Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations  Nature.com

Novel FFPE proteomics method suggests prolactin induced protein as hormone induced cytoskeleton remodeling spatial biomarker | Communications Biology  Nature.com

Massively parallel sample preparation for multiplexed single-cell proteomics using nPOP  Nature.com

Proteomic analysis of cardiorespiratory fitness for prediction of mortality and multisystem disease risks  Nature.com

Identifying proteomic risk factors for cancer using prospective and exome analyses of 1463 circulating proteins and risk of 19 cancers in the UK Biobank  Nature.com

Optimizing differential expression analysis for proteomics data via high-performing rules and ensemble inference  Nature.com

EXCRETE workflow enables deep proteomics of the microbial extracellular environment | Communications Biology  Nature.com

Automated single-cell proteomics providing sufficient proteome depth to study complex biology beyond cell type classifications  Nature.com

Serum proteomics reveal APOE-ε4 -dependent and APOE-ε4 -independent protein signatures in Alzheimer’s disease  Nature.com

quantms: a cloud-based pipeline for quantitative proteomics enables the reanalysis of public proteomics data  Nature.com

Proteomic signatures improve risk prediction for common and rare diseases  Nature.com

A multi-species benchmark for training and validating mass spectrometry proteomics machine learning models  Nature.com

Spatial proteomics identifies JAKi as treatment for a lethal skin disease  Nature.com

Proteomic scores and dietary patterns  Nature.com

An Inflection Point in High-Throughput Proteomics with Orbitrap Astral: Analysis of Biofluids, Cells, and Tissues  ACS Publications

Spatial proteomics of single cells and organelles on tissue slides using filter-aided expansion proteomics  Nature.com

Deep Plasma Proteomics with Data-Independent Acquisition: Clinical Study Protocol Optimization with a COVID-19 Cohort  ACS Publications

Application of Proteomics in Cancer: Recent Trends and Approaches for Biomarkers Discovery  Frontiers

Seer Showcases Deep Proteomics Capabilities, Announces Co-Marketing Deal with Thermo Fisher Scientific  Genetic Engineering & Biotechnology News

Proteomic analysis of the combined effects of cannabigerol and 3- O -ethyl ascorbic acid on kinase-dependent signalling in UVB-irradiated human keratinocytes  Nature.com

Will it be inflation? Striketober? The supply chain? Our hosts make their case, and the choice is up to you.

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After many, many delays, the Micro-Face comic book is here! And we answer the burning question: Why did it take so long to make a comic book? | Come see Planet Money Live in NYC on May 10th! One night only. Tickets on sale here. And buy our now-ready Micro-Face comic book.

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On today's show - how your social circle is one of the strongest predictors of economic mobility and how pop music reflects the economy.

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Liz Truss, the new Prime Minister of the UK, was determined to change the British economy. Instead, her government's mini-budget helped kick off a mini-financial crisis.

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This episode was first released as a bonus episode for Planet Money+ listeners last month. We're sharing it today for all listeners. To hear more episodes like this one and support NPR in the process, sign up for Planet Money+ at plus.npr.org.

Planet Money+ supporters: we'll have a fresh bonus episode for you next week!

"Save aggressively for retirement when you're young." "The stock market is a sure-fire long-term bet." "Fixed-rate mortgages are better than adjustable-rate mortgages." Popular financial advice like this appears in all kinds of books by financial thinkfluencers. But how does that advice stack up against more traditional economic thinking?

That's the question Yale economist James Choi set out to answer in a paper called Popular Personal Financial Advice Versus The Professors. In this interview, he tells Greg Rosalsky what he found. Their talk marks another edition of Behind The Newsletter, in which Greg shares conversations with policy makers and economists who appear in the Planet Money newsletter.

Subscribe to the newsletter at https://www.npr.org/newsletter/money.

Read more about James Choi's paper here: https://www.npr.org/sections/money/2022/09/06/1120583353/money-management-budgeting-tips

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Soccer star Lionel Messi is currently hoping to lead Argentina to victory in the World Cup. His path to global fame was shaped by a crisis in Argentina's economy.

