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Supplementation of nano-bubble curcumin extract improves gut microbiota composition and exercise performance in mice

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Food Funct., 2020, 11,3574-3584
DOI: 10.1039/C9FO02487E, Paper
Yi-Ming Chen, Wan-Chun Chiu, Yen-Shuo Chiu, Tong Li, Hsin-Ching Sung, Chien-Yu Hsiao
NCE supplementation was able to modulate the gut microbiota increased the Lactobacillus genus.
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Fucoxanthin alleviates palmitate-induced inflammation in RAW 264.7 cells through improving lipid metabolism and attenuating mitochondrial dysfunction

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Food Funct., 2020, 11,3361-3370
DOI: 10.1039/D0FO00442A, Paper
Siyu Li, Xiaomeng Ren, Yuandong Wang, Jiangning Hu, Haitao Wu, Shuang Song, Chunhong Yan
Fucoxanthin mitigated palmitate-induced inflammation in macrophages through promoting fatty acid oxidation and ameliorating mitochondrial dysfunction.
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Capsaicin—the major bioactive ingredient of chili peppers: bio-efficacy and delivery systems

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Food Funct., 2020, 11,2848-2860
DOI: 10.1039/D0FO00351D, Review Article
Muwen Lu, Chengyu Chen, Yaqi Lan, Jie Xiao, Run Li, Junqing Huang, Qingrong Huang, Yong Cao, Chi-Tang Ho
The mechanisms of bio-efficacy of capsaicin and delivery systems with enhanced bioavailability were reviewed.
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Seaweed Porphyra yezoensis polysaccharides with different molecular weights inhibit hydroxyapatite damage and osteoblast differentiation of A7R5 cells

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Food Funct., 2020, 11,3393-3409
DOI: 10.1039/C9FO01732A, Paper
Ling-Hong Huang, Hong Liu, Jia-Yun Chen, Xin-Yuan Sun, Zhi-hui Yao, Jin Han, Jian-Ming Ouyang
Porphyra yezoensis polysaccharide could effectively reduce the cell damage and osteogenic transformation of vascular smooth muscle cells induced by hydroxyapatite crystals.
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Girinimbine from curry leaves promotes gastro protection against ethanol induced peptic ulcers and improves healing via regulation of anti-inflammatory and antioxidant mechanisms

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Food Funct., 2020, 11,3493-3505
DOI: 10.1039/D0FO00053A, Paper
Syam Mohan, Yahya Hasan Hobani, Emad Shaheen, Alaa Sayed Abou-Elhamd, Aymen abdelhaleem, Hassan A. Alhazmi, Siddig Ibrahim Abdelwahab
Curry leaves (Murraya koenigii) are a leafy spice used in Indian cookery for its fragrant aroma.
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Preparation of theasinensin A and theasinensin B and exploration of their inhibitory mechanism on α-glucosidase

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Food Funct., 2020, 11,3527-3538
DOI: 10.1039/C9FO03054A, Paper
Sainan Tao, Guijie Chen, Weiqi Xu, Yujia Peng, Peng Wan, Yi Sun, Xiaoxiong Zeng, Zhonghua Liu
Theasinensin A (TSA) and theasinensin B (TSB), dimers of tea catechins produced during the processing of oolong tea and black tea, had superior inhibitory effects on α-glucosidase.
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Ethanolamides of essential α-linolenic and linoleic fatty acids suppress short-term food intake in rats

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Food Funct., 2020, 11,3066-3072
DOI: 10.1039/C9FO02884F, Paper
Mandy Ho, G. Harvey Anderson, Lin Lin, Richard P. Bazinet, Ruslan Kubant
α-Linolenoylethanolamide and linoleoylethanolamide suppress short-term food intake in rats.
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Purification, characterization and molecular cloning of a dicaffeoylquinic acid-hydrolyzing esterase from human-derived Lactobacillus fermentum LF-12

