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Long COVID, Big Bills: Grim Legacy of Even Short Hospital Stays

By www.medicinenet.com
Published On :: Mon, 29 Aug 2022 00:00:00 PDT

Title: Long COVID, Big Bills: Grim Legacy of Even Short Hospital Stays
Category: Health News
Created: 8/25/2021 12:00:00 AM
Last Editorial Review: 8/26/2021 12:00:00 AM


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Pentagon Says Troops Must Start Lining Up Now for COVID Shots

By www.medicinenet.com
Published On :: Mon, 29 Aug 2022 00:00:00 PDT

Title: Pentagon Says Troops Must Start Lining Up Now for COVID Shots
Category: Health News
Created: 8/25/2021 12:00:00 AM
Last Editorial Review: 8/26/2021 12:00:00 AM


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Fratelli Beretta Antipasto Trays Are the Source of Salmonella Outbreak: CDC

By www.medicinenet.com
Published On :: Mon, 29 Aug 2022 00:00:00 PDT

Title: Fratelli Beretta Antipasto Trays Are the Source of Salmonella Outbreak: CDC
Category: Health News
Created: 8/27/2021 12:00:00 AM
Last Editorial Review: 8/27/2021 12:00:00 AM


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America's Love Affair With Sleeping Pills May Be Waning

By www.medicinenet.com
Published On :: Mon, 29 Aug 2022 00:00:00 PDT

Title: America's Love Affair With Sleeping Pills May Be Waning
Category: Health News
Created: 8/24/2022 12:00:00 AM
Last Editorial Review: 8/24/2022 12:00:00 AM


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COVID Boosters Targeted to Latest Variants Could Be Ready After Labor Day

By www.medicinenet.com
Published On :: Mon, 29 Aug 2022 00:00:00 PDT

Title: COVID Boosters Targeted to Latest Variants Could Be Ready After Labor Day
Category: Health News
Created: 8/24/2022 12:00:00 AM
Last Editorial Review: 8/24/2022 12:00:00 AM


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Kids Getting Spinal Surgeries May Cut Back on Opioids

By www.medicinenet.com
Published On :: Thu, 11 Aug 2022 00:00:00 PDT

Title: Kids Getting Spinal Surgeries May Cut Back on Opioids
Category: Health News
Created: 8/11/2022 12:00:00 AM
Last Editorial Review: 8/11/2022 12:00:00 AM


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Neighborhood May Affect a Couple's Odds of Conceiving

By www.medicinenet.com
Published On :: Wed, 3 Aug 2022 00:00:00 PDT

Title: Neighborhood May Affect a Couple's Odds of Conceiving
Category: Health News
Created: 8/3/2022 12:00:00 AM
Last Editorial Review: 8/3/2022 12:00:00 AM


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Cheap, Same-Day Test Could Help Spot Miscarriage Risk

By www.medicinenet.com
Published On :: Fri, 19 Aug 2022 00:00:00 PDT

Title: Cheap, Same-Day Test Could Help Spot Miscarriage Risk
Category: Health News
Created: 8/18/2022 12:00:00 AM
Last Editorial Review: 8/19/2022 12:00:00 AM


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Vegan? Weightlifting May Protect Your Bones

By www.medicinenet.com
Published On :: Fri, 5 Aug 2022 00:00:00 PDT

Title: Vegan? Weightlifting May Protect Your Bones
Category: Health News
Created: 8/5/2022 12:00:00 AM
Last Editorial Review: 8/5/2022 12:00:00 AM


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'Stepped' Approach to Treating Diabetic Eye Disease May Be Best

By www.medicinenet.com
Published On :: Fri, 15 Jul 2022 00:00:00 PDT

Title: 'Stepped' Approach to Treating Diabetic Eye Disease May Be Best
Category: Health News
Created: 7/15/2022 12:00:00 AM
Last Editorial Review: 7/15/2022 12:00:00 AM


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Having Ideal Heart Health May Lessen the Risk for Brain Vessel Disease

By www.medicinenet.com
Published On :: Thu, 18 Aug 2022 00:00:00 PDT

Title: Having Ideal Heart Health May Lessen the Risk for Brain Vessel Disease
Category: Health News
Created: 8/17/2022 12:00:00 AM
Last Editorial Review: 8/18/2022 12:00:00 AM


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Are Cholesterol Tests Always Accurate?

