An absorbing mechanism includes a positioning member, an absorbing member, and at least one separating member. The positioning member defines a receiving chamber, for receiving a plurality of workpieces. The attaching member is constructed for absorbing the workpieces. The at least one separating member comprises a main body and a detaching portion. The main body is mounted on the positioning member. The detaching portion protrudes from the main body toward an axis of the positioning member, and forming an inclined surface away from the main body. The inclined surface defines at least one blow hole. The inclined surface towards the receiving chamber.

A storage system for items such as substrate carriers includes at least one stocker including a plurality of storage areas each adapted to store at least one storage device. At least one movable support is arranged on the at least one stocker. A control controls movement of the at least one movable support at least between a first position wherein the at least one movable support receives the at least one storage device outside one of the storage areas and a second position wherein the at least one movable support is arranged substantially within the one of the storage areas.

A grain bin access door and chute system that can be retrofitted into existing grain bins or installed in new grain bins. The access panel includes an outer door and an inner door and allows a user to quickly access and assess the grain within a bin without fear of falling into the grain or through the crust of grain which can form a bridge on the top of grain. The access door includes a lever-controlled chute door and pipe-chute connection. This allows grain to be gravity fed into awaiting grain trucks or rail cars without using a more dangerous grain auger and without relying on outside energy sources. Additionally, grain transferred through a gravity-fed method is less likely to become damaged than grain transferred through a grain auger. An optional grain agitator may likewise be installed within the grain bin.

A combine harvester grain bulk tank and grain unloading system includes opposed bulk tank augers and an unloading auger formed in a grain bulk tank of a combine harvester. The bulk tank augers are for receiving and conveying grain through the bulk tank to the unloading auger, and the unloading auger is for receiving grain from the bulk tank augers and conveying grain to a grain unloading spout for grain unloading. A primary drive gear is coupled to the unloading auger and to an input, a secondary drive gear is drivingly coupled to the bulk tank augers, and a clutch is coupled between the primary drive gear and the secondary drive gear, which is movable between an engaged position for transferring power from the input to the unloading auger and to the bulk tank augers, and a disengaged position for isolating the bulk tank augers from the primary drive gear.

Boom drive apparatus for substrate transport systems and methods are described. The boom drive apparatus is adapted to drive one or more multi-arm robots rotationally mounted to the boom to efficiently put or pick substrates. The boom drive apparatus has a boom including a hub, a web, a first pilot above the web, and a second pilot below the web, a first driving member rotationally mounted to the first pilot, a second driving member rotationally mounted to the second pilot, a first driven member rotationally mounted to the boom above the a web, a second driven member rotationally mounted to the boom below the a web, and a first and second transmission members coupling the driving members to driven members located outboard on the boom. Numerous other aspects are provided.

Source support arm of a liquid crystal panel transportation device is provided, which includes a primary arm section. The primary arm section includes a plurality of ancillary arm sections that are rotatable to open mounted thereon. A liquid crystal panel transportation device is also disclosed, which includes a support arm having a primary arm section and ancillary arm sections that are mounted to the primary arm section and are rotatable to open.

The present invention is a cardboard sheet batch division device for dividing batches, disposed on the downstream side of a batch-forming device for separating loaded cardboard sheets and forming batches of a predetermined sheet count. The cardboard sheet batch division device for dividing batches comprises: a transfer conveyor for transferring batches formed by the batch-forming device in a predetermined transfer direction; and batch division means furnished with two separating members respectively contacting the leading edge portion and the trailing edge portion of a batch on the transfer conveyor, for dividing the batch into two sub-batches, upper and lower, by moving the two separating members relative to one another in a direction parallel to the predetermined transfer direction.

A system for aligning an end effector with a substrate in a substrate transport apparatus. The system comprises a first sensor connected to the end effector and a controller for moving the substrate transport apparatus. The sensor has a sensing path pointed in an outward direction. The sensing path does not intersect the substrate when the substrate is located on the end effector. The controller for moving the substrate transport apparatus moves the substrate transport apparatus, based at least partially upon input from the sensor, to position the end effector at a predetermined position relative to the substrate to pick up the substrate onto the end effector.