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Food Funct., 2020, 11,3235-3244
DOI: 10.1039/D0FO00029A, Paper
Yujin Liu, Minhao Xie, Peng Wan, Guijie Chen, Chunxu Chen, Dan Chen, Shijie Yu, Xiaoxiong Zeng, Yi Sun
Dicaffeoylquinic acids (DiCQAs), the main components of kudingcha made from the leaves of Ilex kudingcha, could be transformed by gut microbiota.
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Oleacein inhibits STAT3, activates the apoptotic machinery, and exerts anti-metastatic effects in the SH-SY5Y human neuroblastoma cells

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Food Funct., 2020, 11,3271-3279
DOI: 10.1039/D0FO00089B, Paper
Santa Cirmi, Marilena Celano, Giovanni Enrico Lombardo, Valentina Maggisano, Antonio Procopio, Diego Russo, Michele Navarra
The present findings demonstrate that oleacein, the main secoiridoid of extravirgin olive oil, acts against neuroblastoma cells, by reducing cell adhesion and migration, inducing apoptotic death and modulating STAT3-dependent pathway.
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Inducing secondary structural interplays between scallop muscle proteins and soy proteins to form soluble composites

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Food Funct., 2020, 11,3351-3360
DOI: 10.1039/C9FO03106E, Paper
Chao Wu, Jiamei Wang, Xiaokang Na, Zhenyu Wang, Xianbing Xu, Tao Wang
Scallop muscle proteins and soya proteins were packed into a composite with tunable internal, molecular arrangements of the secondary structures.
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Quantifying dietary vitamin K and its link to cardiovascular health: a narrative review

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Food Funct., 2020, 11,2826-2837
DOI: 10.1039/C9FO02321F, Review Article
Claire R. Palmer, Lauren C. Blekkenhorst, Joshua R. Lewis, Natalie C. Ward, Carl J. Schultz, Jonathan M. Hodgson, Kevin D. Croft, Marc Sim
Potential beneficial pathways by which vitamin K may reduce the risk of cardiovascular disease mortality.
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Colonization and immunoregulation of Lactobacillus plantarum BF_15, a novel probiotic strain from the feces of breast-fed infants

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Food Funct., 2020, 11,3156-3166
DOI: 10.1039/C9FO02745A, Paper
Na Zhang, Chen Li, Zhihua Niu, Hongyan Kang, Miaoshu Wang, Bo Zhang, Hongtao Tian
Immunosuppression is a manifestation imbalance in the immune system, often during unhealthy states.
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Protocatechuic acid and quercetin glucosides in onions attenuate changes induced by high fat diet in rats

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Food Funct., 2020, 11,3585-3597
DOI: 10.1039/C9FO02633A, Paper
Katarzyna Grzelak-Błaszczyk, Joanna Milala, Krzysztof Kołodziejczyk, Michał Sójka, Andrzej Czarnecki, Monika Kosmala, Robert Klewicki, Bartosz Fotschki, Adam Jurgoński, Jerzy Juśkiewicz
Yellow onion waste from industrial peeling was used to obtain three pure preparations: protocatechuic acid (PA), quercetin diglycosides (QD) and quercetin monoglycosides (QM).
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Integrated anti-hyperlipidemic bioactivity of whole Citrus grandis [L.] osbeck fruits—multi-action mechanism evidenced using animal and cell models

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Food Funct., 2020, 11,2978-2996
DOI: 10.1039/C9FO02290B, Paper
Li-Yun Lin, Boa-Chan Huang, Kuan-Chou Chen, Robert Y. Peng
Multi- antihyperlipidemic mechanism revealed by the pomelo phytonutrients. Both the sterol synthesis and lipogenesis pathways are affected by the pomelo phytonutrients. Dotted line: from citation. Solid line: verified in this experiment.
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Proteomic landscape of liver tissue in old male mice that are long-term treated with polysaccharides from Sargassum fusiforme

