from Antimicrobial Activity of Ceftolozane-Tazobactam and Comparators against Clinical Isolates of Haemophilus influenzae from the United States and Europe [Susceptibility] By aac.asm.org Published On :: 2020-04-21T08:01:09-07:00 Nine hundred Haemophilus influenzae clinical isolates from 83 U.S. and European medical centers were tested for susceptibility by reference broth microdilution methods against ceftolozane-tazobactam and comparators. Results were stratified by β-lactamase production and infection type. Overall, ceftolozane-tazobactam MIC50/90 values were 0.12/0.25 mg/liter, and 99.0% of isolates were inhibited at the susceptible breakpoint of ≤0.5 mg/liter; the highest MIC value was only 2 mg/liter. Our results support using ceftolozane-tazobactam to treat H. influenzae infections. Full Article
from Molecular and Clinical Characterization of Multidrug-Resistant and Hypervirulent Klebsiella pneumoniae Strains from Liver Abscess in Taiwan [Epidemiology and Surveillance] By aac.asm.org Published On :: 2020-04-21T08:01:09-07:00 Hypervirulent Klebsiella pneumoniae strains are the major cause of liver abscesses throughout East Asia, and these strains are usually antibiotic susceptible. Recently, multidrug-resistant and hypervirulent (MDR-HV) K. pneumoniae strains have emerged due to hypervirulent strains acquiring antimicrobial resistance determinants or the transfer of a virulence plasmid into a classic MDR strain. In this study, we characterized the clinical and microbiological properties of K. pneumoniae liver abscess (KPLA) caused by MDR-HV strains in Taiwan. Patients with community onset KPLA were retrospectively identified at Taipei Veterans General Hospital during January 2013 to May 2018. Antimicrobial resistance mechanisms, capsular types, and sequence types were determined. MDR-HV strains and their parental antimicrobial-susceptible strains further underwent whole-genome sequencing (WGS) and in vivo mice lethality tests. Thirteen MDR-HV strains were identified from a total of 218 KPLA episodes. MDR-HV strains resulted in similar outcomes to antimicrobial-susceptible strains. All MDR-HV strains were traditional hypervirulent clones carrying virulence capsular types. The major resistance mechanisms were the overexpression of efflux pumps and/or the acquisition of ESBL or AmpC β-lactamase genes. WGS revealed that two hypervirulent strains had evolved to an MDR phenotype due to mutation in the ramR gene and the acquisition of an SHV-12-bearing plasmid, respectively. Both these MDR-HV strains retained high virulence compared to their parental strains. The spread of MDR-HV K. pneumoniae strains in the community raises significant public concerns, and measures should be taken to prevent the further acquisition of carbapenemase and other resistance genes among these strains in order to avoid the occurrence of untreatable KPLA. Full Article
from The tale of two genes: from next-generation sequencing to phenotype [RESEARCH REPORT] By molecularcasestudies.cshlp.org Published On :: 2020-04-01T06:30:17-07:00 An 18-yr-old man with a history of intellectual disability, craniofacial dysmorphism, seizure disorder, and obesity was identified to carry a de novo, pathogenic variant in ASXL1 (c.4198G>T; p.E1400X) associated with the diagnosis of Bohring–Opitz syndrome based on exome sequencing. In addition, he was identified to carry a maternally inherited and likely pathogenic variant in MC4R (c.817C>T; p.Q273X) associated with monogenic obesity. Dual genetic diagnosis occurs in 4%–6% of patients and results in unique clinical phenotypes that are a function of tissue-specific gene expression, involved pathways, clinical expressivity, and penetrance. This case highlights the utility of next-generation sequencing in patients with an unusual combination of clinical presentations for several pillars of precision medicine including (1) diagnosis, (2) prognosis and outcome, (3) management and therapy, and (4) utilization of resources. Full Article
from [Cell Signaling] Store-Operated Calcium Channels: From Function to Structure and Back Again By cshperspectives.cshlp.org Published On :: 2020-05-01T06:30:17-07:00 Store-operated calcium (Ca2+) entry (SOCE) occurs through a widely distributed family of ion channels activated by the loss of Ca2+ from the endoplasmic reticulum (ER). The best understood of these is the Ca2+ release-activated Ca2+ (CRAC) channel, which is notable for its unique activation mechanism as well as its many essential physiological functions and the diverse pathologies that result from dysregulation. In response to ER Ca2+ depletion, CRAC channels are formed through a diffusion trap mechanism at ER–plasma membrane (PM) junctions, where the ER Ca2+-sensing stromal interaction molecule (STIM) proteins bind and activate hexamers of Orai pore-forming proteins to trigger Ca2+ entry. Cell biological studies are clarifying the architecture of ER–PM junctions, their roles in Ca2+ and lipid transport, and functional interactions with cytoskeletal proteins. Molecular structures of STIM and Orai have inspired a multitude of mutagenesis and electrophysiological studies that reveal potential mechanisms for how STIM is toggled between inactive and active states, how it binds and activates Orai, and the importance of STIM-binding stoichiometry for opening the channel and establishing its signature characteristics of extremely high Ca2+ selectivity and low Ca2+ conductance. Full Article