By www.medicinenet.com
Published On :: Wed, 9 Mar 2022 00:00:00 PDT

Title: Are Cholesterol Tests Always Accurate?
Category: Diseases and Conditions
Created: 3/9/2022 12:00:00 AM
Last Editorial Review: 3/9/2022 12:00:00 AM


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26 Natural Ways to Lower Your Cholesterol Levels

By www.medicinenet.com
Published On :: Wed, 6 Jul 2022 00:00:00 PDT

Title: 26 Natural Ways to Lower Your Cholesterol Levels
Category: Health and Living
Created: 7/6/2022 12:00:00 AM
Last Editorial Review: 7/6/2022 12:00:00 AM


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Disability Payments Can Help Keep Veterans With Diabetes Out of the Hospital

By www.medicinenet.com
Published On :: Fri, 8 Jul 2022 00:00:00 PDT

Title: Disability Payments Can Help Keep Veterans With Diabetes Out of the Hospital
Category: Health News
Created: 7/8/2022 12:00:00 AM
Last Editorial Review: 7/8/2022 12:00:00 AM


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Common Diabetes Drug May Contain Traces of Carcinogen

By www.medicinenet.com
Published On :: Fri, 12 Aug 2022 00:00:00 PDT

Title: Common Diabetes Drug May Contain Traces of Carcinogen
Category: Health News
Created: 8/12/2022 12:00:00 AM
Last Editorial Review: 8/12/2022 12:00:00 AM


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Rapid Loss of Smell May Be an Early Sign of Alzheimer's

By www.medicinenet.com
Published On :: Fri, 29 Jul 2022 00:00:00 PDT

Title: Rapid Loss of Smell May Be an Early Sign of Alzheimer's
Category: Health News
Created: 7/29/2022 12:00:00 AM
Last Editorial Review: 7/29/2022 12:00:00 AM


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Lifestyle May Be Key to Helping You Avoid Dementia

By www.medicinenet.com
Published On :: Fri, 5 Aug 2022 00:00:00 PDT

Title: Lifestyle May Be Key to Helping You Avoid Dementia
Category: Health News
Created: 8/4/2022 12:00:00 AM
Last Editorial Review: 8/5/2022 12:00:00 AM


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Abnormal Upper Heart Chamber May Boost Dementia Risk

By www.medicinenet.com
Published On :: Wed, 10 Aug 2022 00:00:00 PDT

Title: Abnormal Upper Heart Chamber May Boost Dementia Risk
Category: Health News
Created: 8/10/2022 12:00:00 AM
Last Editorial Review: 8/10/2022 12:00:00 AM


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Everyday Activities That Can Cut Your Odds for Dementia

By www.medicinenet.com
Published On :: Mon, 15 Aug 2022 00:00:00 PDT

Title: Everyday Activities That Can Cut Your Odds for Dementia
Category: Health News
Created: 8/12/2022 12:00:00 AM
Last Editorial Review: 8/15/2022 12:00:00 AM


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AHA News: People With Dementia May Be Less Likely to Receive an Advanced Treatment For Stroke

By www.medicinenet.com
Published On :: Wed, 24 Aug 2022 00:00:00 PDT

Title: AHA News: People With Dementia May Be Less Likely to Receive an Advanced Treatment For Stroke
Category: Health News
Created: 8/24/2022 12:00:00 AM
Last Editorial Review: 8/24/2022 12:00:00 AM


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Too Much TV Time May Really Harm Your Brain

By www.medicinenet.com
Published On :: Wed, 24 Aug 2022 00:00:00 PDT

Title: Too Much TV Time May Really Harm Your Brain
Category: Health News
Created: 8/23/2022 12:00:00 AM
Last Editorial Review: 8/24/2022 12:00:00 AM


