Drink Local Life under the COVID-19 pandemic is rough for everyone, individuals and businesses alike.…

Drink Local In tumultuous times, one thing remains true: People still want their spirits.…

Drink Local For the majority of regional craft breweries, most revenue comes from two avenues: direct-to-consumer sales out of a tasting room and selling beer to local bars and restaurants.…

The chafing.…

A coalition of immigrant-focused organizations has created the Spokane Relief Fund for Undocumented Immigrants, in order to help families who are unable to access federal aid during the coronavirus shutdowns. The partners sponsoring the work include the Spokane Immigrant Rights Coalition (SIRC), the Hispanic Business and Professional Association, Latinos en Spokane, Mujeres in Action and Raiz.…

The Cannabis Issue Like the best gas station treats that tempt even the most mature adults on a good road trip, gummies cater to that need to chew on something sweet while basking in the sunshine.…

A library of macrocyclic compounds of the formula (I) where part (A) is a bivalent radical, a —(CH2)y— bivalent radical or a covalent bond;where part (B) is a bivalent radical, a —(CH2)z— bivalent radical, or a covalent bond;where part (C) is a bivalent radical, a —(CH2)t— bivalent radical, or a covalent bond; andwhere part (T) is a —Y-L-Z— radical wherein Y is CH2 or CO, Z is NH or O and L is a bivalent radical. These compounds are useful for carrying out screening assays or as intermediates for the synthesis of other compounds of pharmaceutical interest. A process for the preparation of these compounds in a combinatorial manner, is also disclosed.

A computer implemented method of constructing formal definitions in intelligent glossaries for interpreting text, comprising the steps of: providing at least one Distinction having a Boundary, an Indication, a Counter-indication and a Frame; modeling each Distinction as a diagram to provide a Distinction Model; verifying each distinction model as being an instantiation of a generic Distinction Pattern; providing at least one Arrangement made of nonintersecting Marks of Distinction containing Indications from the verified Distinction Model; writing at least one Formulation for each Indication appearing in verified Distinction model and Arrangement, providing well-founded Indications; calculating precise Formulations in Natural Language from well-founded Indications by substituting Variables symbols and/or replacing Constants symbols to transform imprecise Formulations into precise Formulations; selecting a Definition type and embedding at least one precise Formulation and Definition type as a formal Definition in an Intelligent Glossary to provide computerized Semantic Systems of Intelligent Glossaries.

The disclosed embodiments describe a method, an apparatus, an application specific integrated circuit, and a server that provides a fast and efficient look up for data analysis. The apparatus and server may be configured to obtain data segments from a plurality of input devices. The data segments may be individual unique subsets of the entire data set obtained by a plurality input devices. A hash function may be applied to an aggregated set of the data segments. A result of the hash function may be stored in a data structure. A codebook may be generated from the hash function results.

A method for producing fatty acid alkyl esters from biolipids through transesterification and/or esterification reactions uses a flow-through cavitation device for generating cavitation bubbles in a fluidic reaction medium. The fluidic medium is passed through sequential compartments in the cavitation device having varying diameters and inner surface features to create localized reductions in fluid pressure thus vaporizing volatile alcohols and creating an increased surface area and optimized conditions for the reaction to occur at the gas-liquid interface around the bubbles.

This invention relates to an improved process for the preparation of green fatty acid methyl esters (FAME; commonly called as biodiesel) from different triglyceride oils using mixed metal oxides derived from layered double hydroxides (referred here as LDHs) as reusable solid heterogeneous base catalysts. This process uses very low alcohohoil molar ratio and catalyst and/or products are easily separable after the reaction through simple physical processes. The properties of thus obtained biodiesel meet the standard biodiesel values and can directly be used as transport fuel.

The invention generally relates to compositions and methods of their use. More specifically, the invention relates to the use of a compound in modulating erythropoiesis in a subject by mediating the activity and/or quantity of a member present in the LPA3-mediated signaling pathway, such as lysophosphatidic acid receptor subtype 3 (LPA3).

