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Interaction between the C terminus of NMDA receptor subunits and multiple members of the PSD-95 family of membrane-associated guanylate kinases

M Niethammer
Apr 1, 1996; 16:2157-2163
Articles




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An American Family: Anniversary Edition




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Make your thunder heard. Join us in the Thunderclap for the Intl Year of Family Farming

Help raise the profile of the IYFF 2014 and its role in eradicating hunger Family farming is the predominant form of agriculture in the world with more than 500 million family farmers playing a key role in securing a future where more quality food is produced in a sustainable way.  For this reason, the 2014 International Year of Family Farming plays a [...]




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Family farming is part of the solution to the hunger problem

The United Nations launched the 2014 International Year of Family Farming to stress the vast potential family farmers have to eradicate hunger and preserve natural resources. In both developed and developing countries, more than 500 million, or nine out of ten, farms are managed by families, making family farms the predominant form of agriculture. They not only produce about 80% [...]




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A Family

A Family




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Canadian in Korean baseball league bracing for season without family, fans

The Korean baseball league opens its delayed season Tuesday in empty stadiums across South Korea and Canada's Jamie Romak, along with the rest of the league's players, are getting used to a new baseball normal that includes rules against high fives and spitting, daily temperature checks and the absence of fans.



  • Sports/Baseball/MLB

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Decorate a guitar, skateboard, or bike to help veterans, foster children – AZFamily

Decorate a guitar, skateboard, or bike to help veterans, foster children  AZFamily



  • IMC News Feed

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Family of Toronto PSW who died of COVID-19 says his death was due to lack of PPE at his workplace

Leonard Rodriquez's grieving loved ones say he was a man who would drop everything to help those in need. But they say his death could have been prevented if he'd had the personal protective gear he needed to do his job.



  • News/Canada/Toronto

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I was totally prepared to quarantine for COVID-19 — and my family got it anyway

Living on a 10-acre plot of land 100 kilometres outside Toronto, David Stevens thought he and his family were well prepared to ride out the COVID-19 quarantine. But after a call from his mother, he learned that even the best laid plans can go wrong.




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Windsor filmmaker shoots horror movie at home — starring his family

Making a film when you can't leave home means being creative — with everything from the scenery to your cast. C.J. Bernauer talked to Windsor Morning host Tony Doucette about his new short horror film, called 'You're It.'



  • News/Canada/Windsor

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God transforms a family

A woman and her husband accept the Lord after hearing the gospel from an OM team visiting the island of Sante Marie.




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A mission trip for the whole family

Ministry opportunities in Hungary open up the mission experience for families with younger children.




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Joy to a family in need

Workers deliver shoes to schools, bring food to the poor and help construct a kitchen for a family in the indigenous community of Chimaltenango.




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Mission Trips for the Whole Family

Getting the whole family involved in a short term missions trip is an unforgettable experience!




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Family at sea

The story of a Dutch/Finnish family aboard Logos Hope




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The family business

Nassau, Bahamas :: The Esposito family from Argentina enjoys serving God together on board Logos Hope, bringing professional skills and supporting each other.




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Patient- and Family-Centered Care in the Emergency Department for Children With Autism

BACKGROUND:

Emergency department (ED) care processes and environments impose unique challenges for children with autism spectrum disorder (ASD). The implementation of patient- and family-centered care (PFCC) emerges as a priority for optimizing ED care. In this article, as part of a larger study, we explore PFCC in the context of ASD. Our aims were to examine how elements of PFCC were experienced and applied relative to ED care for children with ASD.

METHODS:

Qualitative interviews were conducted with parents and ED service providers, drawing on a grounded theory approach. Interviews were audio recorded, transcribed verbatim, and analyzed by using established constant comparison methods. Data were reviewed to appraise the reported presence or absence of PFCC components.

RESULTS:

Fifty-three stakeholders (31 parents of children with ASD and 22 ED service providers) participated in interviews. Results revealed the value of PFCC in autism-based ED care. Helpful attributes of care were a person-centered approach, staff knowledge about ASD, consultation with parents, and a child-focused environment. Conversely, a lack of staff knowledge and/or experience in ASD, inattention to parent expertise, insufficient communication, insufficient family orientation to the ED, an inaccessible environment, insufficient support, a lack of resources, and system rigidities were identified to impede the experience of care.

CONCLUSIONS:

Findings amplify PFCC as integral to effectively serving children with ASD and their families in the ED. Resources that specifically nurture PFCC emerge as practice and program priorities.




