earn

G-Protein Signaling in Alzheimer's Disease: Spatial Expression Validation of Semi-supervised Deep Learning-Based Computational Framework

Systemic study of pathogenic pathways and interrelationships underlying genes associated with Alzheimer's disease (AD) facilitates the identification of new targets for effective treatments. Recently available large-scale multiomics datasets provide opportunities to use computational approaches for such studies. Here, we devised a novel disease gene identification (digID) computational framework that consists of a semi-supervised deep learning classifier to predict AD-associated genes and a protein–protein interaction (PPI) network-based analysis to prioritize the importance of these predicted genes in AD. digID predicted 1,529 AD-associated genes and revealed potentially new AD molecular mechanisms and therapeutic targets including GNAI1 and GNB1, two G-protein subunits that regulate cell signaling, and KNG1, an upstream modulator of CDC42 small G-protein signaling and mediator of inflammation and candidate coregulator of amyloid precursor protein (APP). Analysis of mRNA expression validated their dysregulation in AD brains but further revealed the significant spatial patterns in different brain regions as well as among different subregions of the frontal cortex and hippocampi. Super-resolution STochastic Optical Reconstruction Microscopy (STORM) further demonstrated their subcellular colocalization and molecular interactions with APP in a transgenic mouse model of both sexes with AD-like mutations. These studies support the predictions made by digID while highlighting the importance of concurrent biological validation of computationally identified gene clusters as potential new AD therapeutic targets.




earn

Sebastian Thrun on the Future of Learning

Why the American Ingenuity Award winner believes higher education should be a basic human right




earn

This Elephant Learned to Speak Korean

Koshik, an elephant in a South Korean zoo, learned to say five different Korean words (Still: iStock/ROMAOSLO)




earn

How Chimpanzees Learn

Primatologist Tetsuro Matsuzawa studies chimps in hopes of uncovering how they learn and communicate




earn

Visiting Lafcadio Hearns Japan

The temples and scenery of Japans San-in coast are as captivating now as they were when Lafcadio Hearn wrote about them in the 19th century (Produced by: Brendan McCabe; Narration by: T.A. Frail; Music by: Kevin MacLeod; Photos by: Hans Sautter / Aurora Select).




earn

Can You Learn The Steps to This 18th-Century Dance?

Julie Montagu, the American-born Viscountess Hinchingbrooke, is meeting up with an expert on 18th century dance. Her aim is to learn about the dances performed in that era.




earn

Whitecaps player alleging sexual misconduct stunned to learn of coach's rehiring

Malloree Enoch alleges she was sexually coerced by former Whitecaps coach Hubert Busby Jr., who was recently reinstated as head coach of the Jamaican women's national team.



  • News/Canada/British Columbia

earn

Montreal's Fournier Beaudry, Sorensen earn ice dance bronze for 4th medal in 4 events

Montreal's Laurence Fournier Beaudry and Nikolaj Sorensen finished the Rostelecom Cup in bronze position Saturday for their fourth medal in as many figure skating competitions this season.



  • Sports/Olympics/Winter Sports/Figure Skating

earn

Students become 'junior historians' for a hands-on approach to Remembrance Day learning

Some educators are giving history classes new relevance by teaching students to be junior historians: offering engaging entry points into Canada's past and inspiring connections to the world today.




earn

CME Group Inc. Reports All-Time Record Revenue, Adjusted Operating Income, Adjusted Net Income and Adjusted Earnings Per Share for Q3 2024

Record revenue of $1.6 billion Record quarterly ADV of 28.3 million contracts - the second consecutive quarter of volume, open interest growth across every asset class CHICAGO, Oct. 23, 2024...




earn

SolidWorks World 2009 to Feature Exciting Keynotes, Success Stories, and Learning Opportunities

