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6 Reasons Why You Feel So Good After Lifting Weights

From boosting bone strength to balancing hormones, weight lifting offers powerful benefits that support our overall health and wellness.




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California Senate to vote on sign-up for military draft

Coalition Senate floor alert in opposition to California SB-1081

The California Senate will vote this week on a bill to automatically register register draft-age applicants for driver’s licenses and state IDs with the Selective Service System for a possible future military draft.

The floor vote in the state Senate on SB-1081 is expected this week and could come at any time.

[Update: The Senate voted 23-2 in favor of SB-1081, with 15 Senators not voting. The Senate approved minor amendments to the bill by its author, which make the bill somewhat worse. The bill now goes to the state Assembly Committee on Transportation, where it is scheduled for a hearing on Monday, 1 July 2024. See this letter to the Assembly Transportation Committee in opposition to the current version of SB-1081.]

SB-1081 was held in the 'suspense' file by the Senate Appropriations Committee, but was called up and sent to the floor for a vote by the full state Senate despite both Democratic and Republican opposing votes in committee, with only minor amendments that fail to assuage any of the opponents of the bill.

As amended, SB-1081 is still opposed by a diverse coalition including the ACLU, the California Immigrant Policy Center, Asian Americans Advancing Justice, and the Military Law Task Force of the National Lawyers Guild.




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U.S. House committee proposes "automatic" sign-up for military draft

Yesterday, during markup of the National Defense Authorization Act (NDAA) for Fiscal Year 2025, the U.S. House Armed Services Committee approved an amendment to the NDAA that would automatically register all draft-aged male U.S. residents with the Selective Service System for a possible military draft, based on information from other Federal databases.

This system of automatic draft registration would replace the system in effect since 1980 in which young men can decide for themselves whether or not to sign up for the draft -- and so many choose not to register that the Selective Service database would be useless for an actual draft.




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Congress moves toward stepped-up registration for a military draft


[Excerpt from the summary released by the Senate Armed Services Committee of the version of the NDAA for FY 2025 approved by the SASC and to be voted on by the full Senate.]

A proposal to expand registration for a possible military draft to young women as well as young men is moving forward again this year in Congress, along with a seductively simple-seeming but in practice unfeasible proposal to switch from the current system in which young men are required to register with the Selective Service System (SSS) to a system in which the SSS tries to identify and locate everyone eligible for a future draft and automatically register them based on other existing Federal databases from the Social Security Administration, IRS, U.S. Citizenship and Immigration Services, etc.

Today both the U.S. Senate Armed Service Committee and the full U.S. House of Representatives approved different proposals to expand and/or make it harder to avoid the requirement for men ages 18-26 to register with the Selective Service System for a possible military draft.

The proposals for changes to Selective Service registration were approved during consideration of the Senate and House versions of the National Defense Authorization Act for Fiscal Year 2025, a "must-pass" annual bill that typically runs to more than a thousand pages.

The Senate Armed Services Committee (SASC) approved a version of the NDAA that would expand Selective Service registration to include young women as well as young men. This version of the NDAA will now go to the floor as the starting point for consideration and approval by the full Senate.

Also today the full House of Representatives approved a different version of the NDAA that would make Selective Service registration automatic while keeping it for men only.

A House amendment proposed by Rep. Warren Davidson (R-OH), a West Point graduate and Army veteran, which would have replaced the provision to make draft registration automatic with a provision to repeal the Military Selective Service Act, was not "made in order" by the Rules Committee to be considered or voted on by the full House. There was no separate House floor vote on the proposed change to Selective Service registration, only a single vote on the entirety of the NDAA as a package.

The SASC markup was conducted in closed session, and only a summary of highlights of the version adopted by the SASC was released. It's not clear whether the SASC version also includes the provision in the House version of the NDAA to try to make Selective Service registration 'automatic' or only the provision to expand the registration requirement (with which compliance is currently low) to young women as well as young men. A spokesperson for the SASC told The Hill today that the full text of the Senate version of the NDAA won't be released until sometime in July.