The invention is directed to a pulverulent compound of the formula NiaM1bM2cOx(OH)y where M1 is at least one element selected from the group consisting of Fe, Co, Zn, Cu and mixtures thereof, M2 is at least one element selected from the group consisting of Mn, Al, Cr, B, Mg, Ca, Sr, Ba, Si and mixtures thereof, 0.3≦a≦0.83, 0.1≦b≦0.5, 0.01≦c≦0.5, 0.01≦x≦0.99 and 1.01≦y≦1.99, wherein the ratio of tapped density measured in accordance with ASTM B 527 to the D50 of the particle size distribution measured in accordance with ASTM B 822 is at least 0.2 g/cm3·μm. The invention is also directed to a method for the production of the pulverulent compound and the use as a precursor material for producing lithium compounds for use in lithium secondary batteries.

The invention in particular has as an object detecting incompatibility between equipment items of a on-board system. A logic interface associated with one equipment item comprises at least one input while a logic interface associated with another equipment item comprises at least one output. The input and the output are connected. After a minimal data definition level associated with the input and a data definition level associated with the output have been obtained (505), the said minimal data definition level associated with the input is compared (515) with the said data definition level associated with the output. Following this comparison, if the said minimal data definition level associated with the input is lower than the said data definition level associated with the output, an alarm indicating an incompatibility of these two equipment items is generated (545).

Memory devices adapted to repair single unprogrammable cells during a program operation, and to repair columns containing unprogrammable cells during a subsequent erase operation. Programming of such memory devices includes determining that a single cell is unprogrammable and repairing the single cell, and repairing a column containing the single cell responsive to a subsequent erase operation.

In this application, a set of orthogonal functions is introduced whose power spectral densities are all rectangular shape. To find the orthogonal function set, it was considered that their spectrums (Fourier transforms of the functions) are either real-valued or imaginary-valued, which are corresponding to even and odd real-valued time domain signals, respectively. The time domain functions are all considered real-valued because they are actually physical signals. The shape of the power spectral densities of the signals are rectangular thus, the Haar orthogonal function set can be employed in the frequency domain to decompose them to several orthogonal functions. Based on the inverse Fourier transform of the Haar orthogonal functions, the time domain functions with rectangular power spectral densities can be determined. This is equivalent to finding the time-domain functions by taking the inverse Fourier transform of the frequency domain Walsh functions. The obtained functions are sampled and truncated to generate finite-length discrete signals. Truncation destroys the orthogonality of the signals. The Singular Value Decomposition method is used to restore the orthogonality of the truncated discrete signals.

A system (200) and a method (100) of operating a computing device to perform memoization are disclosed. The method includes determining whether a result of a function is stored in a cache and, if so, retrieving the result from the cache and, if not, calculating the result and storing it in the cache. The method (100) includes transforming (104) by the computing device at least one selected from the input parameters and the output parameters of the function, the transforming being based on an analysis of the function and its input arguments to establish whether or not there is a possible relationship reflecting redundancy among the input parameters and output parameters of the function. The transforming may include at least one of: use of symmetry, scaling, linear shift, interchanging of variables, inversion, polynomial and/or trigonometric transformations, spectral or logical transformations, fuzzy transformations, and systematic arrangement of parameters.

The present invention is directed to a coating composition including a (meth)acrylate binder resin, a UV initiator, an organic solvent, and silica particles surface-treated with a (meth)acrylate compound, a coating film including a cured product of the coating composition, and a method of producing the coating film. The present invention makes it possible to provide a coating material having high transmittance and a low level of haze, and excellent scratch resistance and self-healing capabilities.

