a Re: Scandal of “newborn gang” that put profits ahead of babies’ lives rocks Turkey’s health system By www.bmj.com Published On :: Tuesday, November 12, 2024 - 14:09 Full Article
a Re: Decompression alone or with fusion for degenerative lumbar spondylolisthesis (Nordsten-DS): five year follow-up of a randomised, multicentre, non-inferiority trial By www.bmj.com Published On :: Tuesday, November 12, 2024 - 16:16 Full Article
a A Comprehensive Gender-related Secretome of Plasmodium berghei Sexual Stages By www.mcponline.org Published On :: 2020-12-01 Felicia GrassoDec 1, 2020; 19:1986-1996Research Full Article
a Citrus Vascular Proteomics Highlights the Role of Peroxidases and Serine Proteases during Huanglongbing Disease Progression By www.mcponline.org Published On :: 2020-12-01 Jessica Y. FrancoDec 1, 2020; 19:1936-1951Research Full Article
a Global lysine acetylation and 2-hydroxyisobutyrylation reveal the metabolism conversion mechanism in Giardia lamblia By www.mcponline.org Published On :: 2020-12-29 Wenhe ZhuDec 29, 2020; 0:RA120.002353v1-mcp.RA120.002353Research Full Article
a Novel Proteomic Profiling of Epididymal Extracellular Vesicles in the Domestic Cat Reveals Proteins Related to Sequential Sperm Maturation with Differences Observed between Normospermic and Teratospermic Individuals By www.mcponline.org Published On :: 2020-12-01 Tricia RowlisonDec 1, 2020; 19:2090-2103Research Full Article
a Separation and identification of permethylated glycan isomers by reversed phase nanoLC-NSI-MS By www.mcponline.org Published On :: 2020-12-29 Simone KurzDec 29, 2020; 0:RA120.002266v1-mcp.RA120.002266Research Full Article
a High-throughput and site-specific N-glycosylation analysis of human alpha-1-acid glycoprotein offers a great potential for new biomarker discovery By www.mcponline.org Published On :: 2020-12-29 Toma KeserDec 29, 2020; 0:RA120.002433v1-mcp.RA120.002433Research Full Article
a Stoichiometry of Nucleotide Binding to Proteasome AAA+ ATPase Hexamer Established by Native Mass Spectrometry By www.mcponline.org Published On :: 2020-12-01 Yadong YuDec 1, 2020; 19:1997-2014Research Full Article
a Identification of novel serological autoantibodies in Takayasu arteritis patients using HuProt arrays By www.mcponline.org Published On :: 2020-12-17 Xiao-Ting WenDec 17, 2020; 0:RA120.002119v1-mcp.RA120.002119Research Full Article
a Interspecies differences in proteome turnover kinetics are correlated with lifespans and energetic demands By www.mcponline.org Published On :: 2020-12-28 Kyle SwovickDec 28, 2020; 0:RA120.002301v1-mcp.RA120.002301Research Full Article
a Global Proteome and Phosphoproteome Characterization of Sepsis-induced Kidney Injury By www.mcponline.org Published On :: 2020-12-01 Yi-Han LinDec 1, 2020; 19:2030-2046Research Full Article
a A Mouse Brain-based Multi-omics Integrative Approach Reveals Potential Blood Biomarkers for Ischemic Stroke By www.mcponline.org Published On :: 2020-12-01 Alba SimatsDec 1, 2020; 19:1921-1935Research Full Article
a Multi-sample mass spectrometry-based approach for discovering injury markers in chronic kidney disease By www.mcponline.org Published On :: 2020-12-20 Ji Eun KimDec 20, 2020; 0:RA120.002159v1-mcp.RA120.002159Research Full Article
a OpenPepXL: An Open-Source Tool for Sensitive Identification of Cross-Linked Peptides in XL-MS By www.mcponline.org Published On :: 2020-12-01 Eugen NetzDec 1, 2020; 19:2157-2167Technological Innovation and Resources Full Article
a Kinome Profiling of Primary Endometrial Tumors Using Multiplexed Inhibitor Beads and Mass Spectrometry Identifies SRPK1 as Candidate Therapeutic Target By www.mcponline.org Published On :: 2020-12-01 Alison M. KurimchakDec 1, 2020; 19:2068-2089Research Full Article
a A Novel Mechanism for NF-{kappa}B-activation via I{kappa}B-aggregation: Implications for Hepatic Mallory-Denk-Body Induced Inflammation By www.mcponline.org Published On :: 2020-12-01 Yi LiuDec 1, 2020; 19:1968-1985Research Full Article
a The role of Data-Independent Acquisition for Glycoproteomics By www.mcponline.org Published On :: 2020-12-28 Zilu YeDec 28, 2020; 0:R120.002204v1-mcp.R120.002204Review Full Article
a Temporal Quantitative Proteomics of mGluR-induced Protein Translation and Phosphorylation in Neurons By www.mcponline.org Published On :: 2020-12-01 Charlotte A. G. H. van GelderDec 1, 2020; 19:1952-1967Research Full Article
a Proteome-wide Analysis Reveals Substrates of E3 Ligase RNF146 Targeted for Degradation By www.mcponline.org Published On :: 2020-12-01 Litong NieDec 1, 2020; 19:2015-2029Research Full Article