Floor amendments are still possible in the Senate before it approves its version of the NDAA. But as of now, it seems likely that competing bad proposals with respect to expansion and/or attempted enforcement through automation of Selective Service -- one from the Republican-majority House to try to make it automatic, and one from the Democratic-majority Senate to expand it to women -- will be included in the House and Senate versions of the NDAA and go to the eventual House-Senate conference committee to sort out in closed-door negotiations late this year, after the elections.

It's possible that either or both of these proposals were included as "bargaining chips" intended to be withdrawn in exchange for concessions on other issues during the conference negotiations. The conference committee could include either, neither, both, or some other compromise on Selective Service in its final package of compromises, which typically are voted on and approved "en bloc" without further amendments.

Either of these misguided proposals would be the most significant change to the Military Selective Service Act since 1980. There have been no hearings, debate, or recorded vote on either of these proposals, and there appear unlikely to be any. The decision will probably be made in secret by the House-Senate conference committee for the NDAA.




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Congress debates women and the draft, but not war and the draft

"Firestorm erupts over requiring women to sign up for military draft", reads the headline on a story today on TheHill.com.

Unfortunately, that firestorm amounts mostly to an exchange of sound bites and social-media posts, not a real debate, much less a hearing with independent witnesses, in either the House or Senate. It focuses on the proposal included in the Senate version of the annual National Defense [sic] Authorization Act (NDAA) to expand registration with the Selective Service System to include young women as well as young men, rather than on what may be a more significant proposal in the House version of the same bill to try to make draft registration automatic by basing the list of potential draftees on information aggregated from other Federal records rather than provided by registrants themselves -- denying potential draftees the chance to indicate their opposition to being drafted, and to obstruct the mobilization for total war, by opting out of draft registration.

Most importantly, the current "debate" ignores both the profound and quite possibly insolvable practical problems with trying to compile a registry of potential draftees from other existing Federal databases, and the more fundamental issue with any contingency planning or preparation for a draft: the way that, even when a draft is not active, the perceived availability of a draft as a fallback emboldens warmakers to embark on wars that people wouldn't volunteer to fight.




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Rep. Houlahan fails to justify move toward a draft

[First published on Antiwar.com.]


[“I have an amendment at the desk.” Rep. Chrissy Houlahan introduces a proposal from the Selective Service System to automate draft registration in the House Armed Services Committee, May 22, 2024.]

Under fire for proposing an ill-considered amendment to this year’s National Defense Authorization Act (NDAA) to “automatically” register all young men in the U.S. for a possible military draft, Rep. Chrissy Houlahan (D-PA) has issued a statement that casts more doubt on her understanding of the current draft law and on the wisdom of her proposed changes to Selective Service registration.

Rep. Houlahan starts by claiming that “This new legislation saves taxpayers significant money.” But there’s absolutely no evidence to support this claim.




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Draft bills dead in California but still alive in Congress

A proposal to automatically register applicants for California driver's licenses with the Selective Service System for a possible military draft was pulled by its author, Sen. Bob Archuleta (D-Pico Rivera), just before a scheduled hearing today in the state Assembly Transportation Committee. This was the last scheduled meeting of that committee before the deadline for consideration of bills in this year's legislative session, so the bill is effectively dead for the year.

Like similar laws in other states, California SB-1081 faced opposition from a coalition of peace, civil liberties, and immigrant rights organizations, on both policy and fiscal grounds. Pulling the bill before the hearing today was a face-saving way for Sen. Archuleta to avoid a vote by the committee not to advance his bill to the Assembly floor. This was at least the seventh time that similar proposals in California have been rejected, but the Selective Service System and its California state directors keep finding new sponsors to reintroduce them in the state legislature.

Meanwhile, however, an ill-considered proposal to try to automate draft registration introduced at the instigation of the Selective Service System by Rep. Chrissy Houlahan (D-PA) remains under consideration as part of the House version of this year's National Defense [sic] Authorization Act (NDAA), along with a proposal to expand draft registration to include young women as well as young men in the Senate version of the NDAA.

There's a chance that both of these proposals for changes to Selective Service registration could be removed during back-room negotiations in the House-Senate conference committee on the NDAA later this year, after the elections. But we've seen this movie before. These bad ideas will be back again next year, regardless of which party wins which federal elections.