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3 Big Pharmacy Chains Must Pay $650 Million to Ohio Counties for Role in Opioid Crisis

By www.medicinenet.com
Published On :: Thu, 18 Aug 2022 00:00:00 PDT

Title: 3 Big Pharmacy Chains Must Pay $650 Million to Ohio Counties for Role in Opioid Crisis
Category: Health News
Created: 8/18/2022 12:00:00 AM
Last Editorial Review: 8/18/2022 12:00:00 AM


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Magic Mushroom Hallucinogen May Treat Problem Drinking

By www.medicinenet.com
Published On :: Thu, 25 Aug 2022 00:00:00 PDT

Title: Magic Mushroom Hallucinogen May Treat Problem Drinking
Category: Health News
Created: 8/24/2022 12:00:00 AM
Last Editorial Review: 8/25/2022 12:00:00 AM


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Brain-Eating Amoeba From River May Have Caused Child's Death

By www.medicinenet.com
Published On :: Fri, 19 Aug 2022 00:00:00 PDT

Title: Brain-Eating Amoeba From River May Have Caused Child's Death
Category: Health News
Created: 8/19/2022 12:00:00 AM
Last Editorial Review: 8/19/2022 12:00:00 AM


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Monkeypox Cases May Finally Be Ebbing, With Declines Seen in Europe, WHO Says

By www.medicinenet.com
Published On :: Thu, 25 Aug 2022 00:00:00 PDT

Title: Monkeypox Cases May Finally Be Ebbing, With Declines Seen in Europe, WHO Says
Category: Health News
Created: 8/25/2022 12:00:00 AM
Last Editorial Review: 8/25/2022 12:00:00 AM


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Banded Squats: Benefits and 11 Ways to Do Them

By www.medicinenet.com
Published On :: Mon, 8 Aug 2022 00:00:00 PDT

Title: Banded Squats: Benefits and 11 Ways to Do Them
Category: Health and Living
Created: 8/8/2022 12:00:00 AM
Last Editorial Review: 8/8/2022 12:00:00 AM


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Playing Football, Hockey in High School Ups Odds for Stimulant Abuse

By www.medicinenet.com
Published On :: Mon, 15 Aug 2022 00:00:00 PDT

Title: Playing Football, Hockey in High School Ups Odds for Stimulant Abuse
Category: Health News
Created: 8/15/2022 12:00:00 AM
Last Editorial Review: 8/15/2022 12:00:00 AM


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More Athletes Are Getting Their Nutrition Through an IV. This Should Stop, Experts Say

By www.medicinenet.com
Published On :: Thu, 18 Aug 2022 00:00:00 PDT

Title: More Athletes Are Getting Their Nutrition Through an IV. This Should Stop, Experts Say
Category: Health News
Created: 8/17/2022 12:00:00 AM
Last Editorial Review: 8/18/2022 12:00:00 AM


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Dietary Supplements: Are You Throwing Money Away?

By www.medicinenet.com
Published On :: Tue, 2 Aug 2022 00:00:00 PDT

Title: Dietary Supplements: Are You Throwing Money Away?
Category: Health News
Created: 8/2/2022 12:00:00 AM
Last Editorial Review: 8/2/2022 12:00:00 AM


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Helmets Protect Young Lacrosse Players, Study Finds

By www.medicinenet.com
Published On :: Thu, 25 Aug 2022 00:00:00 PDT

Title: Helmets Protect Young Lacrosse Players, Study Finds
Category: Health News
Created: 8/25/2022 12:00:00 AM
Last Editorial Review: 8/25/2022 12:00:00 AM


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Does Tinnitus Ever Go Away?

