adu In the news: Venezuela’s Maduro foils overthrow bid, blames Guaidó and the US By www.thenewhumanitarian.org Published On :: Fri, 08 May 2020 11:45:57 +0000 The botched raid comes amid concerns over the regime’s ability to cope with COVID-19, given its run-down economy and health systems. Full Article
adu African countries could gradually ease measures to slow coronavirus By www.theeastafrican.co.ke Published On :: 2020-05-09T10:35:57Z Wealthier African countries tend to impose more stringent rules, which have cost the continent $65 billion. Full Article
adu China starts campaign to help new graduates find jobs as economy slumps By www.scmp.com Published On :: Fri, 08 May 2020 08:00:23 +0800 Beijing has kicked off a campaign to help graduates entering the labour market as the country faces growing pressure to reboot the sagging economy and tackle unemployment.Ten initiatives were announced to find jobs for this year’s 8.74 million new graduates in an online launch on Wednesday by officials from the labour, education, human resources, and industry and information technology ministries.The “100-day” campaign – highlighting the urgency for young people to find work – includes more… Full Article
adu UNSW graduate, Chinese Vice Minister investigated for 'severe violations of discipline and law' By www.smh.com.au Published On :: Mon, 20 Apr 2020 07:46:03 GMT The move comes a month after Sun Lijung played a key role in the Chinese Communist Party's response to the coronavirus crisis. Full Article
adu Coronavirus: Repatriated graduate documents quarantine on Youtube (Videos) By cyprus-mail.com Published On :: Sat, 09 May 2020 12:59:17 +0000 A Cypriot national who recently returned from London on one of the dozens of repatriation flights has documented her journey and experience in quarantine on her Youtube channel. Alina Nazrulloeva, who posted the videos on her channel FOMOthevlog, arrived on the island a week ago after getting a call informing... The post Coronavirus: Repatriated graduate documents quarantine on Youtube (Videos) appeared first on Cyprus Mail. Full Article Cyprus coronavirus picks4 quarantine Repatriations
adu Deepika Padukone highlights importance of music, songs By feedproxy.google.com Published On :: Wed, 06 May 2020 15:53:23 +0500 The actress is in self-isolation with husband Ranveer Singh and the couple has been keeping their fans updated on social media. Full Article
adu Sanjay Leela Bhansali wants to cast Ranbir Kapoor, Deepika Padukone for his next film By feedproxy.google.com Published On :: Thu, 07 May 2020 22:23:00 +0500 Sanjay Leela Bhansali wants to cast Ranbir Kapoor, Deepika Padukone for his next film Full Article
adu Irrfan Khan, Deepika Padukone's throwback video playing tennis wins hearts By feedproxy.google.com Published On :: Sat, 09 May 2020 18:45:52 +0500 Irrfan Khan shared the screen with Deepika in 'Piku' Full Article
adu Inside the camps in Cox’s Bazar, lives are gradually being rebuilt -- by Manmohan Parkash By blogs.adb.org Published On :: Thu, 08 Aug 2019 09:37:53 +0800 At Camp No 5, in Cox's Bazar, there are about 632,000 displaced people still living in terrible conditions. But an international humanitarian effort is helping people in the community in southern Bangladesh live a better life. Full Article
adu What is the ‘graduation approach’? -- by Palak Rawal By blogs.adb.org Published On :: Wed, 09 Oct 2019 08:02:44 +0800 Countries around the world are taking an integrated approach to address the complexities of poverty. Full Article
adu Illegal buildings in Tamil Nadu face the axe By www.indianrealtynews.com Published On :: Sat, 15 Feb 2014 12:26:55 +0000 CHENNAI: Thousands of unauthorised buildings in the state are facing demolition after the Madras high court on Monday quashed two government orders that proposed to legalise illegal structures built till July 1, 2007. The first bench comprising Chief Justice R K Agrawal and Justice M Sathyanaryanan said: “But for the lackadaisical attitude on the part of the authorities, such an alarming and mushrooming growth of unauthorized and illegal constructions would not have come into place.” The bench was delivering verdict on two PILs against October 30, 2012 government orders extending amnesty schemes for illegal buildings constructed between 1999 and July 1, 2007. “The state government and statutory authorities concerned are […] Full Article Chennai