Preparation for a military draft, and reliance on the perceived availability of a fallback draft as the basis for planning of endless, unlimited, unpopular wars, won't stop until Congress repeals the Military Selective Service Act and ends draft registration entirely, either through a standalone bill like the Selective Service Repeal Act or through a provision in this or a future year's NDAA.




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A war draft today can't work. Let us count the ways.

[Originally published by Responsible Statecraft, the journal of the Quincy Institute]

Two proposals that would radically alter the current system for registering Americans for a future draft were introduced recently in Congress without any hearings or debate.

They raise practical issues about whether any draft today would even be possible.

As part of this year’s National Defense Authorization Act, the House voted this month to make registration with the Selective Service System of all draft-eligible men ages 18-26 “automatic.” In addition, the version of the NDAA on its way to the Senate floor would expand draft registration to include young women now, too.

Debate about the draft has typically been framed around whether the U.S. “needs'' a draft. Debate about women and the draft has been framed around whether women “should” be required to register. But the bigger question we face is three fold: will women sign up voluntarily (if in fact registration is not “automatic”), is “automatic” registration based on other databases feasible, and can registration or a draft – for men and/or women -- even be enforced.

When I was invited to testify before the National Commission on Military, National, and Public Service (NCMNPS) in 2019, I told them that “any proposal that includes a compulsory element is a naïve fantasy unless it includes a credible enforcement plan and budget.... Women will be more likely to resist being forced into the military than men have been, and more people will support them in their resistance.”




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Playbook for a military draft

[I'm often asked, "Why should we care about draft registration if there isn't going to be a draft?" In the article below, which was first published earlier today on Antiwar.com, I look at what war planners say about why draft registration is an important weapon in the arsenal of military strategy, even if there isn't going to be a draft -- and what that says about why draft registration ought to be equally important to antiwar activists, even when an actual draft isn't active or likely.]


[Stages of mobilization for war. Image from CNAS report based on Department of Defense mobilization plan. Note the absence of a Congressional declaration of war at any stage up to and including total military mobilization.]

A new report released 18 June 2024 by the Center for a New American Security (CNAS) provides a remarkably candid window into the flawed and dangerous thinking of military strategists who support continual "readiness" for an on-demand military draft, even while they claim -- perhaps truthfully -- not to prefer a draft, even as Plan B, but only as Plan F for "Fallback" in case of prolonged and total war. (Thanks to longtime anti-draft activist Eric Garris of Antiwar.com for bringing this report to my attention.)

The CNAS report is intended to show supporters of the current bipartisan mainstream U.S. foreign policy and military consensus why the U.S. should step up planning and preparation for a draft as a tool of deterrence. But for those outside that consensus who think current U.S. policy is already bellicose enough, especially those who assume that opposing draft registration and other steps toward readiness for a draft should be a low priority for antiwar activists because the U.S. will never again (or at least not soon) activate a draft, the CNAS report provides an important lesson in how preparedness for a draft is itself a tool of war, even in "peacetime".

The CNAS report shows how its authors want to use readiness for a draft, and the circumstances in which they think it should be used.

The fundamental argument of the CNAS report is that a "credible" capability to quickly activate a draft is an important deterrent, especially to other great-power military "peers" and potential adversaries.

As with nuclear weapons, to speak of readiness for a draft as a deterrent is another way to speak of preparation for a draft as a threat. As also with nuclear weapons, that threat is itself a weapon.

Preparation for a draft is used as a weapon when it is used to threaten escalating war to another level of death and destruction, even when that threat isn't carried out. The "credibility" of U.S. readiness to implement a draft -- stressed repeatedly in the CNAS report -- is relevant only to the use of that readiness for a draft as a threat.

Proponents of draft registration and readiness for a draft such as the authors of the CNAS report argue that if, and only if, the great-power enemies of the U.S. believe that we are able and willing to activate a draft, we can use that threat of draft-enabled rapid and total military escalation and total war as a tool of diplomatic and military policy.

Resistance to planning and preparation for a draft is thus a way to rein in those policies that are based on the ability to rush into total war, and the threat to do so.




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Senate joins House in proposal for "automatic" draft registration

Contrary to earlier reports, the U.S. Senate has joined the House of Representatives in moving toward a foolhardy attempt to 'automatically' register all draft-eligible U.S. citizens and residents for a possible military draft, by extracting and aggregating information obtained from other Federal agencies.