This episode was made in collaboration with NPR and Futuro Studios's The Last Cup podcast.

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2022 was a year of big economic changes. But what economic story most defined the year? Our hosts from Planet Money and The Indicator battle it out over what should be crowned the indicator of the year. Subscribe to Planet Money+ in Apple Podcasts or at plus.npr.org/planetmoney

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All sorts of lessons (even about economics) can be learned from kids' books. On today's show, we visit an elementary school to try to teach third graders econ using some beloved childrens' classics. And, along the way, we learn a few things ourselves.

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The 90s sit-com Seinfeld is often called "a show about nothing." Lauded for its observational humor, this quick-witted show focussed on four hapless New Yorkers navigating work, relationships...yada yada yada.

Jerry, George, Elaine & Kramer set themselves apart from the characters who populated shows like Friends or Cheers, by being the exact opposite of the characters audiences would normally root for. These four New Yorkers were overly analytical, calculating, and above all, selfish.

In other words, they had all the makings of a fascinating case study in economics.

Economics professors Linda Ghent and Alan Grant went so far as to write an entire book on the subject, Seinfeld & Economics. The book points readers to economic principles that appear throughout the show, ideas like economic utility, game theory, and the best way to allocate resources in the face of scarcity.

On today's show, we make the case that Seinfeld is, at its heart, not a show about nothing, but a show about economics. And that understanding Seinfeld can change the way you understand economics itself.

This episode was produced by Alyssa Jeong Perry with help from Emma Peaslee. It was edited by Keith Romer. It was mastered by Robert Rodriguez and fact-checked by Sierra Juarez. Jess Jiang is our acting executive producer.

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In the early 90s, when a young economist named Michael Kremer finished his PhD, there had been a few economic studies based on randomized trials. But they were rare. In part because randomized trials – in which you recruit two statistically identical groups, choose one of them to get a treatment, and then compare what happens to each group – are expensive, and they take a lot of time.

But then, by chance, Michael had the opportunity to run a randomized trial in Busia, Kenya. He helped a nonprofit test whether the aid they were giving to local schools helped the students. That study paved the way for more randomized trials, and for other economists to use the method.

On today's show, how Busia, Kenya, became the place where economists pioneered a more scientific way to study huge problems, from contaminated water to low graduation rates, to HIV transmission. And how that research changed government programs and aid efforts around the world.

This episode was produced by James Sneed with help from Willa Rubin. It was engineered by James Willetts. It was fact-checked by Sierra Juarez and Emma Peaslee. It was edited by Molly Messick. Jess Jiang is our acting executive producer.

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Innovation is crucial for game-changing advancements in society, whether it's treatments for serious diseases, developments in AI technology, or rocket science.

Today on the show, we're airing two episodes from our daily economics show The Indicator. First, a new paper suggests that breakthrough innovations are more likely at smaller, younger companies. We talk to an inventor who left a big pharmaceutical company to start afresh, leading to some incredible treatments for serious diseases.

Then, it's off to Mars — or at least, on the way. Elon Musk's company SpaceX did a first test launch of a rocket meant to go all the way to the red planet. The rocket made it up off of the launch pad and lumbered briefly through the sky before self-destructing over the Gulf of Mexico. Suffice it to say, it's not quite ready. NPR science correspondent Geoff Brumfiel walks us through SpaceX's business plan as we try to figure out if this company has the funding and business acumen to reach its moonshot goal.

These two Indicator episodes were originally produced by Corey Bridges & Brittany Cronin, engineered by Katherine Silva & James Willets, and fact-checked by Dylan Sloan & Sierra Juarez. Kate Concannon edits the show.

The Planet Money version of this episode was produced by Willa Rubin, engineered by Robert Rodriguez, and edited by Keith Romer.

Help support Planet Money and get bonus episodes by subscribing to Planet Money+ in Apple Podcasts or at plus.npr.org/planetmoney.