a Identification of Microorganisms by Liquid Chromatography-Mass Spectrometry (LC-MS1) and in Silico Peptide Mass Libraries By www.mcponline.org Published On :: 2020-12-01 Peter LaschDec 1, 2020; 19:2125-2138Technological Innovation and Resources Full Article
a Unraveling the MAX2 Protein Network in Arabidopsis thaliana: Identification of the Protein Phosphatase PAPP5 as a Novel MAX2 Interactor By www.mcponline.org Published On :: 2020-12-28 Sylwia StrukDec 28, 2020; 0:RA119.001766v1-mcp.RA119.001766Research Full Article
a CMMB (Carboxylate Modified Magnetic Bead) -based isopropanol gradient peptide fractionation (CIF) enables rapid and robust off-line peptide mixture fractionation in bottom-up proteomics By www.mcponline.org Published On :: 2020-12-22 Weixian DengDec 22, 2020; 0:RA120.002411v1-mcp.RA120.002411Research Full Article
a Systematic identification of P. falciparum sporozoite membrane protein interactions reveals an essential role for the p24 complex in host infection By www.mcponline.org Published On :: 2020-12-22 Julia KnöckelDec 22, 2020; 0:RA120.002432v1-mcp.RA120.002432Research Full Article
a In depth characterization of the Staphylococcus aureus phosphoproteome reveals new targets of Stk1 By www.mcponline.org Published On :: 2020-12-17 Nadine PrustDec 17, 2020; 0:RA120.002232v1-mcp.RA120.002232Research Full Article
a On the robustness of graph-based clustering to random network alterations By www.mcponline.org Published On :: 2020-11-04 R. Greg StaceyNov 4, 2020; 0:RA120.002275v1-mcp.RA120.002275Research Full Article
a Thyroglobulin interactome profiling defines altered proteostasis topology associated with thyroid dyshormonogenesis By www.mcponline.org Published On :: 2020-11-18 Madison T WrightNov 18, 2020; 0:RA120.002168v1-mcp.RA120.002168Research Full Article
a Proteome analysis reveals a significant host-specific response in Rhizobium leguminosarum bv viciae endosymbiotic cells By www.mcponline.org Published On :: 2020-11-19 David DuránNov 19, 2020; 0:RA120.002276v1-mcp.RA120.002276Research Full Article
a A proteomics-based assessment of inflammation signatures in endotoxemia By www.mcponline.org Published On :: 2020-12-07 Sean A BurnapDec 7, 2020; 0:RA120.002305v1-mcp.RA120.002305Research Full Article
a A potential role for the Gsdf-eEF1{alpha} complex in inhibiting germ cell proliferation: A protein-interaction analysis in medaka (Oryzias latipes) from a proteomics perspective By www.mcponline.org Published On :: 2020-12-08 Xinting ZhangDec 8, 2020; 0:RA120.002306v1-mcp.RA120.002306Research Full Article
a Proteogenomic characterization of the pathogenic fungus Aspergillus flavus reveals novel genes involved in aflatoxin production By www.mcponline.org Published On :: 2020-11-24 Mingkun YangNov 24, 2020; 0:RA120.002144v1-mcp.RA120.002144Research Full Article
a Quantitative proteomics reveal neuron projection development genes ARF4, KIF5B and RAB8A associated with Hirschsprung disease By www.mcponline.org Published On :: 2020-11-17 Qin ZhangNov 17, 2020; 0:RA120.002325v1-mcp.RA120.002325Research Full Article
a Proteomic analyses identify differentially expressed proteins and pathways between low-risk and high-risk subtypes of early-stage lung adenocarcinoma and their prognostic impacts By www.mcponline.org Published On :: 2020-11-30 Juntuo ZhouNov 30, 2020; 0:RA120.002384v1-mcp.RA120.002384Research Full Article
a A proteomic approach to understand the clinical significance of acute myeloid leukemia-derived extracellular vesicles reflecting essential characteristics of leukemia By www.mcponline.org Published On :: 2020-11-30 Ka-Won KangNov 30, 2020; 0:RA120.002169v1-mcp.RA120.002169Research Full Article
a Prediction and validation of mouse meiosis-essential genes based on spermatogenesis proteome dynamics By www.mcponline.org Published On :: 2020-11-30 Kailun FangNov 30, 2020; 0:RA120.002081v1-mcp.RA120.002081Research Full Article
a The Mechanism of NEDD8 Activation of CUL5 Ubiquitin E3 Ligases By www.mcponline.org Published On :: 2020-12-02 Ryan J LumpkinDec 2, 2020; 0:RA120.002414v1-mcp.RA120.002414Research Full Article
a Imaging Mass Spectrometry and Lectin Analysis of N-linked Glycans in Carbohydrate Antigen Defined Pancreatic Cancer Tissues By www.mcponline.org Published On :: 2020-11-24 Colin T. McDowellNov 24, 2020; 0:RA120.002256v1-mcp.RA120.002256Research Full Article
