bio

Proteomics in systems biology : methods and protocols

Location: Sciences Library Library- QH506.M45 v.1394




bio

Regenerative Medicine - from Protocol to Patient 1. Biology of Tissue Regeneration

Location: Electronic Resource- 




bio

Regenerative Medicine - from Protocol to Patient 3. Tissue Engineering, Biomaterials and Nanotechnology

Location: Electronic Resource- 




bio

Research in Computational Molecular Biology 20th Annual Conference, RECOMB 2016, Santa Monica, CA, USA, April 17-21, 2016, Proceedings

Location: Electronic Resource- 




bio

Quantitative biomedical optics : theory, methods, and applications

Location: Engineering Library- R857.O6B54 2016




bio

Biomedical imaging : the chemistry of labels, probes, and contrast agents

Location: Sciences Library Library- RC78.7.D53B56 2012




bio

Handbook of Bioceramics and Biocomposites

Location: Electronic Resource- 




bio

Biotechnology of Extremophiles: Advances and Challenges

Location: Electronic Resource- 




bio

Synthetic Biology Analysed Tools for Discussion and Evaluation

Location: Electronic Resource- 




bio

Asier eta biok = Asier y yo

Location: Main Media Collection - Video record 42382 DVD




bio

Sacromonte : the wise of the tribe = Sacromonte : los sabios de la tribu

Location: Main Media Collection - Video record 42384 DVD




bio

Evolutionary Bioinformatics

Location: Electronic Resource- 




bio

Biotechnology of Plant Secondary Metabolism Methods and Protocols

Location: Electronic Resource- 




bio

Immunotherapy and Biomarkers in Neurodegenerative Disorders

Location: Electronic Resource- 




bio

Hydrocarbon and Lipid Microbiology Protocols Single-Cell and Single-Molecule Methods

Location: Electronic Resource- 




bio

Hydrocarbon and Lipid Microbiology Protocols Ultrastructure and Imaging

Location: Electronic Resource- 




bio

Introduction to biostatistical applications in health research with Microsoft Office Excel

Location: Engineering Library- R858.H57 2016




bio

Our energy future : introduction to renewable energy and biofuels

Location: Engineering Library- TP339.J65 2016




bio

Orthopaedic biomechanics

Location: Engineering Library- QP301.O715 2013




bio

Adopting biometric technology : challenges and solutions

Location: Engineering Library- TK7882.B56D367 2016




bio

Supermacroporous cryogels : biomedical and biotechnological applications

Location: Engineering Library- R857.M3S853 2016




bio

Abiotic Stress Physiology of Horticultural Crops

Location: Electronic Resource- 




bio

The Biology Of Why Coronavirus Is So Deadly

The Biology Of Why Coronavirus Is So Deadly

COVID-19 is caused by a coronavirus called SARS-CoV-2. Coronaviruses belong to a group of viruses that infect animals, from peacocks to whales. They’re named for the bulb-tipped spikes that project from the virus’s surface and give the appearance of a corona surrounding it.

A coronavirus infection usually plays out one of two ways: as an infection in the lungs that includes some cases of what people would call the common cold, or as an infection in the gut that causes diarrhea. COVID-19 starts out in the lungs like the common cold coronaviruses, but then causes havoc with the immune system that can lead to long-term lung damage or death.

SARS-CoV-2 is genetically very similar to other human respiratory coronaviruses, including SARS-CoV and MERS-CoV. However, the subtle genetic differences translate to significant differences in how readily a coronavirus infects people and how it makes them sick.

 

SARS-CoV-2 virus particles (pink dots) on a dying cell. National Institute of Allergy and Infectious Diseases, NIH

 

SARS-CoV-2 has all the same genetic equipment as the original SARS-CoV, which caused a global outbreak in 2003, but with around 6,000 mutations sprinkled around in the usual places where coronaviruses change. Think whole milk versus skim milk.

Compared to other human coronaviruses like MERS-CoV, which emerged in the Middle East in 2012, the new virus has customized versions of the same general equipment for invading cells and copying itself. However, SARS-CoV-2 has a totally different set of genes called accessories, which give this new virus a little advantage in specific situations. For example, MERS has a particular protein that shuts down a cell’s ability to sound the alarm about a viral intruder. SARS-CoV-2 has an unrelated gene with an as-yet unknown function in that position in its genome. Think cow milk versus almond milk.

 

How the virus infects

 

Every coronavirus infection starts with a virus particle, a spherical shell that protects a single long string of genetic material and inserts it into a human cell. The genetic material instructs the cell to make around 30 different parts of the virus, allowing the virus to reproduce. The cells that SARS-CoV-2 prefers to infect have a protein called ACE2 on the outside that is important for regulating blood pressure.