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When it comes to big questions about the economy, we're still kind of in the dark ages. Why do some economies grow so much faster than others? How long is the next recession going to last? How do we stop inflation without wrecking the rest of the economy? These questions are the domain of macroeconomics. But even some macroeconomists themselves admit: While we have many theories about how the economy works, we have very few satisfying answers.

Emi Nakamura wants to change all that. She's a superstar economist who is a pioneer in the field of "empirical macroeconomics." She finds clever ways of using data to untangle some of the oldest mysteries in macroeconomics, about the invisible hand, the consequences of government spending, and the inner workings of inflation.

Recently we called her up to ask her why the economy is so difficult to understand in first place, and how she's trying to find answers anyway. She gets into all of that, and how Jeff Goldblum shaped her career as an economist, in this episode.

This show was hosted by Jeff Guo and Nick Fountain. It was produced by Dave Blanchard with help from Sam Yellowhorse Kesler. It was engineered by Josephine Nyounai and fact checked by Sierra Juarez. Keith Romer edited the show. Alex Goldmark is our executive producer.

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When economists and policymakers talk about getting inflation under control, there's an assumption they often make: bringing inflation down will probably result in some degree of layoffs and job loss. But that is not the way things have played out since inflation spiked last year. Instead, so far, inflation has come down, and unemployment has stayed low.

So where does the idea of this tradeoff – between inflation and unemployment – come from?

That story starts in the 1940s, with a soft-spoken electrical engineer-turned-crocodile hunter-turned-economist named Bill Phillips. Phillips was consumed by the notion that there are underlying forces at work in the economy. He thought that if macroeconomists could only understand how those forces work, they could keep the economy stable.

On today's show, how the Phillips Curve was born, why it went mainstream, and why universal truths remain elusive in macroeconomics.

This episode was hosted by Willa Rubin and Nick Fountain, and produced by Sam Yellowhorse Kesler. It was edited by Molly Messick, and engineered by Maggie Luthar. Sierra Juarez checked the facts.

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There seems to be headlines about floods, wildfires, or hurricanes every week. Scientists say this might be the new normal — that climate change is making natural disasters more and more common.

Tatyana Deryugina is a leading expert on the economics of natural disasters — how we respond to them, how they affect the economy, and how they change our lives. And back when Tatyana first started researching natural disasters she realized that there's a lot we don't know about their long-term economic consequences. Especially about how individuals and communities recover.

Trying to understand those questions of how we respond to natural disasters is a big part of Tatyana's research. And her research has some surprising implications for how we should be responding to natural disasters.

This episode was hosted and reported by Jeff Guo. It was produced by Emma Peaslee and edited by Jess Jiang. It was fact checked by Sierra Juarez and engineered by Josephine Nyounai. Alex Goldmark is our executive producer.

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You might expect to find economic concepts in the pages of an economics textbook. But you know where you can really see a lot of economic concepts in action? Buffets.

Here at Planet Money we believe there's a lot of economics going on at the all-you-eat buffet, tucked in between the mountains of brisket and troughs of mashed potatoes. From classic concepts like adverse selection, sunk costs, diminishing marginal returns, to more exotic economic mysteries, like the flat rate pricing bias.

Today on the show, we're headed to the place where the modern buffet may have been born: Las Vegas. Our mission? To feast ourselves on all the economics we can handle at the all-you-can-eat buffet. And along the way, an economist and fellow buffet-lover will teach us his hyper-rational strategy for optimizing his buffet experience.

Today's show was produced by James Sneed and Nick Fountain with help from Emma Peaslee. It was edited by Jess Jiang, engineered by James Willetts, and fact-checked by Sierra Juarez. Alex Goldmark is our executive producer.

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Some of the most influential and beloved novels of the last few years have been about money, finance, and the global economy. Some overtly so, others more subtly. It got to the point where we just had to call up the authors to find out more: What brought them into this world? What did they learn? How were they thinking about economics when they wrote these beautiful books?