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Food Funct., 2020, 11,3632-3644
DOI: 10.1039/D0FO00187B, Paper
Peichao Chen, Ya Zhang, Man Xu, Hongjun Chen, Huixi Zou, Xu Zhang, Haibin Tong, Cuiping You, Mingjiang Wu
The polysaccharides extracted from Sargassum fusiforme delays the aging process via mitochondria-associated anti-oxidation.
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Chronic flavanol-rich cocoa powder supplementation reduces body fat mass in endurance athletes by modifying the follistatin/myostatin ratio and leptin levels

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Food Funct., 2020, 11,3441-3450
DOI: 10.1039/D0FO00246A, Paper
Jose Ángel García-Merino, Diego Moreno-Pérez, Beatriz de Lucas, Maria Gregoria Montalvo-Lominchar, Elsa Muñoz, Lara Sánchez, Fernando Naclerio, Karen Marlene Herrera-Rocha, Martha Rocío Moreno-Jiménez, Nuria Elisabeth Rocha-Guzmán, Mar Larrosa
Flavanols-rich cocoa reduced body fat composition in athletes through modulation of follistatin and leptin levels.
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The effect of culinary doses of spices in a high-saturated fat, high-carbohydrate meal on postprandial lipemia and endothelial function: a randomized, controlled, crossover pilot trial

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Food Funct., 2020, 11,3191-3200
DOI: 10.1039/C9FO02438G, Paper
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Kristina S. Petersen, Connie J. Rogers, Sheila G. West, David N. Proctor, Penny M. Kris-Etherton
Lower doses of spices (2 and 6 g) than previously tested may attenuate postprandial lipemia and impairments in endothelial function caused by a high-saturated fat, high-carbohydrate meal.
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Addition of flavonols and polysaccharides as excipient ingredients into epicatechin rich green tea extract inhibited free radical formation and glucose uptake

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Food Funct., 2020, 11,3105-3111
DOI: 10.1039/C9FO03020D, Paper
So-Hee Yoo, Yeong-Eun Lee, Jin-Oh Chung, Chan-Su Rha, Yong-Deog Hong, Mi-Young Park, Soon-Mi Shim
Results from the current study suggested that whole green tea components rich in flavonols and polysaccharides could be potential hypoglycemic excipient ingredients into green tea catechins by enhancing catechin absorption.
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Whole-wheat flour particle size influences dough properties, bread structure and in vitro starch digestibility

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Food Funct., 2020, 11,3610-3620
DOI: 10.1039/C9FO02587A, Paper
Suyun Lin, Jing Gao, Xiaoxuan Jin, Yong Wang, Zhizhong Dong, Jian Ying, Weibiao Zhou
Whole-wheat flour (WWF) particle size is critical to dough properties, bread quality, and in vitro starch digestibility of bread.
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Impact of functional foods and nutraceuticals on high blood pressure with a special focus on meta-analysis: review from a public health perspective

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Food Funct., 2020, 11,2792-2804
DOI: 10.1039/D0FO00357C, Review Article
Kamesh Venkatakrishnan, Hui-Fang Chiu, Chin-Kun Wang
In recent times many researchers are expressing immense interest in nutraceuticals and functional foods for combating various diseases or abnormal conditions, especially against hypertension (HT).
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cis 9, trans 11, but not trans 10, cis 12 CLA isomer, impairs intestinal epithelial barrier function in IPEC-J2 cells and mice through activation of GPR120-[Ca2+]i and the MLCK signaling pathway

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Food Funct., 2020, 11,3657-3667
DOI: 10.1039/D0FO00376J, Paper
Han Su, Weijie Zhao, Fenglin Zhang, Min Song, Fangfang Liu, Jisong Zheng, Mingfa Ling, Xiaohua Yang, Qiang Yang, Haiwen He, Lin Chen, Xumin Lai, Xiaotong Zhu, Lina Wang, Ping Gao, Gang Shu, Qingyan Jiang, Songbo Wang
In vitro and in vivo studies show that c9, t11-CLA, but not t10, c12-CLA isomer, impairs intestinal epithelial barrier function in IPEC-J2 cells and mice via activation of GPR120-[Ca2+]i and the MLCK pathway.
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Cloning, expression and comparison of the properties of Scy p 9, a Scylla paramamosain allergen