a Peptidomics-driven strategy reveals peptides and predicted proteases associated with oral cancer prognosis By www.mcponline.org Published On :: 2020-11-11 Leandro Xavier NevesNov 11, 2020; 0:RA120.002227v1-mcp.RA120.002227Research Full Article
a Spatially Resolved Activity-based Proteomic Profiles of the Murine Small Intestinal Lipases By www.mcponline.org Published On :: 2020-12-01 Matthias SchittmayerDec 1, 2020; 19:2104-2114Research Full Article
a Proteomic identification of Coxiella burnetii effector proteins targeted to the host cell mitochondria during infection By www.mcponline.org Published On :: 2020-11-11 Laura F FieldenNov 11, 2020; 0:RA120.002370v1-mcp.RA120.002370Research Full Article
a The peptide vaccine of the future By www.mcponline.org Published On :: 2020-12-07 Annika NeldeDec 7, 2020; 0:R120.002309v1-mcp.R120.002309Review Full Article
a Proteome Turnover in the Spotlight: Approaches, Applications & Perspectives By www.mcponline.org Published On :: 2020-11-30 Alison B. RossNov 30, 2020; 0:R120.002190v1-mcp.R120.002190Review Full Article
a Accelerating the field of epigenetic histone modification through mass spectrometry-based approaches By www.mcponline.org Published On :: 2020-11-17 Congcong LuNov 17, 2020; 0:R120.002257v1-mcp.R120.002257Review Full Article
a PTM-Shepherd: analysis and summarization of post-translational and chemical modifications from open search results By www.mcponline.org Published On :: 2020-12-01 Daniel J. GeiszlerDec 1, 2020; 0:TIR120.002216v1-mcp.TIR120.002216Technological Innovation and Resources Full Article
a ReactomeGSA - Efficient Multi-Omics Comparative Pathway Analysis By www.mcponline.org Published On :: 2020-12-01 Johannes GrissDec 1, 2020; 19:2115-2124Technological Innovation and Resources Full Article
a Mutation-independent Proteomic Signatures of Pathological Progression in Murine Models of Duchenne Muscular Dystrophy By www.mcponline.org Published On :: 2020-12-01 Tirsa L. E. van WesteringDec 1, 2020; 19:2047-2067Research Full Article
a Protein modification characteristics of the malaria parasite Plasmodium falciparum and the infected erythrocytes By www.mcponline.org Published On :: 2020-11-04 Jianhua WangNov 4, 2020; 0:RA120.002375v1-mcp.RA120.002375Research Full Article
a ProAlanase is an Effective Alternative to Trypsin for Proteomics Applications and Disulfide Bond Mapping By www.mcponline.org Published On :: 2020-12-01 Diana SamodovaDec 1, 2020; 19:2139-2156Technological Innovation and Resources Full Article
a Plasma proteomic data can contain personally identifiable, sensitive information and incidental findings By www.mcponline.org Published On :: 2020-12-17 Philipp Emanuel GeyerDec 17, 2020; 0:RA120.002359v1-mcp.RA120.002359Research Full Article
a Pluripotency of embryonic stem cells lacking clathrin-mediated endocytosis cannot be rescued by restoring cellular stiffness [Molecular Biophysics] By www.jbc.org Published On :: 2020-12-04T00:06:06-08:00 Mouse embryonic stem cells (mESCs) display unique mechanical properties, including low cellular stiffness in contrast to differentiated cells, which are stiffer. We have previously shown that mESCs lacking the clathrin heavy chain (Cltc), an essential component for clathrin-mediated endocytosis (CME), display a loss of pluripotency and an enhanced expression of differentiation markers. However, it is not known whether physical properties such as cellular stiffness also change upon loss of Cltc, similar to what is seen in differentiated cells, and if so, how these altered properties specifically impact pluripotency. Using atomic force microscopy (AFM), we demonstrate that mESCs lacking Cltc display higher Young's modulus, indicative of greater cellular stiffness, compared with WT mESCs. The increase in stiffness was accompanied by the presence of actin stress fibers and accumulation of the inactive, phosphorylated, actin-binding protein cofilin. Treatment of Cltc knockdown mESCs with actin polymerization inhibitors resulted in a decrease in the Young's modulus to values similar to those obtained with WT mESCs. However, a rescue in the expression profile of pluripotency factors was not obtained. Additionally, whereas WT mouse embryonic fibroblasts could be reprogrammed to a state of pluripotency, this was inhibited in the absence of Cltc. This indicates that the presence of active CME is essential for the pluripotency of embryonic stem cells. Additionally, whereas physical properties may serve as a simple readout of the cellular state, they may not always faithfully recapitulate the underlying molecular fate. Full Article
