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Cyclization reactions of 1,6-dienes and 1,6-enynes by dual cobalt photocatalysis

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00311J, Research Article
Pei-Ting Li, Zi-Fa Shi, Wei Yu
Two triphenylamine-derived organophotocatalysts were developed. Their photocatalytic capacity was exploited to enable the [CoIII]-H-mediated cycloisomerization of 1,6-dienes and reductive cyclization of 1,6-enynes under visible light irradiation.
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Iodine-catalyzed intermolecular 1,2-thio (seleno)amination of alkenes with 1,2,3-triazoles and disulfides (diselenides) in air

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00246F, Research Article
Jian Ji, Xuwen Chen, Zongjing Hu, Cong Guan, Jinhua Liu, Yaqi Deng, Shunying Liu
Iodine-catalyzed 1,2-thio (seleno)amination of alkenes via direct N- and C-centered radical cross-coupling was established to elicit highly regioselective β-triazolized thioalkyl compounds.
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Spiro-centre substitution effects in the intramolecular spin–spin interactions of spirobiacridine diradicals

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00419A, Research Article
Open Access
Shinichi Ogawa, Takuya Kanetomo, Masaya Enomoto
Spirodiradicals with the Si and Ge spiro atoms exhibit a S = 1 state. The magnetic interaction in the Si derivative was found to be lower than that in the Ge derivative, implying a negative effect on σ*(Si–Cα)–π* hyperconjugation.
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Three-component Friedel–Crafts-type difunctionalization of ynamides with (hetero)arenes and iodine(III) electrophile

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00489B, Research Article
Open Access
Jun Kikuchi, Toya Nagata, Shingo Ito, Naohiko Yoshikai
A three-component Friedel–Crafts type difunctionalization of ynamides with an iodine(III) electrophile and electron-rich (hetero)arenes has been developed, enabling regio- and stereoselective synthesis of densely functionalized enamides.
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Correction: Stereodivergent and enantioselective total syntheses of isochaetominines A–C and four pairs of isochaetominine C enantiomers: a six-step approach

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO90034K, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Zhong-Yi Mao, Hui Geng, Tian-Tian Zhang, Yuan-Ping Ruan, Jian-Liang Ye, Pei-Qiang Huang
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Visible-light-mediated catalyst-free synthesis of trifluoromethyl(spiro)-epoxides bearing contiguous quaternary centers

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00184B, Research Article
Jingchuan Lin, Yu Zhang, Jinxin Wang, Xinyu Han, Shenglan Zhu, Tong Li, Yanping Zhu, Wei-Dong Zhang
Herein, we describe a non-covalent complex-mediated epoxidation strategy that can yield highly selective central spiro-epoxides by irradiation with visible light without the need for catalyst addition.
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Base-induced azofluoroalkylation of unactivated alkenes via halogen atom transfer

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Org. Chem. Front., 2024, 11,2161-2170
DOI: 10.1039/D3QO02114A, Research Article
Jing Zhang, Yanchuang Zhao, Yu-Yi Zhu, Peng Lei, Hanru Liu, Chang-Sheng Wang, Shuya Xing, Yong Liu, Shao-Fei Ni, Thomas Castanheiro, Li-Wen Xu, Xinxin Shao
A base-induced three-components coupling employing unactivated alkenes, fluoroalkyl iodides and diazonium salts under mild reaction conditions has been developed.
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Sulfamide instead of urea in Biginelli reaction: from black box to reality

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Org. Chem. Front., 2024, 11,2155-2160
DOI: 10.1039/D3QO01926H, Research Article
Alexander Yu. Lyapunov, Andriy V. Tarnovskiy, Sergey Yu. Boron, Eduard B. Rusanov, Galyna P. Grabchuk, Dmytro M. Volochnyuk, Serhiy V. Ryabukhin
The scope and limitations of the classical Biginelli reaction have been expanded to principally novel substrates: sulfamide and its monosubstituted analogues.
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Unprecedented single-electron-transfer reduction-based N → C acyl migration reactions of imides enabled by redox-neutral photocatalysis