By www.medicinenet.com
Published On :: Fri, 3 Jun 2022 00:00:00 PDT

Title: Does Tinnitus Ever Go Away?
Category: Diseases and Conditions
Created: 6/3/2022 12:00:00 AM
Last Editorial Review: 6/3/2022 12:00:00 AM


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Cheaper Over-the-Counter Hearing Aids Should Be in Stores by October, FDA Says

By www.medicinenet.com
Published On :: Wed, 17 Aug 2022 00:00:00 PDT

Title: Cheaper Over-the-Counter Hearing Aids Should Be in Stores by October, FDA Says
Category: Health News
Created: 8/16/2022 12:00:00 AM
Last Editorial Review: 8/17/2022 12:00:00 AM


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Will Joint Pain From Menopause Go Away?

By www.medicinenet.com
Published On :: Tue, 24 May 2022 00:00:00 PDT

Title: Will Joint Pain From Menopause Go Away?
Category: Diseases and Conditions
Created: 5/24/2022 12:00:00 AM
Last Editorial Review: 5/24/2022 12:00:00 AM


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Experimental Drug May Ease Hot Flashes

By www.medicinenet.com
Published On :: Tue, 14 Jun 2022 00:00:00 PDT

Title: Experimental Drug May Ease Hot Flashes
Category: Health News
Created: 6/13/2022 12:00:00 AM
Last Editorial Review: 6/14/2022 12:00:00 AM


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Shorter Menstrual Cycles May Affect Timing of Menopause

By www.medicinenet.com
Published On :: Thu, 25 Aug 2022 00:00:00 PDT

Title: Shorter Menstrual Cycles May Affect Timing of Menopause
Category: Health News
Created: 8/25/2022 12:00:00 AM
Last Editorial Review: 8/25/2022 12:00:00 AM


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Your Salt Shaker May Prove Deadly, Study Finds

By www.medicinenet.com
Published On :: Tue, 12 Jul 2022 00:00:00 PDT

Title: Your Salt Shaker May Prove Deadly, Study Finds
Category: Health News
Created: 7/11/2022 12:00:00 AM
Last Editorial Review: 7/12/2022 12:00:00 AM


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What Time of Day Is Blood Pressure Highest?

By www.medicinenet.com
Published On :: Thu, 14 Jul 2022 00:00:00 PDT

Title: What Time of Day Is Blood Pressure Highest?
Category: Diseases and Conditions
Created: 7/14/2022 12:00:00 AM
Last Editorial Review: 7/14/2022 12:00:00 AM


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When Is Blood Pressure Lowest and Highest During the Day?

By www.medicinenet.com
Published On :: Tue, 26 Jul 2022 00:00:00 PDT

Title: When Is Blood Pressure Lowest and Highest During the Day?
Category: Diseases and Conditions
Created: 7/26/2022 12:00:00 AM
Last Editorial Review: 7/26/2022 12:00:00 AM


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Moving Away From Opioids to Treat Dental Pain

By www.medicinenet.com
Published On :: Fri, 19 Aug 2022 00:00:00 PDT

Title: Moving Away From Opioids to Treat Dental Pain
Category: Health News
Created: 8/19/2022 12:00:00 AM
Last Editorial Review: 8/19/2022 12:00:00 AM


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9 Vitamins That May Help With Vaginal Dryness

By www.medicinenet.com
Published On :: Wed, 3 Aug 2022 00:00:00 PDT

Title: 9 Vitamins That May Help With Vaginal Dryness
Category: Health and Living
Created: 8/3/2022 12:00:00 AM
Last Editorial Review: 8/3/2022 12:00:00 AM


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Being Social May Be Key to 'Sense of Purpose' as You Age

By www.medicinenet.com
Published On :: Tue, 12 Jul 2022 00:00:00 PDT

Title: Being Social May Be Key to 'Sense of Purpose' as You Age
Category: Health News
Created: 7/12/2022 12:00:00 AM
Last Editorial Review: 7/12/2022 12:00:00 AM


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Steps to Long Life: Short Walk Each Day Helps Folks Over 85

By www.medicinenet.com
Published On :: Thu, 25 Aug 2022 00:00:00 PDT

Title: Steps to Long Life: Short Walk Each Day Helps Folks Over 85
Category: Health News
Created: 8/25/2022 12:00:00 AM
Last Editorial Review: 8/25/2022 12:00:00 AM


