Kadian Morgan was overwhelmed with grief as she leaned against a wall outside her gate on Jackson Lane, East Kingston, yesterday, tears streaming down her face. Her 19-year-old son, Kayshan 'Bem Bem' Smith, was lying in the morgue after being...

After parking his taxi cab along the sidewalk, Leon Thompson exited his vehicle and held on tightly to the tiny hands of his four small passengers. They all walked towards a makeshift bridge, and Thompson lifted each child, making four trips,...

PORT-AU-PRINCE, Haiti (AP) — Haiti's main airport remained closed on Tuesday, a day after violence erupted as the country swore in its new prime minister in a politically tumultuous transition.

Visual Abstract

Elisa Vidal
Dec 1, 2020; 61:1733-1746
Research Articles

Thibaut Bourgeois
Dec 11, 2020; 0:jlr.RA120000737v1-jlr.RA120000737
Research Articles

For data that is being loaded from a SAS Stored Process Server, an insertion process might fail to a MySQL database with a warning, as well as an error message that says "During insert: Incorrect datetime value…"

Recent studies have highlighted an important role for lysophosphatidylcholine acyltransferase 3 (LPCAT3) in controlling the PUFA composition of cell membranes in the liver and intestine. In these organs, LPCAT3 critically supports cell membrane-associated processes such as lipid absorption or lipoprotein secretion. However, the role of LPCAT3 in macrophages remains controversial. Here, we investigated LPCAT3’s role in macrophages both in vitro and in vivo in mice with atherosclerosis and obesity. To accomplish this, we used the LysMCre strategy to develop a mouse model with conditional Lpcat3 deficiency in myeloid cells (Lpcat3KOMac). We observed that partial Lpcat3 deficiency (approx. 75% reduction) in macrophages alters the PUFA composition of all phospholipid (PL) subclasses, including phosphatidylinositols and phosphatidylserines. A reduced incorporation of C20 PUFAs (mainly arachidonic acid [AA]) into PLs was associated with a redistribution of these FAs toward other cellular lipids such as cholesteryl esters. Lpcat3 deficiency had no obvious impact on macrophage inflammatory response or endoplasmic reticulum (ER) stress; however, Lpcat3KOMac macrophages exhibited a reduction in cholesterol efflux in vitro. In vivo, myeloid Lpcat3 deficiency did not affect atherosclerosis development in LDL receptor deficient mouse (Ldlr-/-) mice. Lpcat3KOMac mice on a high-fat diet displayed a mild increase in hepatic steatosis associated with alterations in several liver metabolic pathways and in liver eicosanoid composition. We conclude that alterations in AA metabolism along with myeloid Lpcat3 deficiency may secondarily affect AA homeostasis in the whole liver, leading to metabolic disorders and triglyceride accumulation.

Spatial changes of FAs in the retina in response to different dietary n-3 formulations have never been explored, although a diet rich in EPA and DHA is recommended to protect the retina against the effects of aging. In this study, Wistar rats were fed for 8 weeks with balanced diet including either EPA-containing phospholipids (PLs), EPA-containing TGs, DHA-containing PLs, or DHA-containing TGs. Qualitative changes in FA composition of plasma, erythrocytes, and retina were evaluated by gas chromatography-flame ionization detector. Following the different dietary intakes, changes to the quantity and spatial organization of PC and PE species in retina were determined by LC coupled to MS/MS and MALDI coupled to MS imaging. The omega-3 content in the lipids of plasma and erythrocytes suggests that PLs as well as TGs are good omega-3 carriers for retina. However, a significant increase in DHA content in retina was observed, especially molecular species as di-DHA-containing PC and PE, as well as an increase in very long chain PUFAs (more than 28 carbons) following PL-EPA and TG-DHA diets only. All supplemented diets triggered spatial organization changes of DHA in the photoreceptor layer around the optic nerve. Taken together, these findings suggest that dietary omega-3 supplementation can modify the content of FAs in the rat retina.

Secrets and Spies: UK Intelligence Accountability After Iraq and Snowden Book sysadmin 15 January 2020

How can democratic governments hold intelligence and security agencies to account when what they do is largely secret? Jamie Gaskarth explores how intelligence professionals view accountability in the context of 21st century politics.