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Food Funct., 2020, 11,3006-3019
DOI: 10.1039/D0FO00004C, Paper
Xin-Rong He, Yi-Meng Cheng, Yang Yang, Jie-Jing Xie, Ka-Hou Chu, Yong-Xia Zhang, Gui-Xia Chen, Hong Liu, Min-Jie Cao, Guang-Ming Liu
This study investigated the properties of Scy p 9 in mud crab (Scylla paramamosain).
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Black mulberry ethanol extract attenuates atherosclerosis-related inflammatory factors and downregulates PPARγ and CD36 genes in experimental atherosclerotic rats

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Food Funct., 2020, 11,2997-3005
DOI: 10.1039/C9FO02736J, Paper
Yun-Guo Liu, Jia-Li Yan, Yan-Qing Ji, Wen-Jing Nie, Yan Jiang
Atherosclerosis (AS) is the pathological basis of various vascular diseases and currently is seriously affecting human health.
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The impact of oligosaccharide content, glycosidic linkages and lactose content of galacto-oligosaccharides (GOS) on the expression of mucus-related genes in goblet cells

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Food Funct., 2020, 11,3506-3515
DOI: 10.1039/D0FO00064G, Paper
Susana Figueroa-Lozano, Chengcheng Ren, Huifang Yin, Hien Pham, Sander van Leeuwen, Lubbert Dijkhuizen, Paul de Vos
Galacto-oligosaccharides (GOS) are molecules known to impact goblet cell function and mucus composition. Our results show that their molecular structure have a direct effect on goblet cells and impact mucus synthesis-related genes.
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Molecular mechanisms of selenium-biofortified soybean protein and polyphenol conjugates in protecting mouse skin damaged by UV-B

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Food Funct., 2020, 11,3563-3573
DOI: 10.1039/C9FO02560J, Paper
Xing Zhang, Hui He, Tao Hou
A new selenium-biofortified protein and polyphenol conjugate with high antioxidant activity and stability for the treatment of photooxidation-related diseases.
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Correction: 5-Heptadecylresorcinol attenuates oxidative damage and mitochondria-mediated apoptosis through activation of the SIRT3/FOXO3a signaling pathway in neurocytes

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Food Funct., 2020, 11,3749-3749
DOI: 10.1039/D0FO90012E, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Jie Liu, Yu Wang, Yiming Hao, Zongwei Wang, Zihui Yang, Ziyuan Wang, Jing Wang
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Lycium barbarum polysaccharides ameliorate intestinal barrier dysfunction and inflammation through the MLCK-MLC signaling pathway in Caco-2 cells

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Food Funct., 2020, 11,3741-3748
DOI: 10.1039/D0FO00030B, Paper
Wei Li, Mingbo Gao, Ting Han
Impairment of the intestinal barrier often occurs in inflammatory bowel diseases, and pro-inflammatory factors play a vital role in the pathogenesis of intestinal diseases.
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Cherry stem infusions: antioxidant potential and phenolic profile by UHPLC-ESI-QTOF-MS

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Food Funct., 2020, 11,3471-3482
DOI: 10.1039/C9FO02693B, Paper
Juliana Peixoto, Gerardo Álvarez-Rivera, Rita C. Alves, Anabela S. G. Costa, Nelson Andrade, Andreia Moreira, Alejandro Cifuentes, Fátima Martel, M. Beatriz P. P. Oliveira, Elena Ibáñez
This study highlights not only the antioxidant potential of cherry stem infusion but also the need to globally harmonize the control and regulation of herbal products.
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Correction: Matrix-mediated distribution of 4-hydroxy-2-hexanal (nonenal) during deep-frying of chicken breast and potato sticks in vegetable oil