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Families Experiences With Family Navigation Services in the Autism Treatment Network

BACKGROUND AND OBJECTIVES:

Families of children with autism spectrum disorder (ASD) often experience challenges navigating multiple systems to access services. Family navigation (FN) is a model to provide information and support to access appropriate services. Few studies have been used to examine FN’s effectiveness for families of children with ASD. This study used mixed methods to (1) characterize FN services received by a sample of families in the Autism Treatment Network; (2) examine change in parent-reported activation, family functioning, and caregiver strain; and (3) explore families’ experiences with FN services.

METHODS:

Family characteristics and parent outcomes including parent activation, family functioning, and caregiver strain were collected from 260 parents in the Autism Treatment Network. Descriptive statistics and linear mixed models were used for aims 1 and 2. A subsample of 27 families were interviewed about their experiences with FN services to address aim 3.

RESULTS:

Quantitative results for aims 1 and 2 revealed variability in FN services and improvement in parent activation and caregiver strain. Qualitative results revealed variability in family experiences on the basis of FN implementation differences (ie, how families were introduced to FN, service type, intensity, and timing) and whether they perceived improved skills and access to resources.

CONCLUSIONS:

Findings suggest FN adaptations occur across different health care delivery systems and may result in highly variable initial outcomes and family experiences. Timing of FN services and case management receipt may contribute to this variability for families of children with ASD.




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Family Engagement in the Autism Treatment and Learning Health Networks

Family involvement in the Autism Intervention Research Network on Physical Health, the Autism Treatment Network, and the Autism Learning Health Network, jointly the Autism Networks, has evolved and grown into a meaningful and robust collaboration between families, providers, and researchers. Family involvement at the center of the networks includes both local and national network-wide coproduction and contribution. Family involvement includes actively co-authoring research proposals for large grants, equal membership of network committees and workgroups, and formulating quality improvement pathways for local recruitment efforts and other network initiatives. Although families are involved in every aspect of network activity, families have been the driving force of specifically challenging the networks to concentrate research, education, and dissemination efforts around 3 pillar initiatives of addressing comorbidities of anxiety, attention-deficit/hyperactivity disorder, and irritability in autism during the networks’ upcoming funding cycle. The expansion of the networks’ Extension for Community Healthcare Outcomes program is an exciting network initiative that brings best practices in autism care to community providers. As equal hub members of each Extension for Community Healthcare Outcomes team, families ensure that participants are intimately cognizant of family perspectives and goals. Self-advocacy involvement in the networks is emerging, with plans for each site to have self-advocacy representation by the spring of 2020 and ultimately forming their own coproduction committee. The Autism Treatment Network, the Autism Intervention Research Network on Physical Health, and the Autism Learning Health Network continue to be trailblazing organizations in how families are involved in the growth of their networks, production of meaningful research, and dissemination of information to providers and families regarding emerging work in autism spectrum disorders.




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A family affair: Why Jake Wightman went to Seb Coe for advice

SUCCESS in athletics can often be a family affair. Scots such as Callum Hawkins and Eilish McColgan have thrived under the tutelage of their parents, while track star Jake Wightman is another who has preferred to turn to his family to coach him to success on the track.




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'It feels like a family'

OM MTI workers teach the Bible and foster a growing community of Jesus followers among a group of factory workers with polio.




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Issue of the day: How to make video calls to keep in touch with family

If you can't see elderly parents, or friends with medical conditions, what can you do to keep in touch? You can send a letter, of course, or make a landline phone call, but video calls allow you to speak and see each other.




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Cult Scottish films: From comedies to crime capers, 1970s sci-fi noir and dark family dramas

IT’S all too easy to lose track of many of the quirky, moving, interesting films that have been shot in Scotland over the years. Some of the sparkling gems on these pages attracted decent reviews upon release before fading from view; others slipped under most people’s radar. The 10 films here are funny, or dark, or insightful. All have something to say; all are worth tracking down, and watching, whether it’s for the first time, or the first time since they were released.




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VIDEO: An 'Unschooling' Family Trusts Children to Guide Their Own Learning

Rather than adhering to a specific curriculum, families who "unschool" believe learning happens naturally and should be driven by a student's interests. Education Week spent a "school" day with the Matica family to see this decades-old approach to home schooling in action.




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A Parent-Led Family-Focused Treatment Program for Overweight Children Aged 5 to 9 Years: The PEACH RCT

For treatment of obesity in preadolescent children, approaches that focus on parents taking sole responsibility for implementing weight-management strategies may be most effective. However, the optimal content, intensity, and duration of programs for obese children remain unclear.

Targeting parents only, a 10% relative weight loss is achievable in moderately obese preadolescent children and can be maintained 2 years from baseline, which justifies an investment in treatment as a secondary obesity-prevention strategy. (Read the full article)




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Family-centered Program Deters Substance Use, Conduct Problems, and Depressive Symptoms in Black Adolescents

Conduct problems, substance use, substance use problems, and depressive symptoms increase as black adolescents enter high school. Although family-centered prevention programs deter these problems during middle school, no such programs have been developed and evaluated for black high school students.