Sir Richard Branson, Jeff Ray, Jon Hirschtick, and World-Class Companies to Shine at World’s Largest Annual SolidWorks Gathering




earn

New version of SolidWorks Education Edition nearly doubles e-learning content

Expanded 3D CAD curriculum gives instructors more time for individual instruction and special projects




earn

Pittsburg State Engineering Technology Students Learn Faster, Easier with 1,000 New Licenses of SolidWorks software

Off-Campus, Around-the-Clock Access and Integrated Simulation are Big Advantages for Students




earn

Youth learn new methods to share their faith

OMer Richard Sharp teaches practical and relevant methods of sharing the Gospel with Portuguese young people at a youth camp.




earn

English learning opens the door for community

OMers work with a Hungarian church to invest in relationships through every season.




earn

The three things I learnt

OMer Patrick shares his biggest takeaways from serving in sports ministry in Hungary for two years.




earn

Learning to love each other

Paul and Vivienne, volunteers from the UK, recently visited a centre for asylum seekers in one of Sweden’s large cities and share about their experiences.




earn

Going Off The GRID to learn about God

A French couple attended the Off The GRID discipleship programme in New Zealand, where they learned about missions and God.




earn

Learning how to live for Christ

Fazeen is a graduate of OM's training programme, through which God changed her life's perspective and direction.




earn

Learning to love Muslim friends

Long-term worker teaches Transform seminar about loving Muslim women, encouraging two participants to deepen relationships with Muslim friends back home.




earn

DeVos May Bypass Congress to Get Rid of the Office for English-Learners. Can She?

The answer is unclear but "the threat is real," English-language-learner advocacy groups say. The advocates say the Education Department has evaded their questions about the future of the office of English-language acquisition.




earn

What Early-Childhood Accountability Can Learn From K-12's Mistakes

Education needs to stop going around in circles, writes Stanford’s Thomas S. Dee.




earn

How to Assess English-Learners' Needs From a Distance? Here's Some Help

With schools unable to conduct in-person evaluations, schools must find new ways to determine if students need English-language-learner support services.




earn

English-Learners and Virtual Learning During COVID-19: Will Federal Guidance Help?

New sheets outlines how districts can support English-learner students, but concedes that "schools may not be able to provide all services in the same manner they are typically provided."




earn

DeVos Appoints New Director for English-Learner Office

The selection of Lorena Orozco McElwain as director of the office of English language acquisition shakes up a long-standing tradition.




earn

How Will Schools Measure English-Learners' 'COVID-Slide' Learning Loss?

Native-language assessments may more fully reflect what English-language learners know and can do academically after months away from school. But not all states offer them.




earn

Schools Failed English-Learners During the Shutdown. How Can They Do Better?

A new report urges districts to pay close attention to how they choose and use technology for students who are not yet fluent in English.




earn

How Will Schools Teach English-Language Learners This Fall?

A new database offers a state-by-state look at guidance on supporting English-learner students and their families amid the global pandemic.




earn

Measuring Learning Growth

Would measurement approaches based on "learning growth" resolve some of the concerns over NCLB?




earn

Expanded Learning Time

Should school time be expanded to accommodate new demands? And if so, How?




earn

Teaching and Learning in the Pandemic

A more deliberate approach to curriculum, instruction, assessment, and teacher professional development this fall could mean a better experience for students; the lack of one could turn equity gaps into chasms.




earn

Are Aspiring Teachers Learning Classroom Management? It Varies

The strategy of reinforcing good behavior with praise is the least likely to be taught in teacher-prep programs, an analysis finds.




earn

In-Person Learning Expands, Student Absences Up, Teachers Work Longer, Survey Shows

Support for in-person teaching is rising, but hybrid approaches to instruction remain the most popular, an EdWeek Research Center survey finds.




earn

Faculty earn Advancing Equity and Inclusion Grant for project-based learning

A pair of multidisciplinary faculty members at Penn State Shenango received an Advancing Equity and Inclusion Grant from the Schreyer Institute for Teaching Excellence to help fund a series of four online workshops focused on project-based learning. 