from Timely News and Notes for Primary Care Providers from the American Diabetes Association By clinical.diabetesjournals.org Published On :: 2020-04-15T12:00:21-07:00 Full Article
from Accuracy of Self-reported Colonic Polyps: Results from the Prostate, Lung, Colorectal, and Ovarian Screening Trial Study of Colonoscopy Utilization By cebp.aacrjournals.org Published On :: 2020-05-01T00:05:36-07:00 Background: Colonoscopy follow-up recommendations depend on the presence or absence of polyps, and if found, their number, size, and histology. Patients may be responsible for conveying results between primary and specialty care or providing medical information to family members; thus, accurate reporting is critical. This analysis assessed the accuracy of self-reported colonoscopy findings. Methods: 3,986 participants from the Study of Colonoscopy Utilization, an ancillary study nested within the Prostate, Lung, Colorectal, and Ovarian Screening Trial, were included. Self-reports of polyp and adenoma were compared to medical records, and measures of sensitivity and specificity were calculated. Correlates of accurate self-report of polyp were assessed using logistic regression and weighted to account for study sampling. Results: The sensitivity and specificity of self-reported polyp findings were 88% and 85%, respectively, and for adenoma 11% and 99%, respectively. Among participants with a polyp, older age was associated with lower likelihood while polyp severity and non-white race were associated with increased likelihood of accurate recall. Among participants without a polyp, having multiple colonoscopies was associated with lower likelihood while family history of colorectal cancer was associated with increased likelihood of accurate recall. Among both groups, longer time since colonoscopy was associated with lower likelihood of accurate recall. Conclusions: Participants recalled with reasonable accuracy whether they had a prior polyp; however, recall of histology, specifically adenoma, was much less accurate. Impact: Identification of strategies to increase accurate self-report of colonic polyps are needed, particularly for patient–provider communications and patient reporting of results to family members. Full Article
from Screen to Save: Results from NCI's Colorectal Cancer Outreach and Screening Initiative to Promote Awareness and Knowledge of Colorectal Cancer in Racial/Ethnic and Rural Populations By cebp.aacrjournals.org Published On :: 2020-05-01T00:05:36-07:00 Background: The Center to Reduce Cancer Health Disparities (CRCHD), NCI, implemented Screen to Save, NCI's Colorectal Cancer Outreach and Screening Initiative to promote awareness and knowledge of colorectal cancer in racial/ethnic and rural populations. Methods: The initiative was implemented through CRCHD's National Outreach Network (NON). NON is a national network of Community Health Educators (CHE), aligned with NCI-designated Cancer Centers across the nation. In phases I and II, the CHEs focused on the dissemination of cancer-related information and implementation of evidence-based educational outreach. Results: In total, 3,183 pre/post surveys were obtained from male and female participants, ages 50 to 74 years, during the 347 educational events held in phase I. Results demonstrated all racial/ethnic groups had an increase in colorectal cancer–related knowledge, and each group strongly agreed that the educational event increased the likelihood that they would engage in colorectal cancer–related healthful behaviors (e.g., obtain colorectal cancer screening and increase physical activity). For phase II, Connections to Care, event participants were linked to screening. Eighty-two percent of the participants who obtained colorectal cancer screening during the 3-month follow-up period obtained their screening results. Conclusions: These results suggest that culturally tailored, standardized educational messaging and data collection tools are key change agents that can serve to inform the effectiveness of educational outreach to advance awareness and knowledge of colorectal cancer. Impact: Future initiatives should focus on large-scale national efforts to elucidate effective models of connections to care, related to colorectal cancer screening, follow-up, and treatments that are modifiable to meet community needs. Full Article
from One Size Does Not Fit All: Marked Heterogeneity in Incidence of and Survival from Gastric Cancer among Asian American Subgroups By cebp.aacrjournals.org Published On :: 2020-05-01T00:05:36-07:00 Background: Asian Americans are at higher risk for noncardia gastric cancers (NCGC) relative to non-Hispanic Whites (NHW). Asian Americans are genetically, linguistically, and culturally heterogeneous, yet have mostly been treated as a single population in prior studies. This aggregation may obscure important subgroup-specific cancer patterns. Methods: We utilized data from 13 regional United States cancer registries from 1990 to 2014 to determine secular trends in incidence and survivorship from NCGC. Data were analyzed for NHWs and the six largest Asian American subgroups: Chinese, Japanese, Filipino, Korean, Vietnamese, and South Asian (Indian/Pakistani). Results: There exists