Using the UK as a case study, this book provides the first systematic exploration of how accountability is understood inside the secret world. It is based on new interviews with current and former UK intelligence practitioners, as well as extensive research into the performance and scrutiny of the UK intelligence machinery.

The result is the first detailed analysis of how intelligence professionals view their role, what they feel keeps them honest, and how far external overseers impact on their work.

The UK gathers material that helps inform global decisions on such issues as nuclear proliferation, terrorism, transnational crime, and breaches of international humanitarian law. On the flip side, the UK was a major contributor to the intelligence failures leading to the Iraq war in 2003, and its agencies were complicit in the widely discredited U.S. practices of torture and ‘rendition’ of terrorism suspects. UK agencies have come under greater scrutiny since those actions, but it is clear that problems remain.

Secrets and Spies is the result of a British Academy funded project (SG151249) on intelligence accountability. The book is published as part of the Insights series.

Praise for Secrets and Spies

About the author

Jamie Gaskarth is Professor of Foreign Policy and International Relations at The Open University. He was previously senior lecturer at the University of Birmingham where he taught strategy and decision-making. His research focused on the ethical dilemmas of leadership and accountability in intelligence, foreign policy, and defence. He is author/editor or co-editor of six books and served on the Academic Advisory panel for the 2015 UK National Security Strategy and Strategic Defence and Security Review.

Purchase

• UK (via Amazon)
• Rest of world (via Brookings Institution Press)
• Students (via Browns Books)

Odubel Herrera smiled and patted his stomach. The paunch that he carried into Spring Training 2018 is no longer there. Herrera has reported to camp leaner and, as he said Friday morning at Spectrum Field, motivated to bounce back from the worst season of his four-year career.

South Africa After the Elections: Balancing Domestic and International Policy Priorities 16 May 2019 — 1:30PM TO 2:30PM Anonymous (not verified) 9 May 2019 Chatham House | 10 St James's Square | London | SW1Y 4LE

The government that emerges from the 8 May election in South Africa faces immediate domestic and international foreign policy demands. Attracting Foreign Direct Investment to stimulate job growth, accelerating anti-corruption and good governance efforts are at the forefront of the new government’s agenda.

International ambitions will be upgraded such as UN security council reform, maximizing South Africa’s G20, BRICS and IBSA membership and preparing for South Africa’s chairmanship of the African Union (AU) in 2020.

At this meeting, the speakers – Moeletsi Mbeki, deputy chairman of SAIIA and author with Nobantu Mbeki of A Manifesto for Social Change: How to Save South Africa, and Elizabeth Sidiropoulos, chief executive of SAIIA and currently co-editing a volume on A South African Foreign Policy for the 2020s which will be published in 2019 – will reflect on the election and discuss the new government’s domestic and international policy agenda. The meeting will be chaired by Ann Grant, former British High Commissioner to South Africa (2000-05) with past experience working for Oxfam, Standard Chartered Bank and Tullow Oil.

Zimbabwe After Mugabe Expert comment sysadmin 12 September 2019

He was the founding father of modern Zimbabwe, but he leaves behind a contested legacy and a country at a crossroads.

Robert Mugabe’s death at age 95, after nearly 60 years at the helm of Zimbabwe’s liberation and post-independence politics, is a momentous occasion. Mugabe was the founding father of modern Zimbabwe, with all its stunning successes and grievous failures. As he moves into national legend, contestations over his legacy demonstrate that, in death as in life, the man known as Gushungo (from his family lineage) still continues to polarize opinion.

His failings are well known, including the mass murders of more than 30,000 civilians in Matabeleland during the 1980s Gukurahundi campaigns, and the killings and torture of opposition activists in the 2000s and 2010s.

The land reform process, although necessary, was handled in a haphazard way, contributing to the economic crash and 2008’s ‘year zero’, when Zimbabwe was plagued with a worthless currency, no food in the shops, unsafe drinking water and the spread of cholera and typhoid.

Nevertheless, Mugabe is genuinely mourned by millions in Zimbabwe and beyond. Partly this is for what he achieved in building Zimbabwe’s education, health and economy, and for giving land – however haphazardly – to millions of Zimbabweans.