The infection begins when the long spike proteins that protrude from the virus particle latch on to the cell’s ACE2 protein. From that point, the spike transforms, unfolding and refolding itself using coiled spring-like parts that start out buried at the core of the spike. The reconfigured spike hooks into the cell and crashes the virus particle and cell together. This forms a channel where the string of viral genetic material can snake its way into the unsuspecting cell.

An illustration of the SARS-CoV-2 spike protein shown from the side (left) and top. The protein latches onto human lung cells. 5-HT2AR/Wikimedia

SARS-CoV-2 spreads from person to person by close contact. The Shincheonji Church outbreak in South Korea in February provides a good demonstration of how and how quickly SARS-CoV-2 spreads. It seems one or two people with the virus sat face to face very close to uninfected people for several minutes at a time in a crowded room. Within two weeks, several thousand people in the country were infected, and more than half of the infections at that point were attributable to the church. The outbreak got to a fast start because public health authorities were unaware of the potential outbreak and were not testing widely at that stage. Since then, authorities have worked hard and the number of new cases in South Korea has been falling steadily.

 

How the virus makes people sick

 

SARS-CoV-2 grows in type II lung cells, which secrete a soap-like substance that helps air slip deep into the lungs, and in cells lining the throat. As with SARS, most of the damage in COVID-19, the illness caused by the new coronavirus, is caused by the immune system carrying out a scorched earth defense to stop the virus from spreading. Millions of cells from the immune system invade the infected lung tissue and cause massive amounts of damage in the process of cleaning out the virus and any infected cells.

Each COVID-19 lesion ranges from the size of a grape to the size of a grapefruit. The challenge for health care workers treating patients is to support the body and keep the blood oxygenated while the lung is repairing itself.

 

How SARS-CoV-2 infects, sickens and kills people

 

SARS-CoV-2 has a sliding scale of severity. Patients under age 10 seem to clear the virus easily, most people under 40 seem to bounce back quickly, but older people suffer from increasingly severe COVID-19. The ACE2 protein that SARS-CoV-2 uses as a door to enter cells is also important for regulating blood pressure, and it does not do its job when the virus gets there first. This is one reason COVID-19 is more severe in people with high blood pressure.

SARS-CoV-2 is more severe than seasonal influenza in part because it has many more ways to stop cells from calling out to the immune system for help. For example, one way that cells try to respond to infection is by making interferon, the alarm signaling protein. SARS-CoV-2 blocks this by a combination of camouflage, snipping off protein markers from the cell that serve as distress beacons and finally shredding any anti-viral instructions that the cell makes before they can be used. As a result, COVID-19 can fester for a month, causing a little damage each day, while most people get over a case of the flu in less than a week.

At present, the transmission rate of SARS-CoV-2 is a little higher than that of the pandemic 2009 H1N1 influenza virus, but SARS-CoV-2 is at least 10 times as deadly. From the data that is available now, COVID-19 seems a lot like severe acute respiratory syndrome (SARS), though it’s less likely than SARS to be severe.

 

What isn’t known

 

There are still many mysteries about this virus and coronaviruses in general – the nuances of how they cause disease, the way they interact with proteins inside the cell, the structure of the proteins that form new viruses and how some of the basic virus-copying machinery works.

Another unknown is how COVID-19 will respond to changes in the seasons. The flu tends to follow cold weather, both in the northern and southern hemispheres. Some other human coronaviruses spread at a low level year-round, but then seem to peak in the spring. But nobody really knows for sure why these viruses vary with the seasons.

What is amazing so far in this outbreak is all the good science that has come out so quickly. The research community learned about structures of the virus spike protein and the ACE2 protein with part of the spike protein attached just a little over a month after the genetic sequence became available. I spent my first 20 or so years working on coronaviruses without the benefit of either. This bodes well for better understanding, preventing and treating COVID-19.

By Benjamin Neuman, Professor of Biology, Texas A&M University-Texarkana. This article is republished from The Conversation under a Creative Commons license. Read the original article.

The Conversation Thu, 04/02/2020 - 14:02
Categories




bio

Algae here, alien life out there — Cal State L.A.-JPL partnership connects engineers to astrobiology

JPL hires Cal State Los Angeles civil engineering students with NASA grant. The interns can do research for NASA and learn about connections between astrobiology and science here on Earth.




bio

Smelling Illness: Volatile Organic Compounds as Neurological Disease Biomarkers

Scientists advance Parkinson’s disease biomarker research one sniff at a time.




bio

Automating Liquid Biopsy: Unleashing New Potential in Diagnostics

Discover how automation increases the efficiency and reliability of blood-based liquid biopsy assays.




bio

Transforming 3D biology using AI: Tomocube’s HT-X1™ Plus accelerates cellular and organoids label-free analysis