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Org. Chem. Front., 2024, 11,2344-2350
DOI: 10.1039/D3QO01955A, Research Article
Linge Huai, Li Zhang, Zhentao Wang, Yewen Fang
N → C acyl migration: in the absence of a base, redox-neutral photocatalyzed acyl migration reactions have been realized via the reaction of N-vinylimides with alkyl radicals derived from alkyl silicates.
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Stereoselective skeletal modification of tryptanthrins to install chiral piperidine-2-ones enabled by Brønsted acid catalysis

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Org. Chem. Front., 2024, 11,2171-2177
DOI: 10.1039/D3QO02029K, Research Article
Rong Zeng, Xiang Zhang, Yuan-Yuan Lei, Zhuo-Zhuo Zhang, Min Jiang, Qing-Zhu Li, Jun-Long Li, Bo Han
An asymmetric formal [4 + 2] cyclisation between azlactones and aza-dienes derived from simple tryptanthrins has been developed. With this established protocol, yielding a series of novel piperidine-2-one-fused tryptanthrins with up to >99 : 1 er under mild conditions.
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Iron(III)/quinoxaline-derived N,N-ligand catalyzed oxygen transfer reaction of N-vinyl nitrones through selective 4π-electrocyclization and N–O bond cleavage

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Org. Chem. Front., 2024, 11,2277-2282
DOI: 10.1039/D3QO01999C, Research Article
Yan-Jiao Lu, Feng-Lan Lu, Jin-Qi Zhang, Chun-Hua Chen, Cui Liang, Xiao-Pan Ma, Dong-Liang Mo
We describe an iron(III)/quinoxaline-derived N,N-ligand promoted O-transfer reaction of N-vinyl nitrones through selective O-4π-electrocyclization and N–O bond cleavage to prepare a variety of 2,5-dihydrooxazoles in good yields.
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Synthesis of benzothiophenes via sulfonium-[3,3]-rearrangement of aryl sulfoxides with allenenitriles

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Org. Chem. Front., 2024, 11,2208-2214
DOI: 10.1039/D4QO00121D, Research Article
Lei Zhang, Kun Wan, Huanhuan Wang, Mengyao Wang, Ao Cui, Xin Huang, Bo Peng
A facile synthesis of benzothiophenes from readily available aryl sulfoxides and allenenitriles has been established through sulfonium-rearrangement triggered cyclization.
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Dynamic kinetic resolution of α-F-β-ketone amides (esters) via Ir/f-diaphos-catalyzed asymmetric hydrogenation

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Org. Chem. Front., 2024, 11,2201-2207
DOI: 10.1039/D4QO00125G, Research Article
Pengtao Yang, Dingguo Song, Lingxin Chen, Xianghua Zhao, Yirui Chen, Feiyang Shen, Fei Ling, Weihui Zhong
Highly reactive and highly stereoselective asymmetric hydrogenation of α-F-β-ketone amides (esters) via Ir/f-diaphos-catalyzed dynamic kinetic resolution is reported.
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Deoxygenation of N-heterocyclic N-oxides using isopropanol as a recyclable reductant

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Org. Chem. Front., 2024, 11,2249-2268
DOI: 10.1039/D4QO00208C, Research Article
Ho Kyeong Ryu, Yun Do Song, Jun Hee Lee
An organic photoredox-based recyclable strategy that facilitates the chemoselective deoxygenation of various functionalised N-heterocyclic N-oxides is presented.
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A formal (3 + 2) annulation–Cannizzaro cascade of bifunctional peroxides for the synthesis of dihydrofurans

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Org. Chem. Front., 2024, 11,2215-2219
DOI: 10.1039/D4QO00215F, Research Article
Yiwei Chen, Min Gao, Qianlan Xu, Jiumeng Zhang, Lin Hu
Tunable tandem processes of bifunctional peroxides allow the divergent construction of functionalized dihydrofurans and epoxides by simply changing the basic conditions.
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Synthesis of enantiopure 1,2,3-triazolylidene-type mesoionic carbene (MIC) conjugate acids featuring a rigid bicyclic scaffold

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Org. Chem. Front., 2024, 11,2178-2181
DOI: 10.1039/D4QO00269E, Research Article
Vojtěch Dočekal, Mohand Melaimi, Simona Petrželová, Jan Veselý, Xiaoyu Yan, Guy Bertrand
Chiral NHCs have found numerous applications as ligands for transition metals and in their own right for asymmetric catalysis. We report a synthetic route from L-malic acid to enantiopure 1,2,3-triazoliums with the chiral center in a fused ring.
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Iridium-catalyzed reductive γ-lactonization of ortho-acylbenzoic acids in water: sustainable access to phthalides