But it was his assertion of black and African identity and pride which made Mugabe connect with millions. I grew up in Ian Smith’s Rhodesia, where being a black African was, by law, a cardinal sin and, at times, a capital offence. Mugabe helped to make being black not just acceptable but also a cause for celebration.

What now for the country?

Mugabe continues to shape Zimbabwe’s politics. Emmerson Mnangagwa’s government has tried to differentiate itself from Mugabe’s administrations, avoiding his radical and ideologically driven language and policies. But Zimbabwe’s military, which played a critical role in Mugabe’s 2017 removal, remains influential over government policy.

Mnangagwa wants to be seen as a moderate, accessible for regular meetings with private sector and international investors through the Presidential Advisory Commission, the Tripartite Negotiating Forum, investment meetings and other forums.

Politically, Zimbabwe’s bipartisan Parliamentary Portfolio Committees have emerged over the past year as key institutions able to effectively hold the government and other institutions to account. Contentious Mugabe-era legislation such as the Public Order and Security Act has been revised in line with Zimbabwe’s constitution. And the ongoing multiparty dialogue is a useful start towards a much-needed national political dialogue.

Through its Transitional Stabilization Programme, the Mnangagwa administration has outlined an ambitious economic reform agenda. There has been some progress; in January, the government reported a $113 million budget surplus, and publicly available audits of state-owned enterprises by Public Auditor Mildred Chiri have exposed the rot at the heart of institutions such as the National Social Security Authority.

The government has streamlined bureaucracy and legislation to improve Zimbabwe’s business climate; and the newly empowered Zimbabwe Anti-Corruption Commission has begun probing some high-profile fraud cases.

Zimbabwe’s global re-engagement with international financial institutions, a process which had stalled in Mugabe’s later years, is now making some progress, with Zimbabwe joining the Staff Monitored Programme with the IMF in mid-2019. The introduction of a new currency in February was designed to end the chaos of multiple US-dollar exchange rates and the dominance of the black market, but has had limited results.

Hardship

But the Mnangagwa administration’s attempts to stabilize the Zimbabwean economy have also included deep cuts in government spending, and the resulting austerity has brought severe hardship for ordinary Zimbabweans. Massive fuel, power and water shortages and the sky-rocketing cost of living are all reminiscent of the Mugabe era, damaging the credibility of the government’s promise of an economic dividend.

Shortages have also hit tourism, which had rebounded in recent years, and the new national currency initiative has pushed inflation to an official 180%. Violent urban protests took place in 2018 and 2019.

While government is right to commit to reforms, and has taken steps, such as cost-of-living allowances, to help mitigate the worst impacts, many Zimbabweans view the official ‘austerity for prosperity’ message with deep scepticism, and the current state of the economy has encouraged more young Zimbabweans to leave the country. Government and the business community need to prioritize people over statistics, and put social protection, anti-poverty programmes and economic democracy at the forefront of economic reform.

Getting public services working again will also require a broad national economic consensus and could look to capitalize on diaspora-led initiatives in education, agriculture, health and other sectors.

But this will require the opposition Movement for Democratic Change to recognize Mnangagwa’s legitimacy in return for substantive talks between government and the opposition and strengthened outreach to Zimbabwe’s nearly 5-million strong global diaspora, many in the United Kingdom, unsure of what tomorrow will bring, and an increasingly troubled South Africa.

The future

Robert Mugabe’s funeral will bring together the great and the good, not just from Zimbabwe but from all over the world. Robert Mugabe was always a voice and never an echo, and his passing, as with those of other Zimbabwean change-makers of all races and backgrounds, is an opportunity to reflect on the legacy of the liberation era.

But more importantly, it is also an opportunity to think about what lies ahead. Zimbabweans have proved to be resilient and innovative; but it will require a collective effort and a national re-engagement to ensure that Zimbabwe’s future is not its past. And with Mugabe now gone, the Zimbabwe government must prove that it can and will do better.