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Food Funct., 2020, 11,3750-3750
DOI: 10.1039/D0FO90018D, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Lukai Ma, Guoqin Liu, Weiwei Cheng, Xinqi Liu, Huifan Liu, Qin Wang
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Dietary intakes of flavonoids and carotenoids and the risk of developing an unhealthy metabolic phenotype

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Food Funct., 2020, 11,3451-3458
DOI: 10.1039/C9FO02852H, Paper
Nazanin Moslehi, Mahdieh Golzarand, Farhad Hosseinpanah, Parvin Mirmiran, Fereidoun Azizi
This study was designed to investigate prospective associations between dietary habitual intakes of flavonoids and carotenoids and the development of an unhealthy metabolic phenotype separately in normal-weight and excess weight individuals.
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Hot-water extract of ripened Pu-erh tea attenuates DSS-induced colitis through modulation of the NF-κB and HIF-1α signaling pathways in mice

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Food Funct., 2020, 11,3459-3470
DOI: 10.1039/C9FO02803J, Paper
Yina Huang, Liang Qiu, Xuan Mi, Zhihong Zhang, Di Xu, Xueying Tao, Keyu Xing, Qinglong Wu, Hua Wei
There was lots of information on anti-obesity and reduced risk of cardiovascular disease, to our best knowledge, little was known about the prevention of colitis by RPT. We firstly assessed effects of RPT on phenotypic improvements of DSS-induced colitis in mice.
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Inflammation and cardiovascular disease: are marine phospholipids the answer?

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Food Funct., 2020, 11,2861-2885
DOI: 10.1039/C9FO01742A, Review Article
Ronan Lordan, Shane Redfern, Alexandros Tsoupras, Ioannis Zabetakis
This review presents the latest research on the cardioprotective effects of n-3 fatty acids (FA) and n-3 FA bound to polar lipids (PL). Overall, n-3 PL may have enhanced bioavailability and potentially bioactivity versus free FA and ester forms of n-3 FA.
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Potential neurotoxicity of 5-hydroxymethylfurfural and its oligomers: widespread substances in carbohydrate-containing foods

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Food Funct., 2020, Advance Article
DOI: 10.1039/C9FO02526J, Paper
Cheng Wang, Zhenru Liu, Tian Hu, Youjia Li, Rui Liu, Junjie Zhang, Huaizhen He
5-Hydroxymethylfurfural (5-HMF) and its acid-catalyzed oligomers can inhibit nerve cell proliferation and induce neurological deficits at near or below the reported 24 h dietary intake of 5-HMF in humans.
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Alleviating effects of noni fruit polysaccharide on hepatic oxidative stress and inflammation in rats under a high-fat diet and its possible mechanisms

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Food Funct., 2020, 11,2953-2968
DOI: 10.1039/D0FO00178C, Paper
Xiaobing Yang, Wenjing Mo, Chuanjin Zheng, Wenzhi Li, Jian Tang, Xiaoyong Wu
Non-alcoholic fatty liver disease is associated with gut microbiota, oxidative stress, and inflammation.
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Ergosterol peroxide from Pleurotus ferulae inhibits gastrointestinal tumor cell growth through induction of apoptosis via reactive oxygen species and endoplasmic reticulum stress

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Food Funct., 2020, Advance Article
DOI: 10.1039/C9FO02454A, Paper
Yi Yang, Xiaoyu Luo, Mayila Yasheng, Jun Zhao, Jinyu Li, Jinyao Li
Ergosterol peroxide was purified from Pleurotus ferulae by silica gel chromatography, Sephadex LH-20 chromatography and recrystallization and named as PFEP, which was identified by ESI-MS and NMR.
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Flavonoids isolated from loquat (Eriobotrya japonica) leaves inhibit oxidative stress and inflammation induced by cigarette smoke in COPD mice: the role of TRPV1 signaling pathways