substantial heterogeneity in NCGC incidence between Asian subgroups, with Koreans (48.6 per 100,000 person-years) having seven-fold higher age-adjusted incidence than South Asians (7.4 per 100,000 person-years). Asians had generally earlier stages of diagnosis and higher rates of surgical resection compared with NHWs. All Asian subgroups also demonstrated higher 5-year observed survival compared with NHWs, with Koreans (41.3%) and South Asians (42.8%) having survival double that of NHWs (20.1%, P < 0.001). In multivariable regression, differences in stage of diagnosis and rates of resection partially explained the difference in survivorship between Asian subgroups. Conclusions: We find substantial differences in incidence, staging, histology, treatment, and survivorship from NCGC between Asian subgroups, data which challenge our traditional perceptions about gastric cancer in Asians. Both biological heterogeneity and cultural/environmental differences may underlie these findings. Impact: These data are relevant to the national discourse regarding the appropriate role of gastric cancer screening, and identifies high-risk racial/ethnic subgroups who many benefit from customized risk attenuation programs. Full Article
from Projected Reductions in Absolute Cancer-Related Deaths from Diagnosing Cancers Before Metastasis, 2006-2015 By cebp.aacrjournals.org Published On :: 2020-05-01T00:05:36-07:00 Background: New technologies are being developed for early detection of multiple types of cancer simultaneously. To quantify the potential benefit, we estimated reductions in absolute cancer–related deaths that could occur if cancers diagnosed after metastasis (stage IV) were instead diagnosed at earlier stages. Methods: We obtained stage-specific incidence and survival data from the Surveillance, Epidemiology, and End Results Program for 17 cancer types for all persons diagnosed ages 50 to 79 years in 18 geographic regions between 2006 and 2015. For a hypothetical cohort of 100,000 persons, we estimated cancer-related deaths under assumptions that cancers diagnosed at stage IV were diagnosed at earlier stages. Results: Stage IV cancers represented 18% of all estimated diagnoses but 48% of all estimated cancer-related deaths within 5 years. Assuming all stage IV cancers were diagnosed at stage III, 51 fewer cancer-related deaths would be expected per 100,000, a reduction of 15% of all cancer-related deaths. Assuming one third of metastatic cancers were diagnosed at stage III, one third diagnosed at stage II, and one third diagnosed at stage I, 81 fewer cancer-related deaths would be expected per 100,000, a reduction of 24% of all cancer-related deaths, corresponding to a reduction in all-cause mortality comparable in magnitude to eliminating deaths due to cerebrovascular disease. Conclusions: Detection of multiple cancer types earlier than stage IV could reduce at least 15% of cancer-related deaths within 5 years, affecting not only cancer-specific but all-cause mortality. Impact: Detecting cancer before stage IV, including modest shifts to stage III, could offer substantial population benefit. Full Article
from Selected Articles from This Issue By cebp.aacrjournals.org Published On :: 2020-05-01T00:05:36-07:00 Full Article
from NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors By cancerres.aacrjournals.org Published On :: 2020-05-04T05:35:17-07:00 Determining mechanisms of resistance to αPD-1/PD-L1 immune-checkpoint immunotherapy is key to developing new treatment strategies. Cancer-associated fibroblasts (CAF) have many tumor-promoting functions and promote immune evasion through multiple mechanisms, but as yet, no CAF-specific inhibitors are clinically available. Here we generated CAF-rich murine tumor models (TC1, MC38, and 4T1) to investigate how CAFs influence the immune microenvironment and affect response to different immunotherapy modalities [anticancer vaccination, TC1 (HPV E7 DNA vaccine), αPD-1, and MC38] and found that CAFs broadly suppressed response by specifically excluding CD8+ T cells from tumors (not CD4+ T cells or macrophages); CD8+ T-cell exclusion was similarly present in CAF-rich human tumors. RNA sequencing of CD8+ T cells from CAF-rich murine tumors and immunochemistry analysis of human tumors identified significant upregulation of CTLA-4 in the absence of other exhaustion markers; inhibiting CTLA-4 with a nondepleting antibody overcame the CD8+ T-cell exclusion effect without affecting Tregs. We then examined the potential for CAF targeting, focusing on the ROS-producing enzyme NOX4, which is upregulated by CAF in many human cancers, and compared this with TGFβ1 inhibition, a key regulator of the CAF phenotype. siRNA knockdown or pharmacologic inhibition [GKT137831 (Setanaxib)] of NOX4 “normalized” CAF to a quiescent phenotype and promoted intratumoral CD8+ T-cell infiltration, overcoming the exclusion effect; TGFβ1 inhibition could prevent, but not reverse, CAF differentiation. Finally, NOX4 inhibition restored immunotherapy response in CAF-rich tumors. These findings demonstrate that CAF-mediated immunotherapy resistance can be effectively overcome through NOX4 inhibition and could improve outcome in a broad range of cancers.Significance:NOX4 is critical for maintaining the immune-suppressive CAF phenotype in tumors. Pharmacologic inhibition of NOX4 potentiates immunotherapy by overcoming CAF-mediated CD8+ T-cell exclusion.Graphical Abstract:http://cancerres.aacrjournals.org/content/canres/80/9/1846/F1.large.jpg.See related commentary by Hayward, p. 1799 Full Article
