Whether mutations in cancer driver genes directly affect cancer immune phenotype and T cell immunity remains a standing question. ARID1A is a core member of the polymorphic BRG/BRM-associated factor chromatin remodeling complex. ARID1A mutations occur in human cancers and drive cancer development. Here, we studied the molecular, cellular, and clinical impact of ARID1A aberrations on cancer immunity. We demonstrated that ARID1A aberrations resulted in limited chromatin accessibility to IFN-responsive genes, impaired IFN gene expression, anemic T cell tumor infiltration, poor tumor immunity, and shortened host survival in many human cancer histologies and in murine cancer models. Impaired IFN signaling was associated with poor immunotherapy response. Mechanistically, ARID1A interacted with EZH2 via its carboxyl terminal and antagonized EZH2-mediated IFN responsiveness. Thus, the interaction between ARID1A and EZH2 defines cancer IFN responsiveness and immune evasion. Our work indicates that cancer epigenetic driver mutations can shape cancer immune phenotype and immunotherapy.

This isn’t in the photos, but it’s foggy and cold this morning in western Washington. It’s the weirdest summer I’ve ever experienced — foggy, frigid mornings, cool days, and then freezing nights! It’s not very pleasant for a desert creature like myself, but it’s quite nice to sit inside and write in my blog a least. I have to say, it sure is weird, though. It’s August and I wear a sweater or sweatshirt most of the time and then I’m still cold! ^^; There are a few sunny days here and there, though. I get out on those days, into the wilderness and bright blue beyond. Sometimes, I just drive and drive in my still-unnamed yellow bug, and other times I find something that not a lot of people know about. This is about one of them. ^^ I love to wander, to find all of the nooks and crannies of wherever I happen to be. Tourist sites? Well, they’re usually cool and I want to see them, but it’s the little, hidden things off the beaten trail that really get my soul revving. So, Johns River (no apostrophe, it was named back when apostrophes weren’t used on maps) was one of those things. I found out about it by googling and googling, thinking that someone, somewhere, must have written about something other than the two really traveled trails in Grays Harbor. I mean, this area is the gateway to the wild peninsula of Washington, where according to Stephanie Meyer and Patricia Briggs, vampires and werewolves run wild. I also loooooooove mountain meadows. Johns river is not in the mountains, so I suppose that it mostly qualifies as grassland surrounded by trees? It’s just a little concrete path, and it’s not even a mile (0.6 miles one way) long, but with the river on one side and a huge expanse of pasture to the other side, it took my breath away.   Just look at this. Elk supposedly graze around here a lot, and I didn’t see any since I went during midday, but I bet it’s really a sight at sunset. It’s not far, so I will definitely have to come back. Can’t you just imagine little river sprites lounging on the bank, cleaning themselves? And little fairies flitting through the air? I bet this is a really magical place at sunset.   The little shack in the distance is off the trail. It’s supposedly for hunters (YUCK) and photographers. It would make a wonderful place to watch the sprites from. This shack is at the very end of the trail, and the same thing. It’s boring inside. I didn’t see any geldings, but I saw a few mosquitoes and a spider. If you’re lucky enough to have a horse that loves to take you along on its adventures, you can continue. I was wearing shorts, so I didn’t go, because ticks! But I will come back. Yes, I will come back. :3 Road to nowhere. Ignore the buildings. They’re only there for magical curse removal. Here’s a panorama of wildness. I’m feeling really magical today, can’t you tell? I think it’s because I have Daniel Waples playing in the background, and it’s all foggy outside. That reminds me that I want a handpan so badly. I need to find a handpan that I can afford soooooo badly, because I think it’s a music that speaks to my inner essence. Does anyone know what these gorgeous purple flowers are? They’re not lavender. The River People watch over this creek. Be careful to please them. It’s me. Sometimes I wear bright colors, sometimes I wear pastels. I don’t think that a magical being has to stick to  neutrals. (That hand thing is a shaka, a very cool gesture that I learned during my time in Hawaii that means “hang loose.” I like to think that it also means that you should be yourself and follow your instincts.) I think that I’ll go research handpans again. I should write down how much they cost so that I can be sure to stock my Airstream with one when I get it. ???? Here’s to the future! Excelsior! (Is that a good “to infinity, and beyond!!” kind of quote? If not, what should I use instead? I feel like “banzai!” is overused) Oh, and I’ve been arting on my Tumblr lately. I’ve been writing a serial ficiton that is mysterious connected to my soon-to-come comic, Denkiki on my other tumblr. Go check them out!  I’m going to start using my mailing list soon, too, to keep people updated, so stay tuned and I’ll post the link soon! Or make it a popup, I’m not sure. But I want to offer something cool for when people sign up. ???? Chaoness!