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Org. Chem. Front., 2024, 11,2220-2230
DOI: 10.1039/D3QO02019C, Research Article
Yang Chen, Jingyu Zhang, Hongguang Du, Renshi Luo, Jiaxi Xu, Zhanhui Yang
Iridium-catalyzed reductive γ-lactonization of ortho-acylbenzoic acids in water provides a practical and sustainable route to phthalides.
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Rhodium-catalyzed C–C bond alkenylation and arylation of α-branched N-sulfonyl amines

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Org. Chem. Front., 2024, 11,2182-2188
DOI: 10.1039/D3QO02140H, Research Article
Lun Xu, Yucheng Liu, Hang Shi, Lun Li
In this work, we described a rhodium-catalyzed C–C bond cleavage of α-branched amines via β-carbon elimination, then formed a five-membered rhodacycle intermediate, which can be captured by styrene(alkenylation) or silane(arylation).
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Electrode-switchable: exploring this new strategy to achieve regiodivergent azidoiodination of alkenes

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Org. Chem. Front., 2024, 11,2189-2194
DOI: 10.1039/D3QO01935G, Research Article
Xin-Lei Sun, Chen-Xi Xia, Yue Ren, Yu-Jin Li, Zhi-Qian Cao, Ling-Guo Meng
An “electrode-switchable” organic electrochemistry method for the azidoiodination of alkenes, where the choice of anode dictates the regiodivergent alkene azidoiodination, reveals a novel pathway for controlled regioisomers.
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Selective photochemical synthesis of primary arylamines and symmetric diarylamines via amination of aryl bromides using Ni(NH3)6Cl2 as a nitrogen source and catalyst

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Org. Chem. Front., 2024, 11,2313-2318
DOI: 10.1039/D4QO00116H, Research Article
Zhehui Xu, Jianyang Dong, Geyang Song, Fuqiang Kong, Gang Li, Dong Xue
The selective synthesis of primary arylamines and diarylamines via coupling reactions with ammonia as a nitrogen source is still challenging.
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Photo-induced catalyst-free formal carbon insertion of acylsilanes into B–B and B–Si bonds

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Org. Chem. Front., 2024, 11,2339-2343
DOI: 10.1039/D4QO00139G, Research Article
Xiongxiong Lu, Qingbin Zhao, Hao Zhang, Pan Xu, Xuenian Chen, Zhenxing Liu
A formal carbon insertion of acylsilanes into B–B and B–Si bonds has been developed. The in situ formed siloxycarbene under blue LED irradiation worked as the intermediate for the reaction. When 2-furyl and 2-thiophenyl acylsilanes were used, the B(pin) ring was enlarged to a six-membered ring.
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Origin of site-selectivity of hydrogen atom transfer in carbohydrate C–H alkylations via photoredox catalysis

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Org. Chem. Front., 2024, 11,2269-2276
DOI: 10.1039/D4QO00073K, Research Article
Yujie Ji, Lingfei Hu, Han Gao, Yan-Bo Wu, Xiangying Lv, Gang Lu
Two major factors, i.e., C–H σ orbital energy and C–H BDE, account for the HAT site-selectivity of carbohydrates with the quinuclidine radical cation.
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Fe-catalyzed B–H and Si–H insertion reactions of gem-dihaloalkanes

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Org. Chem. Front., 2024, 11,2241-2248
DOI: 10.1039/D4QO00136B, Research Article
Xinyu Wang, Zhaobin Wang
We present an approach involving Fe-catalyzed B–H and Si–H insertion of gem-dichloroalkanes. In contrast to previous strategies, our method uses gem-dihaloalkanes as non-stabilized carbene precursors and operates through a radical reaction pathway.
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Frustrated Lewis pair chemistry of alkynes

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Org. Chem. Front., 2024, 11,2375-2396
DOI: 10.1039/D4QO00217B, Review Article
Jing Guo, Maying Yan, Douglas W. Stephan
This review is focused on the chemistry of frustrated Lewis pairs (FLPs) with alkynes and surveys the range of stoichiometric and catalytic reactions enabled by this concept.
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A dearomatization–rearomatization strategy for construction of 4H-quinolizin-4-ones via C–H bond functionalization of pyridines