from Highlights from Recent Cancer Literature By cancerres.aacrjournals.org Published On :: 2020-05-04T05:35:17-07:00 Full Article
from Advanced ADC Histogram, Perfusion, and Permeability Metrics Show an Association with Survival and Pseudoprogression in Newly Diagnosed Diffuse Intrinsic Pontine Glioma: A Report from the Pediatric Brain Tumor Consortium [FUNCTIONAL] By www.ajnr.org Published On :: 2020-04-09T06:30:48-07:00 BACKGROUND AND PURPOSE: Diffuse intrinsic pontine glioma is a lethal childhood brain cancer with dismal prognosis and MR imaging is the primary methodology used for diagnosis and monitoring. Our aim was to determine whether advanced diffusion, perfusion, and permeability MR imaging metrics predict survival and pseudoprogression in children with newly diagnosed diffuse intrinsic pontine glioma. MATERIALS AND METHODS: A clinical trial using the poly (adenosine diphosphate ribose) polymerase (PARP) inhibitor veliparib concurrently with radiation therapy, followed by maintenance therapy with veliparib + temozolomide, in children with diffuse intrinsic pontine glioma was conducted by the Pediatric Brain Tumor Consortium. Standard MR imaging, DWI, dynamic contrast-enhanced perfusion, and DSC perfusion were performed at baseline and approximately every 2 months throughout treatment. ADC histogram metrics of T2-weighted FLAIR and enhancing tumor volume, dynamic contrast-enhanced permeability metrics for enhancing tumors, and tumor relative CBV from DSC perfusion MR imaging were calculated. Baseline values, post-radiation therapy changes, and longitudinal trends for all metrics were evaluated for associations with survival and pseudoprogression. RESULTS: Fifty children were evaluable for survival analyses. Higher baseline relative CBV was associated with shorter progression-free survival (P = .02, Q = 0.089) and overall survival (P = .006, Q = 0.055). Associations of higher baseline mean transfer constant from the blood plasma into the extravascular extracellular space with shorter progression-free survival (P = .03, Q = 0.105) and overall survival (P = .03, Q = 0.102) trended toward significance. An increase in relative CBV with time was associated with shorter progression-free survival (P < .001, Q < 0.001) and overall survival (P = .004, Q = 0.043). Associations of longitudinal mean extravascular extracellular volume fraction with progression-free survival (P = .03, Q = 0.104) and overall survival (P = .03, Q = 0.105) and maximum transfer constant from the blood plasma into the extravascular extracellular space with progression-free survival (P = .03, Q = 0.102) trended toward significance. Greater increases with time were associated with worse outcomes. True radiologic progression showed greater post-radiation therapy decreases in mode_ADC_FLAIR compared with pseudoprogression (means, –268.15 versus –26.11, P = .01.) CONCLUSIONS: ADC histogram, perfusion, and permeability MR imaging metrics in diffuse intrinsic pontine glioma are useful in predicting survival and pseudoprogression. Full Article
from Brain Metastases: Insights from Statistical Modeling of Size Distribution [ADULT BRAIN] By www.ajnr.org Published On :: 2020-04-09T06:30:48-07:00 BACKGROUND AND PURPOSE: Brain metastases are a common finding on brain MRI. However, the factors that dictate their size and distribution are incompletely understood. Our aim was to discover a statistical model that can account for the size distribution of parenchymal metastases in the brain as measured on contrast-enhanced MR imaging. MATERIALS AND METHODS: Tumor volumes were calculated on the basis of measured tumor diameters from contrast-enhanced T1-weighted spoiled gradient-echo images in 68 patients with untreated parenchymal metastatic disease. Tumor volumes were then placed in rank-order distributions and compared with 11 different statistical curve types. The resultant R2 values to assess goodness of fit were calculated. The top 2 distributions were then compared using the likelihood ratio test, with resultant R values demonstrating the relative likelihood of these distributions accounting for the observed data. RESULTS: Thirty-nine of 68 cases best fit a power distribution (mean R2 = 0.938 ± 0.050), 20 cases best fit an exponential distribution (mean R2 = 0.957 ± 0.050), and the remaining cases were scattered among the remaining distributions. Likelihood ratio analysis revealed that 66 of 68 cases had a positive mean R value (1.596 ± 1.316), skewing toward a power law distribution. CONCLUSIONS: The size distributions of untreated brain metastases favor a power law distribution. This finding suggests that metastases do not exist in isolation, but rather as part of a complex system. Furthermore, these results suggest that there may be a relatively small number of underlying variables that substantially influence the behavior of these systems. The identification of these variables could have a profound effect on our understanding of these lesions and our ability to treat them. Full Article