The proposal for "automatic" draft registration is among several previously-undisclosed provisions related to Selective Service in the newly-release version of the National Defense [sic] Authorization Act (NDAA) for Fiscal Year 2025 approved by the Senate Armed Services Committee (SASC) and to be considered by the full Senate.

The 1,197-page SASC proposal for this year's NDAA was approved by the committee in closed session last month, and only a summary was released. At the time, a spokesperson for the SASC told me that if "automatic" Selective Service registration had been included in the bill, it would have been included in the summary. That proves to have been incorrect: The proposal for "automatic" draft registration was included in the SASC version of the bill, but not in the summary.




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Summer of the military draft: What the U.S. government and think tanks are planning and why

[Originally published by Responsible Statecraft, the journal of the Quincy Institute]

How did this suddenly become the summer of “the draft”?

There are a number of proposals in the annual defense policy bill (National Defense Authorization Act, NDAA) that deal with the subject. There is one to expand Selective Service registration to women. Another that would make Selective Service registration for American men "automatic."

Still another proposed amendment to the NDAA, which has also been introduced as a freestanding bill, S. 4881, would repeal the Military Selective Service Act entirely. Meanwhile, the Center for a New American Security just published an exhaustive blueprint for modernizing mobilization, including readiness to activate conscription.

All this talk has compelled “fact checkers” to insist that no, the U.S. government isn’t suddenly "laying the groundwork" for a draft.

But saying the U.S. isn’t preparing for a draft is like saying it isn’t preparing for nuclear war. Just as the Department of Defense is tasked with maintaining readiness to initiate nuclear strikes whenever the Commander-In-Chief so orders, the Selective Service System has the sole mission of maintaining readiness to hold a draft lottery within five days and start selecting draftees and sending out notices to report for induction whenever Congress and the President so order.

As such, there are currently ten thousand draft board members who have been appointed and trained to adjudicate claims for deferment or exemption. As recently as this month, states have been openly seeking volunteers to fill empty slots. And both the SSS and hawkish think-tanks have been war-gaming the government’s contingency plans to activate a draft.


[Timeline for a draft, counting from “Mobilization Day” (M=0), from SSS Agency Response Plan (ARP) Workshop (September 7, 2023)]

There’s room for argument about how likely it is that the U.S. would launch nuclear missiles or activate a draft. But there’s no question that it’s planning and preparing for both, as it has been for decades. It would seem that after years of atrophy, the government is stepping up its attention to military mobilization and readiness for a draft.

Maybe it’s time to ask whether more easy and efficient ways of tapping into human capital for war make it easier to get into one and whether it is in our best interest to do so.




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"Realists" think we need to prepare for a draft so we can win a war with China.

[First published on Antiwar.com]

Fantasies underlying push for conscription are delusional and dangerous.

Doubling down on their recent war-game exercises and report on the (un)readiness of the U.S. to activate a military draft, Taren Sylvester and Katherine Kuzminski of the Center for a New American Security (CNAS) have a new article in War on the Rocks, “Preparing for the Possibility of a Draft Without Panic,” laying out why they think the U.S. needs to prepare for a draft in order to be able to win an all-out war with China over Taiwan.

CNAS and War on the Rocks like to describe themselves as “realists”. But their arguments for stepped-up planning and preparation for a draft are strikingly unrealistic, in at least four respects:




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Military draft sign-ups plunge as war fears rise

Fewer young Americans are willing to fight the government’s wars.

[Also published on Antiwar.com. Portions of this article were first published by Responsible Statecraft and are reprinted by permission.]

Of men in the U.S. who turned 18 in 2023, fewer than 40% signed up for the draft – down from more than 60% in 2020 before the start of the war in Ukraine.

This eye-popping and previously undisclosed admission, as well as other revelations equally damning to plans to increase readiness to activate a draft, was included in documents released recently by the Selective Service System (SSS) in response to a Freedom Of Information Act request.