This study demonstrates that participation in a family-centered preventive intervention reduces conduct problems, substance use, and substance use problems among black adolescents by more than 30% compared with adolescents in an attention control condition across nearly 2 years. (Read the full article)




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Early Childhood Family Intervention and Long-term Obesity Prevention Among High-risk Minority Youth

The evidence base for obesity prevention is extremely limited. Although minority youth are at higher risk of obesity, and early childhood is a critical period for prevention, only 1 program has demonstrated sustained effects on obesity in young minority children.

Among youth at high risk for obesity based on income, minority status, and child behavior problems, early intervention that promotes effective parenting led to meaningful differences in obesity in preadolescence. Early family intervention is an innovative and promising approach. (Read the full article)




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Chronic Disabling Fatigue at Age 13 and Association With Family Adversity

Chronic fatigue syndrome (CFS) is a disabling illness. Some children with chronic disabling fatigue are housebound. Some primary care physicians find making the diagnosis of CFS difficult.

Chronic disabling fatigue is more common in 13-year-olds than previously realized with a population prevalence of ~2.0%. Chronic disabling fatigue in teenagers is more common in those with higher levels of early family adversity. (Read the full article)




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Family Experiences and Pediatric Health Services Use Associated With Family-Centered Rounds

Family-centered rounds (FCR) show promise for higher patient care satisfaction. Many previous studies are limited by small sample size and observational or pre-post designs, and health care service outcomes have not been previously examined.

Our study uses an FCR assessment tool and a comparison group of non-FCR patients. We found that FCR are associated with improved family experiences, with no additional burden to health care service use. (Read the full article)




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Culturally Tailored, Family-Centered, Behavioral Obesity Intervention for Latino-American Preschool-aged Children

Childhood obesity is already prevalent by preschool age, particularly among Latinos. Parents have tremendous influence on factors that contribute to childhood obesity (eg, diet, physical activity); thus, family plays a crucial role in pediatric obesity prevention.

This randomized controlled trial examined the effect of a behavioral intervention involving Latino-American parent–preschool-aged child dyads. The intervention resulted in reductions in absolute BMI across the 3-month study period, with patterns suggesting the largest effect for obese children. (Read the full article)




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Efficacy of Family-Based Weight Control Program for Preschool Children in Primary Care

Overweight children are at risk for becoming obese adults, especially if they have an obese parent. Family-based behavioral interventions, largely implemented in specialized settings, have shown efficacy in weight control in youth aged ≥8 years.

This study demonstrates the efficacy of a family-based behavioral weight control program translated to be implemented in the primary care setting. The work underscores the importance of pediatricians intervening early and shifting their focus from the child to the family. (Read the full article)




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Occurrence and Family Impact of Elopement in Children With Autism Spectrum Disorders

Anecdotal accounts that suggest elopement behavior occurs in children with autism spectrum disorders (ASDs), that injuries and fatalities can result, and that associated family burden and stress are substantial. However, there has been little research characterizing the phenomenon or its frequency.

Nearly half of children with an ASD elope, and more than half of these "go missing." Elopement is associated with autism severity, and is often goal-directed. Addressing elopement behavior is an important aspect of intervention for many individuals with ASDs. (Read the full article)




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The Association of Telomere Length With Family Violence and Disruption

Poor health in children is associated with exposure to family violence and disruption. Telomere length has been hypothesized to be a lasting biological indicator of exposure to early adversity and potentially predictive of negative health outcomes throughout the life course.

Telomere length reflects exposure to family violence and disruption and may be an early indicator of the biological impact of early adversity. Children exposed to interpersonal violence and family disruptions had significantly shorter telomeres. Gender moderated these associations. (Read the full article)




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Single-Family Room Care and Neurobehavioral and Medical Outcomes in Preterm Infants

The single-family room (SFR) NICU is a major response to improve care and reduce developmental morbidity in preterm infants. However, no studies have examined how and why this model is associated with changes in medical and neurobehavioral outcome.

This study shows improved medical and neurodevelopmental outcome in infants hospitalized in the SFR model of care. More important, improvements occurred specifically in relation to increases in maternal involvement and developmental support afforded by the SFR environment. (Read the full article)




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Childhood Obesity and Interpersonal Dynamics During Family Meals

Family meals are protective for child health, but there are inconsistent findings in relation to child weight status. More research is needed examining why family meals are protective for child health and whether there are differences by child weight status.