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Org. Chem. Front., 2024, 11,2319-2325
DOI: 10.1039/D3QO01990J, Research Article
Dong Qiu, Yijin Su
Herein, the synthesis of 4H-quinolizin-4-ones from N-(2-methoxy-2-oxoethyl) pyridinium salts and alkenes through dearomative cycloaddition and rearomative ring expansion has been developed.
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Regioselective electrochemical cascade C–H sulfonylation–bromination of indolizines to access difunctionalized indolizines

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Org. Chem. Front., 2024, 11,2306-2312
DOI: 10.1039/D4QO00035H, Research Article
Wenxuan Jiang, Xiang Liu, Chuanying Zhu, Meiyi Chen, Weidan Li, Hua Cao
Regioselective electrochemical C–H sulfonylation–bromination between indolizines, sodium sulfinates, and KBr has been established in an undivided cell, in which KBr serves as both the brominating agent and electrolyte.
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Photoinduced alkylation of pyrazolones via β-scission of unstrained aliphatic alcohol derivatives

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Org. Chem. Front., 2024, 11,2289-2296
DOI: 10.1039/D4QO00077C, Research Article
Xinxin Geng, Pan Tao, Yujun Li, Ke Zheng
An efficient radical approach was reported for the transformation of unstrained aliphatic alcohols through the β-scission of alkoxyl radicals.
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Nickel/photoredox-catalyzed carbonylative transformations of α-phosphorus-, α-sulfur-, and α-boron-substituted alkyl halides

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Org. Chem. Front., 2024, 11,2297-2305
DOI: 10.1039/D4QO00167B, Research Article
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Le-Cheng Wang, Xiao-Feng Wu
A novel dual nickel/photoredox catalyzed direct amino- and alkoxycarbonylation of α-heteroatom substituted organohalides has been developed.
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Prins cyclization of 1,3-dioxinone: synthesis of 11-epi-badkhysin

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Org. Chem. Front., 2024, 11,2332-2338
DOI: 10.1039/D4QO00162A, Research Article
Xiaoliang Xu, Ping Hua, Yiren Xu, Baoqing He, Jingfeng Zhao, Liang Li, Wen Chen, Hongbin Zhang
The asymmetric synthesis of highly functional 11-epi-badkhysin has been accomplished using a structure-unit based approach.
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Palladium-catalyzed asymmetric [4 + 3] cycloaddition of acyclic α,β-unsaturated imines with trimethylenemethane donors: access to chiral non-fused azepines

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Org. Chem. Front., 2024, 11,2326-2331
DOI: 10.1039/D4QO00064A, Research Article
Ting-Peng Li, Shuixiu Su, Jia-Huan Shen, Meng Zang, Yang-Zi Liu, Quannan Wang, Wei-Ping Deng
An efficient approach for the construction of non-fused azepines in good yields with high enantioselectivity via Pd-catalyzed asymmetric [4 + 3] cycloaddition was developed.
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Advancement in the C–H bond alkylation of (hetero)arenes catalyzed by the most abundant transition metal–iron

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Org. Chem. Front., 2024, 11,2397-2417
DOI: 10.1039/D4QO00063C, Review Article
Chandini Pradhan, Benudhar Punji
Advancement in the direct C–H bond alkylation of arenes and heteroarenes using the catalysts based on the most abundant transition metal, iron, is summarized.
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Catalytic intermolecular hydrofunctionalizations of ynamides

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Org. Chem. Front., 2024, 11,2351-2374
DOI: 10.1039/D4QO00301B, Review Article
Ying-Ying Zhao, Yu-Jing Jia, Yan-Cheng Hu
This review carefully summarizes the advances achieved in catalytic hydrofunctionalization of ynamides and is categorized by the bond formation type including C−C, C−X, C−O, C−N, C−S, C−P, C−Si, and C−Ge bonds.
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Correction: Cu-catalyzed arylation of S-tosyl peptides with arylboronic acids

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Org. Chem. Front., 2024, 11,2418-2418
DOI: 10.1039/D4QO90029D, Correction
Open Access
  This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
Junjie Ying, Jingrong Huang, Chenguang Liu, Fa-Jie Chen, Chunfa Xu, Fen-Er Chen
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NHC and photoredox catalysis dual-catalyzed 1,4-mono-/di-fluoromethylative acylation of 1,3-enynes