The present disclosure relates to processes for reducing the concentration of RfC≡CX impurities in fluoroolefins. The process involves: contacting a mixture comprising at least one fluoroolefin and at least one RfC≡CX impurity with at least one amine to reduce the concentration of the at least one RfC≡CX impurity in the mixture; wherein Rf is a perfluorinated alkyl group, and X is H, F, Cl, Br or I. The present disclosure also relates to processes for making at least one hydrotetrafluoropropene product selected from the group consisting of CF3CF═CH2, CF3CH═CHF, and mixtures thereof and reducing the concentration of CF3C═CH impurity generated during the process. The present disclosure also relates to processes for making at least one hydrochlorotrifluoropropene product selected from the group consisting of CF3CCl═CH2, CF3CH═CHCl, and mixtures thereof and reducing the concentration of CF3C≡CH impurity generated during the process.

A heat transfer fluid emulsion includes a heat transfer fluid, and liquid droplets dispersed within the heat transfer fluid, where the liquid droplets are substantially immiscible with respect to the heat transfer fluid and have dimensions that are no greater than about 100 nanometers. In addition, the thermal conductivity of the heat transfer fluid emulsion is greater than the thermal conductivity of the heat transfer fluid.

A data processing system arranged for receiving over a network, according to a data transfer protocol, data directed to any of a plurality of destination identities, the data processing system comprising: data storage for storing data received over the network; and a first processing arrangement for performing processing in accordance with the data transfer protocol on received data in the data storage, for making the received data available to respective destination identities; and a response former arranged for: receiving a message requesting a response indicating the availability of received data to each of a group of destination identities; and forming such a response; wherein the system is arranged to, in dependence on receiving the said message.

A binary library overload instruction is received at an embedded computing device that executes a write-protected firmware build. The binary library overload instruction specifies a write-protected binary library of the write-protected firmware build to be overloaded by execution of an alternative binary library instead of the write-protected binary library of the write-protected firmware build. The alternative binary library is configured within a random access memory (RAM) storage area to execute instead of the write-protected binary library as specified in the received binary library overload instruction. The write-protected firmware build is executed using the alternative binary library instead of the write-protected binary library specified in the binary library overload instruction.

Routing methods for an integrated circuit design layout are disclosed. The layout can include design netlists and library cells. A multiple-level global routing can generate topological wire for each net. An area oriented graph-based detail routing on the design can be performed. A post route optimization after the detail routing can be performed to further improve the routing quality. Some methods can be single threaded all or some of the time, and/or multi-threaded some or all of the time.

An elongated segmented soap bar is segmented longitudinally into a plurality of soap bodies separate and discrete from one another. Adjacent soap bodies are movable with respect to one another between at least two different configurations including at least an arc configuration with the plurality of soap bodies disposed in an arc. At least one coupler couples the plurality of soap bodies together to allow the adjacent soap bodies to move with respect to one another between the at least two different configurations.

An electrochemical finishing system for super conducting radio frequency (SCRF) cavities including a low viscosity electrolyte solution that is free of hydrofluoric acid, an electrode in contact with the electrolyte solution, the SCRF cavity being spaced apart from the electrode and in contact with the electrolyte solution and a power source including a first electrical lead electrically coupled to the electrode and a second electrical lead electrically coupled to the cavity, the power source being configured to pass an electric current between the electrode and the workpiece, wherein the electric current includes anodic pulses and cathodic pulses, and wherein the cathodic pulses are interposed between at least some of the anodic pulses. The SCRF cavity may be vertically oriented during the finishing process.

An additive manufacturing method for forming nearly monolithic SRF niobium cavities and end group components of arbitrary shape with features such as optimized wall thickness and integral stiffeners, greatly reducing the cost and technical variability of conventional cavity construction. The additive manufacturing method for forming an SRF cavity, includes atomizing niobium to form a niobium powder, feeding the niobium powder into an electron beam melter under a vacuum, melting the niobium powder under a vacuum in the electron beam melter to form an SRF cavity; and polishing the inside surface of the SRF cavity.

A message screen display comprises a static non-scrollable display area for display of at least part of a first message, the first message having an associated first message time. The message screen display further comprises a scrollable display area for display of at least part of a second message, the second message having an associated second message time. The message screen display further comprises a feature applied to at least part of the first message that varies based on time as referenced to the associated first message time.