The peptide hormone ghrelin is produced in cardiomyocytes and acts through the myocardial growth hormone secretagogue receptor (GHSR) to promote cardiomyocyte survival. Administration of ghrelin may have therapeutic effects on post–myocardial infarction (MI) outcomes. Therefore, there is a need to develop molecular imaging probes that can track the dynamics of GHSR in health and disease to better predict the effectiveness of ghrelin-based therapeutics. We designed a high-affinity GHSR ligand labeled with ¹⁸F for imaging by PET and characterized its in vivo properties in a canine model of MI. Methods: We rationally designed and radiolabeled with ¹⁸F a quinazolinone derivative ([¹⁸F]LCE470) with subnanomolar binding affinity to GHSR. We determined the sensitivity and in vivo and ex vivo specificity of [¹⁸F]LCE470 in a canine model of surgically induced MI using PET/MRI, which allowed for anatomic localization of tracer uptake and simultaneous determination of global cardiac function. Uptake of [¹⁸F]LCE470 was determined by time–activity curve and SUV analysis in 3 regions of the left ventricle—area of infarct, territory served by the left circumflex coronary artery, and remote myocardium—over a period of 1.5 y. Changes in cardiac perfusion were tracked by [¹³N]NH₃ PET. Results: The receptor binding affinity of LCE470 was measured at 0.33 nM, the highest known receptor binding affinity for a radiolabeled GHSR ligand. In vivo blocking studies in healthy hounds and ex vivo blocking studies in myocardial tissue showed the specificity of [¹⁸F]LCE470, and sensitivity was demonstrated by a positive correlation between tracer uptake and GHSR abundance. Post-MI changes in [¹⁸F]LCE470 uptake occurred independently of perfusion tracer distributions and changes in global cardiac function. We found that the regional distribution of [¹⁸F]LCE470 within the left ventricle diverged significantly within 1 d after MI and remained that way throughout the 1.5-y duration of the study. Conclusion: [¹⁸F]LCE470 is a high-affinity PET tracer that can detect changes in the regional distribution of myocardial GHSR after MI. In vivo PET molecular imaging of the global dynamics of GHSR may lead to improved GHSR-based therapeutics in the treatment of post-MI remodeling.

This analysis aimed to identify clinical factors associated with positivity on repeat ⁶⁸Ga-PSMA-11 PET/CT after a negative scan in patients with recurrent prostate cancer (PCa) under observation. Methods: This single-center, retrospective analysis included patients who underwent at least 2 ⁶⁸Ga-PSMA-11 PET/CT scans (PET1 and PET2) at UCLA between October 2016 and June 2021 for recurrent PCa with negative PET1 and no PCa-related treatments between the 2 scans. Using Prostate Cancer Molecular Imaging Standardized Evaluation criteria to define negative and positive scans, the final cohort was divided into PET2-negative (PET2-Neg) and PET2-positive (PET2-Pos). The same PET1 was used twice in the more than 2 PET cases with inclusion criteria fulfilled. Patient characteristics and clinical parameters were compared between the 2 cohorts using Mann–Whitney U test and Fisher exact test. Areas under the curve (AUCs) of the receiver operating characteristic and the Youden index were computed to determine the discrimination ability of statistically significant factors and specific cut points that maximized sensitivity and specificity, respectively. Results: The final analysis included 83 sets of 2 PET/CT scans from 70 patients. Thirty-nine of 83 (47%) sets were PET2-Neg, and 44 of 83 (53%) sets were PET2-Pos. Prostate-specific antigen (PSA) increased from PET1 to PET2 for all 83 (100%) sets of scans. Median PSA at PET1 was 0.4 ng/mL (interquartile range, 0.2–1.0) and at PET2 was 1.6 ng/mL (interquartile range, 0.9–3.8). We found higher serum PSA at PET2 (median, 1.8 vs. 1.1 ng/mL; P = 0.015), absolute PSA difference (median, 1.4 vs. 0.7 ng/mL; P = 0.006), percentage of PSA change (median, +270.4% vs. +150.0%: P = 0.031), and median PSA velocity (0.044 vs. 0.017 ng/mL/wk, P = 0.002) and shorter PSA doubling time (DT; median, 5.1 vs. 8.3 mo; P = 0.006) in the PET2-Pos cohort than in the PET2-Neg cohort. Receiver operating characteristic curves showed cutoffs for PSA at PET2 of 4.80 ng/mL (sensitivity, 34%; specificity, 92%; AUC, 0.66), absolute PSA difference of 0.95 ng/mL (sensitivity, 62%; specificity, 71%; AUC, 0.68), percentage of PSA change of a positive 289.50% (sensitivity, 48%; specificity, 82%; AUC, 0.64), PSA velocity of 0.033 ng/mL/wk (sensitivity, 57%; specificity, 80%; AUC, 0.70), and PSA DT of 7.91 mo (sensitivity, 71%; specificity, 62%; AUC, 0.67). Conclusion: Patients with recurrent PCa under observation after a negative ⁶⁸Ga-PSMA-11 PET/CT scan with markedly elevated serum PSA levels and shorter PSA DT are more likely to have positive findings on repeat ⁶⁸Ga-PSMA-11 PET/CT.