IBM Australia (NYSE: IBM) and The Sauce, today published the first Australian BPO Report 2012 (ABPO Report), which investigates the current state of business process outsourcing in Australia and points to future trends. Global expansion is seen to be the key driver and benefit of outsourcing decisions amongst 71 percent of organisations surveyed. The report also showed significant anticipated growth in business process outsourcing activity among large organisations with between 1,000 to 5,000 employees (this constituted one-third of all respondents). This group of Australian organisations is expecting an increase of 20 percent over the next two years.

Continued from Day Four. (From the beginning.) On Friday we packed all of our stuff back up and headed out.  We were barely out of the resort when: This tire is flat. Apparently all that gravel out to Horne Lake Caves the day before also included a small screw.  We limped around the corner to … Continue reading Summer Horrification — Day Five — Englishman River and Rathtrevor

Seattle, WA - The U.S. Environmental Protection Agency has settled two federal Clean Water Act cases with Coleman Oil Company, LLC, located in Lewiston, Idaho, owner and operator of a former oil bulk terminal in Wenatchee, Washington, adjacent to the Columbia River.

Hi AllWell with the weather being so beautiful at the minute we decided to go to the Yellow River yesterday. It's only 20 km north of the city. So we hopped onto a bus which was stuffed to the gills seriously the driver could only just shut the doors

Gov. Cuomo is down with Robert De Niro portraying him in a movie about the coronavirus pandemic, should there be one, and he also took a moment to play the role of the Manhattan-born actor.

The victim, believed to be in her 40s, was hit at the intersection of Atlantic Ave. and Pennsylvania Ave. in East New York about 4:30 a.m., cops said.

The on-duty driver was heading south on Flatbush Ave. near Avenue R in Marine Park around 6 p.m. when he lost control of his truck, said police.

A driver abandoned his wrecked vehicle and left one of his passengers to die after a drunken off-duty cop in a muscle car t-boned his vehicle in Brooklyn early Sunday, police said. NYPD Officer Rohan Shaw was driving a white 2019 Nissan GT-R, zooming east on Foster Ave. just before 5 a.m., when a black 2016 Mazda 6 rolled through a stop sign on E. 55th St. and right into the cop’s path, police said.

The 8:15 a.m. crash at Pennsylvania and Blake Aves. in East New York happened just paces from three neighborhood schools and about two miles from where a 10-year-old girl was fatally struck by a school bus Tuesday, officials said.

More than 200 mourners filed into the Love Fellowship Tabernacle church in East New York Thursday night for Payson Lott’s wake and funeral. The youngster was struck and killed by an unlicensed driver as he crossed a street in his neighborhood.

Two thousand workers from the Amalgamated Transit Union’s Local 1181 voted overwhelmingly to authorize the strike against their employer, which operates about 900 of the city’s more than 8,000 school bus routes.

A fomer-long haul truck driver behind bars for allegedly killing three women in Tennessee and Wyoming in the 1990s is now being investigated for any ties he may have to other cold murder cases, police said.

Gov. Cuomo is down with Robert De Niro portraying him in a movie about the coronavirus pandemic, should there be one, and he also took a moment to play the role of the Manhattan-born actor.

The NYPD will limit entry at Hudson River Park Piers 45 and 46 in Manhattan and Domino Park in Williamsburg to ensure social distancing during coronavirus.

When Clippers coach Doc Rivers watches Kawhi Leonard, he sees hallmarks of other prolific scorers he has coached.