Today on the show: we get to the bottom of it. We talk to three bestselling contemporary novelists — Min Jin Lee (Pachinko and Free Food for Millionaires), Emily St. John Mandel (Station Eleven, The Glass Hotel and Sea of Tranquility), and Hernan Diaz (Trust, In the Distance) – about how the hidden forces of economics and money have shaped their works.

This episode was hosted by Mary Childs and Alexi Horowitz-Ghazi. It was produced by Willa Rubin, edited by Molly Messick, and engineered by Neisha Heinis. Fact-checking by Sierra Juarez.

Help support Planet Money and get bonus episodes by subscribing to Planet Money+ in Apple Podcasts or at plus.npr.org/planetmoney.

Always free at these links: Apple Podcasts, Spotify, Google Podcasts, the NPR app or anywhere you get podcasts.

Find more Planet Money: Facebook / Instagram / TikTok / Our weekly Newsletter.

Music: Universal Music Production - "This Summer," "Music Keeps Me Dancing," "Rain," and "All The Time."

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There are tons of markets that don't exist because people just don't want to allow a market – for whatever reason, people feel icky about putting a price on something. For example: Surrogacy is a legal industry in parts of the United States, but not in much of the rest of the world. Assisted end-of-life is a legal medical transaction in some states, but is illegal in others.

When we have those knee-jerk reactions and our gut repels us from considering something apparently icky, economics asks us to look a little more closely.

Today on the show, we have three recommendations of things that may feel kinda wrong but economics suggests may actually be the better way. First: Could the matching process of organ donation be more efficient if people could buy and sell organs? Then: Should women seek revenge more often in the workplace? And finally, what if insider trading is actually useful?

This episode was hosted by Mary Childs and Greg Rosalsky. It was produced by Willa Rubin and edited by Jess Jiang. It was engineered by Cena Loffredo. Fact-checking by Sierra Juarez. Alex Goldmark is Planet Money's executive producer.

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The Department of Defense's proposed budget for 2024 is $842 billion. That is about 3.5% of the U.S.'s GDP. The military buys everything from pens and paper clips to fighter jets and submarines. But the market for military equipment is very different from the commercial market.

On today's episode, we're bringing you two stories from The Indicator's series on defense spending that explore that market. As the U.S. continues to send weapons to Ukraine and Israel, we first look at why defense costs are getting so high. Then, we dive into whether bare-bones manufacturing styles are leaving the U.S. military in a bind.

The original Indicator episodes were produced by Cooper Katz McKim with engineering from Maggie Luthar and James Willetts. It was fact-checked by Sierra Juarez and Angel Carreras. They were edited by Kate Concannon and Paddy Hirsch. Alex Goldmark is Planet Money's executive producer.

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Réka Juhász is a professor of economics at the University of British Columbia, and she studies what's known as industrial policy.

That's the general term for whenever the government tries to promote specific sectors of the economy. The idea is that they might be able to supercharge growth by giving money to certain kinds of businesses, or by putting up trade barriers to protect certain industries. Economists have long been against it. Industrial policy has been called a "taboo" subject, and "one of the most toxic phrases" in economics. The mainstream view has been that industrial policy is inefficient, even harmful.

For a long time, politicians largely accepted that view. But in the past several years, countries have started to embrace industrial policy—most notably in the United States. Under President Biden, the U.S. is set to spend hundreds of billions of dollars on industrial policy, to fund things like microchip manufacturing and clean energy projects. It's one of the most ambitious tests of industrial policy in U.S. history. And the billion dollar question is ... will it work?

On today's show, Réka takes us on a fun, nerdy journey to explain the theory behind industrial policy, why it's so controversial, and where President Biden's big experiment might be headed.

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Dynamic pricing is an increasingly common phenomenon: You can see it when Uber prices surge during rainy weather, or when you're booking a flight at the last minute or buying tickets to your favorite superstar's concert. On an earnings call last week, Wendy's ignited a minor controversy by suggesting it would introduce dynamic pricing in its restaurants, but the company quickly clarified that it wasn't planning on using it for "surge pricing."

One place you hardly ever see dynamic pricing? American supermarkets.