from House For Rent in SwanPark (Town House, Villa, Shop House) -7 minutes from Nhon Trach Industrial By batdongsan.com.vn Published On :: Fri, 03 Apr 2020 15:11:39 GMT * House For Rent in Swan Park, Swan Bay (Town House, Villa, Shop House): - Extremely cool and green environment - Modern Singapore design, suitable for small families, senior experts or representative offices ... Very convenient location: - 2 minutes to the administrative cent... Full Article
from Hot! Saigon eco-villas for sale from 1000-1200$/m2 Call (+84) 968020129 (zalo, viber) By batdongsan.com.vn Published On :: Thu, 12 Dec 2019 22:56:00 GMT The project with million-dollar canal model and the Marina for all Village apartments - First appeared in Saigon. Call (+84) 968020129 (zalo, viber) Security Villa - The surrounding neighbourhoods are classy like you!- Location: P. Long Phuoc. District 9, TP. HCM. (25 minutes fro... Full Article
from Saigon eco-villas - Priced from 1000-1200$/m2 - Call (+84) 968020129 (zalo, viber) By batdongsan.com.vn Published On :: Thu, 12 Dec 2019 22:59:00 GMT The project with million-dollar canal model and the Marina for all Village apartments - First appeared in Saigon. Call (+84) 968020129 (zalo, viber) Security Villa - The surrounding neighbourhoods are classy like you! - Location: Long Phuoc. District 9, HCMC (25 minutes from... Full Article
from Call now! Saigon eco-villas only from 1000-1200$/m2 - Tel. (+84) 968020129 (zalo, viber) By batdongsan.com.vn Published On :: Thu, 12 Dec 2019 23:02:00 GMT The project with million-dollar canal model and the Marina for all Village apartments - First appeared in Saigon. Call (+84) 968020129 (zalo, viber) Security Villa - The surrounding neighbourhoods are classy like you!- Location: P. Long Phuoc. District 9, TP. HCM. (25 minutes fro... Full Article
from QUY NHON GRAND CENTER PRIME LOCATION ARTERIAL ROAD, PRICE ONLY FROM 38 MILLIONS VND/M2 By batdongsan.com.vn Published On :: Thu, 16 Apr 2020 16:13:00 GMT QUY NHON GRAND CENTER PRIME LOCATION ARTERIAL ROAD, PRICE ONLY FROM 38 million VND/M2 Long-term apartment. Location: + 1 Nguyen Tat Thanh street, Ly Thuong Kiet ward, Quy Nhon city. + Owns four frontage roads: Nguyen Tat Thanh, Ly Thuong Kiet, Ton Duc Thang, and Mai Xuan Thuong. ... Full Article
from Serviced apartments for rent in Phu My Hung, from 9,5 million VND/month By batdongsan.com.vn Published On :: Sat, 04 Jan 2020 10:44:13 GMT Serviced apartments for rent in Hung Gia - Hung Phuoc, Phu My Hung, District 7. Area: 40 m2 (with a kitchen, depending on your needs). Nice, clean, fully furnished Rental from 9,5 million VND/month, including all fees: laundry, room cleaning, water, cable TV, reception 24/24 ...Y... Full Article
from Serviced apartments for rent in Phu My Hung, from 7millions VND/month By batdongsan.com.vn Published On :: Wed, 15 Jan 2020 14:56:31 GMT Serviced apartments for rent in Hung Gia - Hung Phuoc, Phu My Hung, District 7.Design: 1 bedroom, 1 toilet, 1 bathtub. Nice, clean, fully furnished Price: 7 million VND/month, including all fees: laundry, room cleaning (3 times a week), water, cable TV, reception 24/24 ...You onl... Full Article
from Serviced apartments for rent in Phu My Hung, from 7millions to 10 million VND/month By batdongsan.com.vn Published On :: Wed, 15 Jan 2020 14:56:52 GMT Serviced apartment for rent in the center of Phu My Hung area, District 7 Price: 7 - 10 million/month for the size: 30m to 40m One large bedroom, 1 bathroom with bathtub, new house, spacious and breezy Full interior, ready to move in All fee included: Domestic water bill, Cable T... Full Article
from Serviced Room/Studio for rent in Phu My Hung, District 7. Just from 300$/month By batdongsan.com.vn Published On :: Wed, 04 Mar 2020 21:03:03 GMT - Room (studio) with full option, kitchen equipments; - Size: from 25-45sqm; - Rent: from 300$-600$ (depend on size and interior) The rent included: - Cleaning & Laundry 2-3 times/week - High-speed Internet - Satellite TV - Management fee - Security - Water (using/d... Full Article
from Serviced apartments for rent in Phu My Hung, from 9,5 million VND/month By batdongsan.com.vn Published On :: Sat, 02 May 2020 16:17:11 GMT Serviced apartments for rent in Hung Gia - Hung Phuoc, Phu My Hung, District 7. Area: 40 sqm (with a kitchen, depending on your needs). Nice, clean, fully furnished Rental from 9,5 million VND/month, including all fees: laundry, room-cleaning, water, cable TV, reception 24/24 ...... Full Article
from Sắp xếp bàn làm việc trong những ngày "work from home" By batdongsan.com.vn Published On :: 17:45 03/04/2020 Sắp xếp bàn làm việc gọn gàng, ngăn nắp tạo nên không gian tuyệt hảo để chúng ta tập trung hơn trong công việc, hiệu suất lao động nhờ vậy cũng gia tăng đáng kể ngay cả khi đang làm việc tại nhà trong giai đoạn cách ly toàn xã hội. Full Article
from High-class property located right in Phu My Hung, Dist.7 by Keppel Land - from $195,000 for 2BRs By batdongsan.com.vn Published On :: Fri, 08 May 2020 16:27:00 GMT If you have been looking for a luxury, convenient but cozy accommodation, you are right to choose The Infiniti at Riviera Point - A newly developed project of Keppel Land - a leading Singapore developer. Inspired by Hawaii's spectacular landscape, The Infiniti combines the elemen... Full Article