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00372A, Research Article
Jiuli Xia, Ruiyang Ma, Lihong Wang, Jiaqiong Sun, Guangfan Zheng, Qian Zhang
NHC and photocatalysis dual-catalyzed mono/difluoromethylative acylation of 1,3-enynes was realized, providing fluormethyl-substituted allenyl ketones. SO2 might play a critical role in achieving high reactivity and selectivity.
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Assembly of ionic supramolecular polymers using a decacationic pillar[5]arene to noncovalently crosslink hyaluronic acid for short DNA delivery

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00447G, Research Article
Qian Li, Danying Ma, Yue-Yang Liu, Hui Wang, Wei Zhou, Dan-Wei Zhang, Zhan-Ting Li
A multicationic pillar[5]arene noncovalently crosslinks hyaluronic acid to afford ionic supramolecular polymers for intramolecular delivery of short DNA.
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Selective deletion of one carbon atom from C60 through benzylamine mediated reactions

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00449C, Research Article
Yaqiong Wang, Yiran Wu, Yuming Yu, Jie Su, Yi Qiu, Liangbing Gan
Benzylamine selectively adds to one of the two carbonyl groups on the 9-membered orifice to form an N,O-aminal moiety. Subsequent oxidation and hydrogen atom transfer lead to a decarboxylation process and formation of a nor [59]fullerene derivative.
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Cr-mediated Photocatalytic Decarboxylative Coupling of alpha-Oxo Acids with Benzylic Pyridinium Salts

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Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO00475B, Research Article
Jia Cao, Yan Liu, Zhixiang Wang, Le Liu
Herein, we report the chromium/photoredox dual catalytic synthesis of ketones using α-oxo acids with benzylic pyridinium salts. This reaction proceeded by photocatalytic generation of acyl radical from α-oxo acids and...
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Visible-light Induced [1, 3]-Brook Rearrangements of α-Ketoacylsilanes and Its Subsequent Trapping in a Tandem Annulation with 1, 3, 5-Triazinanes and Azomethine Imines

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Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO00463A, Research Article
Zhong Zhang, Sirui Wu, Yuqiao Zhou, Bao-Lin Li, Siyue Xiao, Xiaohu Zhao, Zhipeng Yu
An unusual visible light-induced [1, 3]-Brook rearrangement of α-ketoacylsilanes for cascade cyclization with 1,3,5-triazinanes and C,N-cyclic azomethine imines has been developed under catalyst-free and mild reaction conditions. The strategy offers...
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Concise synthesis of succinimide-fused densely 1,3-cyclohexadienes via Co-catalyzed [2+2+2] cycloaddition of 1,6-diynes and maleimides

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Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO00435C, Research Article
Jinhui Cai, Kaili Cen, Ziyi Zhai, Yuan Liu, Jiahao Wei, Mixia Ouyang, Guojun He, Shuyu Huang, Feng Zhao
Herein, we report a new route towards succinimide-fused densely 1,3-cyclohexadienes through the reaction of 1,6-diynes with electron-deficient alkenes under cobalt catalysis. This method shown high efficiency, wide substrate scope, good...
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Cobalt-catalysed Csp3–Csp3 cross-coupling of benzyl Katritzky pyridinium salts with Callyl–O electrophiles

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00402G, Research Article
Mengyu Gao, Corinne Gosmini
Different allylbenzyl derivatives are synthesized by Co-catalyzed reductive cross-coupling from functionalized benzyl Katritzky pyridinium salts and various allylic acetates, ethers or carbonates in moderate to good yields under mild conditions.
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Metal-free photoinduced denitrogenative alkylation of vinyl azides with alkyl radicals toward ketones

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00280F, Research Article
Hui Yin, Siqi Jian, Xiujuan Feng, Ming Bao, Xuan Zhang
A metal-free method for the synthesis of ketones via a visible-light induced denitrogenative alkylation of vinyl azides with alkyl radicals is presented.
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Copper-catalyzed oxidative sulfenylation and alkylation of indolin-2-ones for direct construction of sulfur-substituted quaternary carbons