A synergy-based human-machine interface that uses low-dimensional command signals to control a high dimensional virtual, robotic or paralyzed human hand is provided. Temporal postural synergies are extracted from angular velocities of finger joints of five healthy subjects when they perform hand movements that are similar to activities of daily living. Extracted Synergies are used in real-time brain control, where a virtual, robotic or paralyzed human hand is controlled to manipulate virtual or real world objects.

A crucible handling shuttle includes a pair of opposed dual crucible-gripping arms mounted on a rotatable head and moves between an induction furnace pedestal and a crucible loading station, such that one pair of arms pick up a crucible loaded with a preweighed sample, the shuttle moves to the induction furnace, where the other pair of arms grip and remove a spent crucible. The shutter head then rotates to deposit the new sample-holding crucible onto the pedestal and subsequently moves out of the furnace area to a sample disposal chute positioned between the crucible loading station and the furnace, whereupon the spent crucible is dropped for disposal. The shuttle head is then rotated and moved to the loading station to pick up a new crucible.

An apparatus for transferring articles is disclosed herein. The apparatus includes a layer formation table. The apparatus also includes means for supplying articles to the layer formation table. At least one row of the articles is formed at a first end of the layer formation table. The apparatus also includes a programmable robot including an end of arm tool for transferring the at least one row of the articles towards a second end of the layer formation table. The programmable robot is configured to form a plurality of rows of articles on the layer formation table. Each of the rows comprises a plurality of articles in side by side contact creating a void between adjacent articles in each of the rows. The programmable robot is configured to nest the articles of one of the rows in the voids of an adjacent row. The end of arm tool includes a multiplicity of guides which form lanes. The rows of articles fill the lanes. The end of arm tool includes clamping tools which lock the individual rows of articles between the guides.

A substrate transportation path is determined by first determining a trajectory of a first straight line passing through a start point, calculating a trajectory of a circular arc in contact with the first straight line, calculating a trajectory of a second straight line in contact with the circular arc and passing through the end point, then, if the position of the end point is changed, re-calculating the second straight line as a straight line passing through the changed end point and in contact with the circular arc, and allowing the center of the substrate holding unit to move on the first straight line, and then, move on the circular arc from a first contact point, followed by moving on the second straight line from a second contact point so as to reach the end point.

A robot system includes a crane unit, a crane moving mechanism, a robot, and a controller. The crane unit is to suspend a workpiece. The crane unit moves in a horizontal direction via the crane moving mechanism. The robot is to move the crane unit in the horizontal direction via the crane moving mechanism. The controller is configured to control the crane unit to move upwardly to suspend the workpiece after controlling the robot to bring the crane unit into an engaging state in which the crane unit engages with the workpiece located at a first position. The controller is configured to control the crane unit suspending the workpiece to move downwardly to place the workpiece at a second position after controlling the robot to move the crane unit toward the second position while the crane unit suspends the workpiece.

Reinforcement devices and systems for holding a traffic control assembly in compression are provided. The traffic control assembly includes a traffic signal disconnect hanger and/or a traffic signal and a first span wire positioned above the traffic control assembly. In some embodiments, the reinforcement device includes an upper support device connected to the first span wire where the upper support device has a length that is greater than a width of the traffic control assembly and the upper support device is configured to spread the load of the traffic signal assembly to the first span wire. The reinforcement device includes a lower support device operably connected to the traffic signal, a first vertical support member, and a second vertical support member where the first and second vertical members are tensioned when the upper support device, the lower support device and the first and second vertical support members are connected together.

Disclosed is a method for the monitoring of a cabin region of a transport system located outside a field of view, wherein at least one light beam is emitted, passing through the cabin region in the longitudinal direction, and in the event of a disturbance of the at least one light beam path a message is generated. A monitoring device is also provided, with at least one emitter unit for purposes of emitting at least one light beam, with at least one receiver unit for purposes of receiving the emitted light beam, and with at least one messaging unit for purposes of generating a message in the event of a disturbance of the at least one light beam path; also disclosed is an aircraft cabin with at least one such monitoring system.