Various embodiments present a combined visual entity that represents overlapping visual entities. The combined visual entity can include a primary visualization that represents one of the overlapping visual entities and annotations that represent others of the overlapping visual entities. For example, a map view can include multiple geographical entities that overlap. A primary visualization can be rendered that represents one of the multiple geographical entities. The primary visualization can be visually annotated (e.g., with symbols, letters, or other visual indicators) to indicate others of the multiple geographical entities. In some embodiments, a zoom operation can cause visual entities to be added and/or removed from the combined visual entity.

A computer-implemented method of detecting automated identities, including. The method includes, using one or more computing devices, providing for display to a user a first representation of a first profile for a first identity and a second representation of a second profile for a second identity, providing for display to the user a choice indication mechanism for indicating a judgment about the first representation of the first profile for the first identity and the second representation of the second profile for the second identity, receiving an indication of the judgment from the user about the first representation of the first profile for the first identity and the second representation of the second profile for the second identity, and determining whether at least one of the first identity, the second identity, or the user is more or less likely to be automated, based at least in part on the received indication.

Systems, processors, and methods for keeping uncacheable data coherent. A processor includes a multi-level cache hierarchy, and uncacheable load memory operations can be cached at any level of the cache hierarchy. If an uncacheable load misses in the L2 cache, then allocation of the uncacheable load will be restricted to a subset of the ways of the L2 cache. If an uncacheable store memory operation hits in the L1 cache, then the hit cache line can be updated with the data from the memory operation. If the uncacheable store misses in the L1 cache, then the uncacheable store is sent to a core interface unit. Multiple contiguous store misses are merged into larger blocks of data in the core interface unit before being sent to the L2 cache.

Apparatuses and methods for providing data are disclosed. An example apparatus includes a plurality of memories coupled to a data bus. The memories provide data to the data bus responsive, at least in part, to a first address. The plurality of memories further provide at least a portion of the data corresponding to the first address to the data bus during a sense operation for a second address provided to the plurality of memories after the first address. Each of the plurality of memories provides data to the data bus corresponding to the first address at different times. Moreover, a plurality of memories may provide at least 2N bits of data to the data bus responsive, at least in part, to an address, each of the plurality of memories provide N bits of data to the data bus at different times.

A data processing system on an integrated circuit includes a core that performs switching operations responsive to a system clock that draws current from the power supply network. An IR-drop detector includes a resistor ladder having outputs representative of an IR-drop caused by the core during the switching operations. The system further includes a plurality of amplifiers coupled to the outputs indicative of the IR-drop, a plurality of flip-flops coupled to the amplifiers, and a variable clock generator. The variable clock generator outputs a sampling clock comprising a group consisting of a variable phase or a variable frequency to the plurality of flip-flops. The flip-flops are triggered by the sampling clock so that the IR-drop at a time during a clock cycle of the system clock can be detected, and the peak IR-drop value for can be tracked.

The disclosed embodiments relate to pulse oximetry. An exemplary pulse oximeter comprises a probe that is adapted to be attached to a body part of a patient to create a signal indicative of an oxygen saturation of blood of the patient, and a processor that is adapted to receive the signal produced by the probe, to calculate an SPO2 value based on the signal, to detect a plurality of pattern types of SPO2 indicative of pathophysiologic events, and to produce an output indicative of a detected one of the plurality of pattern types.

An intracorporeal marker, for marking a site within living tissue of a host, includes an outer body portion of biodegradable material. An inner body portion is located in the outer body portion. The inner body portion includes biological material that becomes calcified in the living tissue of the host over time. An agent interacts with the biological material to promote calcification of the biological material of the inner body portion in the living tissue of the host.