earn

Professional Learning Is More Meaningful When Done as a Team

High-quality professional learning is difficult to provide in education, principal Jasmine Kullar writes. Here's a solution.




earn

Oops! Teachers' Mistakes Can Help Students Learn

A veteran teacher shares how he puts the latest research on growth mindset into action for his students in this guest blog by Jamie M. Carroll and David Yeager.




earn

2024-25 Teaching and Learning Technologies Faculty Advisory Committee members named

Teaching and Learning with Technology (TLT), part of Penn State University Libraries, has announced the Teaching and Learning Technologies Faculty Advisory Committee for the 2024-25 academic year. The committee is pivotal in guiding TLT on integrating technology within teaching and learning at Penn State.




earn

Author Interview: 'Visible Learning for Mathematics'

Linda M. Gojak and Sara Delano Moore, two of the co-authors of "Visible Learning For Mathematics: What Works Best to Optimize Student Learning", agreed to answer a few questions about the book.




earn

Art education doctoral student serves as artist-in-residence at Learning Factory

Keisha Oliver, who is pursuing a dual-title doctoral degree in art education and African American and diaspora studies, was named a fall 2024 artist-in-residence at the Penn State College of Engineering’s Learning Factory.




earn

Learning From the Nursing Profession in the New Teacher Strike Era

As teacher strikes sweep the nation, Marc Tucker compares the trajectory of teaching to that of the nursing profession, one of high standards of entry and rigorous preparation.




earn

Public Libraries Add Multimedia Learning to Digital Mission

Public libraries are moving deeper into digital learning, often in partnership with schools and other institutions, to help prepare students for the skills they'll need for college and careers.




earn

$27 Million to Aid Early-Learning Multimedia Projects

U.S. Department of Education money will help public television develop projects promoting math and literacy for children ages 2 to 8.




earn

Multimedia Programs Reduce Summer Learning Loss

Summer programs that use multimedia may improve student literacy, numeracy, phonics skills, and math vocabulary, according to a study released by WestEd, a nonprofit education research organization. The report examines the Electric Company's Summer Learning Program, which is sponsored by the Sesame




earn

Penn College nursing faculty member earns doctorate

Tina Marie Kline, associate professor of nursing at Pennsylvania College of Technology, recently completed a doctorate in nursing education and administration from William Carey University.




earn

Grad earns full-time position through Pennsylvania state department program

Lindsay Mitchell, a Penn State World Campus graduate who earned a bachelor's degree in accounting in May, is one of Pennsylvania’s newest auditors after securing a position through an intern-to-hire program. World Campus offers the undergraduate accounting program in partnership with the Penn State Harrisburg School of Business Administration.




earn

Course focuses on best practices for assisting online learners’ supporters

A new professional development course explores how Penn State faculty members and staff can help the parents, guardians and spouses of online learners while following federal and University privacy policies.




earn

Faculty-produced videos on the value of the humanities earn honors

Unique video work done by Penn State Greater Allegheny faculty member Rosemary Martinelli, assistant teaching professor of marketing and communications, has garnered gold, silver and bronze awards on the local and international stages.




earn

How a Summer Learning and Sports Program Adapted to the Pandemic

Leaders at DREAM's REAL Kid's New York summer academic and baseball program decided early on to move the program online. To do that, they relied on their core principle: the value of being on a team.




earn

Penn State Berks students visit 'Field of Screams' for experiential learning

Penn State Berks took learning out of the classroom in early October when 14 students, faculty and staff visited "Field of Screams," a haunted Halloween attraction in Lancaster, Pennsylvania. The event was organized as an experiential learning activity for humanities, arts and social sciences courses (such as "Rhetoric of American Horror Films" and "Transformative Texts") that deal with topics related to horror and monstrosity within popular cultural texts. 




earn

Learning more than sewing

Erna Neufeld teaches sewing skills and shares the Gospel with women in a small Albanian town.