An interface (303) between adjacent ones of light guide sections (310) is inclined with respect to an incident surface (301) and an emission surface (302) of the light guide element (300A) so that an incident surface (311) of at least a part of the light guide sections (310) overlaps a part of a display region (202) in a liquid crystal panel (200A) and an emission surface (312) of said at least a part of the light guide sections (310) overlaps at least a part of a frame region (203) above which an image on the display region (202) is to be displayed. Furthermore, a relation 5°

An input device includes a display section, an input section, and an authentication section. The display section has a display area and displays a plurality of symbols in respective first regions of the display area. The input section receives an input indicating which of the plurality of symbols displayed on the display section is selected by a user by specifying a position in the display area. The authentication section authenticates the user based a result received by the input section. The input section receives an input indicating which of the plurality of symbols is selected, by receiving an input indicating which of a plurality of second regions allocated to each first region is selected. The authentication section authenticates the user based on the first region corresponding to the selected symbol from among the plurality of first regions and the second region selected from among the plurality of second regions.

Presented is a near field communication system and method to automatically establish an interconnection between two electronic devices. The system includes a first electronic device including an NFC chip communicatively coupled to a passive NFC tag, where the NFC tag having an integrated circuit with a predefined information content, a second device including an active NFC reader configured to read the predefined information content from the NFC tag based on an identification of a proximate distance therebetween, and where the NFC tag is capable of transmitting an activation signal to the NFC chip to enable transition of the NFC chip from a first state to a second state such as to establish a near field wireless communication link between the two devices to enable exchange of digital content therebetween.

A wireless media player and a related system and methodology are disclosed. One aspect of the wireless media player system pertains to a virtual connector system, apparatus, and method for the automatic establishment of wireless connectivity with other electronic devices. In one embodiment, the media player device employs the use of integrated Radio Frequency Identification (RFID) technology to exchange communication settings, media capability, and other parameters with an external device that also has integrated RFID technology. The automatic exchange of settings and other information via a proximity-based RFID data exchange allows a media player to quickly establish a secure communication link with another device via a commonly supported wireless protocol such as Ultra Wideband (UWB) or Bluetooth. Another aspect of the media player system pertains to a method of using the captured media capability of the connecting device to customize certain menu options and software parameters in the media player.

In general, the subject matter described in this specification can be embodied in methods, systems, and program products for identifying proximity of a mobile computing device to another mobile computing device. A computing system determines that a set of mobile computing devices are geographically proximate to a first mobile computing device based on identifying that each of the mobile computing devices received a first type of signal from an emitting device for which the first mobile computing device also received the first type of signal. The computing system determines a subset of the mobile computing devices that share a physical space with the first mobile computing device based on identifying that each of the mobile computing devices emitted a second type of signal that was detected by the first mobile computing device, or detected the second type of signal that was emitted by the first mobile computing device.

A method of determining a turbulent condition in an aircraft with a handheld device where the handheld device has at least one of a gyroscope, seismometer, and an accelerometer where the method includes receiving an output from the at least one of the gyroscope, seismometer, and accelerometer while the handheld device is located within the aircraft and providing an indication of a turbulent condition.

The present disclosure describes a microprocessor executable diagnostic module operable to receive, from a vehicle component, a signal regarding a warning and/or error and select a destination for the signal from a plurality of destinations, the plurality of destinations comprising one or more of a vehicle input/output system to present the warning and/or error to a vehicle occupant, an emergency service provider, an emergency responder, a manufacturer of the vehicle, a service facility located in proximity to a current vehicle location, and a remotely located diagnostic service to diagnose a cause of the warning and/or error signal.

An approach is provided to automate predictive vehicle maintenance. In the approach, a vehicle's information handling system receives vehicle data transmissions from a number of other vehicles in geographic proximity to the vehicle. Both the vehicle and the other vehicles correspond to various vehicle types that are used to identify those other vehicles that are similar to the vehicle. The sets of received vehicle data transmissions that are received to similar vehicles are analyzed with respect to a plurality of vehicle maintenance data corresponding to the vehicle. The analysis of the vehicle data transmissions resulting in predictive vehicle maintenance recommendations pertaining to the first vehicle.

A user programmable motor vehicle driving parameter control system includes a motor vehicle including at least one active aerodynamic control element, and a user/vehicle interface member, and a controller including a memory having stored therein a user defined deployment schedule and a processor configured and disposed to selectively deploy the at least one aerodynamic control element based on the user defined deployment schedule.

Methods and systems for a complete vehicle ecosystem are provided. Specifically, systems that when taken alone, or together, provide an individual or group of individuals with an intuitive and comfortable vehicular environment. The present disclosure builds on integrating existing technology with new devices, methods, and systems to provide a complete vehicle ecosystem.