from Private office in CBD Ha Noi, Hai Ba Trung District, Price from 500USD/month By batdongsan.com.vn Published On :: Fri, 21 Feb 2020 10:53:35 GMT Good Location in CBD Hanoi, near Vincom Ba Trieu. A beautifull Luxurious office, professional service in large buildings in the central area with reasonable cost. It's suitable for small-sized companies and foreign representation office. When using serviced offices, now concedes ... Full Article
from Serviced office in CBD of Hanoi, between West lake and Hoan Kiem lake from 200 $/ private room By batdongsan.com.vn Published On :: Fri, 21 Feb 2020 10:56:54 GMT Serviced Office Located in Central of Hanoi, 152 Pho Duc Chinh, Ba Dinh, Hanoi, between Hoan Kiem lake and West Lake, opposite EVN twin tower. 7 minutes to travel to the Financial Area of Hoan Kiem District, HN. A very quiet and professional working space for representation offic... Full Article
from Risks from tax avoidance in real estate transaction By batdongsan.com.vn Published On :: 09:27 29/08/2019 As home sellers commonly propose to state a lower price in the sale contract than the actual transaction value, home buyers have to bear additional risks from such real estate transactions. Full Article
from SAIGON GARDEN RIVERSIDE VILLAGE THE UNIQUE PRODUCT IN DISTRICT 9, PRICE FROM 21 million VND/M By batdongsan.com.vn Published On :: Mon, 04 May 2020 16:42:00 GMT -Location: Long Binh ward, district 9, HCM city. -Price only from 21 million VND/m2. -The house is in the heart of nature, a peaceful place for yourself. -The unique masterpiece in Saigon. ----- HIGHLIGHTS -Landscape channel leading to each villa. -Tennis court and children's pla... Full Article
from Saigon Garden Riverside Villa, District 9 ,HCMC - Lans for sale from 21 mil VND/m2 - 0909235242 By batdongsan.com.vn Published On :: Fri, 06 Dec 2019 16:44:00 GMT Extreme joyful lifestyle at Saigon Garden Riverside Village Escape from the busy city life and back to nature - SAIGON GARDEN VILLA IN DISTRICT 9 Call for booking: 0909235242 ---------------------------------------------- Location: Long Thuan street, Long Phuoc Ward, District 9,... Full Article
from Saigon Garden Riverside Villa, District 9 ,HCMC - Lans for sale from 21 mil VND/m2 - 0973.545.319 By batdongsan.com.vn Published On :: Wed, 11 Dec 2019 23:03:00 GMT Extreme joyful lifestyle at Saigon Garden Riverside Village Escape from the busy city life and back to nature - SAIGON GARDEN VILLA IN DISTRICT 9 Call for booking: 0973.545.319 ---------------------------------------------- Location: Long Thuan street, Long Phuoc Ward, District 9... Full Article
from Saigon Garden Riverside Villa, District 9 ,HCMC - Lans for sale from 21 mil VND/m2 - 0973.545.319 By batdongsan.com.vn Published On :: Wed, 11 Dec 2019 23:04:00 GMT Extreme joyful lifestyle at Saigon Garden Riverside Village Escape from the busy city life and back to nature - SAIGON GARDEN VILLA IN DISTRICT 9 Call for booking: 0973.545.319 ---------------------------------------------- Location: Long Thuan street, Long Phuoc Ward, District 9... Full Article
from Saigon Garden Riverside Villas, District 9, HCMC - Lands for sale from 21-29 mil VND/m2, 0938541596 By batdongsan.com.vn Published On :: Wed, 25 Dec 2019 11:12:00 GMT Extreme joyful lifestyle at Saigon Garden Riverside Village Escape from the busy city life and back to nature - SAIGON GARDEN VILLA IN DISTRICT 9 Call for booking: +84938541596 Ms.Bao Qui Email: qui.nb92@gmail.com ---------------------------------------------- Location: Long Thua... Full Article
from River-nearby Villa land lot, only from 12 million VND/sqm, red book,100% of residence By batdongsan.com.vn Published On :: Mon, 20 Apr 2020 18:11:00 GMT River-nearby Villa land lot, only from 12 million VND/m2, red book, 100% of residence, golf yard of 36 holes BIEN HOA NEWCITY Settlement career - Short-term investments have high profits. Red book of each lot, completed infrastructure, utility Resort. The Golf course has 36 holes... Full Article
from GARDEN VILLAS OF DISTRICT 9 SAIGON GARDEN, PRICE ONLY FROM 21 million VND/M2, DISCOUNT UP TO 18 By batdongsan.com.vn Published On :: Mon, 04 May 2020 16:40:00 GMT -Location: Long Phuoc ward, district 9, Ho Chi Minh city. -Construction unit: Hung Thinh Icons. -Type: Garden villa. -Area: From 1.000 m2/lot. -Utilities: Landscape channel, tennis court Children's playground, marina, clubhouse, green park, etc. -Project legal: Long-term ownershi... Full Article
from GARDEN VILLAS IN SAIGON GARDEN RIVERSIDE VILLAGE, PRICE ONLY FROM 21 million VND/M2 By batdongsan.com.vn Published On :: Mon, 04 May 2020 16:42:00 GMT Project overview: - Location: Long Phuoc ward, district 9, Ho Chi Minh city. - Investor: Sai Gon Garden Resort Property Joint Stock Company. - Scale: 30 ha. - Total lots: 168 lots. - Area: From 1.000 m2/lot. - Type: Garden villa. - Private pool for each villa. - Project legal: Pi... Full Article
from Selling tips from “Queen of Real Estate” Dolly Lenz By batdongsan.com.vn Published On :: 10:27 01/08/2015 With her aggressively successful tactics, mega broker Dolly Lenz has sold over $8.5 billion in premium properties to rich and famous customers. Here are some of her valuable secrets for those looking to sell properties. Full Article
from How to make your listing stand out from the crowd? By batdongsan.com.vn Published On :: 18:46 30/10/2018 Every home seller wants to sell it fast and reach as many buyers as possible. Here are some tips to make your listing stand out to potential buyers from the crowd. Full Article