adu Testing the Graduation Approach in the Philippines By feedproxy.google.com Published On :: 2020-04-30 00:00:00 Drawing on the Philippines as a case study, this brief explores how effective the graduation approach is in reducing poverty and assesses opportunities to apply it in other developing member countries. Full Article
adu U.S. graduates turn regalia into PPE: Wear the cap, donate the gown By feeds.reuters.com Published On :: Thu, 07 May 2020 05:06:33 -0400 In this year's mostly virtual commencement ceremonies, thousands of American graduates are adorning their mortarboards with the slogan "Gowns 4 Good" after donating their gowns to healthcare workers... Full Article lifestyleMolt
adu Robots to the rescue! Arizona students in lockdown will still get their graduation day By feeds.reuters.com Published On :: Fri, 08 May 2020 13:24:26 -0400 Juili Kale's dreams to receive her master's degree diploma in a ceremony cheered on by her family were dashed by the coronavirus - until robots came to the rescue. Full Article lifestyleMolt
adu Class of 2020 graduates with 'robot ceremony' By feeds.reuters.com Published On :: Fri, 08 May 2020 12:56:19 -0400 Arizona State University's Thunderbird School of Global Management utilizes robots to give its students a virtual graduation ceremony. Freddie Joyner has more. Full Article
adu U.S. graduates turn regalia into PPE; Wear the cap, donate the gown By www.reuters.com Published On :: Wed, 06 May 2020 16:28:18 -0400 Gowns 4 Good, a charity started by frontline physician assistant Nathaniel Moore, is asking graduates to donate their gowns to more than 77,000 frontline responders on Gowns4Good.net. Full Article
adu U.S. graduates turn regalia into PPE; Wear the cap, donate the gown By feeds.reuters.com Published On :: Wed, 06 May 2020 16:28:18 -0400 Gowns 4 Good, a charity started by frontline physician assistant Nathaniel Moore, is asking graduates to donate their gowns to more than 77,000 frontline responders on Gowns4Good.net. Full Article
adu Class of 2020 graduates with 'robot ceremony' By feeds.reuters.com Published On :: Fri, 08 May 2020 12:56:19 -0400 Arizona State University's Thunderbird School of Global Management utilizes robots to give its students a virtual graduation ceremony. Freddie Joyner has more. Full Article
adu Class of 2020 graduates with 'robot ceremony' By www.reuters.com Published On :: Fri, 08 May 2020 12:56:19 -0400 Arizona State University's Thunderbird School of Global Management utilizes robots to give its students a virtual graduation ceremony. Freddie Joyner has more. Full Article
adu Obamas, Lady Gaga, LeBron James join forces for U.S. virtual graduations By www.reuters.com Published On :: Tue, 05 May 2020 15:04:23 -0400 Former U.S. President Barack Obama, Lady Gaga, LeBron James and K-Pop band BTS are among dozens of celebrities and world leaders who will salute the class of 2020 in virtual U.S. graduation ceremonies replacing the traditional end of high school and college. Full Article peopleNews
adu Many Adults Delay Getting Help for Eating Disorders By www.medicinenet.com Published On :: Wed, 22 Apr 2020 00:00:00 PDT Title: Many Adults Delay Getting Help for Eating DisordersCategory: Health NewsCreated: 4/21/2020 12:00:00 AMLast Editorial Review: 4/22/2020 12:00:00 AM Full Article
adu Even Moderate Drinking Puts Many Older Adults at Risk By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Even Moderate Drinking Puts Many Older Adults at RiskCategory: Health NewsCreated: 4/28/2010 6:10:00 PMLast Editorial Review: 4/29/2010 12:00:00 AM Full Article
adu Rates of Premature Adult Death Declining Worldwide By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Rates of Premature Adult Death Declining WorldwideCategory: Health NewsCreated: 4/30/2010 8:10:00 AMLast Editorial Review: 4/30/2010 12:00:00 AM Full Article
adu Having Kids Doesn't Inspire Adults to Eat Healthier: Study By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Having Kids Doesn't Inspire Adults to Eat Healthier: StudyCategory: Health NewsCreated: 4/30/2012 2:05:00 PMLast Editorial Review: 5/1/2012 12:00:00 AM Full Article
adu Today's Kids May Be Destined for Adult Heart Disease By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Today's Kids May Be Destined for Adult Heart DiseaseCategory: Health NewsCreated: 5/4/2012 10:05:00 AMLast Editorial Review: 5/4/2012 12:00:00 AM Full Article