The current mixed-methods study used direct observational methods to examine family dynamics during family meals and child weight status. Results indicated that positive family interpersonal and food-related dynamics during family meals were associated with reduced prevalence of childhood obesity. (Read the full article)




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Family-Initiated Dialogue About Medications During Family-Centered Rounds

Family engagement in the care of hospitalized children may improve outcomes, including medication safety. Although family-centered rounds (FCRs) provide a venue for family engagement in care, how families use this venue to influence medication-related topics is unknown.

Most families initiated medication-related dialogue during FCRs, discussing inpatient and home medications. Topics raised were important for medication adherence and safety, even altering treatment plans. Findings suggest specific medication topics that health care team members can anticipate addressing during FCR. (Read the full article)




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Family Hardships and Serum Cotinine in Children With Asthma

Poverty is prevalent among children in the United States, and it has a clear association with negative health outcomes. Smoking and passive smoke exposure are both more common among socioeconomically disadvantaged populations and are associated with asthma morbidity.

Reported family hardships were common among children admitted for asthma or wheezing, and most were associated with detectable tobacco smoke exposure. The cumulative number of hardships was also associated with greater odds of tobacco smoke exposure. (Read the full article)




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Family Experiences With Feeding Tubes in Neurologic Impairment: A Systematic Review

Gastrostomy tube placement is a difficult decision for families of children with neurologic impairment. Better understanding the impact of these tubes on the lives of children and families will help improve decision-making and support from health care providers.

Gastrostomy tube placement has broad-reaching implications for children and their families. There are physical, emotional, and relational challenges and benefits for the child, the parents, and the family unit. Exploring potential outcomes with families may improve decision-making conversations and support. (Read the full article)




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A Tailored Family-Based Obesity Intervention: A Randomized Trial

Although treatment programs for childhood obesity can demonstrate success, long-term outcomes have seldom been evaluated. The benefit of intervention when overweight is identified in a screening assessment and parental recognition of the problem is minimal is understudied.

A low-dose (sessions every 1–3 months), but long-term (2 years), family-based intervention was effective at reducing BMI compared with usual care in children recruited via a weight screening initiative in which many parents had been unaware their child was overweight. (Read the full article)




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Psychosocial Adjustment in School-age Girls With a Family History of Breast Cancer

Many families share genetic cancer risk information with their children, and some parents and providers believe BRCA1/2 testing should be permitted in adolescence. The psychosocial effects and impact on health and risk behaviors of this knowledge is unknown.

In our cohort of 869 mother-daughter pairs, we found no differences in general adjustment, but 10- to 13-year-old girls with breast cancer family histories reported higher breast cancer–specific distress and perceived breast cancer risk. Mother distress was associated with daughter distress. (Read the full article)




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Norton Family Premier

Norton Family's wealth of features and easy setup make it easy for parents to track and manage their children's activity across many devices, though it doesn't work on Macs.




family

Ian Blackford hits out at family's 800-mile holiday to Motherwell as Scots poke fun at bizarre trip

A family who was fined for travelling more than 400 miles for the bank holiday weekend have been slammed online by politicians and Scots.




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Human Development and Family Studies faculty net $3,000 grant for workshop

Faculty from six campuses were awarded a grant from Penn State’s Schreyer Institute for Teaching Excellence to seek a multi-campus approval as a Certified Family Life Educator program.




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We are family: COVID-19 brings Hershey Medical Center front-line staff together

The staff of Hershey Medical Center is one of only several academic hospitals in the country with specialized infrastructure and and training geared around offering care during a contagion outbreak. But they have another advantage, too. “We are all a family,” says one doctor. “And we look out for one another.”




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Men arrested in killing of Family Dollar security guard after face mask dispute

The U.S. coronavirus death toll has surpassed 77,000.




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Schuylkill Speaks: Senior Tara Laubenstine continues Penn State family legacy

Tara Laubenstine comes from a long line of Penn Staters. When she began her college search, she knew exactly where she would apply and eagerly wait to be accepted. This week, she will graduate with her bachelor’s degree in business with a minor in psychology, after which she will pursue a career in human resource management. She made the most of her college experience by becoming involved, and with graduation on the horizon, Laubenstine sat down to speak about her college experience and offer advice to the incoming class.




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New Kensington family of ‘Nittany Neighbors’ support each other during pandemic

The Nittany Neighbors program created at Penn State New Kensington in response to the coronavirus pandemic is testament to the fact that, as campus director of student affairs Theresa Bonk said, "we are a family, and like any family, we take care of our own."




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Justice Committee stresses new laws on family breakdowns must be properly funded if they are to help children

The Scottish Parliament’s Justice Committee is backing Scottish Government plans to change the law on deciding parent-child contact in family breakdown cases.




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A family’s dreams brought back to life

A poor family's dreams are dashed by a father's illness but brought back to life by OM Bangladesh's tailoring programme.




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Increased Risk for Family Violence During the COVID-19 Pandemic