Why is that? Why shouldn't the prices for meat or bread or produce go down as they get older? Why does all the milk in the store cost the same, even when the "sell by" dates are weeks apart? Wouldn't a little more flexibility around prices be better for customers and help reduce waste?

Professors Robert Evan Sanders and Ioannis (Yannis) Stamatopoulus had similar questions. So they set out to discover what was keeping supermarkets from employing a more dynamic approach, and what might convince them it was time for a change ... in pricing.

This episode was hosted by Amanda Aronczyk and Nick Fountain. It was produced by Willa Rubin and edited by Keith Romer. It was engineered by Valentina Rodríguez Sánchez and fact-checked by Sierra Juarez.

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Why do video game workers offer labor at a discount? How can you design a video game for blind and sighted players? Does that design have lessons for other industries?

These and other questions about the business of video games answered in todays episode. The Indicator just wrapped a weeklong series decoding the economics of the video game industry, we're excerpting some highlights.

First, we meet some of the workers who are struggling with the heavy demands placed on them in their booming industry, and how they are fighting back.

Then, we check in on how game developers are pulling in new audiences by creatively designing for people who couldn't always play. How has accessibility become an increasingly important priority for game developers? And, how can more players join in the fun?

You can hear the rest of our weeklong series on the gaming industry at this link, or wherever you get your podcasts.

This episode was hosted by Wailin Wong, Darian Woods, and Adrian Ma. Corey Bridges produced this episode with help from James Sneed. It was edited by Kate Concannon, fact-checked by Sierra Juarez, and engineered by Robert Rodriguez with help from Valentina Rodríguez Sánchez. Alex Goldmark is Planet Money's executive producer.

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Karen McDonough of Quincy, Mass., was enjoying her tea one morning in the dining room when she saw something odd outside her window: a group of people gathering on her lawn. A man with a clipboard told her that her home no longer belonged to her. It didn't matter that she'd been paying her mortgage for 17 years and was current on it. She was a nurse with a good job and had raised her kids there. But this was a foreclosure sale, and she was going to lose her house.

McDonough had fallen victim to what's called a zombie second mortgage. Homeowners think these loans are long dead. But then the loans come back to life because they get bought up, sometimes for pennies on the dollar, by debt collectors that then move to collect and foreclose on people's homes.

On today's episode: An NPR investigation reveals the practice to be widespread. Also, what are zombie mortgages? Is all this legal? And is there any way for homeowners to fight the zombies?

You can read more about zombie second mortgages online at: npr.org/zombie

Correction: An earlier version of this episode description misspelled Karen McDonough's last name as MacDonough.

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On today's episode, we ride through the streets of San Francisco with a long-time junkman, Jon Rolston.

Jon has spent the last two decades clearing out houses and offices of their junk. He's found all sorts of items: a life-time supply of toilet paper, gold rings, $20,000 in cash. Over the years, he's developed a keen eye for what has value and what might sell. He's become a kind of trash savant.

As we ride with Jon, he shows us the whole ecosystem of how our reusable trash gets dealt with — from metals (ferrous and non-ferrous) to tires to cardboard. And we see how our junk can sometimes get a second chance at life.

If you can understand the junk market like Jon, you can understand dozens of trends in our economy.

This episode was hosted by Erika Beras and James Sneed, and produced by James Sneed with help from Emma Peaslee. It was edited by Jess Jiang. Engineering by Josh Newell. It was fact-checked by Sierra Juarez. Alex Goldmark is Planet Money's executive producer.

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Planet Money Summer School is back for eight weeks. Join as we travel back in time to find the origins of our economic way of life. Today we ask surprisingly hard question: What is money? And where did it come from? We travel to a remote island in the Pacific Ocean for the answer. Then we'll visit France in the year 1714, where a man on the lam tries to revolutionize the country's entire monetary system, and comes impressively close to the modern economy we have today, before it all falls apart. Check out our Summer School video cheat sheet on the origins of money at the Planet Money TikTok.

The series is hosted by Robert Smith and produced by Audrey Dilling. Our project manager is Devin Mellor. This episode was edited by Planet Money Executive Producer Alex Goldmark and fact-checked by Sofia Shchukina.