This new system raises the bar in high-resolution, high-throughput 3D imaging for cells and organoids, providing researchers with faster, more detailed, and more accurate insights into biological processes.




bio

Sapient Partners with Rancho BioSciences to Accelerate the Next Generation of its Human Biology Database

Infrastructure expansion will enable rapid ingestion, homogenization of new multi-omics and real-world data for accelerated delivery of multidimensional insights to inform drug development




bio

The biorevolution is here, and the US better be prepared to meet it

With all of Washington consumed by the promise and perils of generative artificial intelligence and everything that comes with it, we risk neglecting the next technology revolution brewing under our very noses. Biotechnologies, built on our deepening understanding of how to read, write, and edit genetic code, the “code of life,” are not just transforming biomedicine but are generating better, more sustainable approaches to manufacturing, agriculture, and environmental health.




bio

Slog AM: City Budget Hearing Tonight, Rob Saka Seeks End of South Lake Union Streetcar, Trump Set on Senator Marco Rubio for Secretary of State

The Stranger's morning news round-up. by Ashley Nerbovig

Goooooood morning: The National Weather Service predicts a 50% chance of rain today, with a breezy evening ahead. Meteorologists expect wind speeds to possibly top 29 miles per hour, so batten down your rotting porch pumpkins people!

Time to talk dollars: Want to tell the City Council how to spend your tax dollars? Go to public comment tonight at 5 pm at City Hall. Or you can participate remotely. You can go to tell them to support a capital gains tax, or oppose cuts to tenant services. Or tell the Council to respect the Jumpstart spend plan and actually use the payroll tax to pay for affordable housing, as it was intended. Check back on the blog for more coverage of the budget from Hannah. 

ICYMI: With the blowout loss for former Council Member Tanya Woo, Hannah tells City Council Member Sara Nelson to count her days. Local politicos plan to mount a serious challenge to the conservative Council President Nelson next year in the hopes of ousting her and her pro-cop, pro-business agenda out of office.

Rob Saka Seeks Street Car phase-out: Saka proposed phasing out the South Lake Union streetcar and redirecting the funding to bus service in the City. The budget for the street car is about $4.4 million, which isn't a whole lot of money when you consider Saka wants $2 million to remove the Delridge median so he can take a left turn.

Last week, the Office of Police Accountability (OPA) completed its investigation into Seattle Police Department (SPD) Officer Kevin Dave, who hit and killed 23-year-old Jaahnavi Kandula as she crossed through a crosswalk in January 2023. The OPA found Dave violated the department's driving policies as well as its policies requiring officers to follow the law. The City must hold a Loudermill hearing for Dave, which allows him to tell his side of the story before deciding on his discipline, so it may be a couple months before we know the final outcome. In the meantime, Dave continues to fight the traffic ticket Republican City Attorney Ann Davison issued him for his killing of Kandula. Seattle Municipal Court shows Dave's next hearing is scheduled for 8:30 am on December 18 in courtroom 301. 

BREAKING: OPA concluded its investigation into SPD Officer Kevin Dave on Friday and sustained policy violations for breaking the law and vehicle operation. Next step will be deciding discipline for him.

— Ashley Nerbovig (@AshleyNerbovig) November 11, 2024

What's your plan for this week anyway? Maybe you're checking out Christmas Dive Bar? Or maybe it's too soon? Maybe you're trying to enjoy something with more Thanksgiving vibes? Well, as always, our sister publication EverOut has you covered with the top 41 things to do this week in Seattle.

Republicans likely to control the US House: As it stands, Republicans have won 214 seats in the House, with Democrats at 205, and 16 races yet to be called. To control the House, Republicans need only to pick up another four seats, which they seem highly likely to do. Congress returned to Washington this week, ready to start setting Trump's right-wing agenda into motion.

Trump plans to pick Senator Marco Rubio for Secretary of State: The worst people in American continue to jockey for a position in Trump's new administration, with Florida Republican Rubio possibly securing the role of America's top diplomat, according to Politico. We're sure to hear more names in the coming days, including people such as Tiffany Justice, co-founder of Moms for Liberty, who Trump may consider for Secretary of Education. The nightmare continues. 