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Stay Independent of Asthma, Allergies This July 4th

By www.medicinenet.com
Published On :: Fri, 1 Jul 2022 00:00:00 PDT

Title: Stay Independent of Asthma, Allergies This July 4th
Category: Health News
Created: 7/1/2022 12:00:00 AM
Last Editorial Review: 7/1/2022 12:00:00 AM


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Looking for Reliable Hay Fever Advice? It's Probably Not on YouTube

By www.medicinenet.com
Published On :: Tue, 16 Aug 2022 00:00:00 PDT

Title: Looking for Reliable Hay Fever Advice? It's Probably Not on YouTube
Category: Health News
Created: 8/16/2022 12:00:00 AM
Last Editorial Review: 8/16/2022 12:00:00 AM


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Kidneys' Resilience May Depend on Your Gender, Study Finds

By www.medicinenet.com
Published On :: Mon, 22 Aug 2022 00:00:00 PDT

Title: Kidneys' Resilience May Depend on Your Gender, Study Finds
Category: Health News
Created: 8/22/2022 12:00:00 AM
Last Editorial Review: 8/22/2022 12:00:00 AM


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Treating central sleep apnoea in heart failure: is positive airway pressure and adaptive servo-ventilation in particular the gold standard?

By err.ersjournals.com
Published On :: 2024-10-30T01:30:15-07:00

Extract

We read with great interest the review article by Randerath et al. [1] recently published in the European Respiratory Review. We would like to congratulate the authors on this clearly structured review, which emphasises the urgent need for an increasingly differentiated view of central sleep apnoea (CSA) in the context of precision medicine.


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Feasibility of Delivering 5-Day Normobaric Hypoxia Breathing in a Hospital Setting

By rc.rcjournal.com
Published On :: 2024-10-25T05:44:12-07:00

BACKGROUND:Beneficial effects of breathing at FIO2 < 0.21 on disease outcomes have been reported in previous preclinical and clinical studies. However, the safety and intra-hospital feasibility of breathing hypoxic gas for 5 d have not been established. In this study, we examined the physiologic effects of breathing a gas mixture with FIO2 as low as 0.11 in 5 healthy volunteers.METHODS:All 5 subjects completed the study, spending 5 consecutive days in a hypoxic tent, where the ambient oxygen level was lowered in a stepwise manner over 5 d, from FIO2 of 0.16 on the first day to FIO2 of 0.11 on the fifth day of the study. All the subjects returned to an environment at room air on the sixth day. The subjects' SpO2, heart rate, and breathing frequency were continuously recorded, along with daily blood sampling, neurologic evaluations, transthoracic echocardiography, and mental status assessments.RESULTS:Breathing hypoxia concentration dependently caused profound physiologic changes, including decreased SpO2 and increased heart rate. At FIO2 of 0.14, the mean SpO2 was 92%; at FIO2 of 0.13, the mean SpO2 was 93%; at FIO2 of 0.12, the mean SpO2 was 88%; at FIO2 of 0.11, the mean SpO2 was 85%; and, finally, at an FIO2 of 0.21, the mean SpO2 was 98%. These changes were accompanied by increased erythropoietin levels and reticulocyte counts in blood. All 5 subjects concluded the study with no adverse events. No subjects exhibited signs of mental status changes or pulmonary hypertension.CONCLUSIONS:Results of the current physiologic study suggests that, within a hospital setting, delivering FIO2 as low as 0.11 is feasible and safe in healthy subjects, and provides the foundation for future studies in which therapeutic effects of hypoxia breathing are tested.