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Last weekend we were all thrown for a loop when President Joe Biden dropped out of the presidential race and endorsed Kamala Harris for the nomination. Just like everyone else, we are trying to quickly wrap our heads around what it means now that Harris is almost certainly going to be the Democratic nominee for president.

We expect to see the Harris campaign come out with some official policy proposals in the coming weeks and months. But for now, all we've got are clues, little breadcrumbs that she has dropped throughout her career that might lead us to a rough idea of what economic policies she might support.

Today on the show, we're going to visit three key moments from Harris' political career that might give us an idea of how her economic agenda might look. First, the 2019 presidential primary debates, where she laid out her own economic policies. Next, a vote in her Senate years that shows where she might fall on future trade agreements. And finally, a fight with some of the country's biggest banks from her very first year as Attorney General of California.

This episode was hosted by Keith Romer and Nick Fountain. It was produced by Emma Peaslee, edited by Jess Jiang with help from Meg Cramer, and fact checked by Sierra Juarez and Sofia Shchukina. Engineering by Kwesi Lee. Alex Goldmark is Planet Money's executive producer.

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Next week, JD Vance and Tim Walz will face off in the only confirmed vice presidential debate ahead of the election. As voters look ahead to what their economic policies might be, we look back to see what they have said and done, and how it turned out.

Planet Money's newsletter author Greg Rosalsky has spent some time combing through the economic records of Vance and Walz, and has some knowledge to share. Why does Walz support universal free school lunches, and why do some criticize him for it? Why have some called Vance a "Khan-servative?" And, how much do these candidates represent a break from the past?

This episode was hosted by Nick Fountain and Greg Rosalsky. It was produced by James Sneed and Emma Peaslee. It was edited by Meg Cramer. Sierra Juarez fact-checked it, and it was engineered by Valentina Rodríguez Sánchez. Alex Goldmark is Planet Money's Executive Producer.

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"Wanna see a trick? Give us any topic and we can tie it back to the economy."

That is the bold promise in Planet Money's tagline. And we believe the show does live up to it. Over the last year, we've told stories about breakdancing, rum, pagers, buffets, colors, and heartbreak.

But then one host wondered: what if we really held ourselves to that promise? What if we challenged ourselves to find economic meaning in the most esoteric and far-flung topics imaginable?

That's when we turned to you, our listeners. And boy did you deliver. You sent in ideas so obscure, so banananas, so guaranteed to stump and bamboozle that our host maybe started to regret her life choices...but she was resolved to give it a try.

This episode was hosted by Sally Helm and Keith Romer. It was produced by James Sneed. It was edited by Molly Messick and fact-checked by Sierra Juarez. Engineering by Kwesi Lee. Alex Goldmark is Planet Money's executive producer.

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(For our story on this year's Nobel in Economics, check out our daily show, The Indicator!)

Let's face it. Economics is filled with terms that don't always make sense to the average person. Terms that sometimes mean what you think they mean, but sometimes not at all. Not even close.

We surveyed 188 economists. And we asked them: What are the most misunderstood terms in the field of economics?

On today's show, their answers! Hear stories about near recessions, a problem with insurance, econ at your local movie theater, and... an economics term that will make undergrads blush. Strap in, and bring your popcorn!

This episode was hosted by Amanda Aronczyk and Alexi Horowitz-Ghazi. It was produced by Sam Yellowhorse Kesler with help from Sean Saldana. It was edited by Jess Jiang, engineered by Valentina Rodríguez Sánchez and fact-checked by Sierra Juarez. Alex Goldmark is our executive producer.

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New episodes of TED Radio Hour with host Manoush Zomorodi begin March 13.

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Sunnyvale, CA – Deep learning will transform medicine, but not in the way that many advocates think. Biological complexity, rare mutations and confounding factors work against us, so that even if we sequence 100,000 genomes, it won’t be enough. Brendan Frey is engineering the future of personalized medicine. A professor in the University of Toronto’s Faculty […]