The Dow Jones Industrial Average and the S&P 500 hit new highs in early trading on Wednesday as former President Donald Trump claimed victory in Tuesday's presidential election over Kamala Harris.

A Qantas airlines flight made an emergency landing at Sydney Airport on Friday afternoon after suffering engine failure shortly after takeoff, the company said.

Private prison stocks soared Monday after President-elect Donald Trump announced immigration hardliner Tom Homan as the nation's next "border czar." GeoGroup jumped 4.5%, while CoreCivic increased 6.3%.

An explosion at a food-coloring factory in Louisville, Ky., hospitalized at least 11, including two in critical condition, on Tuesday afternoon.

Lionel Messi said Inter Miami will get ready to "come back stronger next year" after the Herons' upset loss to Atlanta United in the first round of the 2024 MLS Cup playoffs.

FC Cincinnati midfielder Marco Angulo has died from injuries he sustained from a car crash, the MLS franchise and Ecuadorian Football Association announced Tuesday. He was 22.

Police in a small South Carolina town are warning residents to keep their doors and windows locked after 43 monkeys escaped from a research facility.

A kangaroo that escaped from its Florida enclosure while fleeing from a bear has been safely returned home three weeks later.

An emperor penguin is being cared for by wildlife experts after becoming the first member of its species to make the 2,200-mile trek from Antarctica to Australia.

A baby goat stranded on a Hawaii cliff was rescued by members of the public after four days.

After a decade of forward deployment in Japan, the USS Germantown departed U.S. Fleet Activities Sasebo on Wednesday.

The USS John S. McCain on Friday headed to its new homeport in Naval Station Everett, Wash., after 24 years in Yokosuka, Japan, the Navy said.

Four U.S. Marines remain hospitalized after an attack near Hamid Karzai International Airport in Kabul, Afghanistan, last month as service members were evacuating foreign nationals and refugees.

Private prison stocks soared Monday after President-elect Donald Trump announced immigration hardliner Tom Homan as the nation's next "border czar." GeoGroup jumped 4.5%, while CoreCivic increased 6.3%.

The Federal Aviation Administration has banned flights to-and-from Haiti for at least 30 days after JetBlue and Spirit Airlines planes were hit by gunfire Monday during attempts to land in Port-au-Prince.

The wreckage of the U.S. destroyer USS Edsall, sunk by Japanese forces more than 80 years ago during World War II, has been found at the bottom of the Indian Ocean, according to the U.S. Navy.

An explosion at a food-coloring factory in Louisville, Ky., hospitalized at least 11, including two in critical condition, on Tuesday afternoon.

The U.S. military conducted retaliatory airstrikes Tuesday in Syria, targeting facilities of Iran-backed militias following rockets launched at U.S. forces in the Middle Eastern country.

An unnamed astronaut was released from Ascension Sacred Heart Pensacola in Florida and returned to Johnson Space Center in Houston in good health Saturday, NASA reported.

The state requested a waiver from the federal requirement in January. Failure to meet the 95-percent requirement can lead to funding penalties for states.

Wayne Sanstead, who has been North Dakota's state schools superintendent for nearly three decades, has decided not to run for an eighth term this fall.

The student newspaper at duPont Manual High School in Louisville, Ky., first reported on the state's problematic police training material.