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Development and Validation of a Customized Amplex UltraRed Assay for Sensitive Hydrogen Peroxide Detection in Pharmaceutical Water

By journal.pda.org
Published On :: 2024-10-22T08:20:35-07:00

For clean-room technologies such as isolators and restricted access barrier systems (RABS), decontamination using hydrogen peroxide (H2O2) is increasingly attractive to fulfill regulatory requirements. Several approaches are currently used, ranging from manual wipe disinfection to vapor phase hydrogen peroxide (VPHP) or automated nebulization sanitization. Although the residual airborne H2O2 concentration can be easily monitored, detection of trace H2O2 residues in filled products is rather challenging. To simulate the filling process in a specific clean room, technical runs with water for injection (WfI) are popular. Thus, the ability to detect traces of H2O2 in water is an important prerequisite to ensure a safe and reliable use of H2O2 for isolator or clean room decontamination. The objective of this study was to provide a validated quantitative, fluorometric Amplex UltraRed assay, which satisfies the analytical target profile of quantifying H2O2 in WfI at low nanomolar to low micromolar concentrations (ppb range) with high accuracy and high precision. The Amplex UltraRed technology provides a solid basis for this purpose; however, no commercial assay kit that fulfills these requirements is available. Therefore, a customized Amplex UltraRed assay was developed, optimized, and validated. This approach resulted in an assay that is capable of quantifying H2O2 in WfI selectively, sensitively, accurately, precisely, and robustly. This assay is used in process development and qualification approaches using WfI in H2O2-decontaminated clean rooms and isolators.


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Decoding biology with massively parallel reporter assays and machine learning [Reviews]

By genesdev.cshlp.org
Published On :: 2024-10-16T07:18:56-07:00

Massively parallel reporter assays (MPRAs) are powerful tools for quantifying the impacts of sequence variation on gene expression. Reading out molecular phenotypes with sequencing enables interrogating the impact of sequence variation beyond genome scale. Machine learning models integrate and codify information learned from MPRAs and enable generalization by predicting sequences outside the training data set. Models can provide a quantitative understanding of cis-regulatory codes controlling gene expression, enable variant stratification, and guide the design of synthetic regulatory elements for applications from synthetic biology to mRNA and gene therapy. This review focuses on cis-regulatory MPRAs, particularly those that interrogate cotranscriptional and post-transcriptional processes: alternative splicing, cleavage and polyadenylation, translation, and mRNA decay.


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Association between a recalled positive airway pressure device and incident cancer: a population-based study

By erj.ersjournals.com
Published On :: 2024-11-07T00:35:55-08:00

Background

The real-world consequences of a Philips Respironics recall for positive airway pressure (PAP) devices distributed between 2009 and 2021 are unknown.

Methods

We conducted a retrospective population-based study using health administrative databases (Ontario, Canada) on all new adult PAP users identified through the provincial funding system, free of cancer at baseline, who initiated (claimed) PAP treatment between 2012 and 2018. Everyone was followed from the PAP claim date to the earliest of incident cancer diagnosis, death or end of follow-up (March 2022). We used inverse probability of treatment weighting to balance baseline characteristics between individuals on recalled devices and those on devices from other manufacturers. Weighted hazard ratios of incident cancer were compared between groups.

 Results

Of 231 692 individuals identified, 58 204 (25.1%) claimed recalled devices and 173 488 (74.9%) claimed devices from other manufacturers. A meaningful baseline difference between groups (standardised difference ≥0.10) was noted only by location-relevant covariates; other variables were mostly equally distributed (standardised differences ≤0.06). Over a median (interquartile range) follow-up of 6.3 (4.9–8.0) years, 11 166 (4.8%) developed cancer: unadjusted rates per 10 000 person-years of 78.8 (95% CI 76.0–81.7) in the recall group versus 74.0 (95% CI 72.4–75.6) in others (p=0.0034). Propensity score weighting achieved excellent balance in baseline characteristics between groups (standardised differences ≤0.07). On a weighted sample, there was no statistical difference in the hazard of incident cancer between groups: cause-specific hazard ratio (recalled versus others) 0.97 (95% CI 0.89–1.06).

 Conclusion

In our real-world population study, compared to other manufacturers and adjusting for confounders, recalled Philips Respironics PAP devices do not appear to be independently associated with developing cancer.


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