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Food Funct., 2020, 11,3516-3526
DOI: 10.1039/C9FO02921D, Paper
Tunyu Jian, Jian Chen, Xiaoqin Ding, Han Lv, Jiawei Li, Yuexian Wu, Bingru Ren, Bei Tong, Yuanyuan Zuo, Kelei Su, Weilin Li
Total flavonoids isolated from loquat leaves inhibit inflammation and oxidative stress by regulating TRPV1 and the related pathway in cigarette smoke-induced COPD mice.
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The development of lentil derived protein–iron complexes and their effects on iron deficiency anemia in vitro

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Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00384K, Paper
Ezgi Evcan, Sukru Gulec
Lentil derived proteins have the capacity to chelate iron minerals and hydrolysed protein–iron complexes have functional properties on iron deficiency anemia in in vitro by influencing mRNA levels of iron regulating genes.
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A rapid protocol to distinguish between Citri Exocarpium Rubrum and Citri Reticulatae Pericarpium based on the characteristic fingerprint and UHPLC-Q-TOF MS methods

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Food Funct., 2020, 11,3719-3729
DOI: 10.1039/D0FO00082E, Paper
Liqiang Shi, Rongjin Wang, Tianshu Liu, Jiajie Wu, Hongxu Zhang, Zhiqiang Liu, Shu Liu, Zhongying Liu
Citri Exocarpium Rubrum and Citri Reticulatae Pericarpium were successfully distinguished by the characteristic fingerprint and UHPLC-Q-TOF MS methods.
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Kaempferol modulates TCDD- and t-BHQ-induced drug-metabolizing enzymes and luteolin enhances this effect

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Food Funct., 2020, 11,3668-3680
DOI: 10.1039/C9FO02951F, Paper
Tomoya Kitakaze, Atsushi Makiyama, Rika Nakai, Yuki Kimura, Hitoshi Ashida
Co-treatment with kaempferol and luteolin inhibits AhR- and Nrf2-induced expression of drug-metabolizing enzymes.
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Correction: Efficacy of proprietary Lactobacillus casei for anti-tuberculosis associated gastrointestinal adverse reactions in adult patients: a randomized, open-label, dose–response trial

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Published On ::

Food Funct., 2020, 11,3751-3751
DOI: 10.1039/D0FO90017F, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Song Lin, Shanliang Zhao, Jiahong Liu, Jianwen Zhang, Chao Zhang, Haibo Hao, Yuxia Sun, Jing Cai, Yang Yang, Yan Ma, Yuanyuan Li, Jinyu Wang, Aiguo Ma
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The purification, structural characterization and antidiabetic activity of a polysaccharide from Anoectochilus roxburghii

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Food Funct., 2020, 11,3730-3740
DOI: 10.1039/C9FO00860H, Paper
Yuntao Liu, Tingting Tang, Songqi Duan, Cheng Li, Qinlu Lin, Hejun Wu, Aiping Liu, Bin Hu, Dingtao Wu, Suqing Li, Li Shen, Wenjuan Wu
Anoectochilus roxburghii, a traditional Chinese medicinal herb, has been widely used for treating numerous chronic diseases.
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Usage of supercritical fluid techniques to obtain bioactive alkaloid-rich extracts from cherimoya peel and leaves: extract profiles and their correlation with antioxidant properties and acetylcholinesterase and α-glucosidase inhibitory activities

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Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00342E, Paper
Oscar Galarce-Bustos, Mª Teresa Fernández-Ponce, Antonio Montes, Clara Pereyra, Lourdes Casas, Casimiro Mantell, Mario Aranda
The wastes generated by cherimoya cultivation and processing industries should be contemplated as a valuable source of bioactive alkaloids, with potential in pharmaceutical applications for the treatment or prevention of chronic diseases.
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Comparison of the effects of resveratrol and its derivative pterostilbene on hepatic oxidative stress and mitochondrial dysfunction in piglets challenged with diquat

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Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00732C, Paper
Hao Zhang, Yanan Chen, Yueping Chen, Peilu Jia, Shuli Ji, Jianxiong Xu, Yue Li, Tian Wang
Pterostilbene is more effective than resveratrol in alleviating liver injury, facilitating redox status, and improving mitochondrial function of piglets.
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Bergaptol from blossoms of Citrus aurantium L. var. amara Engl inhibits LPS-induced inflammatory responses and ox-LDL-induced lipid deposition