adu New Guidelines Suggest HIV Screening for All Adults By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: New Guidelines Suggest HIV Screening for All AdultsCategory: Health NewsCreated: 4/29/2013 6:36:00 PMLast Editorial Review: 4/30/2013 12:00:00 AM Full Article
adu Health Food Stores Often Promote Adult-Only Supplements to Teens By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Health Food Stores Often Promote Adult-Only Supplements to TeensCategory: Health NewsCreated: 4/26/2015 12:00:00 AMLast Editorial Review: 4/27/2015 12:00:00 AM Full Article
adu Seizure Control Eases Life for Young Adults With Epilepsy By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Seizure Control Eases Life for Young Adults With EpilepsyCategory: Health NewsCreated: 4/28/2017 12:00:00 AMLast Editorial Review: 5/1/2017 12:00:00 AM Full Article
adu Rydapt Approved for Adults With Acute Myeloid Leukemia By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Rydapt Approved for Adults With Acute Myeloid LeukemiaCategory: Health NewsCreated: 4/28/2017 12:00:00 AMLast Editorial Review: 5/1/2017 12:00:00 AM Full Article
adu Gardening Isn't Just for Adults By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Gardening Isn't Just for AdultsCategory: Health NewsCreated: 4/30/2018 12:00:00 AMLast Editorial Review: 4/30/2018 12:00:00 AM Full Article
adu Most U.S. Adults Support More Mental Health Services for Kids By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Most U.S. Adults Support More Mental Health Services for KidsCategory: Health NewsCreated: 5/1/2018 12:00:00 AMLast Editorial Review: 5/2/2018 12:00:00 AM Full Article
adu Health Tip: When Your Child Graduates High School By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Health Tip: When Your Child Graduates High SchoolCategory: Health NewsCreated: 5/3/2018 12:00:00 AMLast Editorial Review: 5/3/2018 12:00:00 AM Full Article
adu High Measles Rates Mean Kids, Adults Need Proper Vaccination: CDC By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: High Measles Rates Mean Kids, Adults Need Proper Vaccination: CDCCategory: Health NewsCreated: 4/29/2019 12:00:00 AMLast Editorial Review: 4/30/2019 12:00:00 AM Full Article
adu Young Adults Flocking to Energy Drinks By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Young Adults Flocking to Energy DrinksCategory: Health NewsCreated: 4/30/2019 12:00:00 AMLast Editorial Review: 5/1/2019 12:00:00 AM Full Article
adu Overdose Attempts Skyrocket Among Teens, Young Adults: Study By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: Overdose Attempts Skyrocket Among Teens, Young Adults: StudyCategory: Health NewsCreated: 5/1/2019 12:00:00 AMLast Editorial Review: 5/2/2019 12:00:00 AM Full Article
adu When Young Adults Vape, Blood Pressure, Heart Rate May Spike By www.medicinenet.com Published On :: Sat, 9 May 2020 00:00:00 PDT Title: When Young Adults Vape, Blood Pressure, Heart Rate May SpikeCategory: Health NewsCreated: 4/30/2020 12:00:00 AMLast Editorial Review: 5/1/2020 12:00:00 AM Full Article
adu Do C-Section Babies Become Heavier Adults? By www.medicinenet.com Published On :: Wed, 15 Apr 2020 00:00:00 PDT Title: Do C-Section Babies Become Heavier Adults?Category: Health NewsCreated: 4/14/2020 12:00:00 AMLast Editorial Review: 4/15/2020 12:00:00 AM Full Article
adu Tough Childhoods Are Tough on Adult Hearts: Study By www.medicinenet.com Published On :: Thu, 7 May 2020 00:00:00 PDT Title: Tough Childhoods Are Tough on Adult Hearts: StudyCategory: Health NewsCreated: 5/6/2020 12:00:00 AMLast Editorial Review: 5/7/2020 12:00:00 AM Full Article
adu Family Ties Help Young Adults With Type 1 Diabetes Flourish By www.medicinenet.com Published On :: Wed, 8 Apr 2020 00:00:00 PDT Title: Family Ties Help Young Adults With Type 1 Diabetes FlourishCategory: Health NewsCreated: 4/8/2020 12:00:00 AMLast Editorial Review: 4/8/2020 12:00:00 AM Full Article