An enhanced encryption keypad (100) capable of preventing illegal disassembly for an automated teller machine comprises a key panel (101) and a main control board (102). A removal detection protection circuit is disposed inside a main chip of the main control board (102), and at least one pin of the removal detection protection circuit is guided out from a surface (1021) of a side of the main control board (102) near the key panel to form a removal detection point (1022). The removal detection point (1022) has two opened signal contact points. The two opened signal contact points are conducted by a conductive adhesive (103) to activate the removal detection protection circuit. A conductive protection ring (1023) isolated from the removal detection point is disposed at the periphery of the removal detection point. The conductive protection ring (1023) is connected to the removal detection protection circuit inside the main control chip. A protection circle (1024) is disposed at the periphery of the conductive protection ring and the corresponding conductive adhesive. The present application effectively protects the encryption keypad from illegal attacks on the removal detection point from the side.

A configurable light timer adapted to receive data to control the operation of the configurable light timer is disclosed. The configurable light timer comprises a control circuit; an input portion coupled to receive a portable memory device by way of a connector on the configurable light timer, wherein the portable memory device stores data to be used by the configurable light timer and is adapted to be removed after the data is downloaded; and a memory coupled to receive the data stored on the portable memory device; wherein control circuit accesses the data from the memory after the data is downloaded and the portable memory device is removed. A method of receiving data to control the operation of the configurable light timer is also disclosed.

A communication process between two constitutive elements of the network of electricity distribution in a domestic or industrial premise including circuit breakers, electrical modules, switches, electrical plugs and light connection devices. The process including the following steps: assignment by a protocol such as DHCP, BootP or RARP of a first IP address to a first element of the power distribution network, assignment of a second IP address to a second element, and establishment of a communication between the first and second elements of the power distribution network.

The invention relates to a universal wireless trainable transceiver unit with integrated bidirectional wireless interface functionality, and a method for same. Using a scan, push button or untrained channel mode, a user may enter into a wireless bidirectional interface mode of a trainable transceiver. The interface mode allows a user to select a sub-set of modes that include diagnostics, flash and vehicle interface. Each mode provides the trainable transceiver to communicate wirelessly in a bidirectional manner with another remote device.

The subject matter of the present disclosure is directed to developing a method of measuring the amount of producible oil and the producible oil saturation in shale-oil reservoirs using sample source rock. Further, the physical and chemical properties and amounts of producible oil in shale-oil reservoir samples may be determined. First and second solvents are applied to a sample source rock to extract petroleum from the sample source rock. The extracted source rock, the twice-extracted source rock, and the first and second extracted petroleum may be analyzed to determine the characteristics and properties of the reservoir rock.

A method and apparatus for dating a body sample, such as blood, includes taking at least one spectroscopic measurement of the sample at at least two predetermined positions in the spectrum having spectral characteristics corresponding to at least two predetermined substances present in the sample that have a time varying relationship with each other. A measured relative concentration of each of the predetermined substances is then determined from the measurement, and the measured relative concentrations of the two predetermined substances is compared with a known variation of the relative concentrations of the two predetermined substances over time. A good fit of the measured relative concentrations to the known variation of the relative concentrations is then determined, so as to provide an indication of the age of the sample. Alternatively, instead of measuring the relative concentrations of each of the predetermined substances, the rate of change of the relative concentrations is determined.

A method for detecting electromagnetic waves derived from bacterial DNA, comprising extracting and purifying nucleic acids from a sample; diluting the extracted purified nucleic acids in an aqueous solvent; measuring a low frequency electromagnetic emission over time from the diluted extracted purified nucleic acids in an aqueous solvent; performing a signal analysis of the low frequency electromagnetic emission over time; and producing an output, based on the signal analysis, in dependence on the DNA in the sample. The DNA may be extracted from at least one of blood, feces, urine, saliva, tears, seminal fluid, sweat, seminal and vaginal fluids of a patient, or water to determine, e.g., potability. The samples may be frozen. The extracting and purifying may comprise diluting the sample with an aqueous buffer and mixing; degrading proteins in the diluted sample; precipitating DNA from the buffer solution; and resuspending the precipitated DNA in an aqueous solution.

The present invention relates to a method of identifying a natural substance that is capable of complexation with Ni2+, Cu2+ and/or Fe2+ ions, wherein an extract containing natural substances is led over a stationary phase loaded with Ni2+, Cu2+ and/or Fe2+ ions, which is suitable for immobilized metal affinity chromatography (IMAC).