The present invention is directed to multiple a-lipoic acid-containing hydrophobic compounds (mALAs) capable of acting as scavengers of free radicals, metals and reactive oxygen species (ROS). Methods of synthesizing novel antioxidant mALAs, spontaneous emulsification or nanoprecipitaion thereof to produce antioxidant nanospheres and their use in preventing or treating diseases or conditions caused by oxidative stress and other free radical mediated conditions are also described. Another aspect of this invention is the use of these antioxidant nanospheres for the preparation of antioxidant particulate delivery system of therapeutic agents.

The present invention relates to a method of making low colored bis(2-ethylhexyl) furan-2,5-dicarboxylate (BEHFD) plasticizer via mild hydrogenation of highly colored BEHFD.

Methods are disclosed for synthesizing nanocomposite materials including ferromagnetic nanoparticles with polymer shells formed by controlled surface polymerization. The polymer shells prevent the nanoparticles from forming agglomerates and preserve the size dispersion of the nanoparticles. The nanocomposite particles can be further networked in suitable polymer hosts to tune mechanical, optical, and thermal properties of the final composite polymer system. An exemplary method includes forming a polymer shell on a nanoparticle surface by adding molecules of at least one monomer and optionally of at least one tethering agent to the nanoparticles, and then exposing to electromagnetic radiation at a wavelength selected to induce bonding between the nanoparticle and the molecules, to form a polymer shell bonded to the particle and optionally to a polymer host matrix. The nanocomposite materials can be used in various magneto-optic applications.

Disclosed herein is a method for determining a trajectory for a transfer of a spacecraft from a starting space body to a target space body with respect to a given central space body, wherein the determined trajectory is optimal with respect to a given space mission requirement to be met by the transfer of the spacecraft. The method comprises providing, according to the Pontryagin maximum principle, a physical-mathematical model relating model quantities and physical quantities representing the transfer of the spacecraft with respect to the given central space body.

A family of catheter electrode assemblies includes a flexible circuit having a plurality of electrical traces and a substrate; a ring electrode surrounding the flexible circuit and electrically coupled with at least one of the plurality of electrical traces; and an outer covering extending over at least a portion of the electrode. A non-contact electrode mapping catheter includes an outer tubing having a longitudinal axis, a deployment member, and a plurality of splines, at least one of the plurality of splines comprising a flexible circuit including a plurality of electrical traces and a substrate, a ring electrode surrounding the flexible circuit and electrically coupled with at least one of the plurality of electrical traces; and an outer covering extending over at least a portion of the ring electrode. A method of constructing the family of catheter electrode assemblies is also provided.

A lead for providing electrical stimulation of patient tissue includes a distal lead element, at least two proximal lead elements, and a junction coupling the distal lead element to each of the at least two proximal lead elements. The distal lead element includes a plurality of electrodes and a plurality of conductive wires coupled to the plurality of electrodes and extending along a longitudinal axis of the distal lead element. Each of the at least two proximal lead elements includes a plurality of terminals and a plurality of conductive wires coupled to the plurality of terminals and extending along a longitudinal axis of the proximal lead element. The junction includes a circuit arrangement electrically coupling each of the conductive wires of the distal lead element to at least one of the conductive wires of at least one of the at least two proximal lead elements.

An injection molding system is disclosed that utilizes a melt channel wherein at least a portion of the melt channel has a noncircular cross-section for balancing shear in a melt stream of moldable material that flows therethrough. The noncircular cross-section of the melt channel portion may be, for e.g., capsule-shaped, extended egg-shaped, oval, teardrop-shaped, or peanut-shaped. A flow splitter is also disclosed that is positioned offset from a central axis of an upstream melt channel to protrude between inlets of respective downstream melt channels, where the upstream melt channel splits into the downstream melt channels, to thereby create a narrower inlet into one of the downstream melt channels and a wider inlet into the other of the downstream melt channels.

A method of influencing combustion dynamics, including measuring a combustion dynamics parameter, and controlling a diluent flow (26) delivered to a fuel flow (32) upstream of a pilot burner fuel outlet (40) in response to the measured combustion dynamics parameter.