adu Perceptions of Dental Hygienists About Thesis Completion in Graduate Education By www.jdentaled.org Published On :: 2019-12-01T06:00:18-08:00 Few studies have been published on thesis completion experiences of master’s degree students. However, for doctoral students, dissertation completion has been found to be dependent on individual, relational, and institutional factors. The aim of this study was to examine dental hygienists’ perceptions of their experiences completing a thesis as a requirement for an advanced degree. A qualitative phenomenological research design was used utilizing virtual focus groups with a national purposive sample of dental hygienists (n=25) who had graduated from a degree program in which a thesis was a requirement for the degree. Data analysis used an inductive approach to identify themes using Liechty et al.’s framework of individual, relational, and institutional factors impacting completion of a dissertation. Liechty et al.’s framework is based on Vygotsky’s sociocultural theory of learning. In the results, individual factors identified included family/work responsibilities, lack of understanding of the thesis process, time management, health issues, and reaching personal and professional goals. Relational factors focused primarily on positive and negative experiences with the thesis advisor/committee and support from expert peers/family. Institutional factors included the thesis structure, financial concerns, and challenges in recruiting research participants. This study found many factors influencing the thesis experience that may help guide the process in graduate degree programs. In addition, the findings suggest a need to provide mentoring and support for thesis advisors and committee members to more effectively guide students through the thesis process. Effective modifications of these may improve retention of students and facilitate timely completion of thesis research. Full Article
adu Temporal Dynamics of the Adult Female Lower Urinary Tract Microbiota By mbio.asm.org Published On :: 2020-04-21T01:31:26-07:00 ABSTRACT Temporal dynamics of certain human microbiotas have been described in longitudinal studies; variability often relates to modifiable factors or behaviors. Early studies of the urinary microbiota preferentially used samples obtained by transurethral catheterization to minimize vulvovaginal microbial contributions. Whereas voided specimens are preferred for longitudinal studies, the few studies that reported longitudinal data were limited to women with lower urinary tract (LUT) symptoms, due to ease of accessing a clinical population for sampling and the impracticality and risk of collecting repeated catheterized urine specimens in a nonclinical population. Here, we studied the microbiota of the LUT of nonsymptomatic, premenopausal women using midstream voided urine (MSU) specimens to investigate relationships between microbial dynamics and personal factors. Using 16S rRNA gene sequencing and a metaculturomics method called expanded quantitative urine culture (EQUC), we characterized the microbiotas of MSU and periurethral swab specimens collected daily for approximately 3 months from a small cohort of adult women. Participants were screened for eligibility, including the ability to self-collect paired urogenital specimens prior to enrollment. In this population, we found that measures of microbial dynamics related to specific participant-reported factors, particularly menstruation and vaginal intercourse. Further investigation of the trends revealed differences in the composition and diversity of LUT microbiotas within and across participants. These data, in combination with previous studies showing relationships between the LUT microbiota and LUT symptoms, suggest that personal factors relating to the genitourinary system may be an important consideration in the etiology, prevention, and/or treatment of LUT disorders. IMPORTANCE Following the discovery of the collective human urinary microbiota, important knowledge gaps remain, including the stability and variability of this microbial niche over time. Initial urinary studies preferentially utilized samples obtained by transurethral catheterization to minimize contributions from vulvovaginal microbes. However, catheterization has the potential to alter the urinary microbiota; therefore, voided specimens are preferred for longitudinal studies. In this report, we describe microbial findings obtained by daily assessment over 3 months in a small cohort of adult women. We found that, similarly to vaginal microbiotas, lower urinary tract (LUT) microbiotas are dynamic, with changes relating to several factors, particularly menstruation and vaginal intercourse. Our study results show that LUT microbiotas are both dynamic and resilient. They also offer novel opportunities to target LUT microbiotas by preventative or therapeutic means, through risk and/or protective factor modification. Full Article