This invention relates to the field of preparation technology of optical pH sensor by co-intercalated fluorescein and 1-heptanesulfonic acid sodium into layered double hydroxide. The sensor is composed by conductive materials and the surface LDH films by co-interacted FLU and HES. The synthesis method is: first: synthesis of LDH colloid suspension, subsequently, the FLU and HES co-intercalated LDH colloid solution was prepared following the ion-exchange method, then the thin film of FLU-HES/LDH was spreaded on the surface of the conductive material by electrophoretic deposition, and the oriental pH sensor was synthesized. The advantages of the present invention is: first, the LDH matrix provides chromophore molecules with a confined and stable environment; the novel electrophoretic deposition strategy in this work provides a method for precise control of thickness (ranging from nanometers to micrometers), and the oriental pH sensor show good pH responsive.

A biosensor and method of making are disclosed. The biosensor is configured to detect a target and may include a peptide immobilized on a sensing component, the sensing component having an anode and a cathode. The immobilized peptide may comprise an antimicrobial peptide binding motif for the target. The sensing component has an electrical conductivity that changes in response to binding of the immobilized peptide to the target. The immobilized peptide may bind one or more targets selected from the list consisting of: bacteria, Gram-negative bacteria, Gram-positive bacteria, pathogens, protozoa, fungi, viruses, and cancerous cells. The biosensor may have a display with a readout that is responsive to changes in electrical conductivity of the sensing component. The display unit may be wirelessly coupled to the sensing component. A resonant circuit with an inductive coil may be electrically coupled to the sensing component. A planar coil antenna may be disposed in proximity to the resonant circuit, the planar coil antenna being configured to provide power to the sensing component.

Disclosed are polyvalent macromolecules, compositions comprising the macromolecules, and methods of use. The polyvalent macromolecules have a polymer backbone and pendent groups attached to the polymer backbone. Some or all of the pendent groups have optionally a linker, a surface-seeking group capable of binding strongly to a metal surface, and a spectroscopically detectable chromophore detectable.

The present application provides apparatus and methods for determining the density of a fluid sample. In particular, it provides a sensor device which can be loaded with a fluid sample such as blood, and which further comprises at least one oscillating beam member or resonator. Exposure of the blood sample to clotting agents allows a clotting reaction to commence. The device allows the density of the sample fluid to be monitored with reference to the oscillation of the vibrating beam member, thus allowing the monitoring of the clotting of the fluid sample.

The invention describes biomarkers which can be used to predict the likelihood that an individual will develop Diabetes. The biomarkers can also be used to screen large groups in order to identify individuals at risk of developing Diabetes.

Luminescent labels based on aromatic and heterocyclic compounds, including reactive intermediates used to synthesize these compounds, and methods of synthesizing and using these reporter compounds. These labels combine high photostabilities, large Stokes' shifts and contain a pyrimidinium moiety as a water-soluble group. These luminescent compounds relate generally to the following structure: The methods relate generally to the synthesis and/or use of reporter compounds for fluorescence lifetime or fluorescence polarization based applications.

Methods and systems for selectively capturing analytes, such as cells, e.g., circulating tumor cells (CTCs), from fluid samples are disclosed. The methods include contacting the sample with an analyte binding moiety that selectively binds to the analytes; optionally separating first components of the sample including a majority of the analytes bound to the binding moieties from second components of the sample using size-based separation, e.g., in a microfluidic channel; adding to the first components of the sample a plurality of binding agents under conditions that enable a plurality of the binding agents to be linked to the analyte binding moieties to form multivalent tagging agents bound to the analyte; passing the first components of the sample past a surface to which is attached a plurality of capture agents that selectively bind to the binding agents; and capturing the analytes by providing conditions that enable the multivalent tagging agents bound to the analytes to bind to one or more of the capture agents.

A chemiresistive biosensor for detecting an analyte can include a high specific surface area substrate conformally coated with a conductive polymer, and a binding reagent immobilized on the conductive polymer, wherein the binding reagent has a specific affinity for the analyte. The conductive polymer can be deposited on a substrate by oCVD.