Clippers coach Doc Rivers checks in daily with players and reminds them of their championship goal and not to use hiatus as a reason they can't win.

Clippers coach Doc Rivers spent time Thursday speaking to Rams players and answering questions about winning through teamwork.

C’mon folks. You’re getting to your destinations faster than ever with less than half the traffic on the road so why speed? Yet many of you (not my readers, of course, so pass this onto your friends and acquaintances) are doing so putting all of us at risk.

Gov. Cuomo is down with Robert De Niro portraying him in a movie about the coronavirus pandemic, should there be one, and he also took a moment to play the role of the Manhattan-born actor.

Gov. Cuomo is down with Robert De Niro portraying him in a movie about the coronavirus pandemic, should there be one, and he also took a moment to play the role of the Manhattan-born actor.

A fomer-long haul truck driver behind bars for allegedly killing three women in Tennessee and Wyoming in the 1990s is now being investigated for any ties he may have to other cold murder cases, police said.

The NYPD will limit entry at Hudson River Park Piers 45 and 46 in Manhattan and Domino Park in Williamsburg to ensure social distancing during coronavirus.

New Indianapolis Colts quarterback Philip Rivers has his post-NFL life figured out already.

A local poet and lifelong environmental activist, MacAdams dedicated his life to restoring the Los Angeles River.

"Riverdale" captures the aesthetic of John Cameron Mitchell's "Hedwig and the Angry Inch." Whether the musical's queer politics are intact is another matter.

The author of "We Need to Talk About Kevin" lives that perfect, self-improving quarantine life (or maybe gets drunk and watches British reality TV).

House shopping during the coronavirus quarantine? Here are $500,000 homes with virtual tours in La Quinta, Temecula and Riverside in Riverside County.

Former Chargers quarterback Philip Rivers, who signed with the Indianapolis Colts this offseason, has listed his longtime home in San Diego for sale at $4.199 million.

Longtime Chargers QB Philip Rivers has put his San Diego home up for sale. Kylie Jenner buys in Bel-Air. OneRepublic's Brent Kutzle lists in Topanga.

It was an extraordinary vote of confidence for autonomous driving by the nation's top vehicle safety agency.

In 2017, 939 people were killed by vehicles running red lights, according to AAA. The numbers are rising at a far higher rate than overall U.S. highway fatalities.

With Tesla's Smart Summon feature, the car drives itself to its human owner. It's already being abused, raising public safety questions.

Transportation Secretary Elaine Chao says safety is the top priority for robot cars – but so is intellectual property.

FLUFFY bedding, bowls of treats and a dog shammy awaited our Labrador, Tehya, when we rolled up at Dominoes holiday home in Stoke Gabriel, South Devon - and it wasn't too shabby for Tehya's two-legged friends either, having been luxuriously refurbished just a couple of years ago.

IndyCar driver Zach Veach and a 1909 car are making a guest appearance during the Indianapolis Opera's production of "Elixir of Love."

Motorists crossing the soon-to-b-built Nickel Plate Train will face a safety feature drivers crossing the Monon Trail don't encounter: speed tables

Since 1998, the city of Carmel has spent more than $250 million to build 126 roundabouts in the city. But data doesn't prove safety claims.

Kyle Larson's derogatory comments, which appeared meant for a private channel, went public Sunday night, and he's been suspended by his team and the series.

When Rahal bought the estate in November of 2017 for $6.1 million, it was the most expensive home ever sold in the city.

McLaren Formula 1 driver Lando Norris becomes the latest special guest driver in IndyCar's iRacing Challenge.

In his first dip into the IndyCar world, McLaren Formula 1 driver Lando Norris beat series regulars at Circuit of the Americas.

Get a glimpse of the IndyCar liveries for the 2020 racing season.

Here are the IndyCar Series drivers, with their age, experience anticipated schedule for 2020 and Indianapolis 500 results

When the Chargers legend isn't carrying a team on his back, Rivers has been far more efficient.

How important are counting stats for quarterbacks? How important is winning in the postseason? Those are the questions about Rivers.