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Electronic superhighway : from experiments in art and technology to art after the internet /

Library - Art Library, Location - OSIZ, Call number - FOLIO NX456.5.N49 E54 2016




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Aftermath : the fallout of war--America and the Middle East /

Library - Art Library, Location - OSIZ, Call number - FOLIO TR820.6 .A34 2016




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Nuqṭah va nuqṭah, bāz ham nuqṭah : daftar-i shiʻr

Location: Main Library- PK6561.K43N87 2014




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25 of 43 monkeys have been recovered after escaping a lab in South Carolina last week

A research facility in Yemassee, S.C., has recovered 25 of the 43 monkeys that escaped from the laboratory last week after a caretaker accidentally left the door to their enclosure unsecured.




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After fighting phragmites, scientists try to bring native plants back to wetlands

Wetlands managers have spent years using fire and chemicals to fight phragmites, an invasive reed that chokes everything else out. But coaxing native plants to move back in is difficult.




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1840: Excavations in Nineveh Continue After Christmas

1840: Excavations in Nineveh Continue After Christmas



  • 1800-1899 A.D. Assyrian History


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Ind Seasonal Aircraft Deicing Agents

Indianapolis, IN United States Description Looking For Extra Cash? Part Time Seasonal Opportunities Available Now!! Menzies Aviation is looking for Part Time employees to join our Deicing team at Indianapolis Airport (IND). These positions are seasonal from October through Spring (April/May). Training planned to begin in September. + 1st and 2nd Shift schedules with weekend availability needed. + Competitive Wages $20/hr + No Experience Needed – Paid Training Provided + Uniforms Provided w/ Winter Gear + Opportunities for growth and advancement Essential Duties and Responsibilities include the following. Other duties May be assigned. + Responsible for checking aircraft for leading edge ice and frost. + Application of Deice Fluid Type 1 or Type 4 to aircraft wings fuselage and tail. + Responsible for driving large heavy vehi




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Aircraft Tow Agent

Orlando, FL United States Description Key Responsibilities: • Towing different types of aircrafts safely and securely.• Frequent bending stretching push/pulling stacking and kneeling in small confined locations.• Perform inspection of tow tractor and tow bar prior to each use• Operate motorized equipment.• Responsible for safe push back and communications with the flight crew during push back.• Read and interpret aircraft weight and balance loading instructions hazardous materialidentification labels aircraft loading manifests and baggage and cargo routing tags.• Communicate with Apron Control/Ground Control• Performs other duties as assigned• Operate motorized equipment.• Ensure tasks are performed in a




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Aircraft Tow Agent

Denver, CO United States Description As a member of the Menzies Aviation Aircraft Tow Operations you will be responsible for assisting in the movement of the Aircraft to and from the Gates. Compensation: + $21.50 per hour + $.50 base wage increase after 6 months of service $.50 increase after 1 year of service and $.50 increase after 2 years of service. + $40.00 Monthly Bus/Train Voucher or Free Airport Parking + Frontier Airlines Flight benefits for you and a companion Key Responsibilities: + OVERNIGHT SHIFT ONLY + Towing different types of aircrafts safely and securely.• Frequent bending stretching push/pulling stacking and kneeling in small confined locations.• Perform inspection of tow tractor and tow bar prior to each use• Operate motorized equipment.• Responsible for safe push bac




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Seasonal Aircraft Deicing Agents

Bwi Airport, MD United States Description + A flexible schedule is needed due to the ever changing airline schedules. Essential Duties and Responsibilities include the following. Other duties May be assigned. + Responsible for checking aircraft for leading edge ice and frost. + Application of Deice Fluid Type 1 or Type 4 to aircraft wings fuselage and tail. + Responsible for driving large heavy vehicles around aircraft while deicing operation is being performed. + Responsible for accurate accounting of deicing fluid transactions. + Perform daily quality control checks on equipment and vehicles. + Operate headset/radio to provide communication between ground crew flight crew and dispatch. + Know and comply with all safety procedures/protocols. + Provide additional service as required. + Able to meet the Stations attendance/tardiness standa




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Ind Seasonal Aircraft Deicing Agents

Indianapolis, IN United States Description Looking For Extra Cash? Part Time Seasonal Opportunities Available Now!! Menzies Aviation is looking for Part Time employees to join our Deicing team at Indianapolis Airport (IND). These positions are seasonal from October through Spring (April/May). Training planned to begin in September. + 1st and 2nd Shift schedules with weekend availability needed. + Competitive Wages $20/hr + No Experience Needed – Paid Training Provided + Uniforms Provided w/ Winter Gear + Opportunities for growth and advancement Essential Duties and Responsibilities include the following. Other duties May be assigned. + Responsible for checking aircraft for leading edge ice and frost. + Application of Deice Fluid Type 1 or Type 4 to aircraft wings fuselage and tail. + Responsible for driving large heavy vehi




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Antiquities under Siege: Cultural Heritage Protection after ...