A method of detecting proximity between a media proxy and a client uses a proximity probe to query a plurality of media proxies, forcing the media proxies to respond to a proximity server. The proximity server uses an algorithm to determine which media proxy is closest to the client based on the responses. In an alternate embodiment, the same sorts of proximity probes may be used to determine if two media endpoints have a direct connection such that they may bypass a media proxy.

In the present invention, one or both of an active wheel or a passive wheel is composed of an eccentric transmission wheel and is combined with a synchronous transmission belt for forming an eccentric wheel transmission wheel series, so that when the feet input forces at different angles from the treadle shafts of the treadles to an active wheel shaft combined on the active wheel through cranks, the active wheel forms different transmission speed ratios relative to the passive wheel according to the treadle angle, and random inward packing is performed to the transmission belt (100) of the engage end of the eccentric passive wheel (413) during the transmission for stabling the operation.

The present invention is structured by using one or both of an active wheel and a passive wheel being composed of an eccentric transmission wheel and being combined with a synchronous transmission belt for forming an eccentric wheel transmission wheel series, so that in the reciprocal treadle performed by the human's feet, when the feet input forces at different angles from the treadle shafts of the treadles to an active wheel shaft combined on the active wheel through cranks, the active wheel forms different transmission speed ratios relative to the passive wheel according to the treadle angle.

This invention relates to methods for improved cell-based therapies for retinal degeneration and for differentiating human embryonic stem cells and human embryo-derived into retinal pigment epithelium (RPE) cells and other retinal progenitor cells.

A method for engineering and utilizing large DNA vectors to target, via homologous recombination, and modify, in any desirable fashion, endogenous genes and chromosomal loci in eukaryotic cells. These large DNA targeting vectors for eukaryotic cells, termed LTVECs, are derived from fragments of cloned genomic DNA larger than those typically used by other approaches intended to perform homologous targeting in eukaryotic cells. Also provided is a rapid and convenient method of detecting eukaryotic cells in which the LTVEC has correctly targeted and modified the desired endogenous gene(s) or chromosomal locus (loci) as well as the use of these cells to generate organisms bearing the genetic modification.

A releasable lock nut assembly for securing a bearing on a threaded hub may include a thrust washer including a disk portion and a peripheral skirt extending axially away from the disk portion, the peripheral skirt having a plurality of openings and a characteristic diameter measured at an axial location of the openings, and a protuberance proximate to at least one of the openings. The assembly may also include a lock ring inserted into the thrust washer, where the lock ring includes a plurality of tangs that extend beyond a lock ring major diameter such that the tangs fit within the openings of the thrust washer. The protuberance may be deformed such that all of the peripheral skirt is within the characteristic diameter, and the protuberance may define an internal envelope of the thrust washer where the internal envelope is larger than the major diameter of the lock ring.

The method for machining a series of workpieces (21) via at least one machining jet includes the following steps: each workpiece (21) is associated with an identifier for uniquely identifying the workpiece,during the machining of a respective workpiece, the temporal characteristic of the machining jet is detected by at least one sensor (30),the detected temporal characteristic is evaluated so as to obtain at least one comparative value, andfor detecting incorrect machining, the at least one comparative value is compared with at least one threshold value.

The invention provides a lubricant composition containing (A) an ionic liquid having an anion represented by formula 1: (Rf1-SO2) (Rf2-SO2) N− or formula 2: (Rf3) (Rf3) (Rf3) PF3− wherein Rf1 and Rf2 in formula 1 may be the same or different and are each F, CF3, C2F5, C3F7 or C4F9, and Rf3 in formula 2 may be the same or different and is CF3, C2F5, C3F7 or C4F9; and (B) a fatty acid amine salt in an amount of 0.1 to 5.0 mass %. The lubricant composition of the invention can favorably be used under a high vacuum or an ultra high vacuum, or under high temperatures, and exhibits excellent rust prevention properties.