adu Development of IFN-Stimulated Gene Expression from Embryogenesis through Adulthood, with and without Constitutive MDA5 Pathway Activation [INNATE IMMUNITY AND INFLAMMATION] By www.jimmunol.org Published On :: 2020-05-04T13:00:28-07:00 Key Points The augmented ISG profile of RdRP mice develops largely postnatally. Elevated ISG expression is then maintained through adulthood. The ISG signature in adults requires persistent type I IFN signaling. Full Article
adu Physiological Responses During Field Walking Tests in Adults with Bronchiectasis By rc.rcjournal.com Published On :: 2020-04-28T00:42:49-07:00 BACKGROUND:Field walking tests are commonly used in patients with chronic pulmonary diseases for assessment of functional capacity. However, the physiological demands and magnitude of desaturation on 6-min walk test (6MWT), incremental shuttle walk test (ISWT), and endurance shuttle walk test (ESWT) have not been investigated in patients with bronchiectasis. The objective of this study was to compare the physiological responses and the magnitude of desaturation of subjects with bronchiectasis when performing the 6MWT, ISWT, and ESWT.METHODS:Thirty-two subjects underwent the 6MWT, ISWT, and ESWT on 3 different days. Pulmonary gas exchange, heart rate, and SpO2 were measured in all tests.RESULTS:There were no differences in the peak rate of oxygen uptake, ventilation, dyspnea, and leg fatigue between the tests. Equivalent cardiac demand (ie, heart rate at peak) was observed with the 6MWT (137 ± 21 beats/min) and the ESWT (142 ± 21 beats/min), but this was lower in the ISWT (135 ± 19 beats/min) compared to ESWT (P < .05). Most subjects achieved a vigorous exercise intensity (heart rate of 70–90% of predicted) in all tests. There was no difference in desaturation among the tests (6MWT: −6.8 ± 6.6%, ISWT: −6.1 ± 6.0%, and ESWT: −7.0 ± 5.4%).CONCLUSIONS:The 6MWT, ISWT, and ESWT induced similar physiological responses at the peak of exercise, eliciting a vigorous exercise intensity. The magnitude of desaturation was similar across tests. This means these tests can be used interchangeably for evaluation of exercise-induced desaturation. Full Article
adu Drosophila estrogen-related receptor directs a transcriptional switch that supports adult glycolysis and lipogenesis [Research Papers] By genesdev.cshlp.org Published On :: 2020-05-01T06:30:22-07:00 Metabolism and development must be closely coupled to meet the changing physiological needs of each stage in the life cycle. The molecular mechanisms that link these pathways, however, remain poorly understood. Here we show that the Drosophila estrogen-related receptor (dERR) directs a transcriptional switch in mid-pupae that promotes glucose oxidation and lipogenesis in young adults. dERR mutant adults are viable but display reduced locomotor activity, susceptibility to starvation, elevated glucose, and an almost complete lack of stored triglycerides. Molecular profiling by RNA-seq, ChIP-seq, and metabolomics revealed that glycolytic and pentose phosphate pathway genes are induced by dERR, and their reduced expression in mutants is accompanied by elevated glycolytic intermediates, reduced TCA cycle intermediates, and reduced levels of long chain fatty acids. Unexpectedly, we found that the central pathways of energy metabolism, including glycolysis, the tricarboxylic acid cycle, and electron transport chain, are coordinately induced at the transcriptional level in mid-pupae and maintained into adulthood, and this response is partially dependent on dERR, leading to the metabolic defects observed in mutants. Our data support the model that dERR contributes to a transcriptional switch during pupal development that establishes the metabolic state of the adult fly. Full Article
adu Development and Implementation of the Readiness Assessment of Emerging Adults With Type 1 Diabetes Diagnosed in Youth (READDY) Tool By spectrum.diabetesjournals.org Published On :: 2020-02-14T06:59:49-08:00 Full Article