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00491D, Research Article
Yun-Hao Zhang, Yi-Nuo Wang, Zi-Yu Liu, Si-Han Zheng, Guang-Lin Li, Dexin Feng, Da-Zhen Xu
A rapid and green one-pot access to S-substituted quaternary carbon centers from commercially available feedstock chemicals has been established, providing complex molecules with high chemoselectivity by the use of air as the terminal oxidant.
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Base- and metal-free visible-light driven site-selective α-C(sp3)–H functionalization reaction of glycine derivatives with hydroxamic acid derivatives

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00425F, Research Article
Shiyun He, Hongying Fan, Xue Zhang, Meiling Ye, Jian Chen, Jinyu Hou, Tianle Huang, Li Guo, Guanghui Lv, Yong Wu
A visible-light-mediated radical–radical cross-coupling reaction between hydroxamic acid and N-phenyl glycine derivatives under base and metal free conditions is reported. A series of unnatural amino acids and peptides were obtained in good to excellent yields with good chemo-selectivity.
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A retro-Mannich mediated transformation of Morita–Baylis–Hillman ketones to saturated imidazo[1,2-a]pyridines

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00352G, Research Article
Sachin Sharma, Ajit Kumar Jha, Srinivasan Easwar
Two fruits felled with one stone! – a proof of mechanism and a synthetic method that delivers a privileged heterocyclic motif.
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Development of a photoenzymatic one-pot hybrid system for the direct synthesis of 3,3-disubstituted indole-2-ketones from N-methyl indoles

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00371C, Research Article
Yao Yao, Yuan Yu, Ming-Liang Shi, Xin-Yue Fan, Ru-De Lin, Kun Li, Wen-Dian Li, Fei-Yan Tao, Na Wang
The effective combination of photocatalysis and enzyme catalysis has been widely utilized for the synthesis of high-value-added products.
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Efficient Synthesis of Benzophosphole Oxides by Ag-Promoted Radical Cycloisomerization

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Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D4QO00552J, Research Article
Open Access
Liyao Ma, Sonia Mallet-Ladeira, Julien MONOT, Blanca Maria MARTIN VACA, Didier Bourissou
Cycloisomerization reactions involving C–P bond formation have been overlooked to prepare P-heterocycles. We discovered here a simple, efficient and versatile route to benzophosphole oxides by reacting ortho-alkynyl secondary phosphine oxides...
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Photochemical [2 + 2 + 1] annulation of 2-vinyloxy arylalkynes with bromomalonates via energy transfer

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00249K, Research Article
Shuo Tang, Jiupeng Liu, Min Zhang, Dan Wang, Yong Wang, Jingjing Zhao, Pan Li
A transition-metal-free, oxidant-free and base-free photochemical [2 + 2 + 1] radical annulation of 2-vinyloxy arylalkynes with bromomalonates has been developed.
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Regioselective Oxidative Cleavage of Conjugated Dienes to Access α,β–Unsaturated Nitriles

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Org. Chem. Front., 2024, Accepted Manuscript
DOI: 10.1039/D3QO02101G, Research Article
Yuqing Fu, Yijia Leng, Haotong Bai, Jiaxi Xu, Ning Chen
A highly regioselective oxidative cleavage method has been developed for the synthesis of α,β-unsaturated nitriles from unsymmetric conjugated dienes. This transformation selectively cleaved the terminal C=C double bond, providing moderate...
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Synthesis of oxindole fused 1,3-oxazepanes via hydride transfer initiated ring expansion of pyrrolidine

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00474D, Research Article
Peng He, Zongkang Wang, Qiongwen Kang, Nana Fei, Chengyu Wang, Yanzhong Li
An efficient B(C6F5)3 catalyzed protocol for the synthesis of oxindole fused 1,3-oxazepanes from pyrrolidine substituted aryl alkynones has been developed.
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Substituent-controlled divergent cyclization reactions of benzo[c][1,2]dithiol-3-ones and hexahydro-1,3,5-triazines

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Org. Chem. Front., 2024, Advance Article
DOI: 10.1039/D4QO00356J, Research Article
Bohao Zhang, Sifan He, Na Dong, Antong Zhu, Haojie Duan, Dunjia Wang, Yao Zhou
An unprecedented metal-free divergent cyclization reaction of benzo[c][1,2]dithiol-3-ones with hexahydro-1,3,5-triazines to assemble six- and eight-membered N-containing heterocycles has been developed.
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