A first set of antibodies are bonded to a substrate, and are exposed to and bonded with target antigens. A second set of antibodies are bonded to nanoparticles, and the nanoparticle labeled antibodies are exposed to the targeted antigens. An electromagnetic write-head magnetizes the nanoparticles, and then a read-sensor detects the freshly magnetized nanoparticles. The substrate comprises a flexible film or a Peltier material to allow selective heating and cooling of the antigens and antibodies. Nanoparticles of different magnetic properties may be selectively paired with antibodies associated with different antigens to allow different antigens to be detected upon a single scan by the read-sensor.

There is disclosed a method for producing a molecule immobilizing substrate, comprising at least the steps of: forming, on a substrate, a monomolecular film including hydroxyl groups, cyano groups, or oxiranyl groups, which are oriented toward an outmost surface of the monomolecular film; andchemically modifying the hydroxyl groups, cyano groups, or oxiranyl groups of the monomolecular film to transform them into carboxyl groups, to thereby form, on the substrate, the monomolecular film including the carboxyl groups, which are oriented toward an outmost surface of the monomolecular film. There can be provided: a method for producing a molecule immobilizing substrate which is free of occurrence of an immobilized-molecule peeling problem in the case of conducting an assay by immobilizing molecules on the substrate.

A method for disabling and re-enabling third-party advertisements is disclosed. An Internet accessible “virtual world” or interactive on-line community can have its advertisements disabled by the entering and subsequent validation of a registration code that is associated with a toy into a website, once validated, displaying a virtual representation of the toy on the website, providing virtual world content so that the virtual representation of the toy is caused to interact with the virtual world content and the toy virtual representations of other users, displaying advertisement on the website in a first mode and allowing customization of the virtual world content including the disabling of advertisements in a second mode. In a similar manner the third party advertisements can be re-enabled.

This invention relates, e.g., to a method for determining if a subject has myocardial ischemia, comprising (a) providing a blood sample obtained from a subject suspected of having myocardial ischemia; (b) determining in the sample the amount of one or more of the following proteins: (i) Lumican and/or (ii) Extracellular matrix protein 1 and/or (iii) Carboxypeptidase N; and (c) comparing the amount(s) of the protein(s) to a baseline value that is indicative of the amount of the protein in a subject that does not have myocardial ischemia, wherein a statistically significantly increased amount of the protein(s) compared to the baseline value is indicative of myocardial ischemia. Other proteins indicative of myocardial ischemia are also described, as are methods for treating a subject based on a diagnostic procedure of the invention, and kits for carrying out a method of the invention.

A testing cartridge for metering of a sample to be tested. The testing cartridge includes a casing defining a casing opening and a sliding member defining a sliding member opening. The casing opening or the sliding member opening can define a specified volume, wherein the casing opening and the sliding member opening collectively define a sample application region dimensioned to accommodate receiving an amount of sample exceeding the specified volume. The sliding member is movable transversely to the casing opening by having the sliding member and the casing traverse across each other's respective openings to remove excess sample from the received amount of sample and retain the specified volume from the received amount of sample.

This invention provides a biomolecule modifying substrate comprising biomolecules selectively fixed to given regions thereon. The biomolecule modifying substrate comprises: a substrate at least comprising a first surface and a second surface; a first linker molecule comprising a hydrocarbon chain and a functional group capable of selectively binding to the first surface at one end of the hydrocarbon chain, which is bound to the first surface via such functional group; a second linker molecule comprising a reactive group capable of binding to the hydrocarbon chain of the first linker molecule, which is bound to the first linker molecule via a bond between the reactive group and the hydrocarbon chain; and a biomolecule bound thereto via the second linker molecule.

The present invention provides methods for preventing clumping of cells in microfluidic devices by addition of diazolidinyl urea (DU). DU can be added to samples at the time of collection or can be added to samples post-collection. DU can also be pre-added to sample collection devices.

The invention encompasses analyzers and analyzer systems that include a single particle analyzer, methods of using the analyzers and analyzers systems to analyze samples, either for single particles, e.g., protein molecules, or for multiple particles (multiplexing), methods of doing business based on the use of the analyzers or analyzer systems of the system, and electronic media for storing parameters useful in the analyzers and analyzer systems of the invention.

The invention provides a binding layer comprising a polysaccharide substituted by carboxylic groups or derivatives thereof exhibiting high performance in the binding of ligand molecules and in the interaction thereof with analyte molecules. A method for the preparation of the binding layer and for the assaying of various analyte molecules is also provided.