Antiquities under Siege: Cultural Heritage Protection after the Iraq War [Hardcover]



  • Fine Arts Information

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Aircraft Maintenance Engineer Avionics

Edinburgh, South Australia Australia - Job Description At Boeing, we innovate and collaborate to make the world a better place. From the seabed to outer space, you can contribute to work that matters with a company where diversity, equity and inclusion are shared values. We’re committed t... View




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Aircraft Maintenance Engineer Structures

Nowra, New South Wales Australia - Job Description At Boeing, we innovate and collaborate to make the world a better place. From the seabed to outer space, you can contribute to work that matters with a company where diversity, equity and inclusion are shared values. We’re committed to fo... View




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Aircraft Maintenance Engineer

Nowra, New South Wales Australia - Job Description At Boeing, we innovate and collaborate to make the world a better place. From the seabed to outer space, you can contribute to work that matters with a company where diversity, equity and inclusion are shared values. We’re committed to fo... View




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Aircraft Maintenance Engineer

Oakey, Queensland Australia - Job Description At Boeing, we innovate and collaborate to make the world a better place. From the seabed to outer space, you can contribute to work that matters with a company where diversity, equity and inclusion are shared values. We’re committed to fostering an ... View




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Apprentice Aircraft Maintenance Engineer

Nowra, New South Wales Australia - Job Description At Boeing, we innovate and collaborate to make the world a better place. From the seabed to outer space, you can contribute to work that matters with a company where diversity, equity and inclusion are shared values. We’re committed to fo... View




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WMX Americas closes doors after two days of super-charged debate, collaboration and deal-making

WMX Americas closed its doors after a successful two days. One clear key message from the conference was there has to be a better focus on the customer. Customer experience, customer journey and customer feedback were all key takeaways.




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WMX Europe in Madrid closes its doors after an inspiring event

Last week WMX Europe, organised by Triangle Management Services, closed its doors after two successful days of idea-sharing and partnerships not to mention all the celebrations at the World Post & Parcel Awards 2024.




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Apprentice Aircraft Maintenance Engineer

Nowra, New South Wales Australia - Job Description At Boeing, we innovate and collaborate to make the world a better place. From the seabed to outer space, you can contribute to work that matters with a company where diversity, equity and inclusion are shared values. We’re committed t... View




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Driver dies after crashing on hurricane-damaged highway in North Carolina




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Driver jumps from overpass into Trinity River after crash on I-35 in Fort Worth, causing heavy traffic




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U.S. serviceman finally laid to rest, more than 50 years after being killed in Vietnam




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See it: Vehicle falls into North Carolina gorge after driver disregards I-40 closure following Helene




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Man escapes from SUV after driving into Canandaigua Lake from City Pier




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Artsakh Uprooted: Aftermaths of Displacement

Artsakh Uprooted: Aftermaths of Displacement



  • Armenian
  • Assyrian and Hellenic Genocide News

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CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients

CRISPR Immune Cells Not Only Survive, They Thrive After Infusion Into Cancer Patients

In the first-ever (sanctioned) investigational use of multiple edits to the human genome, a study found that cells edited in three specific ways and then removed from patients and brought back into the lab setting were able to kill cancer months after their original manufacturing and infusion.

This is the first U.S. clinical trial to test the gene editing approach in humans, and the publication of this new data today follows on the initial report last year that researchers were able to use CRISPR/Cas9 technology to successfully edit three cancer patients' immune cells. The ongoing study is a cooperative between Tmunity Therapeutics, the Parker Institute for Cancer Immunotherapy, and the University of Pennsylvania. 

