refrigerant region. The housing includes a boiling element for liquid refrigerant disposed therein. The boiling element is connected to the refrigerant outflow line in the region of the through-opening, such that a liquid passing through the through-opening from the housing passes through the boiling element by suction of a gas refrigerant.

A system includes first and second compressors arranged in parallel, a condenser, expansion device, evaporator, and flow control device fluidly connected. The first compressor includes a first lubricant sump and the second compressor including a second lubricant sump. A lubricant transfer conduit fluidly connects the first lubricant sump and the second lubricant sump. The flow control device is disposed between the evaporator and the first and second compressors, and includes a fluid inlet and two fluid outlets. A first of the two fluid outlets is fluidly connected to the first compressor, a second of the two fluid outlets is fluidly connected to the second compressor. The second fluid outlet includes a nozzle disposed within a flow passage of the flow control device such that a space is maintained between an outer surface of the nozzle and an inner surface of the flow passage.

An ice making machine having a refrigeration system designed for hydrocarbon (HC) refrigerants, and particularly propane (R-290), that includes dual independent refrigeration systems and a unique evaporator assembly comprising of a single freeze plate attached to two cooling circuits. The serpentines are designed in an advantageous pattern that promotes efficiency by ensuring the even bridging of ice during freezing and minimizing unwanted melting during harvest by providing an even distribution of the heat load. The charge limitations imposed with flammable refrigerants would otherwise prevent large capacity ice maker from being properly charged with a single circuit. The ice making machine includes a single water circuit and control system to ensure the proper and efficient production of ice. Material cost is conserved as compared to a traditional dual system icemaker.

A desiccant air conditioning system for treating an air stream entering a building space, including a conditioner configured to expose the air stream to a liquid desiccant such that the liquid desiccant dehumidifies the air stream in the warm weather operation mode and humidifies the air stream in the cold weather operation mode. The conditioner includes multiple plate structures arranged in a vertical orientation and spaced apart to permit the air stream to flow between the plate structures. Each plate structure includes a passage through which a heat transfer fluid can flow. Each plate structure also has at least one surface across which the liquid desiccant can flow. The system includes a regenerator connected to the conditioner for causing the liquid desiccant to desorb water in the warm weather operation mode and to absorb water in the cold weather operation mode from a return air stream.

A system for adaptive cooling and energy harvesting comprising at least one thermoelectric device capable of acting as a thermoelectric cooler and as a thermoelectric generator, a hierarchical multiple-level control system, and electronics controlled by the control system and connected to the thermoelectric device. The electronics selectively configure the thermoelectric device in at least in a thermoelectric cooler operating mode and in a thermoelectric generation operating mode. The thermoelectric device can incorporate quantum-process and quantum-well materials for higher heat transfer and thermoelectric generation efficiencies. The invention provides for thermoelectric devices to additionally operate in temperature sensing mode. The hierarchical control system can comprise a plurality of control system, each of which can operate in isolation and can be interconnected with additional subsystems associated with other hierarchical levels. The hierarchical control system can comprise linear (additive) control, bilinear (additive and multiplicative) control, nonlinear control, and hysteresis.

The end to the fluoride saga in the Southampton city region will put a big hole in the correspondence bag for this paper’s daily letters page.

News you don't want to miss for April 9:

1. Six residents at a nursing home in Hayward have died from covid-19, the East Bay Times reports.…

News you don't want to miss for Easter Weekend:

Oakland will temporarily close 74 miles of city streets to automobile traffic in an effort to give ample space for pedestrians, bike riders, and runners during the covid-19 shelter in place, The Guardian reports.…

News you don't want to miss for April 14:

1. Six of the 15 confirmed covid-19 cases at Santa Rita Jail have recovered, the East Bay Times reports.…

News you don't want to miss for April 23:

1. BART learned on Thursday that $250 million in recent federal relief funds will allow it to balance its budget for this fiscal year, with $78 million remaining, BART Board Director Rebecca Saltzman said.…

News you don't want to miss for May 5:

1. "UC Berkeley is in negotiations to purchase — and then potentially tear down — a 111-year-old rent-controlled apartment building on Walnut Street where some residents have lived for more than 25 years," Berkeleyside reports.…

An emergency anti-hypothermia system has a thermally insulating vest that is sufficiently portable to be carried for emergency use in a pocket, purse, backpack, compartment of a vehicle, ski pole or other location, with the vest providing thermal insulation by being made with thermally insulating air impervious material that also provides for its inflation. A multiplicity of interconnected inflated chambers situated about the vest, provides thermal insulation by anti-conduction, anti-radiation and anti-convection in a highly portable system. An outer surface having radar reflective properties further improves visibility of the vest.