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Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/C9FO00255C, Paper
Chun-Yan Shen, Tian-Xing Wang, Jian-Guo Jiang, Chun-Ling Huang, Wei Zhu
Aberrant activation of inflammation and excess accumulation of lipids play pivotal roles in atherosclerosis (AS) progression. Constituents from Citrus aurantium Linn variant amara Engl (CAVA) were effectively investigated for their...
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Targets and Underlying Mechanisms for Sedative and Hypnotic Activities of Saponins from Semen Ziziphus jujube

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Food Funct., 2020, Accepted Manuscript
DOI: 10.1039/D0FO00098A, Paper
Chun-Yan Shen, Lin Wan, Jing-Jing Zhu, Jian-Guo Jiang
Semen Ziziphus jujube (SZJ) has been widely consumed as edible resources in China to treat insomnia disorders. However, the underlying mechanisms and potential therapeutic targets remained obscure. SZJ-I and SZJ-II...
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Tomato seed oil attenuates hyperlipidemia and modulates gut microbiota in C57BL/6J mice

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Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00133C, Paper
Wen-Sen He, Lingling Li, Jiaxin Rui, Junjie Li, Yuying Sun, Dandan Cui, Bin Xu
TSO can significantly improve fatty acid metabolism and cholesterol metabolism, thereby inhibiting obesity and hypercholesterolemia. TSO can favorably modulate the gut microbiota.
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Red ginseng protects against cisplatin-induced intestinal toxicity by inhibiting apoptosis and autophagy via the PI3K/AKT and MAPK signaling pathways

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Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00469C, Paper
Jun-jie Zhang, Jian-qiang Wang, Xing-yue Xu, Jia-yu Yang, Zi Wang, Shuang Jiang, Ying-ping Wang, Jing Zhang, Rui Zhang, Wei Li
Although growing evidence has shown that ginseng (Panax ginseng C.A. Meyer.) exerts strong protective and preventive effects on cisplatin-induced side effects, the ameliorative effects of ginseng on intestinal damage caused by cisplatin are unknown to date.
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Effects of a β-type glycosidic polysaccharide from Flammulina velutipes on anti-inflammation and gut microbiota modulation in colitis mice

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Food Funct., 2020, Advance Article
DOI: 10.1039/C9FO03017D, Paper
Ruiqiu Zhao, Yang Ji, Xin Chen, Anxiang Su, Gaoxing Ma, Guitang Chen, Qiuhui Hu, Liyan Zhao
Using the Flammulina velutipes polysaccharide (FVP) extracted from our previous study, herein, we investigated the improvement of this β-type glycosidic polysaccharide in alleviating dextran sodium sulfate-induced ulcerative colitis (UC) in mice.
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Effects of polysaccharides from wild morels on immune response and gut microbiota composition in non-treated and cyclophosphamide-treated mice

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Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00597E, Paper
Wenyan Huo, Zhengping Feng, Suying Hu, Langjun Cui, Ting Qiao, Lu Dai, Peng Qi, Liguang Zhang, Yu Liu, Junzhi Li
Polysaccharides from wild morels alter gut microbiota, increase the production of SCFAs and promote the proliferation of lymphocytes in mice.
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Superior hypoglycemic activity of mulberry lacking monosaccharides is accompanied by better activation of the PI3K/Akt and AMPK signaling pathways

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Food Funct., 2020, Advance Article
DOI: 10.1039/D0FO00427H, Paper
Xiao-Shan Long, Sen-Tai Liao, Peng Wen, Yu-Xiao Zou, Fan Liu, Wei-Zhi Shen, Teng-Gen Hu
Mulberry removed monosaccharides (FM) displayed better hypoglycemic activity than untreated mulberry (MP), which may be attributed the stronger effects of FM on activating PI3K/Akt and AMPK signaling pathways.
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