Israel kills 14 in Gaza: Two Israeli strikes killed 14 people in an area Israel had mostly declared to be a humanitarian zone. The deaths included at least two children, according to the Associated Press

Migos’ “Bad And Boujee” (Feat. Lil Uzi Vert): Been a minute since I checked out Tom Breihan's the Number Ones column, and I'm glad I plumbed it for a song today because I normally wouldn't think about Migos around holiday season, but that's when "Bad and Boujee" climbed to the number one spot on the charts, so I suppose that makes it a holiday classic.




bio

Thomasin McKenzie Recruited to Portray Kerri Strug in Olivia Wilde-Directed Biopic

'Perfect' will chronicle the Olympic gymnast's heroic performance at the 1996 Olympics where she completed a final, gold medal-winning vault in the team competition on a badly injured ankle.




bio

Thomasin McKenzie Recruited to Portray Kerri Strug in Olivia Wilde-Directed Biopic

'Perfect' will chronicle the Olympic gymnast's heroic performance at the 1996 Olympics where she completed a final, gold medal-winning vault in the team competition on a badly injured ankle.





bio

FSSAI sets stricter rule for antibiotics in food items

India's food safety regulator, FSSAI, has revised antibiotic residue norms for meat, milk, poultry, eggs, and aquaculture to combat growing antimicrobial resistance. Effective from April 2025, the new limits aim to ensure safer food products by setting stricter contaminant limits, amid rising concerns over antibiotic misuse in agriculture and healthcare.




bio

Trump, defying media predictions, mainly picks seasoned Capitol Hill veterans such as Marco Rubio

President-elect Donald Trump has gone against media expectations by tapping Marco Rubio, Kristi Noem and a number of other Capitol Hill veterans to fill posts in his second administration.



  • bc8dc025-a659-536a-88a9-491ba5ea4546
  • fnc
  • Fox News
  • fox-news/politics
  • fox-news/columns/media-buzz
  • fox-news/person/donald-trump
  • fox-news/politics/executive/white-house
  • fox-news/person/kristi-noem
  • fox-news/person/marco-rubio
  • fox-news/person/joe-biden
  • fox-news/politics
  • article

bio

Foro: teletrabajo, un cambio de vida, una nueva realidad




bio

¿Cuáles son los cambios en la política mundial por cuenta de la pandemia?




bio

Las mujeres en el centro del debate: 8M, feminicidios y cambios culturales

Panelistas debatieron sobre el significado del 8M y de las reflexiones que son necesarias. También analizaron las causas de los feminicidios y la necesidad de un cambio cultural.




bio

Las reflexiones sobre los cambios sociales al cumplirse un año de pandemia

Panelistas reflexionan sobre algunos cambios sociales que han ocurrido luego de un año de pandemia; creen que no hubo un cambio de fondo como sociedad.




bio

¿Qué tan radical es el cambio en la nueva política antidrogas de EE. UU.?

Panelistas consideran que hay cambios en los enfoques de prevención y desarrollo territorial, así como continuidades al no avanzar hacia una visión de legalización de las drogas.




bio

¿Qué tan radical es el cambio en la nueva política antidrogas de EE. UU?

Panelistas consideran que hay cambios en los enfoques de prevención y desarrollo territorial, así como continuidades al no avanzar hacia una visión de legalización de las drogas.




bio

¿Es la COP26 un llamado final para enfrentar el cambio climático?

Panelistas consideran que hay acuerdos sin peso como la deforestación cero al 2030; proponen medidas coercitivas y presencia institucional para enfrentar deforestación y EGI.




bio

¿Cuáles son los cambios a los que se expone Twitter tras su compra?

Panelistas consideran que se debe tener en cuenta el espíritu futurista de Elon Musk; creen que transformaciones en libertad de expresión le pueden dar ventajas.




bio

Elección de Contralor, ¿se justifican los cambios?

Panelistas consideran que cambios no se ajustarían a la normativa, otros plantean que las modificaciones podrían ser de buena fe y en beneficio de la Contraloría.




bio

Vía Congreso, la alternativa para un cambio en las tarifas de energía: Pumarejo

El alcalde Pumarejo aseguró que, si no hay respuesta favorable por parte de las empresas generadoras de energía, se recurrirá al legislativo.




bio

Elecciones Brasil, cambios en Reino Unido y la China de Xi Jinping

Panelistas analizaron la estabilidad o eventual inestabilidad política de varios países que se enfrentan a elecciones, cambios de gobierno o la continuación de regímenes políticos.




bio

¿Cuál es el efecto de la COP27 en la lucha contra el cambio climático?

Panelistas creen que esta es una oportunidad para generar nuevos acuerdos, financiación y revelar estudios sobre el cambio climático.




bio

Cambios al metro de Bogotá: ¿qué le conviene a la ciudad?

Panelistas resaltan que los cambios traerían grandes desafíos jurídicos. Aunque plantean que una red subterráneo le beneficia más a la ciudad




bio

Cambios al metro de Bogotá: ¿qué le conviene a la ciudad?

Panelistas resaltan que los cambios traerían grandes desafíos jurídicos. Aunque plantean que una red subterráneo le beneficia más a la ciudad




bio

¿Cómo encontrar consensos en tiempos de cambio para el país?

Panelistas plantearon cuáles son los elementos que dificultan el debate entre varios sectores sociales y políticos del país para llegar a consensos sobre las reformas.