Pants are provided with a pair of zippers to facilitate the donning of the pants when a pants wearer is wearing large footwear that the pants wearer does not want to remove prior to donning the pants. Each zipper extends between a front thigh portion of each pant leg, along a side portion of the pant leg and terminates at a free end of the pant leg. Unzipping the zipper creates a large opening at the front thigh portion of each pant leg so that the pants wearer can easily put large footwear through the opening and don the pants. The zippers can be zipped up so that the pants wearer can engage in any desired activity.

Every bride wants to look spectacular on her wedding day, so here trainer Janette Cardy shares her top 10 tips for getting in shape and looking radiant.

IT’S the “life-saving” organisation that is slowly emerging from the shadows.

A CRICKETER who asked for his leg to be amputated to cure constant pain is back in the England team.

IT'S the ultimate fun bus.

STOKE Park Infant School was built in 1988/89 to replace the Victorian building which became an infant school in 1958.

A BRAZILIAN restaurant is set to bring the carnival atmosphere from the streets of Rio to the heart of Southampton as Brazil face Colombia in the quarter-finals of the World Cup tonight.

HE'S a snooker legend, get him in there!

MARIO Lemina wants to remain at Galatasaray beyond the end of the season.

A major co-production between five leading regional theatres of The Merchant of Venice will open in Southampton this autumn.

HAMPSHIRE and the Isle of Wight are set to benefit from a £700,000 fund that aims to encourage more people to take up cycling.

The Odeon cinema in Southampton is set to become a hive of entertainment for Final Fantasy fans.

According to a Gematsu report, Final Fantasy XV will see a worldwide release on September 30, 2016.

The colourful, cutesy aesthetics are enough to make a gamer vomit, whilst the complexity of the combat system could keep the most hardcore of role-players happily entertained for dozens of hours.

GUNWHARF Quays are celebrating the New Year by opening a new dining area.

MASTERCHEF winner Shelina Permalloo has launched a crowdfunding appeal to ensure her Southampton restaurant can reopen following its coronavirus closure.

A TURKISH restaurant in Southampton, which launched in a blaze of glory last year winning Best Middle Eastern Restaurant in the UK, is crowd funding to reopen following the coronavirus crisis.

IT’S considered the nation’s favourite cuisine – but did you know that most Indian restaurants in the UK are actually owned by Bangladeshis?

“Writers write.” “Publish or perish.” Even without a global pandemic, writers face constant pressure to produce new material. But for the first-time novelist, publishing a book when bookstores are closed for browsing, signings and readers is particularly tough.

Thanks to Michael Greene of Boone, NC - a virtual dinner concert series, online, was organized as a way to help raise money for local restaurants, servers, and musicians in the Boone area that have been unable to work due to the mandatory closures of businesses because of the Coronavirus. This includes a Go Fund Me page set up to donate a little extra in the case someone can. Maybe this virtual idea spreads all over as a way to say thank you to someone for serving and entertaining all of us in the past. You can find them on Facebook @BooneRelief Posted by Host and Producer of The Friday Feature Interview of the Week, Paul Foster- WNCW Senior Producer, News Director, and Morning Edition Regional Host

Ohio’s secretary of state says an election day with in-person voting is still the plan for this fall, but he’s suggesting some changes in case concerns about coronavirus keep voters away. A key voting rights group agrees, but wants to go further.