adu Prevalence and incidence of, and risk factors for chronic cough in the adult population: the Rotterdam Study By openres.ersjournals.com Published On :: 2020-04-19T07:30:12-07:00 Chronic cough is a common complaint in the general population but there are no precise data on the incidence of, and prospectively examined risk factors for chronic cough in a population-based setting. Therefore, we investigated the period prevalence, incidence and risk factors for chronic cough in adult subjects. In a prospective population-based cohort study among subjects aged ≥45 years, data on chronic cough were collected on two separate occasions using a standardised questionnaire. Chronic cough was defined as daily coughing for at least 3 months duration during the preceding 2 years. Potential risk factors were gathered by interview, physical examination and several investigations. Of the 9824 participants in this study, 1073 (10.9%) subjects had chronic cough at baseline. The prevalence of chronic cough increased with age and peaked in the eighth decade. In subjects aged <70 years, chronic cough was more common in women. During an average follow-up of 6 years, 439 incident cases of chronic cough occurred with an overall incidence rate of 11.6 per 1000 person-years (95% CI 10.6–12.8). In current smokers, the incidence of chronic cough was higher in men. In the multivariable analysis, current smoking, gastro-oesophageal reflux disease (GORD), asthma and COPD were identified as risk factors for chronic cough. Chronic cough is common among adults and highly prevalent in the older population. Current smoking, GORD, asthma and COPD are independent risk factors for chronic cough. Individuals at risk of developing chronic cough may benefit from smoking cessation and control of the underlying disease. Full Article
adu Trends in Emergency Department Visits and Inpatient Admissions for Hyperglycemic Crises in Adults With Diabetes in the U.S., 2006-2015 By care.diabetesjournals.org Published On :: 2020-04-20T12:00:32-07:00 OBJECTIVE To report U.S. national population-based rates and trends in diabetic ketoacidosis (DKA) and hyperglycemic hyperosmolar state (HHS) among adults, in both the emergency department (ED) and inpatient settings. RESEARCH DESIGN AND METHODS We analyzed data from 1 January 2006 through 30 September 2015 from the Nationwide Emergency Department Sample and National Inpatient Sample to characterize ED visits and inpatient admissions with DKA and HHS. We used corresponding year cross-sectional survey data from the National Health Interview Survey to estimate the number of adults ≥18 years with diagnosed diabetes to calculate population-based rates for DKA and HHS in both ED and inpatient settings. Linear trends from 2009 to 2015 were assessed using Joinpoint software. RESULTS In 2014, there were a total of 184,255 and 27,532 events for DKA and HHS, respectively. The majority of DKA events occurred in young adults aged 18–44 years (61.7%) and in adults with type 1 diabetes (70.6%), while HHS events were more prominent in middle-aged adults 45–64 years (47.5%) and in adults with type 2 diabetes (88.1%). Approximately 40% of the hyperglycemic events were in lower-income populations. Overall, event rates for DKA significantly increased from 2009 to 2015 in both ED (annual percentage change [APC] 13.5%) and inpatient settings (APC 8.3%). A similar trend was seen for HHS (APC 16.5% in ED and 6.3% in inpatient). The increase was in all age-groups and in both men and women. CONCLUSIONS Causes of increased rates of hyperglycemic events are unknown. More detailed data are needed to investigate the etiology and determine prevention strategies. Full Article
adu Trends in Bone Mineral Density, Osteoporosis, and Osteopenia Among U.S. Adults With Prediabetes, 2005-2014 By care.diabetesjournals.org Published On :: 2020-04-20T12:00:32-07:00 OBJECTIVE We aimed to evaluate trends in bone mineral density (BMD) and the prevalence of osteoporosis/osteopenia in U.S. adults with prediabetes and normal glucose regulation (NGR) and further investigate the association among prediabetes, osteopenia/osteoporosis, and fracture. RESEARCH DESIGN AND METHODS We collected and analyzed data from the U.S. National Health and Nutrition Examination Surveys during the period from 2005 to 2014. Femoral neck and lumbar spine BMD data were available for 5,310 adults with prediabetes and 5,162 adults with NGR >40 years old. RESULTS A shift was observed toward a lower BMD and a higher prevalence of osteopenia/osteoporosis at the femoral neck and lumbar spine in U.S. adults >40 years old with prediabetes since 2005, especially in men <60 and women ≥60 years old. A shift toward a higher prevalence of osteopenia/osteoporosis at the femoral neck was also observed in adults >40 years old with NGR. Moreover, prediabetes was associated with a higher prevalence of hip fracture, although participants with prediabetes had higher BMD and a lower prevalence of osteopenia/osteoporosis at the femoral neck. CONCLUSIONS There was a declining trend in BMD from 2005 to 2014 in U.S. adults >40 years old with prediabetes and NGR, and this trend was more significant in men <60 years old. Populations with prediabetes may be exposed to relatively higher BMD but a higher prevalence of fracture. Full Article
