sm

Phase 3 trial of Libtayo® (cemiplimab) as monotherapy for first-line advanced non-small cell lung cancer stopped early due to highly significant improvement in overall survival

- Libtayo decreased the risk of death by 32.4% compared to chemotherapy




sm

Takeda agrees license to strengthen plasma pipeline

Takeda in global licensing agreement with ProThera to develop plasma-based therapies for inflammatory conditions.



  • Markets & Regulations

sm

None Better than One? (A Brief Note on VC in Smaller Hubs)

Biotech venture funding metrics continue at historic highs, highlighting that the robust financing environment in the public markets continues to fuel the private markets as well.  – Bruce Booth, partner Atlas Venture in Data Snapshot: Venture-Backed Biotech Financing Riding High, April 2015 Here in Madison, Wisconsin, you might not know that was true if you

Read More




sm

Letters to the Editor: Old Americans shouldn't have to prove their value to combat ageism

The idea that old people are worth something because they contribute significantly to society puts us on a slippery slope.




sm

'Chinese virus' and other COVID-19 racism have designers, stylists of Asian heritage pushing back

Enough is enough, says a growing number of creatives from the fashion industry, including designer Kimora Lee Simmons, stylist Jeanne Yang and designer Prabal Gurung.




sm

Not So Smooth of a “Transition”: FDA Sued Over Deemed BLA Transitions – or Lack Thereof

By Sara W. Koblitz




sm

Not enough evidence that e-cigarettes help to stop smoking, surgeon general says

The surgeon general's report is the first in 30 years to focus entirely on quitting tobacco.




sm

Japan small business aid would cover two-thirds rent for 6 months




sm

Trump and Biden use antagonism against Beijing to win votes




sm

Yokogawa Releases AI-enabled Versions of SMARTDAC+ Paperless Recorders and Data Logging Software, and Environmentally Robust AI-enabled e-RT3 Plus Edge Computing Platform for Industry Applications

Yokogawa Electric Corporation (TOKYO: 6841) announces the release of artificial intelligence (AI)-enabled versions of the GX series panel-mount type paperless recorders, GP series portable paperless recorders, and GA10 data logging software, which are components of the highly operable and expandable SMARTDAC+data acquisition and control system. This new AI functionality includes the future pen, a function developed by Yokogawa that enables the drawing of predicted waveforms. Yokogawa is also releasing a new CPU module for the e-RT3 Plus edge computing platform that is environmentally robust and Python compatible. The GX/GP and e-RT3 release is set for April 8, and the GA10 software will be released on May 13. The SMARTDAC+ system is a product in the OpreX Data Acquisition family, and the e-RT3 Plus is part of the OpreX Control Devices family.




sm

Salsa music pioneer Ismael Quintana died

He became a pioneer of salsa music and was renowned for hits such as Puerto Rico, Adoracion, No se compara and Maestro rumbero.




sm

PSMA PET–CT outperforms conventional imaging in high-risk prostate cancer




sm

Comparing outcomes of SMP and Miniperc




sm

A soluble endoplasmic reticulum factor as regenerative therapy for Wolfram syndrome




sm

The <i>RhHB1</i>/<i>RhLOX4</i> module affects the dehydration tolerance of rose flowers (<i>Rosa hybrida</i>) by fine-tuning jasmonic acid levels




sm

Ultrafast optical response and ablation mechanisms of molybdenum disulfide under intense femtosecond laser irradiation




sm

AAV-mediated cardiac gene transfer of wild-type desmin in mouse models for recessive desminopathies




sm

The lysine methyltransferase SMYD2 is required for normal lymphocyte development and survival of hematopoietic leukemias




sm

IL12B and IL23R polymorphisms are associated with alopecia areata




sm

Mechanism of collective interstitial ordering in Fe–C alloys




sm

Association of <i>MICA</i>-129Met/Val polymorphism with clinical outcome of anti-TNF therapy and MICA serum levels in patients with rheumatoid arthritis




sm

Publisher Correction: ASPI: a public–private partnership to develop treatments for autism




sm

Mechanisms of graft-versus-leukemia effects after allogeneic stem cell transplantation: effects on the leukemia stem cell?




sm

Multilayered mechanisms ensure that short chromosomes recombine in meiosis




sm

Smart-technology spies, a final warning on the environment, and the staggering costs of cancer: Books in brief




sm

Ancient Andean cities boasted cosmopolitan residents




sm

The β-catenin/TCF-4-LINC01278-miR-1258-Smad2/3 axis promotes hepatocellular carcinoma metastasis




sm

Mechanisms by which angiotensin-receptor blockers increase ACE2 levels




sm

Plasma membranes are asymmetric in lipid unsaturation, packing and protein shape




sm

Structure of severe fever with thrombocytopenia syndrome virus L protein elucidates the mechanisms of viral transcription initiation




sm

A Buddhism Critic Goes on a Silent Buddhist Retreat

Something weird happens to a skeptical science writer during a week of meditation, chanting and skygazing




sm

Early assessment of <i>KRAS</i> mutation in cfDNA correlates with risk of progression and death in advanced non-small-cell lung cancer




sm

Associations between sleep bruxism and (peri-)implant complications: lessons learned from a clinical study




sm

Analysis of different characteristics of smile




sm

Single-cell RNA counting at allele and isoform resolution using Smart-seq3




sm

Growth of microorganisms in an interfacially driven space bioreactor analog

npj Microgravity, Published online: 08 April 2020; doi:10.1038/s41526-020-0101-4

Growth of microorganisms in an interfacially driven space bioreactor analog




sm

Cellular thermal shift assay for the identification of drug–target interactions in the <i>Plasmodium falciparum</i> proteome




sm

npj Aging and Mechanisms of Disease




sm

Rituximab for desensitization during HLA-mismatched stem cell transplantation in patients with a positive donor-specific anti-HLA antibody




sm

QKI deficiency leads to osteoporosis by promoting RANKL-induced osteoclastogenesis and disrupting bone metabolism




sm

WTAP and BIRC3 are involved in the posttranscriptional mechanisms that impact on the expression and activity of the human lactonase PON2




sm

Chromosome 11 open reading frame 30 (C11orf30), calpain small subunit 1 (CAPNS1; CAPN4), signal transducer and activator of transcription 6 (STAT6) and ankyrin repeat domain 27 (ANKRD27) as diagnostic markers for eosinophilic esophagitis (EoE)

Genomewide association studies identified four genes that could serve as diagnostic markers and/or therapeutic targets for EoE.




sm

FBP1 loss disrupts liver metabolism and promotes tumorigenesis through a hepatic stellate cell senescence secretome




sm

MicroRNA binding site polymorphism in inflammatory genes associated with colorectal cancer: literature review and bioinformatics analysis




sm

Cardamonin protects against lipopolysaccharide-induced myocardial contractile dysfunction in mice through Nrf2-regulated mechanism




sm

Nuclear receptor crosstalk — defining the mechanisms for therapeutic innovation




sm

Combining radiolabelled therapies for neuroendocrine neoplasms




sm

SIN List criticism based on misunderstandings




sm

Rodent models of post-traumatic stress disorder: behavioral assessment




sm

Emerging functional connectivity differences in newborn infants vulnerable to autism spectrum disorders