Award-winning composer Peter McConnell is no stranger to the world of Plants vs. Zombies . Battle for Neighborville is his third soundtrack for the series. He's also no stranger to the banjo! He's been playing since he was 13, but when he spied a gorgeous 1928 Gibson five-string in a music store he regularly haunts, he knew it would be perfect for the Cheese Mines levels in the game. Peter gave the whole soundtrack a real roots feel, also using a slide guitar. He even wrote his own, in his words, "earnest" folk song, Where Have All the Plants Gone , inspired by legendary folksinger Joan Baez, who's actually a neighbor. Because Plants vs. Zombies Battle for Neighborville is a science fiction game at heart, Peter also added plenty of classic synths. He says the developers at Pop Cap also suggested the sound of the score for The Time Machine, based on the novel by H.G. Wells. Peter says getting the right emotion in his music for a game keeps the writing interesting, whether it's the

We go back in time to two years ago to the day -- May 11th, 2018 -- for this smokin' hot session from Samantha Fish and her band, not long after we'd discovered her music.

Attorneys for Rick Bright, the government scientist who said he had been reassigned and subsequently filed a whistleblower complaint , say a government watchdog agrees that he should be reinstated to his post. Bright was serving as director of the Biomedical Advanced Research and Development Authority, which is working on a vaccine to combat the coronavirus. He said he was ousted from the position last month because he wanted to spend money on safe and vetted treatments for COVID-19 — not on ones without "scientific merit," such as hydroxychloroquine, the anti-malarial drug that President Trump and others had been touting. Trump on Wednesday called Bright "a disgruntled employee who's trying to help the Democrats win an election." Bright's attorneys say that the Office of Special Counsel, which hears whistleblower cases, determined there were "reasonable grounds" to believe that his removal was retaliatory and therefore prohibited. Bright's attorneys say OSC plans to contact the

A meat-packing plant in Waterloo, Iowa, where a coronavirus outbreak exploded a few weeks ago, resumed operations on Thursday after a two-week closure. The reopening of Tyson Foods' largest U.S. pork plant came the same day that health officials in Black Hawk County, where the plant is located, announced that 1,031 of the plant's estimated 2,800 employees have tested positive for the virus. That's higher than previous estimates by state officials. Tony Thompson, sheriff of Black Hawk County, was among the public officials who called for the Waterloo facility to shut down temporarily. His call to close the plant came after he first toured the facility on April 10. Thompson says that when he toured the plant then, he "fully expected" to see barriers, masks and other personal protective equipment in place. That wasn't the case. "What I saw when we went into that plant was an absolute free-for-all," he says. "Some people were wearing bandannas. Some people were wearing surgical masks. ....

Protests over stay-at-home orders because of COVID-19 have become more common around the country. In California, a surprising group is behind some of them: those who oppose mandatory vaccinations. On Thursday, a mash-up of people mingled on the sidewalk in front of California's state Capitol in Sacramento. There were Trump supporters wearing MAGA hats and waving American flags. There were Christians, singing along to religious rock songs and raising their hands in prayer. The event's MC. urged Gov. Gavin Newsom to tune into their event. "Everybody up at the Capitol, tell Gavin Newsom [to tune in to] 107.9 FM, if he wants to hear what we have to say," the MC told the crowd over loudspeakers. "It could be kind of good for him!" There were also mothers with their children at the rally. Many people were not wearing face masks or observing social distancing protocols. They'd all come out to protest California's stay-at-home order, put in place to slow the spread of COVID-19. This week's

Airlines and airport operators in the United Kingdom are not waiting for the British government to publicly confirm their fears. Already, the groups representing major players in the U.K.'s air travel industry are pushing back on a proposal that would require travelers to quarantine after arriving from outside the country. A spokesperson for Airlines UK — a trade body with British Airways, EasyJet and Ryanair as members — says the group understands from government officials that plans for a quarantine are in the works, but that details remain scarce at the moment. "We need to see the detail of what they are proposing. Public health must of course be the priority and we will continue to be guided by Sage advice," the group said in a statement emailed to NPR, noting that support measures will be necessary to ensure "that we still have a UK aviation sector once the quarantine period is lifted." "We will be asking for assurances that this decision has been led by the science and that

The Sahara – the world’s largest desert – was once underwater. Now a 20-year study led by a Stony Brook University professor has profiled the aquatic animals that once lived there.

Cold Spring Harbor Laboratory has won a $750,000 grant from TD Bank to support its new cancer research facility.