adu Possible Modifiers of the Association Between Change in Weight Status From Child Through Adult Ages and Later Risk of Type 2 Diabetes By care.diabetesjournals.org Published On :: 2020-04-20T12:00:32-07:00 OBJECTIVE We investigated the association between changes in weight status from childhood through adulthood and subsequent type 2 diabetes risks and whether educational attainment, smoking, and leisure time physical activity (LTPA) modify this association. RESEARCH DESIGN AND METHODS Using data from 10 Danish and Finnish cohorts including 25,283 individuals, childhood BMI at 7 and 12 years was categorized as normal or high using age- and sex-specific cutoffs (<85th or ≥85th percentile). Adult BMI (20–71 years) was categorized as nonobese or obese (<30.0 or ≥30.0 kg/m2, respectively). Associations between BMI patterns and type 2 diabetes (989 women and 1,370 men) were analyzed using Cox proportional hazards regressions and meta-analysis techniques. RESULTS Compared with individuals with a normal BMI at 7 years and without adult obesity, those with a high BMI at 7 years and adult obesity had higher type 2 diabetes risks (hazard ratio [HR]girls 5.04 [95% CI 3.92–6.48]; HRboys 3.78 [95% CI 2.68–5.33]). Individuals with a high BMI at 7 years but without adult obesity did not have a higher risk (HRgirls 0.74 [95% CI 0.52–1.06]; HRboys 0.93 [95% CI 0.65–1.33]). Education, smoking, and LTPA were associated with diabetes risks but did not modify or confound the associations with BMI changes. Results for 12 years of age were similar. CONCLUSIONS A high BMI in childhood was associated with higher type 2 diabetes risks only if individuals also had obesity in adulthood. These associations were not influenced by educational and lifestyle factors, indicating that BMI is similarly related to the risk across all levels of these factors. Full Article
adu Initial Glycemic Control and Care Among Younger Adults Diagnosed With Type 2 Diabetes By care.diabetesjournals.org Published On :: 2020-04-20T12:00:32-07:00 OBJECTIVE The prevalence of type 2 diabetes is increasing among adults under age 45. Onset of type 2 diabetes at a younger age increases an individual’s risk for diabetes-related complications. Given the lasting benefits conferred by early glycemic control, we compared glycemic control and initial care between adults with younger onset (21–44 years) and mid-age onset (45–64 years) of type 2 diabetes. RESEARCH DESIGN AND METHODS Using data from a large, integrated health care system, we identified 32,137 adults (aged 21–64 years) with incident diabetes (first HbA1c ≥6.5% [≥48 mmol/mol]). We excluded anyone with evidence of prior type 2 diabetes, gestational diabetes mellitus, or type 1 diabetes. We used generalized linear mixed models, adjusting for demographic and clinical variables, to examine differences in glycemic control and care at 1 year. RESULTS Of identified individuals, 26.4% had younger-onset and 73.6% had mid-age–onset type 2 diabetes. Adults with younger onset had higher initial mean HbA1c values (8.9% [74 mmol/mol]) than adults with onset in mid-age (8.4% [68 mmol/mol]) (P < 0.0001) and lower odds of achieving an HbA1c <7% (<53 mmol/mol) 1 year after the diagnosis (adjusted odds ratio [aOR] 0.70 [95% CI 0.66–0.74]), even after accounting for HbA1c at diagnosis. Adults with younger onset had lower odds of in-person primary care contact (aOR 0.82 [95% CI 0.76–0.89]) than those with onset during mid-age, but they did not differ in telephone contact (1.05 [0.99–1.10]). Adults with younger onset had higher odds of starting metformin (aOR 1.20 [95% CI 1.12–1.29]) but lower odds of adhering to that medication (0.74 [0.69–0.80]). CONCLUSIONS Adults with onset of type 2 diabetes at a younger age were less likely to achieve glycemic control at 1 year following diagnosis, suggesting the need for tailored care approaches to improve outcomes for this high-risk patient population. Full Article