from 9 mistakes that prevent your listed home from finding buyers By batdongsan.com.vn Published On :: 15:47 07/09/2019 Every seller wants his homes to be sold smoothly and quickly with the highest possible price. However, there are still houses which have been listed on the market for months without any potential buyer because the sellers make one, or maybe more, of the following popular mistakes: Full Article
from Saigon Garden Riverside Village - The home of emotions. From 21 million/sqm. Hotline 0938169445 By batdongsan.com.vn Published On :: Mon, 02 Dec 2019 13:53:00 GMT Saigon Garden Riverside Villas - From 21-28 Million/sqm. Hotline 0938169445 - Location: Long Phuoc Ward, District 9 - Ho Chi Minh City. - Project name: Saigon Garden Riverside Village - Location: Cau Dinh Street, Long Phuoc Ward, District 9, HCM city. - Scale: 30 hectares - Numbe... Full Article
from Saigon Garden Riverside Village - Land for sale by Hung Thinh Co. - From 21 billion for 1000sqm By batdongsan.com.vn Published On :: Mon, 16 Dec 2019 16:38:00 GMT Saigon Garden Riverside Village - Land for sale by Hung Thinh Corporation. Only 21 bil For 1000sqm- Name of Project: Saigon Garden Riverside Village - Location: Long Phuoc Ward, District 9, HCM City - Scale: 30 ha (the most prestigious Compound model in the area). - Quantity: Onl... Full Article
from Saigon Garden Riverside Villa - District 9 - HCMC - Only from 21mil VND/m2 - 0909235242 By batdongsan.com.vn Published On :: Thu, 19 Dec 2019 10:02:45 GMT Extreme joyful lifestyle at Saigon Garden Riverside Village Escape from the busy city life and back to nature - SAIGON GARDEN VILLA IN DISTRICT 9 Call for booking: 0909235242 ---------------------------------------------- Location: Long Thuan street, Long Phuoc Ward, Distric... Full Article
from Saigon Garden Riverside Villas, District 9, HCMC - Lands for sale from 21-29 mil VND/m2, 0938541596 By batdongsan.com.vn Published On :: Fri, 03 Apr 2020 14:35:00 GMT Extreme joyful lifestyle at Saigon Garden Riverside Village Escape from the busy city life and back to nature - SAIGON GARDEN VILLA IN DISTRICT 9 Call for booking: +84938541596 Ms.Bao Qui Email: qui.nb92@gmail.com ---------------------------------------------- Location: Long Thua... Full Article
from GARDEN VILLAS IN SAIGON GARDEN RIVERSIDE VILLAGE, PRICE ONLY FROM 21 MILLION VND/M2, IDEAL RESI By batdongsan.com.vn Published On :: Mon, 04 May 2020 16:41:00 GMT Project overview: -Location: Long Phuoc ward, district 9, Ho Chi Minh city. -Investor: Sai Gon Garden Resort Property Joint Stock Company. -Scale: 30 ha. -Total lots: 168 lots. -Area: From 1.000 m2/lot. -Type: Garden villa. -Private pool for each villa. -Project legal: Pink book ... Full Article
from Learning from Our Mothers: 8 Lessons from the World's Greatest Trainers By feedproxy.google.com Published On :: Sat, 09 May 2020 08:51:03 +0000 We might pride ourselves on our top-notch LMS and training content, and how it can help learners develop as professionals and as people. But let […] The post Learning from Our Mothers: 8 Lessons from the World's Greatest Trainers appeared first on e-Learning Feeds. Full Article LMS Articles
from Ignoring plea from UN, Justin Trudeau refuses to lift sanctions on poor nations during pandemic By feedproxy.google.com Published On :: Fri, 08 May 2020 20:38:28 +0000 Politics in CanadaThese days, any national leader not actively urging their citizens to drink disinfectant is managing to look (relatively) good on the world stage. Certainly, compared to the neurotic leadership south of the border, Justin Trudeau has emerged as a steady hand on the tiller, quickly providing Canadians with a wide economic safety net and behaving like an adult in the crisis. So it's all the more disappointing that, out of the limelight, he's doing a great deal to make the situation worse during this pandemic for some of the most vulnerable people on the planet. I'm referring to the prime minister's decision to ignore a plea last month from United Nations Secretary-General Antonio Guterres -- and the Pope -- for nations to lift sanctions against other nations in order to help some of the weakest and poorest countries cope with the coronavirus crisis. That sounds like a reasonable request, under the circumstances. Indeed, even if we don't care about the world's vulnerable people, helping them deal with the crisis is in our interests too. As the UN leader noted: "Let us remember that we are only as strong as the weakest health system in our interconnected world." Yet Canada, ignoring the plea from the UN's highest official, continues in the midst of the pandemic to impose sanctions on 20 nations, including Lebanon, Venezuela, Syria, Iran, Libya, Somalia, Nicaragua and Yemen. While Canada's sanctions are typically aimed at punishing the regimes running these countries, the impact of the sanctions falls primarily on ordinary citizens, according to Atif Kubursi, professor emeritus of economics at McMaster University. Kubursi, who also served as a UN under-secretary-general and has extensive UN experience in the Middle East and Asia, says the impact of Canada's sanctions on the people in these countries is devastating. While the sanctions often appear to be directed exclusively at military items, they frequently end up being applied to virtually all goods -- including spare parts needed to operate machinery in hospitals and pharmaceutical companies, notes Kubursi, who signed a letter from prominent Canadians to Trudeau requesting the lifting of sanctions. For instance, if a Syrian businessman wants to buy Canadian products, he has to open an account for the transaction. But Kubursi says the Canadian government instructs Canadian banks not to allow such accounts for the purposes of trade with Syria -- no matter how benign the Canadian product may be, or how urgently it might be needed in Syria. For that matter, Ottawa's sanctions prevent Canadians from using our banks or financial services to transfer money to Syria -- for instance, to family members living in Syria. The impact of sanctions, while always painful, is particularly deadly during the pandemic, when even advanced nations have struggled to obtain life-saving equipment. While Canada's sanctions mostly date back to the Harper era or earlier, the Trudeau government has generally maintained them and even added new ones against Venezuela. Ottawa's sanctions appear primarily aimed at appeasing the U.S., which ruthlessly enforces sanctions against regimes it wishes to destabilize or overthrow. Washington also punishes countries and companies that don't co-operate with its sanctions. Ottawa's willingness to fall in line behind Washington is reflected in the fact it doesn't impose sanctions against U.S allies Saudi Arabia or Israel, despite Saudi Arabia's brutal murder of dissident Jamal Khashoggi and Israel's illegal occupation of the West Bank. Even Israel's announcement that it plans to annex the West Bank in July has produced no sanctions or criticism from Canada. Trudeau's decision to continue sanctioning 20 nations seems quite out of sync with the spirit of the times, when it's hard to find a TV commercial that doesn't proclaim the sentiment that "we're all in this together." That spirit of international togetherness has been amply demonstrated by Cuba, which sent Cuban doctors to Italy to help its overwhelmed health care system and has offered similar medical help to First Nations in Canada. When 36 Cuban doctors arrived in Milan last month, a grateful Italy thanked them and Italians at the airport cheered. Meanwhile, Canada, in the spirit of the international togetherness, rebuffs Cuban doctors, ignores the UN and imposes sanctions on some of the world's poorest nations. Linda McQuaig is an author and journalist. This column, which appeared in The Toronto Star, is based on research from her new book The Sport & Prey of Capitalists. Image: CanadianPM/Video Screenshot/Twitter COVID-19Justin TrudeauLinda McQuaigMay 8, 2020Justin Trudeau should lift Canada's economic sanctions nowTrudeau cannot ignore the damage he is doing to the efforts to fight the novel coronavirus in 20 of the world's poorest countries by maintaining sanctions.The fury of the virus, the folly of war"End the sickness of war and fight the disease that is ravaging our world. It starts by stopping the fighting everywhere. Now," United Nations Secretary General António Guterres said on March 23.Pandemic prompts United Nations call for global ceasefireSeventy countries have heeded the UN secretary-general's call to come together to fight COVID-19. If we can give up war during a pandemic, why can't we give it up permanently? Full Article
from Footage of Cancelled Prince of Persia: Redemption from 2012 Discovered By feedproxy.google.com Published On :: Thu, 07 May 2020 17:49:41 GMT A gameplay trailer for a Prince of Persia reboot, called Prince of Persia: Redemption, was posted on YouTube in March 2012 and was discovered this week. The LinkedIn profile for the former Ubisoft employee Christophe Prelot revealed he worked on a cancelled Prince of Persia title from April 2010 to 2011 as a 3D level artist. The game was in development for the PlayStation 3, Xbox 360 and Windows PC. Ubisoft assistant technical director Marc-Andre Belleau in 2018 left a comment on the video asking, "Where did you get that?!" View the video below: Thanks ResetEra. A life-long and avid gamer, William D'Angelo was first introduced to VGChartz in 2007. After years of supporting the site, he was brought on in 2010 as a junior analyst, working his way up to lead analyst in 2012. He has expanded his involvement in the gaming community by producing content on his own YouTube channel and Twitch channel dedicated to gaming Let's Plays and tutorials. You can contact the author at wdangelo@vgchartz.com or on Twitter @TrunksWD.Full Article - https://www.vgchartz.com/article/443408/footage-of-cancelled-prince-of-persia-redemption-from-2012-discovered/ Full Article Analysis Charts Industry
from Deepfake software translates videos from one language to another By www.newscientist.com Published On :: Fri, 24 Jan 2020 11:20:08 +0000 An AI based on deepfake technology can translate videos of a person speaking in one language into another. In future, it could help people who don’t speak the same language communicate Full Article
from US military face recognition system could work from 1 kilometre away By www.newscientist.com Published On :: Sat, 15 Feb 2020 10:00:46 +0000 The US Special Operations Command is developing a portable face-recognition system designed to identify people 1 kilometre away. It could also be used by law enforcement Full Article