Patients on this trial were treated by Edward A. Stadtmauer, MD, section chief of Hematologic Malignancies at Penn, co-lead author on the study. The approach in this study is closely related to CAR T cell therapy, in which patient immune cells are engineered to fight cancer, but it has some key differences. Just like CAR T, researchers in this study began by collecting a patient's T cells from blood. However, instead of arming these cells with a receptor against a protein such as CD19, the team first used CRISPR/Cas9 editing to remove three genes. The first two edits removed a T cell's natural receptors so they can be reprogrammed to express a synthetic T cell receptor, allowing these cells to seek out and destroy tumors. The third edit removed PD-1, a natural checkpoint that sometimes blocks T cells from doing their job. 

Once the three genes are knocked out, a fourth genetic modification was accomplished using a lentivirus to insert the cancer-specific synthetic T cell receptor, which tells the edited T cells to target an antigen called NY-ESO-1. Previously published data show these cells typically survive for less than a week, but this new analysis shows the edited cells used in this study persisted, with the longest follow up at nine months. 

Several months after the infusion, researchers drew more blood and isolated the CRISPR-edited cells for study. When brought back into the lab setting, the cells were still able to kill tumors. 

The CRISPR-edited T cells used in this study are not active on their own like CAR T cells. Instead, they require the cooperation of a molecule known as HLA-A*02:01, which is only expressed in a subset of patients. This means that patients had to be screened ahead of time to make sure they were a match for the approach. Participants who met the requirements received other clinically-indicated therapy as needed while they waited for their cells to be manufactured. Once that process was completed, all three patients received the gene-edited cells in a single infusion after a short course of chemotherapy. Analysis of blood samples revealed that all three participants had the CRISPR-edited T cells take root and thrive in the patients. While none responded to the therapy, there were no treatment-related serious adverse events. 

CRISPR technology has not previously been tested in humans in the U.S. so the research team had to move through a comprehensive and rigorous series of institutional and federal regulatory approval steps, including approval by the National Institutes of Health's Recombinant DNA Research Advisory Committee and review by the U.S. Food and Drug Administration, as well as Penn's institutional review board and institutional biosafety committee. The entire process required more than two years.

 Researchers say these new data will open the door to later stage studies to investigate and extend this approach to a broader field beyond cancer, several of which are already planned at Penn.

sb admin Thu, 02/06/2020 - 14:52
Categories




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Cedars-Sinai terminates OB-GYN's hospital privileges after complaint investigation

An obstetrician-gynecologist has been barred from practicing at Cedars-Sinai following an investigation into complaints. The doctor has denied wrongdoing.




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Tooth decay still plagues California kids nearly a decade after Medi-Cal promised change

Kids in California struggle with more cavities than kids in most states, despite Medi-Cal efforts to fix dental care administrative hurdles and focus on prevention.




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Infant mortality in the U.S. worsened after Supreme Court limited abortion access

Just months after the Supreme Court limited abortion access, infant mortality rates rose significantly higher, according to a new study.




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Gas prices could rise after vote by California regulators

Gas prices could rise after vote by California regulators




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US lowers El Salvador travel advisory to Level 2 after caucus protest

The United States lowered El Salvador’s travel advisory to Level 2 after protests from the Congressional El Salvador Caucus. The United States had previously refused to lower the country’s travel designation from Level 3, “Reconsider Travel,” the second-highest rating possible, despite the transformation of the country’s crime situation. Over the past decade, the country had […]




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Caps defenseman Mike Green retaliates after attempted slew foot

The Capitals were upset with a lot of calls on Sunday in a 1-0 loss to the New York Rangers. Maybe a better way to say it – they were upset about non-calls. New York, the most disciplined team in the NHL this season, wasn’t whistled for a single penalty. Washington took five – two of them obvious, and dumb, retaliation penalties.




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Bradley Beal crisp in return after six-game absence

Bradley Beal looked like himself again in his first minutes back on the court in a 127-105 victory over Phoenix on Saturday following six missed games with a sprained left ankle.




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PGA Tour adds Tiger Woods to policy board after criticism by players over transparency

The PGA Tour announced it is adding Tiger Woods to its policy board and making changes to its governance after criticism from several players over the lack of transparency in the lead-up to the announced deal between the PGA Tour and the Saudi-backed LIV Golf in June.




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Randy Travis releases new music with the help of AI after a stroke

Randy Travis has released a new song, "Where That Came From," with the help of artificial intelligence. It's his first single since he had a stroke.